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The map label for this gene is nuoN [H]

Identifier: 119867634

GI number: 119867634

Start: 1703442

End: 1705016

Strand: Reverse

Name: nuoN [H]

Synonym: Mkms_1588

Alternate gene names: 119867634

Gene position: 1705016-1703442 (Counterclockwise)

Preceding gene: 119867635

Following gene: 119867633

Centisome position: 29.72

GC content: 69.9

Gene sequence:

>1575_bases
GTGATTCCCACTCCTACCGTCGAATACGGTCTGATCTCGCCCATGCTGATCGTGGTGGGCGCCGCGATCGCCGGTGTGCT
CGTCGAGGCGTTCCTGCCCAGGCGCAGCCGTTACGCGGCACAGCTCACGCTCGCGCTCGGCGCCACGGTCGCCGCACTCG
CGGCCGTCGTCGTGGTGAGCCGGCAGATGTCCGGGGAGATCGGCCGGTCCGCCGTGATGGGATCGGTGGTGGTCGACCGG
CCCGCGCTGTTCCTGCAGGGCACCATCCTGCTCGTCGCCGTCCTCGGGATCCTGCTCATCGCGGAACGGCAGATCCCCGC
CGGCACTGAAACCGAGGATGCCGCAGCGGGACTCGACGCGTTCACCCCGCAGGCCTCGGCGGTGCCCGGCAGCGTCGCCG
AGCGGGTGGCCACCCGGGCCGGGGTGGCGCAGACCGAGGTGTTCCCGCTGACCATGTTCGCCGTCGCGGGCATGCTGCTG
TTCCCCGCCTCCGACGACCTGCTGACCATGTTCATCGCGCTCGAGGTGCTCTCGCTGCCGCTGTACCTGCTGTGCGGGCT
GGCCCGGCGGCGGCGCCTGCTCTCCCAGGAGGCCGCGCTCAAGTACTTCCTGCTCGGCGCGTTCTCCTCGGCGTTCTTCC
TCTACGGCATCGCGATGTTGTACGGCTATGCGGGAACGCTCGACCTGCGCGGAATCGCCGCCGTCGTGGCCGAGGACACC
GGTACGACGTCGCTCGCGCTGACCGGCACCGGCCTGATCCTGGTCGGGGTGTTGTTCAAGGTGGGCGCGGCGCCGTTCCA
CTCCTGGATCCCCGACGTGTACCAGGGGGCCCCGACCCCGGTCACCGCGTTCATGGCGGCCGCCACCAAGATCGCCGCGT
TCGGCGCGCTGCTGCGGATCTTCTACGTGGCCCTGCCCGAGCTGCGCGACGACTGGCGCCCGGTGCTGTGGGCGGTCGCG
ATCCTGACCATGGTCGTCGGCACCGTGACCGCGGTGACCCAGACCGATGTGAAGCGGATGCTCGCCTACTCGGCGATCGC
CCACTCGGGGTTCATCCTCACCGGCGTGATCGCCGAGAACCGCCCGGGTCTGTCGTCGGTGCTGTTCTATCTGTTCGCCT
ACGGGTTCTCCACGCTCGGGGCATTCGCCGTGGTCGGCCTGGTGCGCGACGCCAACGGGCAGGAGGATACGGCGATGGCC
CGCTGGGCGGGCCTCGGCCGGCGCAATCCCCTTGTCGGGGCGGTGTTCTCGTTGTTCCTTCTGGCGTTCGCGGGGATCCC
GCTGACCAGCGGCTTCGTCAGCAAGTTCGCGGTGTTCAAGGCGGCGGGCCAGGGCGGTGCGATACCGCTGGTGGTGGTCG
GGGTGATCGCCAGCGCGATCGCGGCCTACTTCTACGTGCGGCTGATCGTGTTGATGTTCTTCACCGATTCGCCCGCCGAC
GCACCGACGGTCGTGGTGCCCAGCGGGCTGACCACCGCGGCCATCACGGTGACCGCCGCGGTGACGCTCGCCCTCGGGGC
GCTGCCGCAGCCACTGCTCGACCTCGCGAACAACGCCGACCTGTTCCTGCGTTAG

Upstream 100 bases:

>100_bases
CGAAACCCGCACTCGACGTGATCGACCCGGCGGTCGGCCACACGCTGACGACCATCAACCAGCCGGACCCGACGCCGAAG
GTCGCAGAGGGGGCCGCCCG

Downstream 100 bases:

>100_bases
CTTGCGTATATGACCTCCCTCGTCCAGGTGGCCGACGTCGACCACGTCCGCCTGCTCACCATGAACCGGCCCGAGGCGCG
AAATGCGCTCAGCCGCGACC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MIPTPTVEYGLISPMLIVVGAAIAGVLVEAFLPRRSRYAAQLTLALGATVAALAAVVVVSRQMSGEIGRSAVMGSVVVDR
PALFLQGTILLVAVLGILLIAERQIPAGTETEDAAAGLDAFTPQASAVPGSVAERVATRAGVAQTEVFPLTMFAVAGMLL
FPASDDLLTMFIALEVLSLPLYLLCGLARRRRLLSQEAALKYFLLGAFSSAFFLYGIAMLYGYAGTLDLRGIAAVVAEDT
GTTSLALTGTGLILVGVLFKVGAAPFHSWIPDVYQGAPTPVTAFMAAATKIAAFGALLRIFYVALPELRDDWRPVLWAVA
ILTMVVGTVTAVTQTDVKRMLAYSAIAHSGFILTGVIAENRPGLSSVLFYLFAYGFSTLGAFAVVGLVRDANGQEDTAMA
RWAGLGRRNPLVGAVFSLFLLAFAGIPLTSGFVSKFAVFKAAGQGGAIPLVVVGVIASAIAAYFYVRLIVLMFFTDSPAD
APTVVVPSGLTTAAITVTAAVTLALGALPQPLLDLANNADLFLR

Sequences:

>Translated_524_residues
MIPTPTVEYGLISPMLIVVGAAIAGVLVEAFLPRRSRYAAQLTLALGATVAALAAVVVVSRQMSGEIGRSAVMGSVVVDR
PALFLQGTILLVAVLGILLIAERQIPAGTETEDAAAGLDAFTPQASAVPGSVAERVATRAGVAQTEVFPLTMFAVAGMLL
FPASDDLLTMFIALEVLSLPLYLLCGLARRRRLLSQEAALKYFLLGAFSSAFFLYGIAMLYGYAGTLDLRGIAAVVAEDT
GTTSLALTGTGLILVGVLFKVGAAPFHSWIPDVYQGAPTPVTAFMAAATKIAAFGALLRIFYVALPELRDDWRPVLWAVA
ILTMVVGTVTAVTQTDVKRMLAYSAIAHSGFILTGVIAENRPGLSSVLFYLFAYGFSTLGAFAVVGLVRDANGQEDTAMA
RWAGLGRRNPLVGAVFSLFLLAFAGIPLTSGFVSKFAVFKAAGQGGAIPLVVVGVIASAIAAYFYVRLIVLMFFTDSPAD
APTVVVPSGLTTAAITVTAAVTLALGALPQPLLDLANNADLFLR
>Mature_524_residues
MIPTPTVEYGLISPMLIVVGAAIAGVLVEAFLPRRSRYAAQLTLALGATVAALAAVVVVSRQMSGEIGRSAVMGSVVVDR
PALFLQGTILLVAVLGILLIAERQIPAGTETEDAAAGLDAFTPQASAVPGSVAERVATRAGVAQTEVFPLTMFAVAGMLL
FPASDDLLTMFIALEVLSLPLYLLCGLARRRRLLSQEAALKYFLLGAFSSAFFLYGIAMLYGYAGTLDLRGIAAVVAEDT
GTTSLALTGTGLILVGVLFKVGAAPFHSWIPDVYQGAPTPVTAFMAAATKIAAFGALLRIFYVALPELRDDWRPVLWAVA
ILTMVVGTVTAVTQTDVKRMLAYSAIAHSGFILTGVIAENRPGLSSVLFYLFAYGFSTLGAFAVVGLVRDANGQEDTAMA
RWAGLGRRNPLVGAVFSLFLLAFAGIPLTSGFVSKFAVFKAAGQGGAIPLVVVGVIASAIAAYFYVRLIVLMFFTDSPAD
APTVVVPSGLTTAAITVTAAVTLALGALPQPLLDLANNADLFLR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=353, Percent_Identity=22.6628895184136, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI251831108, Length=285, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI145693160, Length=379, Percent_Identity=36.4116094986807, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1788614, Length=351, Percent_Identity=26.7806267806268, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788831, Length=318, Percent_Identity=26.7295597484277, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788613, Length=366, Percent_Identity=24.0437158469945, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788827, Length=311, Percent_Identity=25.08038585209, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788829, Length=245, Percent_Identity=30.6122448979592, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54601; Mature: 54601

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPTPTVEYGLISPMLIVVGAAIAGVLVEAFLPRRSRYAAQLTLALGATVAALAAVVVVS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RQMSGEIGRSAVMGSVVVDRPALFLQGTILLVAVLGILLIAERQIPAGTETEDAAAGLDA
HHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCC
FTPQASAVPGSVAERVATRAGVAQTEVFPLTMFAVAGMLLFPASDDLLTMFIALEVLSLP
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LYLLCGLARRRRLLSQEAALKYFLLGAFSSAFFLYGIAMLYGYAGTLDLRGIAAVVAEDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEECCC
GTTSLALTGTGLILVGVLFKVGAAPFHSWIPDVYQGAPTPVTAFMAAATKIAAFGALLRI
CCCEEEECCCHHHHHHHHHHHCCCHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FYVALPELRDDWRPVLWAVAILTMVVGTVTAVTQTDVKRMLAYSAIAHSGFILTGVIAEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
RPGLSSVLFYLFAYGFSTLGAFAVVGLVRDANGQEDTAMARWAGLGRRNPLVGAVFSLFL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHH
LAFAGIPLTSGFVSKFAVFKAAGQGGAIPLVVVGVIASAIAAYFYVRLIVLMFFTDSPAD
HHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
APTVVVPSGLTTAAITVTAAVTLALGALPQPLLDLANNADLFLR
CCEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEC
>Mature Secondary Structure
MIPTPTVEYGLISPMLIVVGAAIAGVLVEAFLPRRSRYAAQLTLALGATVAALAAVVVVS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RQMSGEIGRSAVMGSVVVDRPALFLQGTILLVAVLGILLIAERQIPAGTETEDAAAGLDA
HHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCC
FTPQASAVPGSVAERVATRAGVAQTEVFPLTMFAVAGMLLFPASDDLLTMFIALEVLSLP
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LYLLCGLARRRRLLSQEAALKYFLLGAFSSAFFLYGIAMLYGYAGTLDLRGIAAVVAEDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEECCC
GTTSLALTGTGLILVGVLFKVGAAPFHSWIPDVYQGAPTPVTAFMAAATKIAAFGALLRI
CCCEEEECCCHHHHHHHHHHHCCCHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FYVALPELRDDWRPVLWAVAILTMVVGTVTAVTQTDVKRMLAYSAIAHSGFILTGVIAEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
RPGLSSVLFYLFAYGFSTLGAFAVVGLVRDANGQEDTAMARWAGLGRRNPLVGAVFSLFL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHH
LAFAGIPLTSGFVSKFAVFKAAGQGGAIPLVVVGVIASAIAAYFYVRLIVLMFFTDSPAD
HHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
APTVVVPSGLTTAAITVTAAVTLALGALPQPLLDLANNADLFLR
CCEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA