Click here to switch to the map view.

The map label for this gene is tmk [H]

Identifier: 119867414

GI number: 119867414

Start: 1460946

End: 1461635

Strand: Direct

Name: tmk [H]

Synonym: Mkms_1364

Alternate gene names: 119867414

Gene position: 1460946-1461635 (Clockwise)

Preceding gene: 119867409

Following gene: 119867415

Centisome position: 25.46

GC content: 71.45

Gene sequence:

>690_bases
ATGCACCAGTTTGCGCCCGGGACGGATCCGGCCGCCGGACGCGGTTACGCTCACCGCGTGCTCATCGCGATCGAAGGTGT
CGACGGCGCAGGCAAGCGCACCCTGACCACCGGCATGCGGGCCGCCTTCGAAGGTGCCGGGCGGTCGGTCGCGACGCTGG
CCTTTCCGCGTTACCACCGGTCGGTCACCGCCGACCTGGCGGCGGAAGCCCTTCACGGCAGACACGGCGACCTCGCCGAG
TCGGTCTATGCGATGGCGGTGTTGTTCGCACTCGACCGTGCCGACGCTCGCGACGAGATCGCACACCTCGCCGCCGCCCA
CGACGTGGTGATCCTGGACCGCTACGTCGCCTCCAACGCCGCCTACAGCGCCGCACGTCTACACCAGTCCGCCGACGGGG
AGGCGGTCGAGTGGGTGAGGTCGCTCGAGTACGACCGACTGGGCCTACCGGCCGCCGACTGGCAGATCCTGCTCGACGTG
CCGACTGCGCTGGCCGCCGAACGGGCCGAACGCCGCGCCGAACAGGAGGCCGACCGCGCCCGCGACGCCTACGAGCGTGA
CGACGGTCTGCAGCGGCGAACCGGCGAGGTGTACCAAGCGCTGGCCGCAACCGACTGGTGCGGGCGCTGGATCGTGGCCG
GACCCGACGTCGACGCGGCGGCGCTGGCCGACGGATTGACCGCTTCCTGA

Upstream 100 bases:

>100_bases
GGTGACGAGGACGGGCGCCGAGCGGCAGTGGACGCAGTGCCCCCCACCAGCAAACTCCCGACCAGCCGGGTAAAGCCTAT
CGGCGTTCGAGGGCGGTCCG

Downstream 100 bases:

>100_bases
GGTCAACCGGAGAAACGCCCTGCGTGGTAGCCGGGTTTTATCGCGATCTGGTGACACCATGGACTCCATGAGGCAAAGGA
TTCTGGTCGTCGATGACGAT

Product: thymidylate kinase

Products: NA

Alternate protein names: Thymidine monophosphate kinase; dTMP kinase; TMPK [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MHQFAPGTDPAAGRGYAHRVLIAIEGVDGAGKRTLTTGMRAAFEGAGRSVATLAFPRYHRSVTADLAAEALHGRHGDLAE
SVYAMAVLFALDRADARDEIAHLAAAHDVVILDRYVASNAAYSAARLHQSADGEAVEWVRSLEYDRLGLPAADWQILLDV
PTALAAERAERRAEQEADRARDAYERDDGLQRRTGEVYQALAATDWCGRWIVAGPDVDAAALADGLTAS

Sequences:

>Translated_229_residues
MHQFAPGTDPAAGRGYAHRVLIAIEGVDGAGKRTLTTGMRAAFEGAGRSVATLAFPRYHRSVTADLAAEALHGRHGDLAE
SVYAMAVLFALDRADARDEIAHLAAAHDVVILDRYVASNAAYSAARLHQSADGEAVEWVRSLEYDRLGLPAADWQILLDV
PTALAAERAERRAEQEADRARDAYERDDGLQRRTGEVYQALAATDWCGRWIVAGPDVDAAALADGLTAS
>Mature_229_residues
MHQFAPGTDPAAGRGYAHRVLIAIEGVDGAGKRTLTTGMRAAFEGAGRSVATLAFPRYHRSVTADLAAEALHGRHGDLAE
SVYAMAVLFALDRADARDEIAHLAAAHDVVILDRYVASNAAYSAARLHQSADGEAVEWVRSLEYDRLGLPAADWQILLDV
PTALAAERAERRAEQEADRARDAYERDDGLQRRTGEVYQALAATDWCGRWIVAGPDVDAAALADGLTAS

Specific function: Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 24563; Mature: 24563

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQFAPGTDPAAGRGYAHRVLIAIEGVDGAGKRTLTTGMRAAFEGAGRSVATLAFPRYHR
CCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHH
SVTADLAAEALHGRHGDLAESVYAMAVLFALDRADARDEIAHLAAAHDVVILDRYVASNA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYSAARLHQSADGEAVEWVRSLEYDRLGLPAADWQILLDVPTALAAERAERRAEQEADRA
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
RDAYERDDGLQRRTGEVYQALAATDWCGRWIVAGPDVDAAALADGLTAS
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCCC
>Mature Secondary Structure
MHQFAPGTDPAAGRGYAHRVLIAIEGVDGAGKRTLTTGMRAAFEGAGRSVATLAFPRYHR
CCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHH
SVTADLAAEALHGRHGDLAESVYAMAVLFALDRADARDEIAHLAAAHDVVILDRYVASNA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYSAARLHQSADGEAVEWVRSLEYDRLGLPAADWQILLDVPTALAAERAERRAEQEADRA
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
RDAYERDDGLQRRTGEVYQALAATDWCGRWIVAGPDVDAAALADGLTAS
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 11369858; 10666613; 11469859; 11914484; 12454011; 12662932 [H]