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The map label for this gene is ubiB

Identifier: 119776336

GI number: 119776336

Start: 3794562

End: 3796211

Strand: Direct

Name: ubiB

Synonym: Sama_3204

Alternate gene names: 119776336

Gene position: 3794562-3796211 (Clockwise)

Preceding gene: 119776335

Following gene: 119776337

Centisome position: 88.12

GC content: 54.06

Gene sequence:

>1650_bases
ATGACCTTCGCCAGTCTTCGCCGTGGATACCAGGTGATTCGCACACTGCTCCACTATGGCCTGGATGACGTACTGCCTCC
CACCCTGCTTCCCGGGTATTTCAAACTGCTGCGCCTGTGCCTGTTCTGGGTACGCAATCGCCACAAAGACAAGTGCGGTG
GTGAACGACTCAAACTCGCCATGCAGGAACTCGGCCCCGTATACATCAAGTTTGGCCAGATGCTCTCCACCCGCCGCGAC
CTGCTGAGCGACGAATGGGCGCAAGAGCTGTCCATGTTGCAAGACAGGGTGCCGGCCTTTGATTCTGCGCTGGCGCGCGA
GGCCATCGAGGCCGAACTTAAGGCTCCCATCGATAGCCTGTTCGATGACTTCGATGACACCCCGCTGGCGTCTGCGTCTA
TTTCTCAGGTGCATACAGCCACCCTCAAGTCCAACGGCCAGCAGGTCGTGCTCAAGGTGCTGCGCCCCAATGTAGAGGCC
AACATCAAGGCCGATTTGGAGTTGATGTTACAGGTGGCCACCTGGGTCAATCGCTTACTGGGTGAAGGCAATCGCCTGCG
ACCGGTGGAAGTGGTGGAAGACTACCAAAACACCATTCTGGGCGAGCTGAACCTCAAGCTTGAGGCCCTCAACGCCACCA
AGCTGAGAAACAATTTTCTCGACTCGGACGCACTCTACATTCCCTATGTGTATGAAGAGCTGTGTCACCCCAGATTGATG
GTGATGGAACGCATCGACGGCATCCCCGTGTCCGACATAGAGGCGCTCAACGCCCAGGGTACCAACCTGAAATTACTGGC
CGAACGTGGCGTGGAGCTCTTTTTCACCCAGGTGTTCCGCGATAACTTTTTCCATGCCGACATGCACCCCGGCAACATTT
TTATCAGCCGTGAGCACCCGGAAAACCCCTTCTACATTGGGCTAGACTGCGGCATCATGGGCAGCCTGAACGAAGAAGAT
AAACGCTATCTGGCGGAAAACTTCCTCGCATTTTTCAATCGGGATTATCACCGTATCGCCCAGTTGTATGTGGAGTCAGG
TTGGGTATCGGCGGATACCGACATCCTGGCGTTCGAGCAGGCCGTTAAGCTGGTGTGCGAGCCCATGTTCAACAAGCCAC
TGAATGAAATCTCCTTTGGCCATGTGCTGCTGGAGCTGTTTCGCACCGCCCGGCGCTTCGATATCGTAGTGCAACCGCAA
CTGGTGCTGCTGGAAAAAACCCTGCTGTATATCGAAGGTCTTGGGCGTCAGCTCTATCCCCAGCTGGATTTGTGGCAAAC
CGCCAAGCCATTTTTGGAGCGCTGGATGGCAGAACAGGTCGGGCCCAAAGCGATATTCAAAAAAGTGCAAACAAATTTGC
CCTTCTGGTCTGATAAACTCCCGGAGTTTCCAGAGCTTATTTATGACAATCTCAAGCTTGGCCGCAAGCTTCTGGGCAGT
CAGCAACAGATGCTCGACAGGTATCTCAAGTATCAGCAAAAGGCGCACAAGAGTAACTTCCTGCTTATCACCTCTGCTGT
TTTGTTGATCTGTGGCACTATTTTGTTTGCCCAAACAGATACACTGTGGCTCGCATCTGCTTGTCTTGGTTCCGGCGCAT
TGGTTTGGGGAGCCGGATGGCGATCCAGACCAAAGAATCGCAAATTTTAG

Upstream 100 bases:

>100_bases
GCATTGATTTTATTCATCTCAAGGACAACATTGACACCCTGGTTCAGGCGGTCGACGCCATGGAACACAGAGTCAATCAG
TTAAGGGACCGCCTCACACC

Downstream 100 bases:

>100_bases
CTAGCACTAAATAATCACAGGTTCATAATAGAATCACTTAATTTTGTAGAGAGGAATTCTTCATGGGTGGTATCAGTATT
TGGCAATTGCTCATCATCGC

Product: ubiquinone biosynthesis protein AarF

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MTFASLRRGYQVIRTLLHYGLDDVLPPTLLPGYFKLLRLCLFWVRNRHKDKCGGERLKLAMQELGPVYIKFGQMLSTRRD
LLSDEWAQELSMLQDRVPAFDSALAREAIEAELKAPIDSLFDDFDDTPLASASISQVHTATLKSNGQQVVLKVLRPNVEA
NIKADLELMLQVATWVNRLLGEGNRLRPVEVVEDYQNTILGELNLKLEALNATKLRNNFLDSDALYIPYVYEELCHPRLM
VMERIDGIPVSDIEALNAQGTNLKLLAERGVELFFTQVFRDNFFHADMHPGNIFISREHPENPFYIGLDCGIMGSLNEED
KRYLAENFLAFFNRDYHRIAQLYVESGWVSADTDILAFEQAVKLVCEPMFNKPLNEISFGHVLLELFRTARRFDIVVQPQ
LVLLEKTLLYIEGLGRQLYPQLDLWQTAKPFLERWMAEQVGPKAIFKKVQTNLPFWSDKLPEFPELIYDNLKLGRKLLGS
QQQMLDRYLKYQQKAHKSNFLLITSAVLLICGTILFAQTDTLWLASACLGSGALVWGAGWRSRPKNRKF

Sequences:

>Translated_549_residues
MTFASLRRGYQVIRTLLHYGLDDVLPPTLLPGYFKLLRLCLFWVRNRHKDKCGGERLKLAMQELGPVYIKFGQMLSTRRD
LLSDEWAQELSMLQDRVPAFDSALAREAIEAELKAPIDSLFDDFDDTPLASASISQVHTATLKSNGQQVVLKVLRPNVEA
NIKADLELMLQVATWVNRLLGEGNRLRPVEVVEDYQNTILGELNLKLEALNATKLRNNFLDSDALYIPYVYEELCHPRLM
VMERIDGIPVSDIEALNAQGTNLKLLAERGVELFFTQVFRDNFFHADMHPGNIFISREHPENPFYIGLDCGIMGSLNEED
KRYLAENFLAFFNRDYHRIAQLYVESGWVSADTDILAFEQAVKLVCEPMFNKPLNEISFGHVLLELFRTARRFDIVVQPQ
LVLLEKTLLYIEGLGRQLYPQLDLWQTAKPFLERWMAEQVGPKAIFKKVQTNLPFWSDKLPEFPELIYDNLKLGRKLLGS
QQQMLDRYLKYQQKAHKSNFLLITSAVLLICGTILFAQTDTLWLASACLGSGALVWGAGWRSRPKNRKF
>Mature_548_residues
TFASLRRGYQVIRTLLHYGLDDVLPPTLLPGYFKLLRLCLFWVRNRHKDKCGGERLKLAMQELGPVYIKFGQMLSTRRDL
LSDEWAQELSMLQDRVPAFDSALAREAIEAELKAPIDSLFDDFDDTPLASASISQVHTATLKSNGQQVVLKVLRPNVEAN
IKADLELMLQVATWVNRLLGEGNRLRPVEVVEDYQNTILGELNLKLEALNATKLRNNFLDSDALYIPYVYEELCHPRLMV
MERIDGIPVSDIEALNAQGTNLKLLAERGVELFFTQVFRDNFFHADMHPGNIFISREHPENPFYIGLDCGIMGSLNEEDK
RYLAENFLAFFNRDYHRIAQLYVESGWVSADTDILAFEQAVKLVCEPMFNKPLNEISFGHVLLELFRTARRFDIVVQPQL
VLLEKTLLYIEGLGRQLYPQLDLWQTAKPFLERWMAEQVGPKAIFKKVQTNLPFWSDKLPEFPELIYDNLKLGRKLLGSQ
QQMLDRYLKYQQKAHKSNFLLITSAVLLICGTILFAQTDTLWLASACLGSGALVWGAGWRSRPKNRKF

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily

Homologues:

Organism=Homo sapiens, GI40254938, Length=255, Percent_Identity=30.5882352941176, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI41393593, Length=305, Percent_Identity=25.9016393442623, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI32261307, Length=317, Percent_Identity=24.6056782334385, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI217035081, Length=210, Percent_Identity=30.952380952381, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI34147522, Length=225, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI2367309, Length=548, Percent_Identity=58.3941605839416, Blast_Score=650, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559152, Length=283, Percent_Identity=26.8551236749117, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI32565180, Length=346, Percent_Identity=24.5664739884393, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325148, Length=440, Percent_Identity=25.9090909090909, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323282, Length=297, Percent_Identity=28.2828282828283, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321319, Length=210, Percent_Identity=27.6190476190476, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI22024280, Length=254, Percent_Identity=30.7086614173228, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24662575, Length=233, Percent_Identity=28.755364806867, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIB_SHEAM (A1SAK0)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_929076.1
- STRING:   A1SAK0
- GeneID:   4605451
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_3204
- NMPDR:   fig|326297.7.peg.3016
- eggNOG:   COG0661
- HOGENOM:   HBG593509
- OMA:   LERFWAD
- PhylomeDB:   A1SAK0
- ProtClustDB:   CLSK907541
- HAMAP:   MF_00414
- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232
- TIGRFAMs:   TIGR01982

Pfam domain/function: PF03109 ABC1; SSF56112 Kinase_like

EC number: NA

Molecular weight: Translated: 63023; Mature: 62892

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x147c93ac)-; HASH(0x14c2dc98)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFASLRRGYQVIRTLLHYGLDDVLPPTLLPGYFKLLRLCLFWVRNRHKDKCGGERLKLA
CCHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
MQELGPVYIKFGQMLSTRRDLLSDEWAQELSMLQDRVPAFDSALAREAIEAELKAPIDSL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHH
FDDFDDTPLASASISQVHTATLKSNGQQVVLKVLRPNVEANIKADLELMLQVATWVNRLL
HHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
GEGNRLRPVEVVEDYQNTILGELNLKLEALNATKLRNNFLDSDALYIPYVYEELCHPRLM
CCCCCCCHHHHHHHHHHHHHHHHCEEEEECHHHHHHHHCCCCCCEECCHHHHHHCCHHHH
VMERIDGIPVSDIEALNAQGTNLKLLAERGVELFFTQVFRDNFFHADMHPGNIFISREHP
HHHHHCCCCCCHHHHHCCCCCCEEEHHHCCHHHHHHHHHHCCCEECCCCCCEEEEECCCC
ENPFYIGLDCGIMGSLNEEDKRYLAENFLAFFNRDYHRIAQLYVESGWVSADTDILAFEQ
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHH
AVKLVCEPMFNKPLNEISFGHVLLELFRTARRFDIVVQPQLVLLEKTLLYIEGLGRQLYP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCEEEECCHHHHHHHHHHHHHHCCHHHCC
QLDLWQTAKPFLERWMAEQVGPKAIFKKVQTNLPFWSDKLPEFPELIYDNLKLGRKLLGS
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
QQQMLDRYLKYQQKAHKSNFLLITSAVLLICGTILFAQTDTLWLASACLGSGALVWGAGW
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCC
RSRPKNRKF
CCCCCCCCH
>Mature Secondary Structure 
TFASLRRGYQVIRTLLHYGLDDVLPPTLLPGYFKLLRLCLFWVRNRHKDKCGGERLKLA
CHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
MQELGPVYIKFGQMLSTRRDLLSDEWAQELSMLQDRVPAFDSALAREAIEAELKAPIDSL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHH
FDDFDDTPLASASISQVHTATLKSNGQQVVLKVLRPNVEANIKADLELMLQVATWVNRLL
HHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
GEGNRLRPVEVVEDYQNTILGELNLKLEALNATKLRNNFLDSDALYIPYVYEELCHPRLM
CCCCCCCHHHHHHHHHHHHHHHHCEEEEECHHHHHHHHCCCCCCEECCHHHHHHCCHHHH
VMERIDGIPVSDIEALNAQGTNLKLLAERGVELFFTQVFRDNFFHADMHPGNIFISREHP
HHHHHCCCCCCHHHHHCCCCCCEEEHHHCCHHHHHHHHHHCCCEECCCCCCEEEEECCCC
ENPFYIGLDCGIMGSLNEEDKRYLAENFLAFFNRDYHRIAQLYVESGWVSADTDILAFEQ
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHH
AVKLVCEPMFNKPLNEISFGHVLLELFRTARRFDIVVQPQLVLLEKTLLYIEGLGRQLYP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCEEEECCHHHHHHHHHHHHHHCCHHHCC
QLDLWQTAKPFLERWMAEQVGPKAIFKKVQTNLPFWSDKLPEFPELIYDNLKLGRKLLGS
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
QQQMLDRYLKYQQKAHKSNFLLITSAVLLICGTILFAQTDTLWLASACLGSGALVWGAGW
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCC
RSRPKNRKF
CCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA