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The map label for this gene is fabF [H]

Identifier: 119776526

GI number: 119776526

Start: 4021792

End: 4023024

Strand: Direct

Name: fabF [H]

Synonym: Sama_3394

Alternate gene names: 119776526

Gene position: 4021792-4023024 (Clockwise)

Preceding gene: 119776525

Following gene: 119776527

Centisome position: 93.4

GC content: 58.56

Gene sequence:

>1233_bases
GTGAGCCGCCGGGTTGTGGTCACAGGCTTTGGCGGCATCAGCAGCCTTGGCCATGACTGGTCATCGATTGCGGCCAGCCT
TAAGGCCATGCAAAACAAAGTGGTACGCATGGACGAGTGGGACAGGTTCGATAATCTCAATACCCGCCTGGCGGCGCCCG
TGACCGACTTTGAAGTACCAGCCCACTATTCGCGCAAGAAAATTCGCTCCATGGGACGGGTATCTTTGATGGCAACCCGC
GCCAGTGAGCTGGCGCTGGAAGATGCAGGCCTGCTTGACAGCGACTTTCTGACCTCAGGGGACGTGGGCATAGCCTACGG
CTCGTCTACCGGCAGCACAGATCCCCTGATTGGCTTCGGCCGCATGCTGGATACAGGCGATATGTCCGGCATCGATGCCA
CCAGCTATATCCGCATGATGGCACACACCACGGCGGTGAACGTAGGCGTGTATTTCGGTCTTCAGGGCCGCATTCATACC
ACTTCCAGCGCCTGCACCTCTGGCAGCCAGGGCATAGGTTACGCCTATGAAGCCATCAAGTACGGTATGCAAACCGCCAT
GTTGGCCGGTGGCGGCGAAGAGCTGTGTCCCAGCGAAGCCGTGGTGTTCGATACCCTGTTTGCCACCAGCACCAAAAACG
ATATGCCCGCGAGCACACCACGGCCGTTTGACAAGAATCGTGATGGTCTGGTGATAGGTGAAGGTGCCTGTACTCTCGTG
CTGGAAGAAATGGAGCACGCCATGGCCCGCGGTGCCCATATTTATGCCGAGCTGGTTGGCTTTGGTACCAACAGCGACGG
TCAGCATGTGACCCAGCCCAACGTAACCACCATGGAAGGGGCTATCCGTCTGGCACTGAAAGATGCCGCACTTACCGCCG
ATGCCATCGGCTATGTCAATGCCCACGGCACCGCCACTGACAGAGGCGATGTGGCCGAAACCCGTGCCACCGCCGCCGTG
TTCGGCAGCCGTATGCCCATTTCGTCGCTGAAGAGTTATACCGGCCACACCCTGGGTGCCTGCGGCGCGCTGGAAGCCTG
GTGCAGCATCATGATGATGAACGAGGGTTGGTTTGCGCCGACCATCAACCTGAACGATATCGACCCCGACTGCGGCGAGC
TCGACTATATCCGCGGCGAACTGCGCGAGCTTGAAACGGATTATGTGATGAGCAATAACTTCGCCTTCGGCGGCATCAAC
ACCTCGCTGATTTTTAAACGCTGGCGGGCATAG

Upstream 100 bases:

>100_bases
TGGGCAAGCCGGAAGAAATCGCTGCACTGGCGGGCTTTTTGATGTCCGATGATGCCGCCTACATTACCCGTCAGGTGATT
TCGGTGAACGGAGGCATGCT

Downstream 100 bases:

>100_bases
CGCAGCCAACTCCAACAGGACGACAGGAGAACACATGAAGAAAATTGCACTGATGTTATTACTCAGCATGGCTTGGTTAC
CGCAGGCCATGGCGGCCAAG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSRRVVVTGFGGISSLGHDWSSIAASLKAMQNKVVRMDEWDRFDNLNTRLAAPVTDFEVPAHYSRKKIRSMGRVSLMATR
ASELALEDAGLLDSDFLTSGDVGIAYGSSTGSTDPLIGFGRMLDTGDMSGIDATSYIRMMAHTTAVNVGVYFGLQGRIHT
TSSACTSGSQGIGYAYEAIKYGMQTAMLAGGGEELCPSEAVVFDTLFATSTKNDMPASTPRPFDKNRDGLVIGEGACTLV
LEEMEHAMARGAHIYAELVGFGTNSDGQHVTQPNVTTMEGAIRLALKDAALTADAIGYVNAHGTATDRGDVAETRATAAV
FGSRMPISSLKSYTGHTLGACGALEAWCSIMMMNEGWFAPTINLNDIDPDCGELDYIRGELRELETDYVMSNNFAFGGIN
TSLIFKRWRA

Sequences:

>Translated_410_residues
MSRRVVVTGFGGISSLGHDWSSIAASLKAMQNKVVRMDEWDRFDNLNTRLAAPVTDFEVPAHYSRKKIRSMGRVSLMATR
ASELALEDAGLLDSDFLTSGDVGIAYGSSTGSTDPLIGFGRMLDTGDMSGIDATSYIRMMAHTTAVNVGVYFGLQGRIHT
TSSACTSGSQGIGYAYEAIKYGMQTAMLAGGGEELCPSEAVVFDTLFATSTKNDMPASTPRPFDKNRDGLVIGEGACTLV
LEEMEHAMARGAHIYAELVGFGTNSDGQHVTQPNVTTMEGAIRLALKDAALTADAIGYVNAHGTATDRGDVAETRATAAV
FGSRMPISSLKSYTGHTLGACGALEAWCSIMMMNEGWFAPTINLNDIDPDCGELDYIRGELRELETDYVMSNNFAFGGIN
TSLIFKRWRA
>Mature_409_residues
SRRVVVTGFGGISSLGHDWSSIAASLKAMQNKVVRMDEWDRFDNLNTRLAAPVTDFEVPAHYSRKKIRSMGRVSLMATRA
SELALEDAGLLDSDFLTSGDVGIAYGSSTGSTDPLIGFGRMLDTGDMSGIDATSYIRMMAHTTAVNVGVYFGLQGRIHTT
SSACTSGSQGIGYAYEAIKYGMQTAMLAGGGEELCPSEAVVFDTLFATSTKNDMPASTPRPFDKNRDGLVIGEGACTLVL
EEMEHAMARGAHIYAELVGFGTNSDGQHVTQPNVTTMEGAIRLALKDAALTADAIGYVNAHGTATDRGDVAETRATAAVF
GSRMPISSLKSYTGHTLGACGALEAWCSIMMMNEGWFAPTINLNDIDPDCGELDYIRGELRELETDYVMSNNFAFGGINT
SLIFKRWRA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=32.6968973747017, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI223972627, Length=166, Percent_Identity=36.144578313253, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI41872631, Length=282, Percent_Identity=29.0780141843972, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788663, Length=411, Percent_Identity=36.9829683698297, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=39.3203883495146, Blast_Score=237, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=30.6763285024155, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=36.3636363636364, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI212642053, Length=348, Percent_Identity=26.1494252873563, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17550940, Length=247, Percent_Identity=27.9352226720648, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=31.3199105145414, Blast_Score=189, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=33.0143540669856, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI19920632, Length=356, Percent_Identity=26.4044943820225, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221330659, Length=356, Percent_Identity=26.4044943820225, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24581345, Length=270, Percent_Identity=25.5555555555556, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43931; Mature: 43800

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRVVVTGFGGISSLGHDWSSIAASLKAMQNKVVRMDEWDRFDNLNTRLAAPVTDFEVP
CCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCEEECCCCCCCCC
AHYSRKKIRSMGRVSLMATRASELALEDAGLLDSDFLTSGDVGIAYGSSTGSTDPLIGFG
CHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCEECC
RMLDTGDMSGIDATSYIRMMAHTTAVNVGVYFGLQGRIHTTSSACTSGSQGIGYAYEAIK
CEECCCCCCCCCHHHHHHHHHHHHEEEEEEEEECCCEEECCCHHCCCCCCCCHHHHHHHH
YGMQTAMLAGGGEELCPSEAVVFDTLFATSTKNDMPASTPRPFDKNRDGLVIGEGACTLV
HHHHHHEEECCCHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHH
LEEMEHAMARGAHIYAELVGFGTNSDGQHVTQPNVTTMEGAIRLALKDAALTADAIGYVN
HHHHHHHHHCCHHEEEEEEECCCCCCCCEECCCCCEEHHHHEEEEEHHHHHHHHHHEEEE
AHGTATDRGDVAETRATAAVFGSRMPISSLKSYTGHTLGACGALEAWCSIMMMNEGWFAP
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCEEE
TINLNDIDPDCGELDYIRGELRELETDYVMSNNFAFGGINTSLIFKRWRA
EEECCCCCCCCCCHHHHHHHHHHHCCCEEEECCEEECCCCHHHHHHHHCC
>Mature Secondary Structure 
SRRVVVTGFGGISSLGHDWSSIAASLKAMQNKVVRMDEWDRFDNLNTRLAAPVTDFEVP
CCEEEEEECCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCEEECCCCCCCCC
AHYSRKKIRSMGRVSLMATRASELALEDAGLLDSDFLTSGDVGIAYGSSTGSTDPLIGFG
CHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCEECC
RMLDTGDMSGIDATSYIRMMAHTTAVNVGVYFGLQGRIHTTSSACTSGSQGIGYAYEAIK
CEECCCCCCCCCHHHHHHHHHHHHEEEEEEEEECCCEEECCCHHCCCCCCCCHHHHHHHH
YGMQTAMLAGGGEELCPSEAVVFDTLFATSTKNDMPASTPRPFDKNRDGLVIGEGACTLV
HHHHHHEEECCCHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHH
LEEMEHAMARGAHIYAELVGFGTNSDGQHVTQPNVTTMEGAIRLALKDAALTADAIGYVN
HHHHHHHHHCCHHEEEEEEECCCCCCCCEECCCCCEEHHHHEEEEEHHHHHHHHHHEEEE
AHGTATDRGDVAETRATAAVFGSRMPISSLKSYTGHTLGACGALEAWCSIMMMNEGWFAP
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCEEE
TINLNDIDPDCGELDYIRGELRELETDYVMSNNFAFGGINTSLIFKRWRA
EEECCCCCCCCCCHHHHHHHHHHHCCCEEEECCEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]