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The map label for this gene is mutT1 [H]

Identifier: 119868007

GI number: 119868007

Start: 2088437

End: 2089372

Strand: Reverse

Name: mutT1 [H]

Synonym: Mkms_1970

Alternate gene names: 119868007

Gene position: 2089372-2088437 (Counterclockwise)

Preceding gene: 119868008

Following gene: 119868003

Centisome position: 36.42

GC content: 69.66

Gene sequence:

>936_bases
TTGTCGAAGACGAAGACGGTGAATGCCGTTGCATCGCCTGCCAAATCCGTGCCCGCCGCCGGTGCGGTGTTGTGGCGGCC
GGGTGGGTCGGCACCCGAGGTCGCCGTCATCCACCGCCCGCGCTACGACGACTGGTCACTGCCCAAGGGCAAGGTCGACC
CCGGGGAGACCGAACCGGTCACCGCCGTGCGTGAGGTGCTCGAGGAGACCGGCTACTCGTGCGTCCTCGGCCGCCGCCTG
GCGTCGGTGAGTTATCCCGTCGAGCAGGGCGTCAAGAAGGTCCGCTACTGGGTCGCCCGCGCCGTCGACGGCACCTTCTC
CCCCAACGACGAAGTAGACGAGTTGATCTGGCTGCCGGTGCGCGAGGCGATGGCCCGGCTGGGCTATCCCCATGATCGGA
AAGTGCTCCGTCGGTTCACGAAGCTGCCGCCCGACACCCGGACGGTGCTCGTCGTGCGGCATGCGACGGCGGGCAGCAAG
TCGCGCTACCGCGGCGACGACCGCATGCGGCCGTTGGACAAGCACGGTCGCGCACAGGCGGAGTCGTTGGTCGGCCAACT
GCTGGCGTTCGGGGCCGACCGCCTCTATGCGGCCGACCGGACCCGCTGTGAGCAGACGATCGCGCCGTTGGCCGAAGAGC
TCGGTCAGCCGGTGCACCCGGAACCGACGCTGACCGAAGAGGCCTACGCCGAGGACAAGAAACCGGCGCGCCTGCGCGTG
CTGGAGATCGCCGCCGAGGCCGGCGCCGCGGAACACACACCGGTGATCTGCTCGCAGGGCAGGGTGATTCCCGACCTGAT
CGAGTGGTGGTGTGACCGCGACGGGGTGCGGCCCGACAAGTCCCGTAACCGCAAGGGCAGTACGTGGGTGCTGTCGCTGG
CCGGGGGGCGCCTGGTCGCCGCCGACCACATCGGCAGCCCACTGGCCCTGAGATAG

Upstream 100 bases:

>100_bases
GCGACCATCAGGTGTCGATGATGCACCGTCATCGGCAGCCGTGACCTGTCGCTTGACACCGGGCCACCCCGCGGGCCCGC
GCTGACCCGCTGGAGTTGAG

Downstream 100 bases:

>100_bases
ACGCCAGAACCGCCGCGGATCGTCATGATCCGCGGCGGTTCGGCGTTTCTCGAACGATTACTTGCGGCCCTTCTTGGCCG
GCGCCTTGCGGGCCGGAGCC

Product: NUDIX hydrolase

Products: CMP; diphosphate [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSKTKTVNAVASPAKSVPAAGAVLWRPGGSAPEVAVIHRPRYDDWSLPKGKVDPGETEPVTAVREVLEETGYSCVLGRRL
ASVSYPVEQGVKKVRYWVARAVDGTFSPNDEVDELIWLPVREAMARLGYPHDRKVLRRFTKLPPDTRTVLVVRHATAGSK
SRYRGDDRMRPLDKHGRAQAESLVGQLLAFGADRLYAADRTRCEQTIAPLAEELGQPVHPEPTLTEEAYAEDKKPARLRV
LEIAAEAGAAEHTPVICSQGRVIPDLIEWWCDRDGVRPDKSRNRKGSTWVLSLAGGRLVAADHIGSPLALR

Sequences:

>Translated_311_residues
MSKTKTVNAVASPAKSVPAAGAVLWRPGGSAPEVAVIHRPRYDDWSLPKGKVDPGETEPVTAVREVLEETGYSCVLGRRL
ASVSYPVEQGVKKVRYWVARAVDGTFSPNDEVDELIWLPVREAMARLGYPHDRKVLRRFTKLPPDTRTVLVVRHATAGSK
SRYRGDDRMRPLDKHGRAQAESLVGQLLAFGADRLYAADRTRCEQTIAPLAEELGQPVHPEPTLTEEAYAEDKKPARLRV
LEIAAEAGAAEHTPVICSQGRVIPDLIEWWCDRDGVRPDKSRNRKGSTWVLSLAGGRLVAADHIGSPLALR
>Mature_310_residues
SKTKTVNAVASPAKSVPAAGAVLWRPGGSAPEVAVIHRPRYDDWSLPKGKVDPGETEPVTAVREVLEETGYSCVLGRRLA
SVSYPVEQGVKKVRYWVARAVDGTFSPNDEVDELIWLPVREAMARLGYPHDRKVLRRFTKLPPDTRTVLVVRHATAGSKS
RYRGDDRMRPLDKHGRAQAESLVGQLLAFGADRLYAADRTRCEQTIAPLAEELGQPVHPEPTLTEEAYAEDKKPARLRVL
EIAAEAGAAEHTPVICSQGRVIPDLIEWWCDRDGVRPDKSRNRKGSTWVLSLAGGRLVAADHIGSPLALR

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX; PF00300 PGAM [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 34227; Mature: 34096

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTKTVNAVASPAKSVPAAGAVLWRPGGSAPEVAVIHRPRYDDWSLPKGKVDPGETEPV
CCCCCCHHHHHCCHHCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHH
TAVREVLEETGYSCVLGRRLASVSYPVEQGVKKVRYWVARAVDGTFSPNDEVDELIWLPV
HHHHHHHHHCCCEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
REAMARLGYPHDRKVLRRFTKLPPDTRTVLVVRHATAGSKSRYRGDDRMRPLDKHGRAQA
HHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHCCCCCCCCCHHHHHHHHH
ESLVGQLLAFGADRLYAADRTRCEQTIAPLAEELGQPVHPEPTLTEEAYAEDKKPARLRV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHH
LEIAAEAGAAEHTPVICSQGRVIPDLIEWWCDRDGVRPDKSRNRKGSTWVLSLAGGRLVA
HHHHHHCCCCCCCCEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEE
ADHIGSPLALR
CCCCCCCCCCC
>Mature Secondary Structure 
SKTKTVNAVASPAKSVPAAGAVLWRPGGSAPEVAVIHRPRYDDWSLPKGKVDPGETEPV
CCCCCHHHHHCCHHCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHH
TAVREVLEETGYSCVLGRRLASVSYPVEQGVKKVRYWVARAVDGTFSPNDEVDELIWLPV
HHHHHHHHHCCCEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
REAMARLGYPHDRKVLRRFTKLPPDTRTVLVVRHATAGSKSRYRGDDRMRPLDKHGRAQA
HHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHCCCCCCCCCHHHHHHHHH
ESLVGQLLAFGADRLYAADRTRCEQTIAPLAEELGQPVHPEPTLTEEAYAEDKKPARLRV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHH
LEIAAEAGAAEHTPVICSQGRVIPDLIEWWCDRDGVRPDKSRNRKGSTWVLSLAGGRLVA
HHHHHHCCCCCCCCEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEE
ADHIGSPLALR
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; H2O [C]

Specific reaction: CTP + H2O = CMP + diphosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]