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The map label for this gene is ilvD

Identifier: 119776411

GI number: 119776411

Start: 3894717

End: 3896573

Strand: Reverse

Name: ilvD

Synonym: Sama_3279

Alternate gene names: 119776411

Gene position: 3896573-3894717 (Counterclockwise)

Preceding gene: 119776412

Following gene: 119776410

Centisome position: 90.49

GC content: 59.61

Gene sequence:

>1857_bases
ATGGCTAAATTACGTTCTGCCACCAGTACCGAAGGCCGCAATATGGCGGGTGCCCGCGCCCTGTGGCGTGCCACCGGCGT
GAAAGATACCGACTTCGGCAAGCCCATCATTGCCATTGCCAACTCCTTTACCCAGTTTGTGCCAGGGCACGTGCACTTAA
AAGACATGGGCTCTCTCGTGGCTTCGGCCATCGAAGAGGCGGGCGGTATCGCCAAAGAATTCAACACCATCGCCGTGGAT
GACGGCATTGCCATGGGTCACGGCGGCATGCTGTATTCGCTACCATCCCGGGAGCTCATTGCCGACAGTGTGGAGTACAT
GGTAAATGCCCACTGCGCCGATGCGTTGGTGTGCATCAGCAACTGCGACAAAATCACCCCCGGCATGTTGATGGCTGCGC
TGCGCCTTAACATCCCCGTGGTGTTTGTTTCCGGTGGCCCGATGGAAGCGGGTAAAACCAAGCTGTCTGACAAGCTCATT
AAGCTCGATTTGGTGGACGCCATGGTGGCCGCGGCGGACGACCGTATCAGCGATGCCGACAGCGAGAAAATCGAGCGCAG
TGCCTGCCCGACCTGCGGCAGCTGCTCTGGCATGTTTACCGCCAACTCCATGAACTGCCTCACCGAAGCGCTGGGTTTGT
CACTGCCGGGCAATGGCTCCATGCTGGCGACCCATGCCGATCGCCGTGAGCTGTTCCTCGAGGCCGGTCGCCGGGTAATG
AAACTTGCCAAGCGTTACTACGGTGACGACGATGCCTCAGTTTTGCCCCGCTCCATTGCCTCGTTCAAGGCCTTTGAAAA
CGCCATGGCGCTGGATGTGGCCATGGGCGGCTCGTCCAATACCGTATTGCACCTGCTGGCGGCGGCCCAGGAAGCCGAGG
TGGATTTCACCATGGATGATATCGACCGCATCAGCCGCAAGGTGCCGCACCTGTGCAAGGTGGCGCCCTCTACGCCCAAA
TACCATATGGAAGATGTGCACCGCGCAGGTGGTGTAATGGCCATTTTGGGTGAGCTGGACCGCGCCGGGCTTTTGCACAC
AGATGTAAACCATGTGGCTTCTGAAGATGGCACCTTGAAATCAGTGCTGGAGCGCTTCGATGTGGTGCTGACCAAAGATG
AAAAAGTGCACGAGTTTTTCCGAGCAGGTCCTGCGGGCATCCCTACGACCCGCGCCTTCAGCCAATCCTGCCGCTGGGAT
ACCCTGGATGATGACCGCCGTGAAGGCTGTATCCGCAGCCGTGAGTTTGCCTTCAGTCAGGAAGGTGGCCTGGCCGTGCT
CTCCGGCAACCTCGCCGAAAACGGCTGTATCGTCAAAACTGCTGGCGTGGATGAGTCCAACCTCAAATTCAGCGGCGTGG
CACGGGTATATGAGAGTCAGGAAGATGCCGTAGCCGGAATCCTTGGCGGCGAAGTGGTGGCCGGTGACGTGGTGGTCATT
CGTTTTGAGGGCCCCAAAGGCGGCCCCGGTATGCAGGAAATGCTCTACCCAACCAGTTACTTAAAGTCACGGGGCCTTGG
CACCCAGTGCGCGCTCATTACCGATGGCCGCTTCTCCGGCGGTACCTCGGGGCTGTCCATCGGTCACGTCTCGCCCGAGG
CGGCCTCAGGCGGCACCATAGGCCTGATTGAAAATGGCGATCGTATCGATATCGATATCCCCGGCCGCAGCATCAAGCTG
CTTGTGAGTGACGCCGAGCTCGAAAGCCGCCGCGCCGCCATGAATGCCAAGGGACCGCTGGCCTGGAAACCGCTGTCACG
GGTTCGCCCTGTGTCGATGGCGCTGAAGGCGTATGCCATGCTCGCCACCAGTGCCGATAAGGGCGCGGTGCGTGATGTCT
CCAAACTGGAGGGCTGA

Upstream 100 bases:

>100_bases
CCAGCGCCTGAGGCAAGTAGCGGATCTCTGTGCCAGTTCACAGCACATAAGTTAGATATTCTGTTTCCATCGAAAAATTG
AAAAAGCAAAGGAAGTTTCA

Downstream 100 bases:

>100_bases
GATGCTGGATTTTTCTGGCTGTGGTGACAGAGATAAATCAGAGGTGAAGCCTGTGGATCTTGCTCATTATTATTTGCAAA
AAATCCTGCTGTCGTCTGTG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MAKLRSATSTEGRNMAGARALWRATGVKDTDFGKPIIAIANSFTQFVPGHVHLKDMGSLVASAIEEAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLI
KLDLVDAMVAAADDRISDADSEKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
KLAKRYYGDDDASVLPRSIASFKAFENAMALDVAMGGSSNTVLHLLAAAQEAEVDFTMDDIDRISRKVPHLCKVAPSTPK
YHMEDVHRAGGVMAILGELDRAGLLHTDVNHVASEDGTLKSVLERFDVVLTKDEKVHEFFRAGPAGIPTTRAFSQSCRWD
TLDDDRREGCIRSREFAFSQEGGLAVLSGNLAENGCIVKTAGVDESNLKFSGVARVYESQEDAVAGILGGEVVAGDVVVI
RFEGPKGGPGMQEMLYPTSYLKSRGLGTQCALITDGRFSGGTSGLSIGHVSPEAASGGTIGLIENGDRIDIDIPGRSIKL
LVSDAELESRRAAMNAKGPLAWKPLSRVRPVSMALKAYAMLATSADKGAVRDVSKLEG

Sequences:

>Translated_618_residues
MAKLRSATSTEGRNMAGARALWRATGVKDTDFGKPIIAIANSFTQFVPGHVHLKDMGSLVASAIEEAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLI
KLDLVDAMVAAADDRISDADSEKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
KLAKRYYGDDDASVLPRSIASFKAFENAMALDVAMGGSSNTVLHLLAAAQEAEVDFTMDDIDRISRKVPHLCKVAPSTPK
YHMEDVHRAGGVMAILGELDRAGLLHTDVNHVASEDGTLKSVLERFDVVLTKDEKVHEFFRAGPAGIPTTRAFSQSCRWD
TLDDDRREGCIRSREFAFSQEGGLAVLSGNLAENGCIVKTAGVDESNLKFSGVARVYESQEDAVAGILGGEVVAGDVVVI
RFEGPKGGPGMQEMLYPTSYLKSRGLGTQCALITDGRFSGGTSGLSIGHVSPEAASGGTIGLIENGDRIDIDIPGRSIKL
LVSDAELESRRAAMNAKGPLAWKPLSRVRPVSMALKAYAMLATSADKGAVRDVSKLEG
>Mature_617_residues
AKLRSATSTEGRNMAGARALWRATGVKDTDFGKPIIAIANSFTQFVPGHVHLKDMGSLVASAIEEAGGIAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIK
LDLVDAMVAAADDRISDADSEKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVMK
LAKRYYGDDDASVLPRSIASFKAFENAMALDVAMGGSSNTVLHLLAAAQEAEVDFTMDDIDRISRKVPHLCKVAPSTPKY
HMEDVHRAGGVMAILGELDRAGLLHTDVNHVASEDGTLKSVLERFDVVLTKDEKVHEFFRAGPAGIPTTRAFSQSCRWDT
LDDDRREGCIRSREFAFSQEGGLAVLSGNLAENGCIVKTAGVDESNLKFSGVARVYESQEDAVAGILGGEVVAGDVVVIR
FEGPKGGPGMQEMLYPTSYLKSRGLGTQCALITDGRFSGGTSGLSIGHVSPEAASGGTIGLIENGDRIDIDIPGRSIKLL
VSDAELESRRAAMNAKGPLAWKPLSRVRPVSMALKAYAMLATSADKGAVRDVSKLEG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=618, Percent_Identity=78.3171521035599, Blast_Score=1003, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=539, Percent_Identity=31.7254174397032, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI2367371, Length=528, Percent_Identity=31.25, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1786464, Length=521, Percent_Identity=30.7101727447217, Blast_Score=168, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6322476, Length=610, Percent_Identity=36.3934426229508, Blast_Score=335, Evalue=9e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_SHEAM (A1SAS5)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_929151.1
- STRING:   A1SAS5
- GeneID:   4605526
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_3279
- NMPDR:   fig|326297.7.peg.3089
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   A1SAS5
- ProtClustDB:   PRK12448
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65538; Mature: 65406

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLRSATSTEGRNMAGARALWRATGVKDTDFGKPIIAIANSFTQFVPGHVHLKDMGSLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
ASAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIKLDLVDAMVAAADDRISDAD
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SEKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHH
KLAKRYYGDDDASVLPRSIASFKAFENAMALDVAMGGSSNTVLHLLAAAQEAEVDFTMDD
HHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHH
IDRISRKVPHLCKVAPSTPKYHMEDVHRAGGVMAILGELDRAGLLHTDVNHVASEDGTLK
HHHHHHHCCHHHCCCCCCCCHHHHHHHHCCCCEEEEHHHCCCCCEECCHHHHHCCCCHHH
SVLERFDVVLTKDEKVHEFFRAGPAGIPTTRAFSQSCRWDTLDDDRREGCIRSREFAFSQ
HHHHHHCEEECCCHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC
EGGLAVLSGNLAENGCIVKTAGVDESNLKFSGVARVYESQEDAVAGILGGEVVAGDVVVI
CCCEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCEEECCEEEE
RFEGPKGGPGMQEMLYPTSYLKSRGLGTQCALITDGRFSGGTSGLSIGHVSPEAASGGTI
EEECCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEE
GLIENGDRIDIDIPGRSIKLLVSDAELESRRAAMNAKGPLAWKPLSRVRPVSMALKAYAM
EEEECCCEEEEEECCCEEEEEEECCHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHH
LATSADKGAVRDVSKLEG
HHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
AKLRSATSTEGRNMAGARALWRATGVKDTDFGKPIIAIANSFTQFVPGHVHLKDMGSLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
ASAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIKLDLVDAMVAAADDRISDAD
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SEKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHH
KLAKRYYGDDDASVLPRSIASFKAFENAMALDVAMGGSSNTVLHLLAAAQEAEVDFTMDD
HHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHH
IDRISRKVPHLCKVAPSTPKYHMEDVHRAGGVMAILGELDRAGLLHTDVNHVASEDGTLK
HHHHHHHCCHHHCCCCCCCCHHHHHHHHCCCCEEEEHHHCCCCCEECCHHHHHCCCCHHH
SVLERFDVVLTKDEKVHEFFRAGPAGIPTTRAFSQSCRWDTLDDDRREGCIRSREFAFSQ
HHHHHHCEEECCCHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC
EGGLAVLSGNLAENGCIVKTAGVDESNLKFSGVARVYESQEDAVAGILGGEVVAGDVVVI
CCCEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCEEECCEEEE
RFEGPKGGPGMQEMLYPTSYLKSRGLGTQCALITDGRFSGGTSGLSIGHVSPEAASGGTI
EEECCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEE
GLIENGDRIDIDIPGRSIKLLVSDAELESRRAAMNAKGPLAWKPLSRVRPVSMALKAYAM
EEEECCCEEEEEECCCEEEEEEECCHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHH
LATSADKGAVRDVSKLEG
HHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA