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The map label for this gene is manA [H]

Identifier: 119867397

GI number: 119867397

Start: 1441000

End: 1442229

Strand: Direct

Name: manA [H]

Synonym: Mkms_1347

Alternate gene names: 119867397

Gene position: 1441000-1442229 (Clockwise)

Preceding gene: 119867396

Following gene: 119867399

Centisome position: 25.12

GC content: 69.02

Gene sequence:

>1230_bases
GTGCATCTGCTGAGGGGAGCAGTGCGGACCTACGCCTGGGGTTCGCGGACGGCGATTGCCGATTTCACCGGAAGGCCAAG
TCCCACACCACATCCGGAGGCCGAACTGTGGTTCGGTGCGCATCCCGGTGATCCGGCGTATCTGCAGGGCGAAGCCGGTG
AGGTCTCGTTGCTCGAGGCGCTGCGCGCCGACCCCGCCGGCCAGTTGGGTGCCGCGGTCGTGGACCGGTTCGGCGAGACG
CTGCCGTTTCTGGTGAAGGTGCTCGCGGCCGACGAGCCGTTGTCGCTGCAGGCCCACCCGAGTGCGCAGCAGGCCGCCGA
GGGCTACGACCGCGAGGAGCGCCTCGGCATCCCGGTGTCGGCGCCGATGCGCAACTACCGCGACCGCAGCCACAAACCCG
AGTTGCTGGTCGCGCTCGACCGGTTCGAGGCGCTGGCCGGGTTCCGTCCGGTCGCGCGCACCGTCGACCTGATGCGCGCG
CTCGGGGTGCCCGAACTGGACCCGTTCGTCAACCTCCTGCACGGGCAGTCCGAACCCGACGGTCTGCGCGCGTTGTTCAC
CACGTGGATCACCGCACCCCAGCCGGATCTCGACGTGCTGGTGCCCGCCGTGCTCGACGGTGCGATCGATTACATCCGCG
CCGGGCAGACTGAATTCGAGGCCGAGGTCAAGACGGTGCTGGAACTCGGCGAACGCTATCCCGGGGACGCCGGCGTGCTG
GCGGCAATGCTGCTCAATCGCATCACGCTGAGTCCGGGGGAGGGGATCTACCTGCCCGCCGGGAATCTGCACGCCTATCT
GCACGGTGTGGGTGTGGAGGTGATGGCCAACTCCGACAACGTTTTACGCGGGGGGTTGACGCCCAAGCACGTCGACGTCC
CCGAACTCCTGCGGGTGCTCGACTTCACGCCGACCCCCGACCTCGTGCTGCGTCCCGAAACCGCCAGGGAAGGAATCGAG
TTCGAGTACAGGACCCCGGCGCCGGAGTTCGCGGTGTCGGTGCTGCGACTCGACGGTGACAACGTCGGCCACGAACTGGA
CGCGCCGTCGCCCCACGACGGACCGCAGGTGCTGGTCTGCACCGAGGGCTGCGCGGAGGTCCGCGCGAAAGGCGGCGACG
TGCTGACACTGCCGCGAGGTGCGGCGGGCTGGGTGACCGCCGACGACGGCCCGATTCAGTTGCTCGCCGCAGTGCCGACG
ACGGTCTTCCGCGTCACCGTCGGGATCTAG

Upstream 100 bases:

>100_bases
GCTGCGGCCGGCGGCAGGGGGATGGAACAGCAATTGGCGAAATTGGCGGTGCGGCTGGAGATGACCGCGGTCTATCTGCG
ACTGGTTCGAGGTTGATCGA

Downstream 100 bases:

>100_bases
CGAGCGGTCTCACCGGCTCCCGACGAGTTCGCGGTCGTGCCCACGGCGGTGGGCGGCCCGTTTCTCCGCCAGCCACAACC
GCATGTTGTGGCCGATGGTG

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MHLLRGAVRTYAWGSRTAIADFTGRPSPTPHPEAELWFGAHPGDPAYLQGEAGEVSLLEALRADPAGQLGAAVVDRFGET
LPFLVKVLAADEPLSLQAHPSAQQAAEGYDREERLGIPVSAPMRNYRDRSHKPELLVALDRFEALAGFRPVARTVDLMRA
LGVPELDPFVNLLHGQSEPDGLRALFTTWITAPQPDLDVLVPAVLDGAIDYIRAGQTEFEAEVKTVLELGERYPGDAGVL
AAMLLNRITLSPGEGIYLPAGNLHAYLHGVGVEVMANSDNVLRGGLTPKHVDVPELLRVLDFTPTPDLVLRPETAREGIE
FEYRTPAPEFAVSVLRLDGDNVGHELDAPSPHDGPQVLVCTEGCAEVRAKGGDVLTLPRGAAGWVTADDGPIQLLAAVPT
TVFRVTVGI

Sequences:

>Translated_409_residues
MHLLRGAVRTYAWGSRTAIADFTGRPSPTPHPEAELWFGAHPGDPAYLQGEAGEVSLLEALRADPAGQLGAAVVDRFGET
LPFLVKVLAADEPLSLQAHPSAQQAAEGYDREERLGIPVSAPMRNYRDRSHKPELLVALDRFEALAGFRPVARTVDLMRA
LGVPELDPFVNLLHGQSEPDGLRALFTTWITAPQPDLDVLVPAVLDGAIDYIRAGQTEFEAEVKTVLELGERYPGDAGVL
AAMLLNRITLSPGEGIYLPAGNLHAYLHGVGVEVMANSDNVLRGGLTPKHVDVPELLRVLDFTPTPDLVLRPETAREGIE
FEYRTPAPEFAVSVLRLDGDNVGHELDAPSPHDGPQVLVCTEGCAEVRAKGGDVLTLPRGAAGWVTADDGPIQLLAAVPT
TVFRVTVGI
>Mature_409_residues
MHLLRGAVRTYAWGSRTAIADFTGRPSPTPHPEAELWFGAHPGDPAYLQGEAGEVSLLEALRADPAGQLGAAVVDRFGET
LPFLVKVLAADEPLSLQAHPSAQQAAEGYDREERLGIPVSAPMRNYRDRSHKPELLVALDRFEALAGFRPVARTVDLMRA
LGVPELDPFVNLLHGQSEPDGLRALFTTWITAPQPDLDVLVPAVLDGAIDYIRAGQTEFEAEVKTVLELGERYPGDAGVL
AAMLLNRITLSPGEGIYLPAGNLHAYLHGVGVEVMANSDNVLRGGLTPKHVDVPELLRVLDFTPTPDLVLRPETAREGIE
FEYRTPAPEFAVSVLRLDGDNVGHELDAPSPHDGPQVLVCTEGCAEVRAKGGDVLTLPRGAAGWVTADDGPIQLLAAVPT
TVFRVTVGI

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=387, Percent_Identity=33.5917312661499, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1787899, Length=393, Percent_Identity=37.9134860050891, Blast_Score=251, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17557650, Length=423, Percent_Identity=26.7139479905437, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71997620, Length=318, Percent_Identity=31.7610062893082, Blast_Score=134, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6320839, Length=415, Percent_Identity=29.3975903614458, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21356061, Length=318, Percent_Identity=32.0754716981132, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 43877; Mature: 43877

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLLRGAVRTYAWGSRTAIADFTGRPSPTPHPEAELWFGAHPGDPAYLQGEAGEVSLLEA
CCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCEEECCCCCHHHHHH
LRADPAGQLGAAVVDRFGETLPFLVKVLAADEPLSLQAHPSAQQAAEGYDREERLGIPVS
HHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCEECCCCHHHHHHCCCCHHHCCCCCC
APMRNYRDRSHKPELLVALDRFEALAGFRPVARTVDLMRALGVPELDPFVNLLHGQSEPD
CHHHHHHCCCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCH
GLRALFTTWITAPQPDLDVLVPAVLDGAIDYIRAGQTEFEAEVKTVLELGERYPGDAGVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHH
AAMLLNRITLSPGEGIYLPAGNLHAYLHGVGVEVMANSDNVLRGGLTPKHVDVPELLRVL
HHHHHHHHCCCCCCEEEECCCCCEEEEEECCEEEEECCCCEEECCCCCCCCCHHHHHHHH
DFTPTPDLVLRPETAREGIEFEYRTPAPEFAVSVLRLDGDNVGHELDAPSPHDGPQVLVC
CCCCCCCEEECCHHHHCCCCEEECCCCHHHEEEEEEECCCCCCCCCCCCCCCCCCEEEEE
TEGCAEVRAKGGDVLTLPRGAAGWVTADDGPIQLLAAVPTTVFRVTVGI
CCCHHHHHHCCCCEEEECCCCCCCEECCCCCEEEEECCCCEEEEEEECC
>Mature Secondary Structure
MHLLRGAVRTYAWGSRTAIADFTGRPSPTPHPEAELWFGAHPGDPAYLQGEAGEVSLLEA
CCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCEEECCCCCHHHHHH
LRADPAGQLGAAVVDRFGETLPFLVKVLAADEPLSLQAHPSAQQAAEGYDREERLGIPVS
HHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCEECCCCHHHHHHCCCCHHHCCCCCC
APMRNYRDRSHKPELLVALDRFEALAGFRPVARTVDLMRALGVPELDPFVNLLHGQSEPD
CHHHHHHCCCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCH
GLRALFTTWITAPQPDLDVLVPAVLDGAIDYIRAGQTEFEAEVKTVLELGERYPGDAGVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHH
AAMLLNRITLSPGEGIYLPAGNLHAYLHGVGVEVMANSDNVLRGGLTPKHVDVPELLRVL
HHHHHHHHCCCCCCEEEECCCCCEEEEEECCEEEEECCCCEEECCCCCCCCCHHHHHHHH
DFTPTPDLVLRPETAREGIEFEYRTPAPEFAVSVLRLDGDNVGHELDAPSPHDGPQVLVC
CCCCCCCEEECCHHHHCCCCEEECCCCHHHEEEEEEECCCCCCCCCCCCCCCCCCEEEEE
TEGCAEVRAKGGDVLTLPRGAAGWVTADDGPIQLLAAVPTTVFRVTVGI
CCCHHHHHHCCCCEEEECCCCCCCEECCCCCEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6397402; 9097039; 9278503 [H]