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The map label for this gene is nuoH [H]

Identifier: 119867643

GI number: 119867643

Start: 1713826

End: 1715076

Strand: Reverse

Name: nuoH [H]

Synonym: Mkms_1597

Alternate gene names: 119867643

Gene position: 1715076-1713826 (Counterclockwise)

Preceding gene: 119867644

Following gene: 119867642

Centisome position: 29.89

GC content: 67.79

Gene sequence:

>1251_bases
GTGATCCACCCCGACCCCACGCTGTTCGGCCACGACCCGTGGTGGCTCATCCTGGCCAAGGCCGTCGGCGTCTTCGTGTT
CCTGGTGCTCACGGTGCTCGCCGCGATCCTGATCGAACGGAAGGTGCTGGGCCGCATGCAGATGCGGTTCGGCCCCAACC
GGGTCGGCCCCAAGGGGCTGTTGCAGTCCCTGGCCGACGGCATCAAGCTCGCGCTCAAGGAGGGCATCACCCCCGCCGGT
GTCGACAAACCGGTCTACCTGCTGGCCCCGGTGATCTCGGTGATCCCGGCGTTCCTCGCGTTCGCGGTGATCCCCATGGG
CGGTGAGGTGTCGGTGTTCGGGCACCGTACGGCGCTGCAGCTGACCGATCTCGCGGTGGCGGTGCTCTACATCCTCGCCG
TCACCTCCGTCGGGGTGTACGGCATCGTGCTCGCGGGCTGGGCGTCCGGGTCGACGTATCCGCTTCTGGGCGGGCTGCGT
TCGAGCGCGCAGGTGGTGTCGTACGAGATCGCGATGGCGCTGTCGTTCGCCACGGTCTTCCTCTACGCCGGCACGATGTC
CACGTCGGGCATCGTCGCCGCTCAGACCTCCACCTGGTACGTCTTCCTGCTGCTGCCGTCGTTCCTGGTGTACGTGACGT
CGATGGTCGGGGAGACCAACCGCGCGCCGTTCGACCTCCCCGAGGCCGAGGGTGAACTGGTGGGCGGTTTCCACACCGAG
TACTCGTCGCTGAAGTTCGCGATGTTCATGCTCGCCGAGTACGTCAACATGACGACGGTCTCGGCGCTGGCCACCACCAT
GTTCCTGGGCGGCTGGCATGCGCCGTGGCCGATCAGCCTGTGGGAAGGCGCCAACAGCGGGTGGTGGCCGCTGCTGTGGT
TCACCGCGAAGGTGTGGGTGTTCCTGTTCGTCTACATCTGGTTGCGGGGCACGCTGCCCCGGCTGCGCTACGACCAGTTC
ATGGCGATCGGGTGGAAGATGCTGATCCCGGTGTCGCTGGCGTGGATCATGATCGTCGCGACCGCCCACAGCCTGCGCAC
CACCGGCCACGGCGGCTGGGCGAGCGGTCTGCTCATCGCAGGCACGGTGCTCACCTTCGGGCTGGCCGTGATCCTATGGC
GCACCATGCGATTCCGGGCCGACCGGACCGTGCCCGCGCGCACCGCCGCGGACGTGTTCCCGATTCCGCCGATACCCGGC
CGTGCGGGCACCGCGCGCACGCCCGAAAGCAGGGAGACGACAGATGCCTAA

Upstream 100 bases:

>100_bases
GGTTACCGCTGAGCTCCCGCGGCTCGCAGGTGCACCGCCAACTCGGTGTGAGCACCGGCGCCATCGTGTCGATCGCCGCG
TCGGGCGGGCGGACGGCGCC

Downstream 100 bases:

>100_bases
GCTGTGGGACGCCGTCGCCGGCTTCGCCGTCACGTTCGGCACGCTGTTCAAGAAACCGATCACCGAGGAGTATCCGGAGA
AACCCGGTCCGGTCGCTCCC

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MIHPDPTLFGHDPWWLILAKAVGVFVFLVLTVLAAILIERKVLGRMQMRFGPNRVGPKGLLQSLADGIKLALKEGITPAG
VDKPVYLLAPVISVIPAFLAFAVIPMGGEVSVFGHRTALQLTDLAVAVLYILAVTSVGVYGIVLAGWASGSTYPLLGGLR
SSAQVVSYEIAMALSFATVFLYAGTMSTSGIVAAQTSTWYVFLLLPSFLVYVTSMVGETNRAPFDLPEAEGELVGGFHTE
YSSLKFAMFMLAEYVNMTTVSALATTMFLGGWHAPWPISLWEGANSGWWPLLWFTAKVWVFLFVYIWLRGTLPRLRYDQF
MAIGWKMLIPVSLAWIMIVATAHSLRTTGHGGWASGLLIAGTVLTFGLAVILWRTMRFRADRTVPARTAADVFPIPPIPG
RAGTARTPESRETTDA

Sequences:

>Translated_416_residues
MIHPDPTLFGHDPWWLILAKAVGVFVFLVLTVLAAILIERKVLGRMQMRFGPNRVGPKGLLQSLADGIKLALKEGITPAG
VDKPVYLLAPVISVIPAFLAFAVIPMGGEVSVFGHRTALQLTDLAVAVLYILAVTSVGVYGIVLAGWASGSTYPLLGGLR
SSAQVVSYEIAMALSFATVFLYAGTMSTSGIVAAQTSTWYVFLLLPSFLVYVTSMVGETNRAPFDLPEAEGELVGGFHTE
YSSLKFAMFMLAEYVNMTTVSALATTMFLGGWHAPWPISLWEGANSGWWPLLWFTAKVWVFLFVYIWLRGTLPRLRYDQF
MAIGWKMLIPVSLAWIMIVATAHSLRTTGHGGWASGLLIAGTVLTFGLAVILWRTMRFRADRTVPARTAADVFPIPPIPG
RAGTARTPESRETTDA
>Mature_416_residues
MIHPDPTLFGHDPWWLILAKAVGVFVFLVLTVLAAILIERKVLGRMQMRFGPNRVGPKGLLQSLADGIKLALKEGITPAG
VDKPVYLLAPVISVIPAFLAFAVIPMGGEVSVFGHRTALQLTDLAVAVLYILAVTSVGVYGIVLAGWASGSTYPLLGGLR
SSAQVVSYEIAMALSFATVFLYAGTMSTSGIVAAQTSTWYVFLLLPSFLVYVTSMVGETNRAPFDLPEAEGELVGGFHTE
YSSLKFAMFMLAEYVNMTTVSALATTMFLGGWHAPWPISLWEGANSGWWPLLWFTAKVWVFLFVYIWLRGTLPRLRYDQF
MAIGWKMLIPVSLAWIMIVATAHSLRTTGHGGWASGLLIAGTVLTFGLAVILWRTMRFRADRTVPARTAADVFPIPPIPG
RAGTARTPESRETTDA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=302, Percent_Identity=38.0794701986755, Blast_Score=203, Evalue=2e-52,
Organism=Escherichia coli, GI1788618, Length=329, Percent_Identity=37.6899696048632, Blast_Score=225, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45260; Mature: 45260

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2 ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHPDPTLFGHDPWWLILAKAVGVFVFLVLTVLAAILIERKVLGRMQMRFGPNRVGPKGL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LQSLADGIKLALKEGITPAGVDKPVYLLAPVISVIPAFLAFAVIPMGGEVSVFGHRTALQ
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHH
LTDLAVAVLYILAVTSVGVYGIVLAGWASGSTYPLLGGLRSSAQVVSYEIAMALSFATVF
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHH
LYAGTMSTSGIVAAQTSTWYVFLLLPSFLVYVTSMVGETNRAPFDLPEAEGELVGGFHTE
HHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCHHHH
YSSLKFAMFMLAEYVNMTTVSALATTMFLGGWHAPWPISLWEGANSGWWPLLWFTAKVWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FLFVYIWLRGTLPRLRYDQFMAIGWKMLIPVSLAWIMIVATAHSLRTTGHGGWASGLLIA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
GTVLTFGLAVILWRTMRFRADRTVPARTAADVFPIPPIPGRAGTARTPESRETTDA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIHPDPTLFGHDPWWLILAKAVGVFVFLVLTVLAAILIERKVLGRMQMRFGPNRVGPKGL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LQSLADGIKLALKEGITPAGVDKPVYLLAPVISVIPAFLAFAVIPMGGEVSVFGHRTALQ
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHH
LTDLAVAVLYILAVTSVGVYGIVLAGWASGSTYPLLGGLRSSAQVVSYEIAMALSFATVF
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHH
LYAGTMSTSGIVAAQTSTWYVFLLLPSFLVYVTSMVGETNRAPFDLPEAEGELVGGFHTE
HHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCHHHH
YSSLKFAMFMLAEYVNMTTVSALATTMFLGGWHAPWPISLWEGANSGWWPLLWFTAKVWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FLFVYIWLRGTLPRLRYDQFMAIGWKMLIPVSLAWIMIVATAHSLRTTGHGGWASGLLIA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
GTVLTFGLAVILWRTMRFRADRTVPARTAADVFPIPPIPGRAGTARTPESRETTDA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA