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The map label for this gene is crt [H]

Identifier: 119776184

GI number: 119776184

Start: 3629316

End: 3630056

Strand: Direct

Name: crt [H]

Synonym: Sama_3052

Alternate gene names: 119776184

Gene position: 3629316-3630056 (Clockwise)

Preceding gene: 119776180

Following gene: 119776188

Centisome position: 84.28

GC content: 49.39

Gene sequence:

>741_bases
ATGAGTAAAATACTCGTCAAGGATCTGGATGGCGTAAGGGTAATCAGCTTTAATCGCCCGGAAAAACGCAATGCTTTAGA
CCTTGATATGTACAGGCAGCTCACAGAATACCTTATGCAAGGTGAGAGCGACAATGACATTCGAGCCTTCTTACTGACCG
GTGAAGCCAATTGTTTCACCTCGGGGAATGATGTTGCTGACTTTTTGCAAAACAGTGAATTAGGTCCAAATCACCCTGCC
GTGCGTTTCCTGTATTGCTTGCTGGAGCTTAGAAAACCCCTGGTGGCAGCTGTGAGTGGCAGCGCGGTTGGTATTGGCAC
TACCTTACTGCTTCACTGCGATCTGGTGTATGCCGATAACAGCGCTAAATTCCAACTGCCCTTTGTGAATTTGGCATTGG
TGCCCGAAGCAGGTGCCAGTATCTTGCTACCCGAATTGGTTGGCTATCAAAAGGCAGCTGAACTCCTATTGCTGGCAGAG
CCCTTCGACGCCGAGACGGCATTGTCATTAAAGCTTATCAATGCCTTGTGTTCCAAAGAGGAATTGCAACAAACGGCGCT
GGATAAGGCCCGTAAACTGGCAAGTCAACCGCCGCAGGCTTTGCAGCAAACCCGGCAATTAATGCGCCCCCACAAACACA
GGGTGCAGCACCAGATGCATCTCGAACTGGAAGCCTTTGGGGAAAGATTAAAAAGCGATGAGGCCAAGGCCCGCTTTCAG
GCATTTCTTACAAAATCCTGA

Upstream 100 bases:

>100_bases
GGACAGCAGGCCAATCAGGCCTAAATTAAACATGTGTTTGAATATCGATTTCAATGTCATACACTCCATGTCAAGCCAAG
CTATTTTTGAGGACAACCCC

Downstream 100 bases:

>100_bases
AACCTCTGCCCCTTGCTAACGACACTGCAGCAATACCGTTAACAAGGGGCAGATTCACTCAGCATTTAGCCCCATCAAGC
CTCCCACTTATCCATTACCA

Product: enoyl-CoA hydratase/isomerase family protein

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSKILVKDLDGVRVISFNRPEKRNALDLDMYRQLTEYLMQGESDNDIRAFLLTGEANCFTSGNDVADFLQNSELGPNHPA
VRFLYCLLELRKPLVAAVSGSAVGIGTTLLLHCDLVYADNSAKFQLPFVNLALVPEAGASILLPELVGYQKAAELLLLAE
PFDAETALSLKLINALCSKEELQQTALDKARKLASQPPQALQQTRQLMRPHKHRVQHQMHLELEAFGERLKSDEAKARFQ
AFLTKS

Sequences:

>Translated_246_residues
MSKILVKDLDGVRVISFNRPEKRNALDLDMYRQLTEYLMQGESDNDIRAFLLTGEANCFTSGNDVADFLQNSELGPNHPA
VRFLYCLLELRKPLVAAVSGSAVGIGTTLLLHCDLVYADNSAKFQLPFVNLALVPEAGASILLPELVGYQKAAELLLLAE
PFDAETALSLKLINALCSKEELQQTALDKARKLASQPPQALQQTRQLMRPHKHRVQHQMHLELEAFGERLKSDEAKARFQ
AFLTKS
>Mature_245_residues
SKILVKDLDGVRVISFNRPEKRNALDLDMYRQLTEYLMQGESDNDIRAFLLTGEANCFTSGNDVADFLQNSELGPNHPAV
RFLYCLLELRKPLVAAVSGSAVGIGTTLLLHCDLVYADNSAKFQLPFVNLALVPEAGASILLPELVGYQKAAELLLLAEP
FDAETALSLKLINALCSKEELQQTALDKARKLASQPPQALQQTRQLMRPHKHRVQHQMHLELEAFGERLKSDEAKARFQA
FLTKS

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI45643119, Length=250, Percent_Identity=30.4, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI260275230, Length=250, Percent_Identity=30.4, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI260274832, Length=250, Percent_Identity=30.4, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI25453481, Length=234, Percent_Identity=26.4957264957265, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI51538573, Length=234, Percent_Identity=26.4957264957265, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4757966, Length=234, Percent_Identity=26.4957264957265, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI51538581, Length=234, Percent_Identity=26.4957264957265, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI31542718, Length=195, Percent_Identity=30.7692307692308, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI194097323, Length=238, Percent_Identity=28.9915966386555, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI4757968, Length=234, Percent_Identity=26.0683760683761, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI49355787, Length=234, Percent_Identity=26.0683760683761, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI221307494, Length=234, Percent_Identity=26.0683760683761, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI221136756, Length=234, Percent_Identity=26.0683760683761, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI221136753, Length=234, Percent_Identity=26.0683760683761, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI70995211, Length=223, Percent_Identity=28.2511210762332, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI116235487, Length=214, Percent_Identity=25.2336448598131, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI68989263, Length=177, Percent_Identity=28.8135593220339, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4502327, Length=221, Percent_Identity=28.9592760180996, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI157694516, Length=223, Percent_Identity=23.7668161434978, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI213417737, Length=223, Percent_Identity=23.7668161434978, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787660, Length=258, Percent_Identity=36.046511627907, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1787659, Length=250, Percent_Identity=30.8, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI221142681, Length=200, Percent_Identity=28.5, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788597, Length=202, Percent_Identity=28.2178217821782, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790281, Length=184, Percent_Identity=27.7173913043478, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87082183, Length=212, Percent_Identity=26.8867924528302, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788682, Length=193, Percent_Identity=25.9067357512953, Blast_Score=61, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17535521, Length=260, Percent_Identity=28.4615384615385, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17554946, Length=244, Percent_Identity=25.8196721311475, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17549921, Length=215, Percent_Identity=30.6976744186047, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25145438, Length=239, Percent_Identity=26.7782426778243, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17540714, Length=201, Percent_Identity=31.3432835820896, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17536985, Length=213, Percent_Identity=26.2910798122066, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=248, Percent_Identity=26.2096774193548, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=253, Percent_Identity=25.296442687747, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558304, Length=205, Percent_Identity=26.8292682926829, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540306, Length=191, Percent_Identity=26.1780104712042, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323314, Length=164, Percent_Identity=25.609756097561, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24654903, Length=216, Percent_Identity=31.0185185185185, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI20129971, Length=238, Percent_Identity=28.9915966386555, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24653477, Length=238, Percent_Identity=28.9915966386555, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24653139, Length=206, Percent_Identity=31.5533980582524, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357171, Length=217, Percent_Identity=30.4147465437788, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24650670, Length=209, Percent_Identity=28.7081339712919, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19920382, Length=209, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19922422, Length=187, Percent_Identity=25.668449197861, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 27388; Mature: 27257

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKILVKDLDGVRVISFNRPEKRNALDLDMYRQLTEYLMQGESDNDIRAFLLTGEANCFT
CCCCEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEC
SGNDVADFLQNSELGPNHPAVRFLYCLLELRKPLVAAVSGSAVGIGTTLLLHCDLVYADN
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEEEEEECC
SAKFQLPFVNLALVPEAGASILLPELVGYQKAAELLLLAEPFDAETALSLKLINALCSKE
CCEEEECEEEEEEECCCCCCCHHHHHHCHHHHHHEEEEECCCCCHHHHHHHHHHHHHCHH
ELQQTALDKARKLASQPPQALQQTRQLMRPHKHRVQHQMHLELEAFGERLKSDEAKARFQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AFLTKS
HHHCCC
>Mature Secondary Structure 
SKILVKDLDGVRVISFNRPEKRNALDLDMYRQLTEYLMQGESDNDIRAFLLTGEANCFT
CCCEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEC
SGNDVADFLQNSELGPNHPAVRFLYCLLELRKPLVAAVSGSAVGIGTTLLLHCDLVYADN
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEEEEEECC
SAKFQLPFVNLALVPEAGASILLPELVGYQKAAELLLLAEPFDAETALSLKLINALCSKE
CCEEEECEEEEEEECCCCCCCHHHHHHCHHHHHHEEEEECCCCCHHHHHHHHHHHHHCHH
ELQQTALDKARKLASQPPQALQQTRQLMRPHKHRVQHQMHLELEAFGERLKSDEAKARFQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AFLTKS
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]