Click here to switch to the map view.

The map label for this gene is mtrB [H]

Identifier: 119867416

GI number: 119867416

Start: 1462457

End: 1464124

Strand: Direct

Name: mtrB [H]

Synonym: Mkms_1366

Alternate gene names: 119867416

Gene position: 1462457-1464124 (Clockwise)

Preceding gene: 119867415

Following gene: 119867417

Centisome position: 25.49

GC content: 69.18

Gene sequence:

>1668_bases
GTGATCTGGGGCGCACGACGGCGGATTCGGGGCGGCTTCTGGCGGTCCGGACCGCTGATCCGCGGCCTCACCGCACTCGG
GCGGGCGCTGAGCCTGGTGTGGCGCCGATCGCTGCAGGTGCGGGTGGTCAGCCTGACGCTGGGGCTCTCACTCGCCGTCA
TCCTCGTGCTCGGCTTCGTGCTGACCAGCCAGATCACCGACCGGATCCTCGAGGTCAAGGTCAAGGCCGCGACCGAGGAG
ATCGAACAGGCCCGCAACACCGTGGGCGGCATCGTCGGCGGCGAGGAGTCCCGCTCACTCGACAGCAGTCTGCAGCTGGC
GAGGAACACGCTGATCGACCGCAAGGCCGACGCGGGAAGCGGACCCGCGGGCGCCTACGACGCCGTGCTCGTCGTACCCG
GTGACGGACCGCGTGCCGCGACCGCCGCGGGGCCGGTCAGCCAGGTGCCGGAGGCGTTGCGCGACTTCGTCAAAGCCGGA
CAGGTCAGCTACCAGTACGCGACCGTCAACGCCGACGGTTTCTCCGGTCCGGCGCTGATCGTCGGCAGCCCGACTGCAAC
GTCCGAGTCGGAAGTGACCAACCTCGAGCTGTACCTGATCTTCCCGCTGAACAACGAGGAGTCGACGATCTCGCTGGTGC
GCGGCACGATGGCCACCGGCGGTGTCGTCCTGCTGGGGTTGTTGGCCGCGATCGCGCTGCTCGTCGCCCGGCAGATCGTG
CTGCCGGTGCGGTCGGCGTCGCGGATCGCCGAGCGGTTCGCCGAGGGACACCTGTCCGAACGTATGCCGGTGCGCGGCGA
GGACGACATGGCCCGGCTGGCGGTTTCCTTCAACGACATGGCCGAGAGCCTGCAGCGCCAGATCACCCAACTCGAGGAGT
TCGGAAACCTGCAGCGGCGCTTCACCTCCGACGTCTCGCACGAGTTGCGCACGCCGTTGACCACGGTCCGCATGGCCGCC
GACCTGATCCACGACCACAGCGACGATCTCGATCCCGCGTTGCGGCGCTCGACCGAGTTGATGGTCAGCGAACTCGACCG
GTTCGAGACACTGCTCAGCGATCTGCTCGAGATCTCCCGGCACGACGCCGGTGTCGCCGAACTGTCGGTGGAGTCGGTGG
ATCTGCGCAGCACGGTGCGCAGCGCCCTGGACAACGTCGGGCACCTCGCCCAGGAGGCGGACATCGAGTTGATCGTCGAC
CAGCCCGCCGAGGAGGTCATCGCCGAGGTGGACCCGCGACGGGTGGAACGCATTCTGCGCAATCTGATCGCCAACGCGAT
CGACCACGCCGAACACAAGCCGGTGCGGATCCGGATGGCCGCCGACGAGGACACCGTCGCCGTCACCGTCCGCGACTACG
GAGTCGGCTTGCGGCCCGGCGAGGAGAAATTGGTGTTCAGCCGGTTCTGGCGGTCGGATCCGTCCCGGGTACGCCGCTCC
GGCGGAACAGGTCTCGGGCTGGCGATCAGCATCGAGGATGCCCGGCTGCACCAGGGCCGGCTCGAGGCCTGGGGGGAGCC
CGGCAACGGGGCCTGCTTCCGGCTGACGCTGCCGCTGGTCCGCGGTCACAAGGTGACGACGAGTCCGCTGCCGCTGAAAC
CGGTTCAGCCCGACCGCAACCCGCGCCGGGGTGGGCGTGAGCGGCAACCGGCGGGGGAGACGGTGTGA

Upstream 100 bases:

>100_bases
GGATACAAGGCCGGACCTCCGTGACGATTCACCGCTCCGCGGTGGCCGTGACGATTCACCGCTCCGCGGTGGCCGTGACC
CTCACCGCTCGGCGGCGGTC

Downstream 100 bases:

>100_bases
GCCGCCTGTGGGCGGTGGTGTGGCTGCTGGTGTTCGCGGTCGCGGCATCGGGGTGTGCGGGAGTGCCGAATTCCTCGGCC
CCGCAGGCGATCGGAACCGT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MIWGARRRIRGGFWRSGPLIRGLTALGRALSLVWRRSLQVRVVSLTLGLSLAVILVLGFVLTSQITDRILEVKVKAATEE
IEQARNTVGGIVGGEESRSLDSSLQLARNTLIDRKADAGSGPAGAYDAVLVVPGDGPRAATAAGPVSQVPEALRDFVKAG
QVSYQYATVNADGFSGPALIVGSPTATSESEVTNLELYLIFPLNNEESTISLVRGTMATGGVVLLGLLAAIALLVARQIV
LPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLQRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAA
DLIHDHSDDLDPALRRSTELMVSELDRFETLLSDLLEISRHDAGVAELSVESVDLRSTVRSALDNVGHLAQEADIELIVD
QPAEEVIAEVDPRRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRS
GGTGLGLAISIEDARLHQGRLEAWGEPGNGACFRLTLPLVRGHKVTTSPLPLKPVQPDRNPRRGGRERQPAGETV

