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The map label for this gene is betP [H]

Identifier: 119867424

GI number: 119867424

Start: 1474059

End: 1475807

Strand: Direct

Name: betP [H]

Synonym: Mkms_1374

Alternate gene names: 119867424

Gene position: 1474059-1475807 (Clockwise)

Preceding gene: 119867423

Following gene: 119867425

Centisome position: 25.69

GC content: 67.35

Gene sequence:

>1749_bases
ATGACGGTCAGTTCAGAGAAGGACAACGAGAAACACCGCCGACGCCGCGTCGAGGCAATCAGGTCGCCGACCGACGAGGC
GATCCCGCATCCCATCCTCGACATCCCGGTCGACGAGGAGGCCTACACCGGCTACCGGGGTCTCGACTGGGTGGTCTTCG
GCGTCACCGCCGTCATCGCGGTGGCATTCCTGGCCTGGGGGTTCGTCAGCACCGAGTCGCTGGCCACGGCGTCGGGGAAC
GCCCTGACCTGGGTGATGGACAACACCGGGTGGCTGTTCGTGCTCACCGCGTCGGGATTCGTGGTCTTCGTGCTGTGGCT
GGCGCTCGGCCGCTACGGCAACATCCCGCTCGGCCGTGACGACGAGGAACCCGAGTTCCGCAGCGTCTCGTGGGTCGCGA
TGATGTTCAGCGCAGGCATGGGCATCGGGCTGATGTTCTTCGGTGTGGCCGAGCCGCTGACCCACTTCGCCACCCCGCCG
CCGGGCGTCGTGCCACAGGGCGGTGCCGAGGCCGGTGCCGAGGCCGTCGAGTCCGCGATGGCCACCACGCTGTTCCACTG
GACCCTCCATCCGTGGGCGATCTACGCCGTCGTCGGGCTGGCCATCGCCTACGGCGTCTACCGCAAGGGCCGGCTGCAAC
TGATCAGCGCGGCGTTCGAACCCCTGATCGGATCCCGGGCCAACGGGCCGTGGGGCAAGGTGATCGACATGCTGGCGATC
TTCGCCACGCTGTTCGGGTCGGCGGCCTCACTGGGCTTGGGCGCGTTGCAGATCCGCAGCGGCCTGCAGATCGTCGGCGG
CATCGGCGAGACCGGCAACACGATCCTCATCGTCATCATCACCGCCCTGACGGTCGCGTTCGTGCTGTCGGCCGTCTCGG
GGGTGGCGCGGGGCATTCAGTGGCTGTCGAACATCAACATGGTGCTCGCCCTGCTGCTGGCGTTGTTCATCTTCGTCGTC
GGCCCGACGGTGTTCATCCTCAATCTGTTGCCGACCTCGATGGGCAGCTACCTCGCCGACCTGGCGATGATGTCGGCCCG
CACCGGCGCCGAGGGTCCCGACGTCGACACCTGGCTGCAGTCGTGGACGATCTTCTACTGGGCCTGGTGGATCTCGTGGA
CCCCGTTCGTCGGCATGTTCATCGCCCGCATCTCGCGCGGACGCACCATCCGGCAGTTCGTCACCGGTGTGCTGCTGGTG
CCGAGCCTGGTGTCGCTGGTGTGGTTCTGCATCCTCGGCGGCGCGGCCATCGACACCCAGCAGGGCGGGGTGGATCTGGC
CGGTGAGGGCAGCAACGAGGAGCAGTTGTTCACCCTGCTCGCCCAGTACCCGATCGCGACCGTGGCCAGCATCGTGGTGA
TGGTGCTGGTGGCGATCTTCTTCGTCTCCGGCGCCGACGCCGCGTCGATCGTCATGGGCTCGCTGTCCGAGCGCGGCACG
ATCAAACCCACCCGGGGTGTGGTGATCTTCTGGGGCGTCACGACGGGCGCGGTGGCGGCGGTGATGCTGCTGGTCGGCGG
CGCGGACGCGCTGACCGGTCTGCAGACCATCACGATCATCGCCGCGCTGCCCTTCGTCCTCGTCATGGTGGGGCTGGCGG
TGGCGCTGGTCAAAGACCTGCGCAACGATCCGCTGGTGGTGCGGAAGAAGTACGCCGCGGAGGCGGTGGACAGTGCGGTC
ATCCACGGCGTCATCGAACACGGCGACGACTTCATCATCTCGGTGGAGAAGGATCCCGACGCCAGGTAG

Upstream 100 bases:

>100_bases
GTCGGAGTCTCTCGAGGAACTCCTGGAAGCCGCTCGGTGACCGGATCGTGGCCGACCTGGGATTGACGAGAATCCCTGCG
CGGGTTCTCATGGTCGGACC

Downstream 100 bases:

>100_bases
CTAGTCTCGCGGGATGCGCGTCTACATCCCGGTCACCCTCGCCATGCTCGCCCAGCTCGTCGCCGACCGGTCGCTGCGCG
CCGTGAACGGCACCGCGTTC

Product: choline/carnitine/betaine transporter

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MTVSSEKDNEKHRRRRVEAIRSPTDEAIPHPILDIPVDEEAYTGYRGLDWVVFGVTAVIAVAFLAWGFVSTESLATASGN
ALTWVMDNTGWLFVLTASGFVVFVLWLALGRYGNIPLGRDDEEPEFRSVSWVAMMFSAGMGIGLMFFGVAEPLTHFATPP
PGVVPQGGAEAGAEAVESAMATTLFHWTLHPWAIYAVVGLAIAYGVYRKGRLQLISAAFEPLIGSRANGPWGKVIDMLAI
FATLFGSAASLGLGALQIRSGLQIVGGIGETGNTILIVIITALTVAFVLSAVSGVARGIQWLSNINMVLALLLALFIFVV
GPTVFILNLLPTSMGSYLADLAMMSARTGAEGPDVDTWLQSWTIFYWAWWISWTPFVGMFIARISRGRTIRQFVTGVLLV
PSLVSLVWFCILGGAAIDTQQGGVDLAGEGSNEEQLFTLLAQYPIATVASIVVMVLVAIFFVSGADAASIVMGSLSERGT
IKPTRGVVIFWGVTTGAVAAVMLLVGGADALTGLQTITIIAALPFVLVMVGLAVALVKDLRNDPLVVRKKYAAEAVDSAV
IHGVIEHGDDFIISVEKDPDAR

Sequences:

>Translated_582_residues
MTVSSEKDNEKHRRRRVEAIRSPTDEAIPHPILDIPVDEEAYTGYRGLDWVVFGVTAVIAVAFLAWGFVSTESLATASGN
ALTWVMDNTGWLFVLTASGFVVFVLWLALGRYGNIPLGRDDEEPEFRSVSWVAMMFSAGMGIGLMFFGVAEPLTHFATPP
PGVVPQGGAEAGAEAVESAMATTLFHWTLHPWAIYAVVGLAIAYGVYRKGRLQLISAAFEPLIGSRANGPWGKVIDMLAI
FATLFGSAASLGLGALQIRSGLQIVGGIGETGNTILIVIITALTVAFVLSAVSGVARGIQWLSNINMVLALLLALFIFVV
GPTVFILNLLPTSMGSYLADLAMMSARTGAEGPDVDTWLQSWTIFYWAWWISWTPFVGMFIARISRGRTIRQFVTGVLLV
PSLVSLVWFCILGGAAIDTQQGGVDLAGEGSNEEQLFTLLAQYPIATVASIVVMVLVAIFFVSGADAASIVMGSLSERGT
IKPTRGVVIFWGVTTGAVAAVMLLVGGADALTGLQTITIIAALPFVLVMVGLAVALVKDLRNDPLVVRKKYAAEAVDSAV
IHGVIEHGDDFIISVEKDPDAR
>Mature_581_residues
TVSSEKDNEKHRRRRVEAIRSPTDEAIPHPILDIPVDEEAYTGYRGLDWVVFGVTAVIAVAFLAWGFVSTESLATASGNA
LTWVMDNTGWLFVLTASGFVVFVLWLALGRYGNIPLGRDDEEPEFRSVSWVAMMFSAGMGIGLMFFGVAEPLTHFATPPP
GVVPQGGAEAGAEAVESAMATTLFHWTLHPWAIYAVVGLAIAYGVYRKGRLQLISAAFEPLIGSRANGPWGKVIDMLAIF
ATLFGSAASLGLGALQIRSGLQIVGGIGETGNTILIVIITALTVAFVLSAVSGVARGIQWLSNINMVLALLLALFIFVVG
PTVFILNLLPTSMGSYLADLAMMSARTGAEGPDVDTWLQSWTIFYWAWWISWTPFVGMFIARISRGRTIRQFVTGVLLVP
SLVSLVWFCILGGAAIDTQQGGVDLAGEGSNEEQLFTLLAQYPIATVASIVVMVLVAIFFVSGADAASIVMGSLSERGTI
KPTRGVVIFWGVTTGAVAAVMLLVGGADALTGLQTITIIAALPFVLVMVGLAVALVKDLRNDPLVVRKKYAAEAVDSAVI
HGVIEHGDDFIISVEKDPDAR

Specific function: High-affinity uptake of glycine betaine [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=471, Percent_Identity=38.2165605095541, Blast_Score=324, Evalue=9e-90,
Organism=Escherichia coli, GI1788102, Length=462, Percent_Identity=31.3852813852814, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1786224, Length=498, Percent_Identity=28.714859437751, Blast_Score=172, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 62037; Mature: 61906

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSSEKDNEKHRRRRVEAIRSPTDEAIPHPILDIPVDEEAYTGYRGLDWVVFGVTAVIA
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHCCCCCCCHHHHHHHHHHHH
VAFLAWGFVSTESLATASGNALTWVMDNTGWLFVLTASGFVVFVLWLALGRYGNIPLGRD
HHHHHHHHHCHHHHHCCCCCEEEEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCC
DEEPEFRSVSWVAMMFSAGMGIGLMFFGVAEPLTHFATPPPGVVPQGGAEAGAEAVESAM
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
ATTLFHWTLHPWAIYAVVGLAIAYGVYRKGRLQLISAAFEPLIGSRANGPWGKVIDMLAI
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FATLFGSAASLGLGALQIRSGLQIVGGIGETGNTILIVIITALTVAFVLSAVSGVARGIQ
HHHHHCCHHHHCHHHHHHHCCCCEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
WLSNINMVLALLLALFIFVVGPTVFILNLLPTSMGSYLADLAMMSARTGAEGPDVDTWLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SWTIFYWAWWISWTPFVGMFIARISRGRTIRQFVTGVLLVPSLVSLVWFCILGGAAIDTQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
QGGVDLAGEGSNEEQLFTLLAQYPIATVASIVVMVLVAIFFVSGADAASIVMGSLSERGT
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
IKPTRGVVIFWGVTTGAVAAVMLLVGGADALTGLQTITIIAALPFVLVMVGLAVALVKDL
CCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNDPLVVRKKYAAEAVDSAVIHGVIEHGDDFIISVEKDPDAR
CCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
>Mature Secondary Structure 
TVSSEKDNEKHRRRRVEAIRSPTDEAIPHPILDIPVDEEAYTGYRGLDWVVFGVTAVIA
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHCCCCCCCHHHHHHHHHHHH
VAFLAWGFVSTESLATASGNALTWVMDNTGWLFVLTASGFVVFVLWLALGRYGNIPLGRD
HHHHHHHHHCHHHHHCCCCCEEEEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCC
DEEPEFRSVSWVAMMFSAGMGIGLMFFGVAEPLTHFATPPPGVVPQGGAEAGAEAVESAM
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
ATTLFHWTLHPWAIYAVVGLAIAYGVYRKGRLQLISAAFEPLIGSRANGPWGKVIDMLAI
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FATLFGSAASLGLGALQIRSGLQIVGGIGETGNTILIVIITALTVAFVLSAVSGVARGIQ
HHHHHCCHHHHCHHHHHHHCCCCEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
WLSNINMVLALLLALFIFVVGPTVFILNLLPTSMGSYLADLAMMSARTGAEGPDVDTWLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SWTIFYWAWWISWTPFVGMFIARISRGRTIRQFVTGVLLVPSLVSLVWFCILGGAAIDTQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
QGGVDLAGEGSNEEQLFTLLAQYPIATVASIVVMVLVAIFFVSGADAASIVMGSLSERGT
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
IKPTRGVVIFWGVTTGAVAAVMLLVGGADALTGLQTITIIAALPFVLVMVGLAVALVKDL
CCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNDPLVVRKKYAAEAVDSAVIHGVIEHGDDFIISVEKDPDAR
CCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]