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The map label for this gene is gcvA [H]

Identifier: 119776671

GI number: 119776671

Start: 4169943

End: 4170797

Strand: Direct

Name: gcvA [H]

Synonym: Sama_3539

Alternate gene names: 119776671

Gene position: 4169943-4170797 (Clockwise)

Preceding gene: 119776670

Following gene: 119776672

Centisome position: 96.84

GC content: 54.74

Gene sequence:

>855_bases
ATGTTTGCTCATCTGCCTTCTCTCAACGGTTTACGGGTTTTCGAAGCAGCGGCCCGTCATCTGAGCTTTAAACTCGCGGC
CAAGGAGCTTGAGCTCACACCGACCGCTGTATCACATCAAATCCGCAATCTGGAAGCGCAGCTGGAGATTCAGCTGTTTA
TTCGCCACACCCGGGCGGTGGAGCTCACAGCTGCGGGGCAAACATTATTTGATACCAGTCGCCAGGTTCTGCGCCAAATA
GAACAGACTCTGACCAATCTTGGGGTCGGCGACGAAACCGACATCCACATCAGTGCGCCCCACGGTTTTGCGGCCCTGTG
GCTGGCACAGCGTTTACCTTACTTTCAGCGCAGATTTCCCGAAGTGCGGGTGTCAGTCAGCCAATCGGATGCCCCCGATA
CCCAGAGCGGACATGTTGCCATTGTCCCCGCAGCCTCACCCCAAGATGCTACCCTGCCGGAGTACTTTGGCATTTACGCC
AGCCCCGCCTATTTGTCCCGCAAACACTCACAGCAAACACTGATGCATGTGCGCCGTCATACTGGTGTCACACAAATCAA
CTGGGATAGTTGGCAGAAAGAGTACGGCAAGTTCAAAGAAGCCCAGCTTATCGAGTTTGATCGTGAAGACCAGCTGGTAC
AGGCCTGCCTCGCCGGGCAAGGACTGGCACTGACCAGCTCCCTATTGGTGTCATCACTGGTGGAAAAAGGCTGGTTGAAA
TCTTGTCTGCCAGACAAGACTCTGCCGGGCTCCGGCTACAACATCCGTCTGCAGCAGGACTCCCACAAAAAGCGCCAAAT
TCAGCAATTTACAAGCTGGCTGGACGAGCAAATCGGCACAGATGCCGACCAATAA

Upstream 100 bases:

>100_bases
GGCTTTTTTATGGATGAATTTAGTTAATCCAATTTGTGGACATTCGCTGTCTAAGAAAGCATTATTTCTTTTATGAATTT
TTTTTATTCATCTATAAACC

Downstream 100 bases:

>100_bases
CCGCCGTGGCAATGACTATCAAGGAAGAACCCCATGTTAAAAGCCATCAAATGGGCACTGCTGCTGGTATTCGTGGTGTG
CGCCAGTCTGTATTTCGCCT

Product: LysR family substrate binding transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MFAHLPSLNGLRVFEAAARHLSFKLAAKELELTPTAVSHQIRNLEAQLEIQLFIRHTRAVELTAAGQTLFDTSRQVLRQI
EQTLTNLGVGDETDIHISAPHGFAALWLAQRLPYFQRRFPEVRVSVSQSDAPDTQSGHVAIVPAASPQDATLPEYFGIYA
SPAYLSRKHSQQTLMHVRRHTGVTQINWDSWQKEYGKFKEAQLIEFDREDQLVQACLAGQGLALTSSLLVSSLVEKGWLK
SCLPDKTLPGSGYNIRLQQDSHKKRQIQQFTSWLDEQIGTDADQ

Sequences:

>Translated_284_residues
MFAHLPSLNGLRVFEAAARHLSFKLAAKELELTPTAVSHQIRNLEAQLEIQLFIRHTRAVELTAAGQTLFDTSRQVLRQI
EQTLTNLGVGDETDIHISAPHGFAALWLAQRLPYFQRRFPEVRVSVSQSDAPDTQSGHVAIVPAASPQDATLPEYFGIYA
SPAYLSRKHSQQTLMHVRRHTGVTQINWDSWQKEYGKFKEAQLIEFDREDQLVQACLAGQGLALTSSLLVSSLVEKGWLK
SCLPDKTLPGSGYNIRLQQDSHKKRQIQQFTSWLDEQIGTDADQ
>Mature_284_residues
MFAHLPSLNGLRVFEAAARHLSFKLAAKELELTPTAVSHQIRNLEAQLEIQLFIRHTRAVELTAAGQTLFDTSRQVLRQI
EQTLTNLGVGDETDIHISAPHGFAALWLAQRLPYFQRRFPEVRVSVSQSDAPDTQSGHVAIVPAASPQDATLPEYFGIYA
SPAYLSRKHSQQTLMHVRRHTGVTQINWDSWQKEYGKFKEAQLIEFDREDQLVQACLAGQGLALTSSLLVSSLVEKGWLK
SCLPDKTLPGSGYNIRLQQDSHKKRQIQQFTSWLDEQIGTDADQ

Specific function: Not known, the gcv operon regulated by the E.coli homolog does not exist in H.influenzae, so it probably acts as a transcriptional regulator on some other operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789173, Length=288, Percent_Identity=28.8194444444444, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1788706, Length=298, Percent_Identity=28.5234899328859, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786448, Length=292, Percent_Identity=28.7671232876712, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787128, Length=292, Percent_Identity=26.7123287671233, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786401, Length=289, Percent_Identity=25.6055363321799, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693193, Length=294, Percent_Identity=26.530612244898, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31925; Mature: 31925

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAHLPSLNGLRVFEAAARHLSFKLAAKELELTPTAVSHQIRNLEAQLEIQLFIRHTRAV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEEEHHHEE
ELTAAGQTLFDTSRQVLRQIEQTLTNLGVGDETDIHISAPHGFAALWLAQRLPYFQRRFP
EEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHCCHHHHCCC
EVRVSVSQSDAPDTQSGHVAIVPAASPQDATLPEYFGIYASPAYLSRKHSQQTLMHVRRH
CEEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TGVTQINWDSWQKEYGKFKEAQLIEFDREDQLVQACLAGQGLALTSSLLVSSLVEKGWLK
CCCCEECHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SCLPDKTLPGSGYNIRLQQDSHKKRQIQQFTSWLDEQIGTDADQ
HHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFAHLPSLNGLRVFEAAARHLSFKLAAKELELTPTAVSHQIRNLEAQLEIQLFIRHTRAV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEEEHHHEE
ELTAAGQTLFDTSRQVLRQIEQTLTNLGVGDETDIHISAPHGFAALWLAQRLPYFQRRFP
EEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHCCHHHHCCC
EVRVSVSQSDAPDTQSGHVAIVPAASPQDATLPEYFGIYASPAYLSRKHSQQTLMHVRRH
CEEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TGVTQINWDSWQKEYGKFKEAQLIEFDREDQLVQACLAGQGLALTSSLLVSSLVEKGWLK
CCCCEECHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SCLPDKTLPGSGYNIRLQQDSHKKRQIQQFTSWLDEQIGTDADQ
HHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]