Sequences:

>Translated_555_residues
MIWGARRRIRGGFWRSGPLIRGLTALGRALSLVWRRSLQVRVVSLTLGLSLAVILVLGFVLTSQITDRILEVKVKAATEE
IEQARNTVGGIVGGEESRSLDSSLQLARNTLIDRKADAGSGPAGAYDAVLVVPGDGPRAATAAGPVSQVPEALRDFVKAG
QVSYQYATVNADGFSGPALIVGSPTATSESEVTNLELYLIFPLNNEESTISLVRGTMATGGVVLLGLLAAIALLVARQIV
LPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLQRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAA
DLIHDHSDDLDPALRRSTELMVSELDRFETLLSDLLEISRHDAGVAELSVESVDLRSTVRSALDNVGHLAQEADIELIVD
QPAEEVIAEVDPRRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRS
GGTGLGLAISIEDARLHQGRLEAWGEPGNGACFRLTLPLVRGHKVTTSPLPLKPVQPDRNPRRGGRERQPAGETV
>Mature_555_residues
MIWGARRRIRGGFWRSGPLIRGLTALGRALSLVWRRSLQVRVVSLTLGLSLAVILVLGFVLTSQITDRILEVKVKAATEE
IEQARNTVGGIVGGEESRSLDSSLQLARNTLIDRKADAGSGPAGAYDAVLVVPGDGPRAATAAGPVSQVPEALRDFVKAG
QVSYQYATVNADGFSGPALIVGSPTATSESEVTNLELYLIFPLNNEESTISLVRGTMATGGVVLLGLLAAIALLVARQIV
LPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLQRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAA
DLIHDHSDDLDPALRRSTELMVSELDRFETLLSDLLEISRHDAGVAELSVESVDLRSTVRSALDNVGHLAQEADIELIVD
QPAEEVIAEVDPRRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRS
GGTGLGLAISIEDARLHQGRLEAWGEPGNGACFRLTLPLVRGHKVTTSPLPLKPVQPDRNPRRGGRERQPAGETV

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=330, Percent_Identity=30, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788393, Length=286, Percent_Identity=28.3216783216783, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1787894, Length=302, Percent_Identity=28.8079470198675, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI87081816, Length=443, Percent_Identity=26.410835214447, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786783, Length=348, Percent_Identity=26.7241379310345, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1786912, Length=325, Percent_Identity=28.9230769230769, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789149, Length=341, Percent_Identity=25.2199413489736, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=28.936170212766, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=28.4552845528455, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI87082128, Length=307, Percent_Identity=26.3843648208469, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=25.7383966244726, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788549, Length=249, Percent_Identity=27.3092369477912, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=247, Percent_Identity=27.9352226720648, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=26.0089686098655, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789403, Length=225, Percent_Identity=31.1111111111111, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1790551, Length=306, Percent_Identity=24.1830065359477, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI48994928, Length=228, Percent_Identity=27.1929824561404, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790861, Length=281, Percent_Identity=25.6227758007117, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=259, Percent_Identity=24.7104247104247, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 60380; Mature: 60380

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIWGARRRIRGGFWRSGPLIRGLTALGRALSLVWRRSLQVRVVSLTLGLSLAVILVLGFV
CCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHH
LTSQITDRILEVKVKAATEEIEQARNTVGGIVGGEESRSLDSSLQLARNTLIDRKADAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
GPAGAYDAVLVVPGDGPRAATAAGPVSQVPEALRDFVKAGQVSYQYATVNADGFSGPALI
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEE
VGSPTATSESEVTNLELYLIFPLNNEESTISLVRGTMATGGVVLLGLLAAIALLVARQIV
EECCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLQRQITQLEEFGNLQRR
HHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTSDVSHELRTPLTTVRMAADLIHDHSDDLDPALRRSTELMVSELDRFETLLSDLLEISR
HHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDAGVAELSVESVDLRSTVRSALDNVGHLAQEADIELIVDQPAEEVIAEVDPRRVERILR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHCCCHHHHHHHHH
NLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRS
HHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHC
GGTGLGLAISIEDARLHQGRLEAWGEPGNGACFRLTLPLVRGHKVTTSPLPLKPVQPDRN
CCCCEEEEEEECHHHHHCCHHHCCCCCCCCCEEEEEEEHHCCCEEECCCCCCCCCCCCCC
PRRGGRERQPAGETV
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MIWGARRRIRGGFWRSGPLIRGLTALGRALSLVWRRSLQVRVVSLTLGLSLAVILVLGFV
CCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHH
LTSQITDRILEVKVKAATEEIEQARNTVGGIVGGEESRSLDSSLQLARNTLIDRKADAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
GPAGAYDAVLVVPGDGPRAATAAGPVSQVPEALRDFVKAGQVSYQYATVNADGFSGPALI
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEE
VGSPTATSESEVTNLELYLIFPLNNEESTISLVRGTMATGGVVLLGLLAAIALLVARQIV
EECCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLQRQITQLEEFGNLQRR
HHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTSDVSHELRTPLTTVRMAADLIHDHSDDLDPALRRSTELMVSELDRFETLLSDLLEISR
HHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDAGVAELSVESVDLRSTVRSALDNVGHLAQEADIELIVDQPAEEVIAEVDPRRVERILR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHCCCHHHHHHHHH
NLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRS
HHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHC
GGTGLGLAISIEDARLHQGRLEAWGEPGNGACFRLTLPLVRGHKVTTSPLPLKPVQPDRN
CCCCEEEEEEECHHHHHCCHHHCCCCCCCCCEEEEEEEHHCCCEEECCCCCCCCCCCCCC
PRRGGRERQPAGETV
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA