Click here to switch to the map view.

The map label for this gene is gppA [H]

Identifier: 119776346

GI number: 119776346

Start: 3805997

End: 3806914

Strand: Reverse

Name: gppA [H]

Synonym: Sama_3214

Alternate gene names: 119776346

Gene position: 3806914-3805997 (Counterclockwise)

Preceding gene: 119776347

Following gene: 119776345

Centisome position: 88.41

GC content: 57.3

Gene sequence:

>918_bases
ATGCAGACACCCGCATACGCAGCAATCACCCTGGGCTCCAACAGTTTTAATATGTTGGTGGCCACCACAGTGGCCGGAAA
GCCCAGGGTTGAAGCCAAATACAAACGCAAGGTGCGTCTTGCCGAAGGGATCGGCTGTGATGGCATGCTCAGTGAGAGTG
TGATGCAGCGGGGGCTGGATTGTCTTTCCATGTTCGCCGAGATGCTGGCCAAACACCATATTCCCGCCGGTCAGGTTGCC
GTAGTGGCAACTGCCACCCTGCGCGCCATTGCCAATGCTGATGAGTTCAAATCCCGAGCCTTGCCGATTTTGGGCGTACC
AATCGATGTTATCTGCGGTATGCGAGAGGCCGAGCTTATCTACCGTGGCATGGTAGCCACCACAGTGGGTGATGGTCGCC
GTCTGGTTATCGACATCGGCGGTGCCAGCACCGAGTTTATTGTTGGTGATGGCGACAAGCTGTTGTTCAAAACCAGCCTG
CCCATGGGCTGCGTGACCTTTAAAAAGCAGTTTTTCAGTGACCTGCCGCTGCAAGAGCGGGACTTCGACGACGCCGAGGC
CGAGGTGCACAGCATCTTGGGCCCCGCTGAAGCCGAGCTTAAACGCCTTGGCTGGCATACAGTGGTAGGCGCCTCCGGTA
CTGTGCAGTCAGTGGTTGAATTACTGGGGCACCGGGGGGAGTCTCAACTCATTACCCGGGCTGTGCTTGAAGGGCTCAAG
CGGGAAATACTGCTCCATGAAGATGCCAGCCTCCAGGACATCCATGGCCTCTGCCCCGAGAGAGCGCCAACCTTTGCCGC
AGGCATCGCCATTTTGCTGGCCTTGTTCCGATTGCTGGAGCTCGACAACCTGGCTTTGTCCGGCGGTGCCCTGCGAGAGG
GTGTACTGCTGGAACTCTCGCAAAAACTCCTCGATTAA

Upstream 100 bases:

>100_bases
ATCGTAATGGTTCGCCACGTCCGTCTGGCTCCCATCGCAGCGGCAGTGGTCGTCCTCCCCGTCATGACAGGACCCGCAGA
CACTCATAAGACAGCCGTAG

Downstream 100 bases:

>100_bases
AACGCCGCTTTGCGGCGTTTTTTCTTTCTGTTCACCTTGATTCCACATGCCTGATGCTCGATAGGTATCGTTTTTGATTA
TTAGTATAGAATAAAATAGA

Product: guanosine-5'-triphosphate,3'-diphosphate diphosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MQTPAYAAITLGSNSFNMLVATTVAGKPRVEAKYKRKVRLAEGIGCDGMLSESVMQRGLDCLSMFAEMLAKHHIPAGQVA
VVATATLRAIANADEFKSRALPILGVPIDVICGMREAELIYRGMVATTVGDGRRLVIDIGGASTEFIVGDGDKLLFKTSL
PMGCVTFKKQFFSDLPLQERDFDDAEAEVHSILGPAEAELKRLGWHTVVGASGTVQSVVELLGHRGESQLITRAVLEGLK
REILLHEDASLQDIHGLCPERAPTFAAGIAILLALFRLLELDNLALSGGALREGVLLELSQKLLD

Sequences:

>Translated_305_residues
MQTPAYAAITLGSNSFNMLVATTVAGKPRVEAKYKRKVRLAEGIGCDGMLSESVMQRGLDCLSMFAEMLAKHHIPAGQVA
VVATATLRAIANADEFKSRALPILGVPIDVICGMREAELIYRGMVATTVGDGRRLVIDIGGASTEFIVGDGDKLLFKTSL
PMGCVTFKKQFFSDLPLQERDFDDAEAEVHSILGPAEAELKRLGWHTVVGASGTVQSVVELLGHRGESQLITRAVLEGLK
REILLHEDASLQDIHGLCPERAPTFAAGIAILLALFRLLELDNLALSGGALREGVLLELSQKLLD
>Mature_305_residues
MQTPAYAAITLGSNSFNMLVATTVAGKPRVEAKYKRKVRLAEGIGCDGMLSESVMQRGLDCLSMFAEMLAKHHIPAGQVA
VVATATLRAIANADEFKSRALPILGVPIDVICGMREAELIYRGMVATTVGDGRRLVIDIGGASTEFIVGDGDKLLFKTSL
PMGCVTFKKQFFSDLPLQERDFDDAEAEVHSILGPAEAELKRLGWHTVVGASGTVQSVVELLGHRGESQLITRAVLEGLK
REILLHEDASLQDIHGLCPERAPTFAAGIAILLALFRLLELDNLALSGGALREGVLLELSQKLLD

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=291, Percent_Identity=46.7353951890034, Blast_Score=242, Evalue=2e-65,
Organism=Escherichia coli, GI1788848, Length=295, Percent_Identity=41.3559322033898, Blast_Score=209, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 32761; Mature: 32761

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPAYAAITLGSNSFNMLVATTVAGKPRVEAKYKRKVRLAEGIGCDGMLSESVMQRGLD
CCCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CLSMFAEMLAKHHIPAGQVAVVATATLRAIANADEFKSRALPILGVPIDVICGMREAELI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCEECCCHHHHCCCHHHHHH
YRGMVATTVGDGRRLVIDIGGASTEFIVGDGDKLLFKTSLPMGCVTFKKQFFSDLPLQER
HHHHHHEEECCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCCC
DFDDAEAEVHSILGPAEAELKRLGWHTVVGASGTVQSVVELLGHRGESQLITRAVLEGLK
CCCHHHHHHHHHCCCHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
REILLHEDASLQDIHGLCPERAPTFAAGIAILLALFRLLELDNLALSGGALREGVLLELS
HHEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHH
QKLLD
HHHCC
>Mature Secondary Structure
MQTPAYAAITLGSNSFNMLVATTVAGKPRVEAKYKRKVRLAEGIGCDGMLSESVMQRGLD
CCCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CLSMFAEMLAKHHIPAGQVAVVATATLRAIANADEFKSRALPILGVPIDVICGMREAELI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCEECCCHHHHCCCHHHHHH
YRGMVATTVGDGRRLVIDIGGASTEFIVGDGDKLLFKTSLPMGCVTFKKQFFSDLPLQER
HHHHHHEEECCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCCC
DFDDAEAEVHSILGPAEAELKRLGWHTVVGASGTVQSVVELLGHRGESQLITRAVLEGLK
CCCHHHHHHHHHCCCHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
REILLHEDASLQDIHGLCPERAPTFAAGIAILLALFRLLELDNLALSGGALREGVLLELS
HHEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHH
QKLLD
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA