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The map label for this gene is gor [H]

Identifier: 119776675

GI number: 119776675

Start: 4174690

End: 4176045

Strand: Reverse

Name: gor [H]

Synonym: Sama_3543

Alternate gene names: 119776675

Gene position: 4176045-4174690 (Counterclockwise)

Preceding gene: 119776676

Following gene: 119776674

Centisome position: 96.98

GC content: 55.97

Gene sequence:

>1356_bases
ATGGCCCAACACTACGATTACATCTGCCTGGGCGCAGGCAGTGGCGGTATTGCGTCCGCCAATCGCGCCGCCATCCGTGG
CGCCAAGGTTTTATTGATTGAAGCCAAGCATGTCGGCGGTACCTGCGTAAACGTTGGCTGTGTGCCGAAAAAAGTGATGT
GGTACGGTGCTCAGGTTGCCGAGGCCATGCATCTTTACGCCAAAGACTATGGCTTTGATGTGGATGTGAAAAACTTCGAC
TGGAACACTCTGGTAGCCAGCCGTGAAGCCTATATTGACCGTGTACATGCCGCCTATGGCCGTGGCTTCGCCAGCAACGG
CGTTACCCTGGTGGAAGGCTATGGTAAGTTTAAGAATAACAACACCATAGAAGTAAACGGTGAAGAATACACGGCCGATC
ATATTCTGATTGCCACCGGTGGCCGCCCAAGCATCCCCAATATTCCGGGCGCAGAGCATGGTATTGACTCCAATGGCTTT
TTTGCCCTGTCCGAACAGCCCAAGCGGGTTGTGGTGGTGGGCGCCGGTTATATTGCAGTGGAGATTGCCGGTGTGCTGCA
TGCCCTTGGCAGCGAAACCCACCTGTGTGTGCGTAAGCACTCACCGCTGCGTAGCTTCGACCCCATGCTGAGTCAGGCGC
TCACAGATGCCATGGCCGAAAATGGCCCCACTCTGCATACCAATGCCGTACCCAAGGCGGTGGAAAAAAATGCCGATGGC
AGTCTGACGCTGCAGCTCGAAAACGGCGAATCCATTACCGTGGACTGCCTGATTTGGGCCATCGGCCGTGAGCCTGCCAC
CGATAAAATCGGTCTGGAAAATACAGATGTAACCCTGGACGACAAGGGTTACGTCATAGTGGATGAATGGCAGCAAACCA
GCGCCAAAGGTATCTACTGCGTCGGCGATATCATGGCTGGCGGTATTGAACTTACGCCAGTGGCCGTGAAAGCCGGACGT
TTCCTGTCTGAGCGCCTCTTTGGCGGCCAGCCCAATGCCAAAATGGACTACAGCCTGGTGCCAACCGTGGTATTCAGCCA
CCCCCCCATAGGCACCATGGGTCTGAGTGAGCCCGATGCCAAGGCGCAGTACGGCGAGGATCAGGTGAAGGTGTACACCT
CGACCTTCACCTCCATGTACACCGCCGTGACCGCGCATCGCCAACCCTGCAAAATGAAGCTGGTGTGCGCCGGTCCGGAC
GAAAAAGTTGTGGGTATCCACGGTATTGGCTTTGGGATGGATGAAATCCTCCAGGGCTTTGGCGTGGCAATCAAGATGGG
GGCCACCAAGGCCGACTTCGATGCCGTGGTAGCTATCCATCCCACCGGCGCCGAAGAGTTTGTTACTATGCGCTGA

Upstream 100 bases:

>100_bases
CCTGTGACAAACTGACTCACAGGCCGGTCTTTGCTCTGGTCTAGGTGCAAAAAGCTCCCTACAATTGAGCCTTTGCCGGT
CGTTCACAACGGAGAGTTAC

Downstream 100 bases:

>100_bases
AATTAAAAAGCCGCTCAATGAGCGGCTTTTTTCTGTCTTATGGTTAACTTGTGCGCTCGACACACTGCCACTATTTGCCT
CAGCAAGGAACCCCAGAGAT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MAQHYDYICLGAGSGGIASANRAAIRGAKVLLIEAKHVGGTCVNVGCVPKKVMWYGAQVAEAMHLYAKDYGFDVDVKNFD
WNTLVASREAYIDRVHAAYGRGFASNGVTLVEGYGKFKNNNTIEVNGEEYTADHILIATGGRPSIPNIPGAEHGIDSNGF
FALSEQPKRVVVVGAGYIAVEIAGVLHALGSETHLCVRKHSPLRSFDPMLSQALTDAMAENGPTLHTNAVPKAVEKNADG
SLTLQLENGESITVDCLIWAIGREPATDKIGLENTDVTLDDKGYVIVDEWQQTSAKGIYCVGDIMAGGIELTPVAVKAGR
FLSERLFGGQPNAKMDYSLVPTVVFSHPPIGTMGLSEPDAKAQYGEDQVKVYTSTFTSMYTAVTAHRQPCKMKLVCAGPD
EKVVGIHGIGFGMDEILQGFGVAIKMGATKADFDAVVAIHPTGAEEFVTMR

Sequences:

>Translated_451_residues
MAQHYDYICLGAGSGGIASANRAAIRGAKVLLIEAKHVGGTCVNVGCVPKKVMWYGAQVAEAMHLYAKDYGFDVDVKNFD
WNTLVASREAYIDRVHAAYGRGFASNGVTLVEGYGKFKNNNTIEVNGEEYTADHILIATGGRPSIPNIPGAEHGIDSNGF
FALSEQPKRVVVVGAGYIAVEIAGVLHALGSETHLCVRKHSPLRSFDPMLSQALTDAMAENGPTLHTNAVPKAVEKNADG
SLTLQLENGESITVDCLIWAIGREPATDKIGLENTDVTLDDKGYVIVDEWQQTSAKGIYCVGDIMAGGIELTPVAVKAGR
FLSERLFGGQPNAKMDYSLVPTVVFSHPPIGTMGLSEPDAKAQYGEDQVKVYTSTFTSMYTAVTAHRQPCKMKLVCAGPD
EKVVGIHGIGFGMDEILQGFGVAIKMGATKADFDAVVAIHPTGAEEFVTMR
>Mature_450_residues
AQHYDYICLGAGSGGIASANRAAIRGAKVLLIEAKHVGGTCVNVGCVPKKVMWYGAQVAEAMHLYAKDYGFDVDVKNFDW
NTLVASREAYIDRVHAAYGRGFASNGVTLVEGYGKFKNNNTIEVNGEEYTADHILIATGGRPSIPNIPGAEHGIDSNGFF
ALSEQPKRVVVVGAGYIAVEIAGVLHALGSETHLCVRKHSPLRSFDPMLSQALTDAMAENGPTLHTNAVPKAVEKNADGS
LTLQLENGESITVDCLIWAIGREPATDKIGLENTDVTLDDKGYVIVDEWQQTSAKGIYCVGDIMAGGIELTPVAVKAGRF
LSERLFGGQPNAKMDYSLVPTVVFSHPPIGTMGLSEPDAKAQYGEDQVKVYTSTFTSMYTAVTAHRQPCKMKLVCAGPDE
KVVGIHGIGFGMDEILQGFGVAIKMGATKADFDAVVAIHPTGAEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=51.304347826087, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=36.7088607594937, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI148277065, Length=432, Percent_Identity=37.037037037037, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI33519430, Length=432, Percent_Identity=37.037037037037, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI33519428, Length=432, Percent_Identity=37.037037037037, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI33519426, Length=432, Percent_Identity=37.037037037037, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI148277071, Length=432, Percent_Identity=37.037037037037, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI291045266, Length=477, Percent_Identity=34.3815513626834, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI291045268, Length=477, Percent_Identity=31.6561844863732, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=29.6296296296296, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=67.6274944567627, Blast_Score=635, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=447, Percent_Identity=28.4116331096197, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=26.133909287257, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=24.0088105726872, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1787114, Length=211, Percent_Identity=30.8056872037915, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=54.1019955654102, Blast_Score=430, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=54.1019955654102, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=32.8389830508475, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=35, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=28.7878787878788, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17559934, Length=194, Percent_Identity=27.319587628866, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=50.1075268817204, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321091, Length=467, Percent_Identity=26.9807280513919, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=467, Percent_Identity=24.1970021413276, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=39.3617021276596, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=39.3617021276596, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=39.3617021276596, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=38.2663847780127, Blast_Score=271, Evalue=5e-73,
Organism=Drosophila melanogaster, GI21358499, Length=465, Percent_Identity=29.0322580645161, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48145; Mature: 48014

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQHYDYICLGAGSGGIASANRAAIRGAKVLLIEAKHVGGTCVNVGCVPKKVMWYGAQVA
CCCCCCEEEEECCCCCCCCCCHHHCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
EAMHLYAKDYGFDVDVKNFDWNTLVASREAYIDRVHAAYGRGFASNGVTLVEGYGKFKNN
HHHHHHHHHCCCEEEECCCCCHHEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
NTIEVNGEEYTADHILIATGGRPSIPNIPGAEHGIDSNGFFALSEQPKRVVVVGAGYIAV
CEEEECCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCEEH
EIAGVLHALGSETHLCVRKHSPLRSFDPMLSQALTDAMAENGPTLHTNAVPKAVEKNADG
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCC
SLTLQLENGESITVDCLIWAIGREPATDKIGLENTDVTLDDKGYVIVDEWQQTSAKGIYC
EEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCEEE
VGDIMAGGIELTPVAVKAGRFLSERLFGGQPNAKMDYSLVPTVVFSHPPIGTMGLSEPDA
EEEHHCCCEEEEEEEEHHHHHHHHHHCCCCCCCEECCEEECEEEECCCCCCCCCCCCCCC
KAQYGEDQVKVYTSTFTSMYTAVTAHRQPCKMKLVCAGPDEKVVGIHGIGFGMDEILQGF
HHHCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHC
GVAIKMGATKADFDAVVAIHPTGAEEFVTMR
CEEEEECCCCCCCEEEEEEECCCCHHEEEEC
>Mature Secondary Structure 
AQHYDYICLGAGSGGIASANRAAIRGAKVLLIEAKHVGGTCVNVGCVPKKVMWYGAQVA
CCCCCEEEEECCCCCCCCCCHHHCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
EAMHLYAKDYGFDVDVKNFDWNTLVASREAYIDRVHAAYGRGFASNGVTLVEGYGKFKNN
HHHHHHHHHCCCEEEECCCCCHHEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
NTIEVNGEEYTADHILIATGGRPSIPNIPGAEHGIDSNGFFALSEQPKRVVVVGAGYIAV
CEEEECCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCEEH
EIAGVLHALGSETHLCVRKHSPLRSFDPMLSQALTDAMAENGPTLHTNAVPKAVEKNADG
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCC
SLTLQLENGESITVDCLIWAIGREPATDKIGLENTDVTLDDKGYVIVDEWQQTSAKGIYC
EEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCEEE
VGDIMAGGIELTPVAVKAGRFLSERLFGGQPNAKMDYSLVPTVVFSHPPIGTMGLSEPDA
EEEHHCCCEEEEEEEEHHHHHHHHHHCCCCCCCEECCEEECEEEECCCCCCCCCCCCCCC
KAQYGEDQVKVYTSTFTSMYTAVTAHRQPCKMKLVCAGPDEKVVGIHGIGFGMDEILQGF
HHHCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHC
GVAIKMGATKADFDAVVAIHPTGAEEFVTMR
CEEEEECCCCCCCEEEEEEECCCCHHEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]