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The map label for this gene is sdhA [H]

Identifier: 119867295

GI number: 119867295

Start: 1331073

End: 1332827

Strand: Reverse

Name: sdhA [H]

Synonym: Mkms_1245

Alternate gene names: 119867295

Gene position: 1332827-1331073 (Counterclockwise)

Preceding gene: 119867296

Following gene: 119867294

Centisome position: 23.23

GC content: 67.64

Gene sequence:

>1755_bases
ATGTTGATTGAACATCGCTACGACGTCGTCATCGTCGGGGCCGGCGGCGCGGGTATGCGCGCCGCGGTCGAGGCGGGTCC
GCGCGCCCGCACCGCGGTGCTGACCAAGCTGTACCCGACCCGCAGCCACACCGGCGCGGCCCAGGGCGGCATGTGCGCCG
CGCTGGCCAACGTCGAAGAGGACAACTGGGAGTGGCACACCTTCGACACCGTCAAGGGCGGCGACTACCTCGCCGACCAG
GACGCCGTCGAGATCATGTGCAAGGAAGCCATCGACGCGGTGCTCGACCTCGAGAAGATGGGGATGCCCTTCAACCGCAC
CCCCGAGGGCCGCATCGACCAGCGCCGGTTCGGCGGGCACACCCGTGACCACGGCAAGGCCCCGGTGCGCCGGGCCTGTT
ACGCCGCCGACCGCACCGGCCACATGATCCTGCAGACGCTGTATCAAAACTGCGTCAAACACGACGTCGAGTTCTTCAAC
GAGTTCTACGCCCTCGACATCACGCTGACCGAGACCCCCGGCGGCCCGGTGGCCACCGGCGTCATCGCCTACGAGTTGGC
GACCGGCGACATCCACGTCTTCCACGCCAAGGCGATCGTGTTCGCCACCGGCGGTTCGGGCCGGATGTACAAGACGACGT
CCAACGCGCACACGCTGACCGGCGACGGGCTGGGCATCGTCTTCCGCAAGGGTCTGCCGCTGGAGGACATGGAGTTCCAC
CAGTTCCACCCGACCGGTCTGGCCGGCCTCGGCATCCTCATCTCCGAGGCCGTGCGCGGTGAGGGCGGTCGCCTGCTCAA
CGGCGACGGCGAACGGTTCATGGAGCGCTACGCGCCGACCATCGTCGACCTCGCCCCGCGTGACATCGTCGCCCGCTCGA
TGGTCCTCGAGGTGCTCGAGGGCCGCGGCGCCGGACCGAACAAGGACTACGTCTACATCGACGTGCGCCACCTCGGCGAG
GACGTCCTCGAGGCGAAGCTGCCCGACATCACCGAATTCGCCCGCACCTACCTCGGTGTCGACCCGGTCAAGGAACTGGT
GCCGGTCTACCCCACCTGCCACTACGTCATGGGCGGCATCCCGACCACCGTGCACGGTCAGGTGCTGCGCGACAACACCA
CGATCGTCCCGGGTCTTTACGCCGCCGGCGAGTGCGCCTGCGTGTCGGTGCACGGCGCCAACCGGCTGGGCACCAACTCG
CTGCTCGACATCAACGTGTTCGGCCGCCGCGCCGGGATCGCCGCCGCCAACTACGCATTGGGCCACGACTTCGTCGACCT
GCCCGAGCGGCCCGCCGAGATGGTGGTCAACTGGGTCGGCGACATCCTCTCCGAGCACGGCAACGAGCGCGTCGCCGACA
TCCGCGGTGCGCTGCAGCAGTCGATGGACAACAACGCCGCGGTGTTCCGCACCGAGGAAACCCTCAAGCAGGCCCTGACC
GACATCCACGCGCTCAAGGAGCGCTACTCGCGAATCACGGTGCAGGACAAGGGAAAACGCTACAACAGCGACCTGCTCGA
GGCGATCGAGCTGGGCTTCCTGCTCGAACTGGCCGAGGTCACCGTCGTCGGCGCGCTGAACCGGAAGGAATCTCGCGGCG
GCCACGCGCGCGAGGACTACCCCAACCGCGACGACACCAACTACATGCGCCACACCATGGCCTACAAGGAGGGCACCGAC
CTGCTCTCCGACGTGCGCCTGGACTACAAGCCCGTGGTGCAGACCCGCTACGAGCCGATGGAACGGAAGTACTGA

Upstream 100 bases:

>100_bases
CTGAACTCGCTGCTGGCGCTGTCGATGATCTTCATCCTCGTTCTCGGCACCTACGTGCTGTTGACGTTCGACGCGAACAT
CTCGTAAGGACTCGGCTCAC

Downstream 100 bases:

>100_bases
CGATGAGACGCTTGCGCCGCGACGAGCCCTCGGGCGAGGAGCGATCGATGAAGAGCGAGAACCGATGAGCGCACCTGCAA
TCGAGAAGAACGAAGCCACC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MLIEHRYDVVIVGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFN
EFYALDITLTETPGGPVATGVIAYELATGDIHVFHAKAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGDGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPNKDYVYIDVRHLGE
DVLEAKLPDITEFARTYLGVDPVKELVPVYPTCHYVMGGIPTTVHGQVLRDNTTIVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRAGIAAANYALGHDFVDLPERPAEMVVNWVGDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALT
DIHALKERYSRITVQDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDTNYMRHTMAYKEGTD
LLSDVRLDYKPVVQTRYEPMERKY

Sequences:

>Translated_584_residues
MLIEHRYDVVIVGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFN
EFYALDITLTETPGGPVATGVIAYELATGDIHVFHAKAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGDGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPNKDYVYIDVRHLGE
DVLEAKLPDITEFARTYLGVDPVKELVPVYPTCHYVMGGIPTTVHGQVLRDNTTIVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRAGIAAANYALGHDFVDLPERPAEMVVNWVGDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALT
DIHALKERYSRITVQDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDTNYMRHTMAYKEGTD
LLSDVRLDYKPVVQTRYEPMERKY
>Mature_584_residues
MLIEHRYDVVIVGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFN
EFYALDITLTETPGGPVATGVIAYELATGDIHVFHAKAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGDGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPNKDYVYIDVRHLGE
DVLEAKLPDITEFARTYLGVDPVKELVPVYPTCHYVMGGIPTTVHGQVLRDNTTIVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRAGIAAANYALGHDFVDLPERPAEMVVNWVGDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALT
DIHALKERYSRITVQDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDTNYMRHTMAYKEGTD
LLSDVRLDYKPVVQTRYEPMERKY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=568, Percent_Identity=48.4154929577465, Blast_Score=504, Evalue=1e-143,
Organism=Escherichia coli, GI1786942, Length=585, Percent_Identity=48.034188034188, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1790597, Length=572, Percent_Identity=39.8601398601399, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=552, Percent_Identity=33.1521739130435, Blast_Score=233, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17550100, Length=576, Percent_Identity=47.3958333333333, Blast_Score=517, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17505833, Length=523, Percent_Identity=48.7571701720841, Blast_Score=500, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6322701, Length=592, Percent_Identity=48.6486486486487, Blast_Score=538, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322416, Length=587, Percent_Identity=49.2333901192504, Blast_Score=520, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320788, Length=488, Percent_Identity=28.2786885245902, Blast_Score=106, Evalue=9e-24,
Organism=Drosophila melanogaster, GI17137288, Length=599, Percent_Identity=47.5792988313856, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24655642, Length=599, Percent_Identity=47.5792988313856, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24655647, Length=599, Percent_Identity=47.5792988313856, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24663005, Length=600, Percent_Identity=45, Blast_Score=485, Evalue=1e-137,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64365; Mature: 64365

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIEHRYDVVIVGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALANVEE
CCEEEEECEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCC
DNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGH
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC
TRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDITLTETPGGPVATG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCEEEE
VIAYELATGDIHVFHAKAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFH
EEEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCEEEEECCCCCCCCCCC
QFHPTGLAGLGILISEAVRGEGGRLLNGDGERFMERYAPTIVDLAPRDIVARSMVLEVLE
CCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCHHEECCCHHHHHHHHHHHHHH
GRGAGPNKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVKELVPVYPTCHYVMGGI
CCCCCCCCCEEEEEHHHCCHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCHHHHHCCC
PTTVHGQVLRDNTTIVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAANYAL
CCCCCCEEEECCCEECCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHH
GHDFVDLPERPAEMVVNWVGDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALT
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHH
DIHALKERYSRITVQDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDY
HHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCC
PNRDDTNYMRHTMAYKEGTDLLSDVRLDYKPVVQTRYEPMERKY
CCCCCHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHCCCHHHCCC
>Mature Secondary Structure
MLIEHRYDVVIVGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALANVEE
CCEEEEECEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCC
DNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGH
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC
TRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDITLTETPGGPVATG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCEEEE
VIAYELATGDIHVFHAKAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFH
EEEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCEEEEECCCCCCCCCCC
QFHPTGLAGLGILISEAVRGEGGRLLNGDGERFMERYAPTIVDLAPRDIVARSMVLEVLE
CCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCHHEECCCHHHHHHHHHHHHHH
GRGAGPNKDYVYIDVRHLGEDVLEAKLPDITEFARTYLGVDPVKELVPVYPTCHYVMGGI
CCCCCCCCCEEEEEHHHCCHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCHHHHHCCC
PTTVHGQVLRDNTTIVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAANYAL
CCCCCCEEEECCCEECCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHH
GHDFVDLPERPAEMVVNWVGDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALT
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHH
DIHALKERYSRITVQDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDY
HHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCC
PNRDDTNYMRHTMAYKEGTDLLSDVRLDYKPVVQTRYEPMERKY
CCCCCHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA