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The map label for this gene is bccA [H]

Identifier: 119867356

GI number: 119867356

Start: 1397868

End: 1399676

Strand: Reverse

Name: bccA [H]

Synonym: Mkms_1306

Alternate gene names: 119867356

Gene position: 1399676-1397868 (Counterclockwise)

Preceding gene: 119867357

Following gene: 119867354

Centisome position: 24.4

GC content: 69.6

Gene sequence:

>1809_bases
GTGGCCAGTCACGCCAGCTCGAAGATCTCCAAGGTGCTTGTCGCCAACCGAGGAGAGATTGCCGTCCGGGTCATCCGCGC
GGCCAAGGACGCCGGGCTGCAGAGCGTGGCCGTCTATGCCGAACCCGACGCCGACGCCCCGCACGTGCGGCTCGCGGACG
AGGCCTTCGCGCTGGGTGGTCAGACCTCGGCCGAGTCGTACCTCGTGTTCGAGAAGCTGCTCGACGCGGCGGAGAAGTCC
GGCGCAAACGCGATCCACCCGGGATACGGCTTCCTGAGCGAGAACGCCGACTTCGCGCAGGCCGTCATCGACGCAGGGCT
GATCTGGATCGGCCCGAGCCCGCAGTCGATCCGCGACCTCGGCGACAAGGTGACCGCCCGTCACATCGCCGCACGCGCAC
AGGCGCCCCTGGTCCCCGGCACGCCGGACCCGGTCAAGGACGCCGACGAGGTGGTCGCGTTCGCCGAGGAGTACGGCGTC
CCGGTCGCGATCAAGGCCGCGTTCGGCGGCGGCGGTCGCGGCATGAAGGTGGCGCGCACCATCCAGGAGATTCCCGAGCT
GTTCGATTCGGCCACCCGTGAGGCCGTGGCCGCGTTCGGCCGCGGTGAGTGCTTCGTCGAGCGCTACCTCGACAAGCCGC
GCCACGTCGAGGCGCAGGTGATCGCCGATCAGCACGGCAACGTCGTCGTCGCGGGCACCCGCGACTGCTCGCTGCAACGC
CGCTTCCAGAAGCTGGTGGAGGAGGCCCCCGCGCCGTTCCTGACCGACGCGCAGCGCAAGGAGATCCACGAGTCGGCCAA
GCGGATCTGCAAGGAGGCCGGCTACTACGGTGCGGGCACCGTGGAGTACCTGGTGGGCCAGGACGGCCTGATCTCGTTCC
TCGAGGTGAACACCCGCCTGCAGGTGGAGCATCCGGTCACCGAGGAGACCTCGGGCATCGACCTGGTCCGCCAGCAGTTC
CGGATCGCCAACGGTGAGCCCCTCGACATCACCGAGGACCCGACACCGCGCGGACACTCGATCGAGTTCCGCATCAACGG
TGAGGACGCCGGGCGCGGCTTCCTGCCCGCCCCAGGCCCCGTCACCACGTTCGAACCGCCCACCGGTCCCGGCGTCCGCC
TGGACTCCGGTGTGGAGTCCGGATCGGTGATCGGCGGTCAGTTCGACTCGATGCTGGCCAAGCTGATCGTCACCGGCGCC
ACCCGCGAGGAGGCGCTGGAGCGCTCACGGCGTGCACTGGCGGAGTTCAAGGTCGAAGGACTCGCCACGGTCATCCCGTT
CCACCGCGCGGTGGTCAGCGATCCCGCCTTCATCGGCGACGAGAACGGCTTCACGGTGCACACCCGGTGGATCGAGACCG
AGTGGGACAACACCATCGAACCGTTCACCGGTGGCGACCCGATCGACGAAGAGGACACCGCACCGCGCCAGACCGTGGTC
GTTGAGGTCGGCGGCCGGCGTCTCGAGGTCTCGCTGCCGGGCGATCTGGTCCTCGGCAACGGTGGCGGCGCCGCCCCTGC
GGGCGTGATCCGCAAGAAGCCGAAGCCGCGTAAGCGCGGTGCGCACGGCGGTGCGGCGACGTCCGGCGACTCGGTGACAG
CGCCCATGCAGGGCACCGTCGTCAAGGTGGCCGTCGAAGAGGGCCAGCAGGTGTCCGCCGGCGATCTGGTCGTGGTCCTC
GAGGCCATGAAGATGGAGAACCCGGTGACCGCCCACAAGGACGGCACCATCACCGGACTCGCGGTCGAGGCGGGCGCCGC
TGTCACCCAGGGCACCGTGCTGGCCGAGATCAAGAGCGACGGCGAGTAA

Upstream 100 bases:

>100_bases
CCGGTTACCGACCGCCTCAGGGGCGACGCTTAAACTCCCCCATTAGTTTCTCAAGACGTTCTTAAGTGAGTGCCCGAAAG
GCATATCAGCAGGAGGCGAA

Downstream 100 bases:

>100_bases
CCCTTCCGCTTTACCCCCGGCGCAGTCGGTTCGGCCCAGGTCGAACCGACTGCGCCGGGTTTTTTGTGCCGCTCGGCGGG
CCCCGACCGCGGTCCGGTGC

Product: carbamoyl-phosphate synthase L chain, ATP-binding

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MASHASSKISKVLVANRGEIAVRVIRAAKDAGLQSVAVYAEPDADAPHVRLADEAFALGGQTSAESYLVFEKLLDAAEKS
GANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAEEYGV
PVAIKAAFGGGGRGMKVARTIQEIPELFDSATREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQR
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAGYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETSGIDLVRQQF
RIANGEPLDITEDPTPRGHSIEFRINGEDAGRGFLPAPGPVTTFEPPTGPGVRLDSGVESGSVIGGQFDSMLAKLIVTGA
TREEALERSRRALAEFKVEGLATVIPFHRAVVSDPAFIGDENGFTVHTRWIETEWDNTIEPFTGGDPIDEEDTAPRQTVV
VEVGGRRLEVSLPGDLVLGNGGGAAPAGVIRKKPKPRKRGAHGGAATSGDSVTAPMQGTVVKVAVEEGQQVSAGDLVVVL
EAMKMENPVTAHKDGTITGLAVEAGAAVTQGTVLAEIKSDGE

Sequences:

>Translated_602_residues
MASHASSKISKVLVANRGEIAVRVIRAAKDAGLQSVAVYAEPDADAPHVRLADEAFALGGQTSAESYLVFEKLLDAAEKS
GANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAEEYGV
PVAIKAAFGGGGRGMKVARTIQEIPELFDSATREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQR
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAGYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETSGIDLVRQQF
RIANGEPLDITEDPTPRGHSIEFRINGEDAGRGFLPAPGPVTTFEPPTGPGVRLDSGVESGSVIGGQFDSMLAKLIVTGA
TREEALERSRRALAEFKVEGLATVIPFHRAVVSDPAFIGDENGFTVHTRWIETEWDNTIEPFTGGDPIDEEDTAPRQTVV
VEVGGRRLEVSLPGDLVLGNGGGAAPAGVIRKKPKPRKRGAHGGAATSGDSVTAPMQGTVVKVAVEEGQQVSAGDLVVVL
EAMKMENPVTAHKDGTITGLAVEAGAAVTQGTVLAEIKSDGE
>Mature_601_residues
ASHASSKISKVLVANRGEIAVRVIRAAKDAGLQSVAVYAEPDADAPHVRLADEAFALGGQTSAESYLVFEKLLDAAEKSG
ANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAEEYGVP
VAIKAAFGGGGRGMKVARTIQEIPELFDSATREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRR
FQKLVEEAPAPFLTDAQRKEIHESAKRICKEAGYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETSGIDLVRQQFR
IANGEPLDITEDPTPRGHSIEFRINGEDAGRGFLPAPGPVTTFEPPTGPGVRLDSGVESGSVIGGQFDSMLAKLIVTGAT
REEALERSRRALAEFKVEGLATVIPFHRAVVSDPAFIGDENGFTVHTRWIETEWDNTIEPFTGGDPIDEEDTAPRQTVVV
EVGGRRLEVSLPGDLVLGNGGGAAPAGVIRKKPKPRKRGAHGGAATSGDSVTAPMQGTVVKVAVEEGQQVSAGDLVVVLE
AMKMENPVTAHKDGTITGLAVEAGAAVTQGTVLAEIKSDGE

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=45.8426966292135, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI295821183, Length=636, Percent_Identity=36.7924528301887, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=44.8888888888889, Blast_Score=365, Evalue=1e-100,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=44.8888888888889, Blast_Score=365, Evalue=1e-100,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=44.8888888888889, Blast_Score=365, Evalue=1e-100,
Organism=Homo sapiens, GI189095269, Length=431, Percent_Identity=42.92343387471, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI65506442, Length=431, Percent_Identity=42.92343387471, Blast_Score=354, Evalue=2e-97,
Organism=Homo sapiens, GI38679977, Length=475, Percent_Identity=33.2631578947368, Blast_Score=229, Evalue=8e-60,
Organism=Homo sapiens, GI38679967, Length=475, Percent_Identity=33.2631578947368, Blast_Score=229, Evalue=8e-60,
Organism=Homo sapiens, GI38679960, Length=475, Percent_Identity=33.2631578947368, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI38679971, Length=475, Percent_Identity=33.2631578947368, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI38679974, Length=475, Percent_Identity=33.2631578947368, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=31.041257367387, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI1789654, Length=441, Percent_Identity=46.2585034013605, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17562816, Length=437, Percent_Identity=46.4530892448513, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17567343, Length=433, Percent_Identity=43.4180138568129, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71987519, Length=431, Percent_Identity=44.7795823665893, Blast_Score=351, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI71997168, Length=513, Percent_Identity=28.2651072124756, Blast_Score=189, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=513, Percent_Identity=28.2651072124756, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI133931226, Length=458, Percent_Identity=29.0393013100437, Blast_Score=182, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6319695, Length=437, Percent_Identity=46.9107551487414, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321376, Length=437, Percent_Identity=46.9107551487414, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319685, Length=428, Percent_Identity=41.3551401869159, Blast_Score=322, Evalue=9e-89,
Organism=Saccharomyces cerevisiae, GI6323863, Length=443, Percent_Identity=30.4740406320542, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=30.4093567251462, Blast_Score=204, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24651757, Length=468, Percent_Identity=43.8034188034188, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI281363050, Length=436, Percent_Identity=46.7889908256881, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652224, Length=436, Percent_Identity=46.7889908256881, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652222, Length=436, Percent_Identity=46.7889908256881, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652220, Length=436, Percent_Identity=46.7889908256881, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652218, Length=436, Percent_Identity=46.7889908256881, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652212, Length=436, Percent_Identity=46.7889908256881, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652210, Length=436, Percent_Identity=46.7889908256881, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652214, Length=436, Percent_Identity=46.7889908256881, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19921944, Length=436, Percent_Identity=46.7889908256881, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652216, Length=436, Percent_Identity=46.7889908256881, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24651759, Length=418, Percent_Identity=43.0622009569378, Blast_Score=332, Evalue=6e-91,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=30.0198807157058, Blast_Score=208, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=30.0198807157058, Blast_Score=208, Evalue=8e-54,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=30.0198807157058, Blast_Score=208, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=30.0198807157058, Blast_Score=208, Evalue=9e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 63670; Mature: 63539

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASHASSKISKVLVANRGEIAVRVIRAAKDAGLQSVAVYAEPDADAPHVRLADEAFALGG
CCCCHHHHHHHHHHCCCCCEEEHEEHHHHHCCCEEEEEEECCCCCCCCEEECHHHHHCCC
QTSAESYLVFEKLLDAAEKSGANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDL
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHH
GDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAEEYGVPVAIKAAFGGGGRGMKVART
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH
IQEIPELFDSATREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHH
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAGYYGAGTVEYLVGQDGLISFLEVNTRL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEE
QVEHPVTEETSGIDLVRQQFRIANGEPLDITEDPTPRGHSIEFRINGEDAGRGFLPAPGP
EECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC
VTTFEPPTGPGVRLDSGVESGSVIGGQFDSMLAKLIVTGATREEALERSRRALAEFKVEG
CCCCCCCCCCCCEECCCCCCCCEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LATVIPFHRAVVSDPAFIGDENGFTVHTRWIETEWDNTIEPFTGGDPIDEEDTAPRQTVV
HHHHHHHHHHHHCCCCEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VEVGGRRLEVSLPGDLVLGNGGGAAPAGVIRKKPKPRKRGAHGGAATSGDSVTAPMQGTV
EEECCEEEEEECCCCEEEECCCCCCCHHHHCCCCCCHHCCCCCCCCCCCCCEECCCCCCE
VKVAVEEGQQVSAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAVTQGTVLAEIKSD
EEEEECCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCEEEEEEECCCCHHCCEEEEEECCC
GE
CC
>Mature Secondary Structure 
ASHASSKISKVLVANRGEIAVRVIRAAKDAGLQSVAVYAEPDADAPHVRLADEAFALGG
CCCHHHHHHHHHHCCCCCEEEHEEHHHHHCCCEEEEEEECCCCCCCCEEECHHHHHCCC
QTSAESYLVFEKLLDAAEKSGANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDL
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHH
GDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAEEYGVPVAIKAAFGGGGRGMKVART
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH
IQEIPELFDSATREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHH
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAGYYGAGTVEYLVGQDGLISFLEVNTRL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEE
QVEHPVTEETSGIDLVRQQFRIANGEPLDITEDPTPRGHSIEFRINGEDAGRGFLPAPGP
EECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC
VTTFEPPTGPGVRLDSGVESGSVIGGQFDSMLAKLIVTGATREEALERSRRALAEFKVEG
CCCCCCCCCCCCEECCCCCCCCEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LATVIPFHRAVVSDPAFIGDENGFTVHTRWIETEWDNTIEPFTGGDPIDEEDTAPRQTVV
HHHHHHHHHHHHCCCCEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VEVGGRRLEVSLPGDLVLGNGGGAAPAGVIRKKPKPRKRGAHGGAATSGDSVTAPMQGTV
EEECCEEEEEECCCCEEEECCCCCCCHHHHCCCCCCHHCCCCCCCCCCCCCEECCCCCCE
VKVAVEEGQQVSAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAVTQGTVLAEIKSD
EEEEECCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCEEEEEEECCCCHHCCEEEEEECCC
GE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]