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The map label for this gene is parE [H]

Identifier: 119776175

GI number: 119776175

Start: 3621035

End: 3622921

Strand: Reverse

Name: parE [H]

Synonym: Sama_3043

Alternate gene names: 119776175

Gene position: 3622921-3621035 (Counterclockwise)

Preceding gene: 119776176

Following gene: 119776174

Centisome position: 84.13

GC content: 54.53

Gene sequence:

>1887_bases
ATGACCAACCTATACAATTCTGATGCCATTGAGGTGCTGAACGGCCTTGAGCCGGTAAAGCGCCGTCCCGGTATGTACAC
CGATACCACACGTCCCAATCACCTGGGACAGGAAGTCATAGACAACAGTGTGGACGAGGCGCTGGCGGGACACGCAAGTC
GTATTGATGTTATTCTGCAAACGGACAATTCCCTCGAGGTCATCGACGACGGTCGGGGTATGCCGGTGGATATCCACCCG
GAAGAGGGCATTCCCGGGGTTGAACTCATTCTCACCAAACTCCACGCCGGTGGTAAATTTTCCAATAAAAACTACCAGTT
TTCCGGTGGTTTACACGGTGTGGGCATTTCGGTAGTAAACGCCCTGTCGCGCCGGGTTGAAATCACAGTGCGTCGGGATG
CTCAGGTCTACGACATGGCCTTCGAGCACGGTGATAAGGTGGAAAGCCTGACCGTGACCGGTACCTGCGGCCGGCGTAAT
ACGGGTACCCGTGTGCATTTCTGGCCGGAGCCAAGCTATTTCGATTCACCCAATTTCTCCATTACCAAGCTGATCCATCT
GCTTAAAGCCAAGGCAGTACTCTGCCCCGGGCTCAGAATCAAATTTACCAACAAGCAAACCGGTGAAGTGCATGAATGGT
ACTTCGAGGCCGGGCTGACGGATTACTTAAAGAGTGCCGTGGGCGATGCCCCCATGCTGCCTCAAGAGCCCTTTGTGGGC
AGTTTTGCCGGTAATAATGAGGCTGCAGACTGGGCTATTACCTGGTTACCCGAGGGCGGCGAATATCTTGCCGAAAGTTA
TGTAAACCTGATCCCCACCCCGCTGGGTGGCACCCACGTGAATGGCTTCCGTCAGGGGCTGCTGGAATCCATGCGGGAGT
TTTGTGAGTTTCGAAACCTCATTCCCCGCGGAATAAAACTCAGTCCTGAAGATATCTGGGATAAAACGGCGTTCATTTTA
TCCATCAAGATGCAGGATCCCCAGTTTGCCGGTCAGACCAAGGAAAAACTCTCCAGCCGTCAGAGCGCGGCCTTTGTGTC
CGGCATCGTTCGCGACGCGTTTTCCCTGTACCTGAACTCCCATACGGATTTGGCGGAAATGCTGGCGGAGATGTGTATCT
CCAACGCCCAGAAGCGTATGAAGGCGGCCAAGAAAGTCGCCCGTAAAAAGGTCACGGCAGGGCCAGCCTTGCCCGGCAAG
CTAACCGACTGCAGTGGTCAGGACCCCATGACCTCAGAACTCTTTTTGGTGGAAGGGGATTCGGCAGGTGGCAGTGCCAA
ACAGGCACGGGATCGCGAGTTTCAGGCCATCATGCCGCTGCGGGGCAAGATTTTGAATACCTGGGAGGTTGAGGCTTCAC
AGGTATTGGCATCTCAGGAAGTACACGATATCTCCGTGGCCATCGGCTGCGACCCTGACAGCGATGATATTTCTGAGCTG
CGTTACGGTAAGGTGTGTATTCTGGCCGACGCCGACTCGGATGGATTGCACATTGCTACCTTGTTGTGTGCACTCTTCCT
CAAGCACTACCGGGTACTCGTGGAGCGTGGCCATGTGTACATCGCCATGCCGCCGCTGTTCCGTATCGATATAGGTAAAG
AGGTATACTACGCCCTCGATGAGTCGGAAAAGCAGGGGATCCTCGACAGGATCGCCGCCGAAGGCAAAAAAGGCAAACCT
CAGGTAACGCGCTTTAAAGGACTGGGTGAAATGAACCCGTTACAGCTGCGTGAGACCACCATGGACCCTAACACCCGTCG
CCTGGTGCAGCTGACCATAGACGACAGTGACGATACCGTCGCGCTGATGGACATGTTGCTGGCGAAAAAGCGCTCCGGCG
ACAGAAAAACTTGGCTTGAAACCAAAGGCGATCTGGCAATCATCTGA

Upstream 100 bases:

>100_bases
GAGCGGCAATTACCGGATATCGCCGCTTTTTTAGAGTTACCTTGACAAACCGACTCGCAGGGCCGCACCATGGCCTGAAT
AACGAAGAATAACGTGCGCC

Downstream 100 bases:

>100_bases
TGTTGCCTGCCCATGATAACGATAACAGGCTAAAGAGAATGTTGAGTAATACACACCTCGGCCGCATGCTGATTGCCTGC
CTCGCCTGTATAGCGACGCA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MTNLYNSDAIEVLNGLEPVKRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHASRIDVILQTDNSLEVIDDGRGMPVDIHP
EEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSRRVEITVRRDAQVYDMAFEHGDKVESLTVTGTCGRRN
TGTRVHFWPEPSYFDSPNFSITKLIHLLKAKAVLCPGLRIKFTNKQTGEVHEWYFEAGLTDYLKSAVGDAPMLPQEPFVG
SFAGNNEAADWAITWLPEGGEYLAESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNLIPRGIKLSPEDIWDKTAFIL
SIKMQDPQFAGQTKEKLSSRQSAAFVSGIVRDAFSLYLNSHTDLAEMLAEMCISNAQKRMKAAKKVARKKVTAGPALPGK
LTDCSGQDPMTSELFLVEGDSAGGSAKQARDREFQAIMPLRGKILNTWEVEASQVLASQEVHDISVAIGCDPDSDDISEL
RYGKVCILADADSDGLHIATLLCALFLKHYRVLVERGHVYIAMPPLFRIDIGKEVYYALDESEKQGILDRIAAEGKKGKP
QVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDSDDTVALMDMLLAKKRSGDRKTWLETKGDLAII

Sequences:

>Translated_628_residues
MTNLYNSDAIEVLNGLEPVKRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHASRIDVILQTDNSLEVIDDGRGMPVDIHP
EEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSRRVEITVRRDAQVYDMAFEHGDKVESLTVTGTCGRRN
TGTRVHFWPEPSYFDSPNFSITKLIHLLKAKAVLCPGLRIKFTNKQTGEVHEWYFEAGLTDYLKSAVGDAPMLPQEPFVG
SFAGNNEAADWAITWLPEGGEYLAESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNLIPRGIKLSPEDIWDKTAFIL
SIKMQDPQFAGQTKEKLSSRQSAAFVSGIVRDAFSLYLNSHTDLAEMLAEMCISNAQKRMKAAKKVARKKVTAGPALPGK
LTDCSGQDPMTSELFLVEGDSAGGSAKQARDREFQAIMPLRGKILNTWEVEASQVLASQEVHDISVAIGCDPDSDDISEL
RYGKVCILADADSDGLHIATLLCALFLKHYRVLVERGHVYIAMPPLFRIDIGKEVYYALDESEKQGILDRIAAEGKKGKP
QVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDSDDTVALMDMLLAKKRSGDRKTWLETKGDLAII
>Mature_627_residues
TNLYNSDAIEVLNGLEPVKRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHASRIDVILQTDNSLEVIDDGRGMPVDIHPE
EGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSRRVEITVRRDAQVYDMAFEHGDKVESLTVTGTCGRRNT
GTRVHFWPEPSYFDSPNFSITKLIHLLKAKAVLCPGLRIKFTNKQTGEVHEWYFEAGLTDYLKSAVGDAPMLPQEPFVGS
FAGNNEAADWAITWLPEGGEYLAESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNLIPRGIKLSPEDIWDKTAFILS
IKMQDPQFAGQTKEKLSSRQSAAFVSGIVRDAFSLYLNSHTDLAEMLAEMCISNAQKRMKAAKKVARKKVTAGPALPGKL
TDCSGQDPMTSELFLVEGDSAGGSAKQARDREFQAIMPLRGKILNTWEVEASQVLASQEVHDISVAIGCDPDSDDISELR
YGKVCILADADSDGLHIATLLCALFLKHYRVLVERGHVYIAMPPLFRIDIGKEVYYALDESEKQGILDRIAAEGKKGKPQ
VTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDSDDTVALMDMLLAKKRSGDRKTWLETKGDLAII

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=582, Percent_Identity=24.0549828178694, Blast_Score=130, Evalue=6e-30,
Organism=Homo sapiens, GI19913406, Length=624, Percent_Identity=23.3974358974359, Blast_Score=114, Evalue=4e-25,
Organism=Escherichia coli, GI1789408, Length=630, Percent_Identity=74.6031746031746, Blast_Score=1015, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=566, Percent_Identity=38.339222614841, Blast_Score=380, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17535065, Length=602, Percent_Identity=23.7541528239203, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI212645845, Length=594, Percent_Identity=23.9057239057239, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI212645657, Length=251, Percent_Identity=27.4900398406374, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=691, Percent_Identity=23.7337192474674, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17136538, Length=626, Percent_Identity=23.0031948881789, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 69412; Mature: 69281

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLYNSDAIEVLNGLEPVKRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHASRIDVILQ
CCCCCCCHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEE
TDNSLEVIDDGRGMPVDIHPEEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVN
CCCCEEEEECCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHH
ALSRRVEITVRRDAQVYDMAFEHGDKVESLTVTGTCGRRNTGTRVHFWPEPSYFDSPNFS
HHHHEEEEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCH
ITKLIHLLKAKAVLCPGLRIKFTNKQTGEVHEWYFEAGLTDYLKSAVGDAPMLPQEPFVG
HHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCC
SFAGNNEAADWAITWLPEGGEYLAESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNL
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IPRGIKLSPEDIWDKTAFILSIKMQDPQFAGQTKEKLSSRQSAAFVSGIVRDAFSLYLNS
CCCCCCCCHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HTDLAEMLAEMCISNAQKRMKAAKKVARKKVTAGPALPGKLTDCSGQDPMTSELFLVEGD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
SAGGSAKQARDREFQAIMPLRGKILNTWEVEASQVLASQEVHDISVAIGCDPDSDDISEL
CCCCCHHHHHCCHHHHCCCCCCCEEEEEEHHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
RYGKVCILADADSDGLHIATLLCALFLKHYRVLVERGHVYIAMPPLFRIDIGKEVYYALD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCEEEEEEC
ESEKQGILDRIAAEGKKGKPQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDSDDTV
CCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCHH
ALMDMLLAKKRSGDRKTWLETKGDLAII
HHHHHHHHHHCCCCCCHHHCCCCCEEEC
>Mature Secondary Structure 
TNLYNSDAIEVLNGLEPVKRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHASRIDVILQ
CCCCCCHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEE
TDNSLEVIDDGRGMPVDIHPEEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVN
CCCCEEEEECCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHH
ALSRRVEITVRRDAQVYDMAFEHGDKVESLTVTGTCGRRNTGTRVHFWPEPSYFDSPNFS
HHHHEEEEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCH
ITKLIHLLKAKAVLCPGLRIKFTNKQTGEVHEWYFEAGLTDYLKSAVGDAPMLPQEPFVG
HHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCC
SFAGNNEAADWAITWLPEGGEYLAESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNL
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IPRGIKLSPEDIWDKTAFILSIKMQDPQFAGQTKEKLSSRQSAAFVSGIVRDAFSLYLNS
CCCCCCCCHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HTDLAEMLAEMCISNAQKRMKAAKKVARKKVTAGPALPGKLTDCSGQDPMTSELFLVEGD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
SAGGSAKQARDREFQAIMPLRGKILNTWEVEASQVLASQEVHDISVAIGCDPDSDDISEL
CCCCCHHHHHCCHHHHCCCCCCCEEEEEEHHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
RYGKVCILADADSDGLHIATLLCALFLKHYRVLVERGHVYIAMPPLFRIDIGKEVYYALD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCEEEEEEC
ESEKQGILDRIAAEGKKGKPQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDSDDTV
CCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCHH
ALMDMLLAKKRSGDRKTWLETKGDLAII
HHHHHHHHHHCCCCCCHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]