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The map label for this gene is alsR [H]

Identifier: 119867442

GI number: 119867442

Start: 1496056

End: 1496976

Strand: Direct

Name: alsR [H]

Synonym: Mkms_1392

Alternate gene names: 119867442

Gene position: 1496056-1496976 (Clockwise)

Preceding gene: 119867437

Following gene: 119867443

Centisome position: 26.08

GC content: 70.03

Gene sequence:

>921_bases
ATGGAGCTGCGTCATCTGCGGTATTTCGCCGCCGTCGCCGACACGTGCCACTTCGGCCGGGCCGCGGATCAGCTGCATGT
GGCTCAGCCGGCGCTGTCCTACGCGATCCGGCAACTCGAGGACGAGCTGGGCGTCACCCTTTTCAACAGGACCACGCGGC
AGGTGTCGCTGACCGCGGCGGGGGAGTTCCTGCAGGGTGAGGCGGCCCGAATACTGACCGGGGTCGACGATGCCGTTCGA
GGGGTACGACGCATCGCGGCCGGACGCAGCGGGTTGGTCCGGTTGGGGGTCACTGGCACCGCGGCCTTCTCGCATCTGCC
GCGCATCGCGCGGGTGGTCAGGCGTGAGTTGCCCGATGTCGCCCTCCAGATCCGGGCGGATCTTCTGACGCCCGATCAGT
GCGACGGGTTGCGCAGCGGTGCAATAGATCTCGGCGTGCTTCGCCCGCCGGCGGTGGGGCAGGGCATCGAGTTGCGCACC
ATCGACGTCGAACCGCTCGTGCTCGCCGTCTCGGTGGACCACCGGCTCGCCGTCGAACCGGTCGTCTCACTGGCGGACCT
GCGCAGCGAACCGTTCATCGCCTACGCCAGCCGCCACTCGGCGGTCAACGACGCCGTCGTCCGCAGCTGCCGGCAGGCCG
GTTTCGTTCCGCACCGCGAGCACGAGGCGCCCGGTACCGCGGTCCTGCTCTCGCTCGTCGCCGCGGGCCTCGGAGTGGCC
GTCGTCCCGGGGTCGGTGCGGGCACTTCCCTTGGAAGGGCTCGTGTTCCGCGACCTGTTGGATGCCCAGACCATCGAGTT
GGCGCTGGCCTGGCGCAGCGGCGAGGACGACCCTCTGGTCGAGGCCGTGGTCGGCGTGCTCGCCGCCGCCTTCTCCGTCC
ACGCGATCGCCGATTCGATGCCAACCGGAAGGCCGCTGTGA

Upstream 100 bases:

>100_bases
TCGAAAACAAGTCCTTGTCCGGTATGGATCGCGGCCATACTCTGGGCCGTGGCGCCGGTCACATCCGCCCGGAGCTGTGA
CTTTCAGAATCGAGACACTC

Downstream 100 bases:

>100_bases
AGATCACTCGGGTCGACGCGATCCCGTTCGCCATTCCCTACACCAAACCCCTGAAGTTCGCCTCGGGTGAGGTCACCGAC
GCCGAACACGTTCTGGTGCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MELRHLRYFAAVADTCHFGRAADQLHVAQPALSYAIRQLEDELGVTLFNRTTRQVSLTAAGEFLQGEAARILTGVDDAVR
GVRRIAAGRSGLVRLGVTGTAAFSHLPRIARVVRRELPDVALQIRADLLTPDQCDGLRSGAIDLGVLRPPAVGQGIELRT
IDVEPLVLAVSVDHRLAVEPVVSLADLRSEPFIAYASRHSAVNDAVVRSCRQAGFVPHREHEAPGTAVLLSLVAAGLGVA
VVPGSVRALPLEGLVFRDLLDAQTIELALAWRSGEDDPLVEAVVGVLAAAFSVHAIADSMPTGRPL

Sequences:

>Translated_306_residues
MELRHLRYFAAVADTCHFGRAADQLHVAQPALSYAIRQLEDELGVTLFNRTTRQVSLTAAGEFLQGEAARILTGVDDAVR
GVRRIAAGRSGLVRLGVTGTAAFSHLPRIARVVRRELPDVALQIRADLLTPDQCDGLRSGAIDLGVLRPPAVGQGIELRT
IDVEPLVLAVSVDHRLAVEPVVSLADLRSEPFIAYASRHSAVNDAVVRSCRQAGFVPHREHEAPGTAVLLSLVAAGLGVA
VVPGSVRALPLEGLVFRDLLDAQTIELALAWRSGEDDPLVEAVVGVLAAAFSVHAIADSMPTGRPL
>Mature_306_residues
MELRHLRYFAAVADTCHFGRAADQLHVAQPALSYAIRQLEDELGVTLFNRTTRQVSLTAAGEFLQGEAARILTGVDDAVR
GVRRIAAGRSGLVRLGVTGTAAFSHLPRIARVVRRELPDVALQIRADLLTPDQCDGLRSGAIDLGVLRPPAVGQGIELRT
IDVEPLVLAVSVDHRLAVEPVVSLADLRSEPFIAYASRHSAVNDAVVRSCRQAGFVPHREHEAPGTAVLLSLVAAGLGVA
VVPGSVRALPLEGLVFRDLLDAQTIELALAWRSGEDDPLVEAVVGVLAAAFSVHAIADSMPTGRPL

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=282, Percent_Identity=36.5248226950355, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1788887, Length=289, Percent_Identity=34.2560553633218, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI2367136, Length=294, Percent_Identity=32.6530612244898, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790399, Length=245, Percent_Identity=33.0612244897959, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI157672245, Length=231, Percent_Identity=34.1991341991342, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI145693105, Length=246, Percent_Identity=30.0813008130081, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788748, Length=253, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87081904, Length=184, Percent_Identity=33.695652173913, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790208, Length=303, Percent_Identity=30.03300330033, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788297, Length=249, Percent_Identity=29.3172690763052, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790262, Length=287, Percent_Identity=25.7839721254355, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789639, Length=242, Percent_Identity=25.6198347107438, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787530, Length=262, Percent_Identity=25.9541984732824, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789204, Length=266, Percent_Identity=27.4436090225564, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994962, Length=82, Percent_Identity=43.9024390243902, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786508, Length=202, Percent_Identity=24.7524752475248, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786713, Length=297, Percent_Identity=26.2626262626263, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786448, Length=127, Percent_Identity=36.2204724409449, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787806, Length=293, Percent_Identity=26.962457337884, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786401, Length=120, Percent_Identity=34.1666666666667, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787589, Length=126, Percent_Identity=34.1269841269841, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32541; Mature: 32541

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLRYFAAVADTCHFGRAADQLHVAQPALSYAIRQLEDELGVTLFNRTTRQVSLTAA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEEEEEC
GEFLQGEAARILTGVDDAVRGVRRIAAGRSGLVRLGVTGTAAFSHLPRIARVVRRELPDV
CHHHCCCHHHHHHCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCHH
ALQIRADLLTPDQCDGLRSGAIDLGVLRPPAVGQGIELRTIDVEPLVLAVSVDHRLAVEP
HHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEEEEEECCCCHHHHH
VVSLADLRSEPFIAYASRHSAVNDAVVRSCRQAGFVPHREHEAPGTAVLLSLVAAGLGVA
HHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEE
VVPGSVRALPLEGLVFRDLLDAQTIELALAWRSGEDDPLVEAVVGVLAAAFSVHAIADSM
ECCCCCEEECCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PTGRPL
CCCCCC
>Mature Secondary Structure
MELRHLRYFAAVADTCHFGRAADQLHVAQPALSYAIRQLEDELGVTLFNRTTRQVSLTAA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEEEEEC
GEFLQGEAARILTGVDDAVRGVRRIAAGRSGLVRLGVTGTAAFSHLPRIARVVRRELPDV
CHHHCCCHHHHHHCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCHH
ALQIRADLLTPDQCDGLRSGAIDLGVLRPPAVGQGIELRTIDVEPLVLAVSVDHRLAVEP
HHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEEEEEECCCCHHHHH
VVSLADLRSEPFIAYASRHSAVNDAVVRSCRQAGFVPHREHEAPGTAVLLSLVAAGLGVA
HHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEE
VVPGSVRALPLEGLVFRDLLDAQTIELALAWRSGEDDPLVEAVVGVLAAAFSVHAIADSM
ECCCCCEEECCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PTGRPL
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]