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The map label for this gene is parC [H]

Identifier: 119776173

GI number: 119776173

Start: 3617593

End: 3619863

Strand: Reverse

Name: parC [H]

Synonym: Sama_3041

Alternate gene names: 119776173

Gene position: 3619863-3617593 (Counterclockwise)

Preceding gene: 119776174

Following gene: 119776170

Centisome position: 84.06

GC content: 56.85

Gene sequence:

>2271_bases
ATGAGTGACGCCATTGACTTAAGCCTGGATGGTGTGGAGCAAATGCCCTTGAGGCGCTTCACCGAAGAGGCCTATCTCAA
CTATTCCATGTACGTAATCATGGACCGGGCCCTTCCCCATATTGGTGATGGCCTCAAACCGGTGCAAAGACGTATCGTCT
ATGCCATGAGTGAACTGGGCCTTAATGCCCAGTCGAAGCACAAGAAATCTGCCCGTACGGTGGGTGACGTGCTGGGTAAA
TATCACCCCCACGGTGACAGTGCCTGTTACGAAGCCATGGTGCTGATGGCGCAGCCGTTTTCCTACCGCTATCCGCTGGT
GGATGGTCAGGGTAACTGGGGTGCTCCTGACGATCCTAAGTCCTTCGCGGCCATGCGATATACAGAAGCGCGGCTGTCGC
GCTTCTCTGAGGTACTGCTCTCTGAGCTCGGCCAGGGCACTGTGGATTGGGGCGTCAACTTTGACGGCACCATGAAAGAG
CCCAAGGTGTTGCCGGCCCGCTTGCCCCACATTCTGCTTAACGGGGTAACCGGTATTGCTGTGGGTATGGCGACGGATAT
ACCGCCCCACAACGCCCGGGAACTGACGCGAGCCTGTATCGAGTTAATTGATAATCCCGCCACTGAGCTTAAGCGCTTGA
TGGAGCTCGTACCGGGTCCTGATTATCCCACAGAGGCGGAAATCATTACCCCCGCCGATGAAATCGCCAAGATTTATGAG
TCCGGCCGTGGCTCCATCAGGATGCGCGCTGTTTACGAGATGGAAAACGGTGAGGTGGTGATTTCTGCGCTGCCGCATCA
GGCCAGCTCCAGTAAGATCCTCGAGCAAATTGCGGCTCAGATGCAGGCGAAAAAGCTGCCGATGGTGACGGATTTGCGCG
ACGAATCCGACCACGAAAATCCGGTGCGACTGGTGTTGGTACCACGTTCTAATCGGGTGGATGTGGAACAGCTGATGGCC
CACCTGTTTGCGACCACCGAGCTTGAAAAGAGCTACCGGGTTAACCTGAATGTGATTGGCCTGGATGGCCGTCCCAAGGT
AAAAGGCCTGAAGGACATGCTGGCCGAGTGGCTGGTTTTCCGTACCGAAACTGTACGTCGCCGTCTGCAATTCCGTCTGG
ACAAGGTGCTGGCAAGGCTGCACATCCTCGAAGCCCTGATGATTGCCTTCCTTAACATCGATGAAGTGATTGAAATCATT
CGCTTCCACGATGAGCCCAAGGCTGAGCTGATGGCGCGTTTCGGGCTGTCGGACCGTCAGGCCGAGGCCATTTTGGAACT
CAAGTTGCGCCATTTGGCCAAGCTCGAAGAGATGAAAATCAAAGCCGAGCAAAGCGAGCTTGAAGAAGAGCGCAATAAGC
TGGAGCAGATCCTGGGGTCGGAGCGTCGTCTCAAGACCCTGATCAAGAAAGAACTGGAAAAGGATGCCGAAACCTACGGT
GACGATCGCCGCTCGCCTCTGGTCGTGCGTGGCGAGTCCCGCGCCCTTACCGAACAGGAGTTGCTGCCCACCGAGCCTGT
GACAGTTGTGCTTTCTGAAAAGGGTTGGGTACGCTGTGCAAAGGGCCACGATATAGACGCAGGTGCTCTGTCTTATAAAG
CGGGCGATGGCTTCCTGTGTGCGGCGCAAGGGCGCAGCAACCAGCAGAGTGTGTTTATCGACAGCTCTGGCCGAGCCTTC
TCAACCGATACCCACACCCTGCCGTCGGCGAGAAGTCAGGGCGAGCCCATTACCACTCGCTTTAATCTGGCGCCTGGCGA
AACCATGGAGCATGTGCTCCTGGGTGAAGAGCAGCACCACTACCTGCTCGCCAGTGACGCAGGTTATGGTTTTGTCTGCT
CTTTTGCCGATATGATTTCCCGTAACAAGGCGGGTAAGGCGCTGCTCAGTTTGCCATCCGGCGCCAAGGCGTTGGCCCCC
CGTCGGGTTGACAAAGACGCCAATCCCTCCATTTTGGCCATCACCAATGAAGGCCGCATGCTGGTCTTTGGACTGGATGC
GCTGCCGCAGCTGGCGAAAGGTAAGGGCAATAAGATTATCGGTATCCCCAGTGAACGGGCCAAAAACCGAGAAGAGCTGT
TGATACACCTGCACCTGGTGCCAGCCGACTCGGCCGTGACCCTGTGGGCTGGCAAACGTAAGCTGACGCTGAAGAGTTCC
GATCTCGAGCATTACCGGGGTGAGCGTGGCCGACGCGGTGCCAAGCTGCCAAGGGGCCTGCAGCGGGTTGACAGTGTCGA
GCTGGGGGAAGGGGATACCCCCGCCTTGTAA

Upstream 100 bases:

>100_bases
ACGGTTCACTGTTTATCTCAGACGATTTGAAAGGCAACGTTTACCGGTTCTTCTACAGGCATGAAGCCGAAGAAGAGGCG
CCAACGCAGGAAGAGCAACC

Downstream 100 bases:

>100_bases
GCGCTGCAAACGTGTGTTTGACACACAATAATAAAAAAGCACTGCCTGGCAGTGCTTTTTTATTTGAATCTGAGTCGCAG
ACTGCGCAGCTAAACCTTAC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 756; Mature: 755

Protein sequence:

>756_residues
MSDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLNAQSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSRFSEVLLSELGQGTVDWGVNFDGTMKE
PKVLPARLPHILLNGVTGIAVGMATDIPPHNARELTRACIELIDNPATELKRLMELVPGPDYPTEAEIITPADEIAKIYE
SGRGSIRMRAVYEMENGEVVISALPHQASSSKILEQIAAQMQAKKLPMVTDLRDESDHENPVRLVLVPRSNRVDVEQLMA
HLFATTELEKSYRVNLNVIGLDGRPKVKGLKDMLAEWLVFRTETVRRRLQFRLDKVLARLHILEALMIAFLNIDEVIEII
RFHDEPKAELMARFGLSDRQAEAILELKLRHLAKLEEMKIKAEQSELEEERNKLEQILGSERRLKTLIKKELEKDAETYG
DDRRSPLVVRGESRALTEQELLPTEPVTVVLSEKGWVRCAKGHDIDAGALSYKAGDGFLCAAQGRSNQQSVFIDSSGRAF
STDTHTLPSARSQGEPITTRFNLAPGETMEHVLLGEEQHHYLLASDAGYGFVCSFADMISRNKAGKALLSLPSGAKALAP
RRVDKDANPSILAITNEGRMLVFGLDALPQLAKGKGNKIIGIPSERAKNREELLIHLHLVPADSAVTLWAGKRKLTLKSS
DLEHYRGERGRRGAKLPRGLQRVDSVELGEGDTPAL

Sequences:

>Translated_756_residues
MSDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLNAQSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSRFSEVLLSELGQGTVDWGVNFDGTMKE
PKVLPARLPHILLNGVTGIAVGMATDIPPHNARELTRACIELIDNPATELKRLMELVPGPDYPTEAEIITPADEIAKIYE
SGRGSIRMRAVYEMENGEVVISALPHQASSSKILEQIAAQMQAKKLPMVTDLRDESDHENPVRLVLVPRSNRVDVEQLMA
HLFATTELEKSYRVNLNVIGLDGRPKVKGLKDMLAEWLVFRTETVRRRLQFRLDKVLARLHILEALMIAFLNIDEVIEII
RFHDEPKAELMARFGLSDRQAEAILELKLRHLAKLEEMKIKAEQSELEEERNKLEQILGSERRLKTLIKKELEKDAETYG
DDRRSPLVVRGESRALTEQELLPTEPVTVVLSEKGWVRCAKGHDIDAGALSYKAGDGFLCAAQGRSNQQSVFIDSSGRAF
STDTHTLPSARSQGEPITTRFNLAPGETMEHVLLGEEQHHYLLASDAGYGFVCSFADMISRNKAGKALLSLPSGAKALAP
RRVDKDANPSILAITNEGRMLVFGLDALPQLAKGKGNKIIGIPSERAKNREELLIHLHLVPADSAVTLWAGKRKLTLKSS
DLEHYRGERGRRGAKLPRGLQRVDSVELGEGDTPAL
>Mature_755_residues
SDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLNAQSKHKKSARTVGDVLGKY
HPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSRFSEVLLSELGQGTVDWGVNFDGTMKEP
KVLPARLPHILLNGVTGIAVGMATDIPPHNARELTRACIELIDNPATELKRLMELVPGPDYPTEAEIITPADEIAKIYES
GRGSIRMRAVYEMENGEVVISALPHQASSSKILEQIAAQMQAKKLPMVTDLRDESDHENPVRLVLVPRSNRVDVEQLMAH
LFATTELEKSYRVNLNVIGLDGRPKVKGLKDMLAEWLVFRTETVRRRLQFRLDKVLARLHILEALMIAFLNIDEVIEIIR
FHDEPKAELMARFGLSDRQAEAILELKLRHLAKLEEMKIKAEQSELEEERNKLEQILGSERRLKTLIKKELEKDAETYGD
DRRSPLVVRGESRALTEQELLPTEPVTVVLSEKGWVRCAKGHDIDAGALSYKAGDGFLCAAQGRSNQQSVFIDSSGRAFS
TDTHTLPSARSQGEPITTRFNLAPGETMEHVLLGEEQHHYLLASDAGYGFVCSFADMISRNKAGKALLSLPSGAKALAPR
RVDKDANPSILAITNEGRMLVFGLDALPQLAKGKGNKIIGIPSERAKNREELLIHLHLVPADSAVTLWAGKRKLTLKSSD
LEHYRGERGRRGAKLPRGLQRVDSVELGEGDTPAL

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=745, Percent_Identity=68.993288590604, Blast_Score=1069, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=697, Percent_Identity=36.441893830703, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI212645845, Length=491, Percent_Identity=23.8289205702648, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=398, Percent_Identity=22.6130653266332, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84154; Mature: 84023

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELG
CCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LNAQSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPK
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCH
SFAAMRYTEARLSRFSEVLLSELGQGTVDWGVNFDGTMKEPKVLPARLPHILLNGVTGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHCHHHHE
VGMATDIPPHNARELTRACIELIDNPATELKRLMELVPGPDYPTEAEIITPADEIAKIYE
EEHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
SGRGSIRMRAVYEMENGEVVISALPHQASSSKILEQIAAQMQAKKLPMVTDLRDESDHEN
CCCCCEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PVRLVLVPRSNRVDVEQLMAHLFATTELEKSYRVNLNVIGLDGRPKVKGLKDMLAEWLVF
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHH
RTETVRRRLQFRLDKVLARLHILEALMIAFLNIDEVIEIIRFHDEPKAELMARFGLSDRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHCCCCHHH
AEAILELKLRHLAKLEEMKIKAEQSELEEERNKLEQILGSERRLKTLIKKELEKDAETYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
DDRRSPLVVRGESRALTEQELLPTEPVTVVLSEKGWVRCAKGHDIDAGALSYKAGDGFLC
CCCCCCEEEECCCCCCCHHHCCCCCCEEEEECCCCCEEECCCCCCCCCCEEEECCCCEEE
AAQGRSNQQSVFIDSSGRAFSTDTHTLPSARSQGEPITTRFNLAPGETMEHVLLGEEQHH
ECCCCCCCCEEEEECCCCEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCC
YLLASDAGYGFVCSFADMISRNKAGKALLSLPSGAKALAPRRVDKDANPSILAITNEGRM
EEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHCCCCCCCCCCCCEEEEECCCCE
LVFGLDALPQLAKGKGNKIIGIPSERAKNREELLIHLHLVPADSAVTLWAGKRKLTLKSS
EEEECHHHHHHHCCCCCEEEECCCHHHCCCEEEEEEEEEECCCCEEEEEECCEEEEEECC
DLEHYRGERGRRGAKLPRGLQRVDSVELGEGDTPAL
CHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELG
CCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LNAQSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPK
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCH
SFAAMRYTEARLSRFSEVLLSELGQGTVDWGVNFDGTMKEPKVLPARLPHILLNGVTGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHCHHHHE
VGMATDIPPHNARELTRACIELIDNPATELKRLMELVPGPDYPTEAEIITPADEIAKIYE
EEHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
SGRGSIRMRAVYEMENGEVVISALPHQASSSKILEQIAAQMQAKKLPMVTDLRDESDHEN
CCCCCEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PVRLVLVPRSNRVDVEQLMAHLFATTELEKSYRVNLNVIGLDGRPKVKGLKDMLAEWLVF
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHH
RTETVRRRLQFRLDKVLARLHILEALMIAFLNIDEVIEIIRFHDEPKAELMARFGLSDRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHCCCCHHH
AEAILELKLRHLAKLEEMKIKAEQSELEEERNKLEQILGSERRLKTLIKKELEKDAETYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
DDRRSPLVVRGESRALTEQELLPTEPVTVVLSEKGWVRCAKGHDIDAGALSYKAGDGFLC
CCCCCCEEEECCCCCCCHHHCCCCCCEEEEECCCCCEEECCCCCCCCCCEEEECCCCEEE
AAQGRSNQQSVFIDSSGRAFSTDTHTLPSARSQGEPITTRFNLAPGETMEHVLLGEEQHH
ECCCCCCCCEEEEECCCCEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCC
YLLASDAGYGFVCSFADMISRNKAGKALLSLPSGAKALAPRRVDKDANPSILAITNEGRM
EEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHCCCCCCCCCCCCEEEEECCCCE
LVFGLDALPQLAKGKGNKIIGIPSERAKNREELLIHLHLVPADSAVTLWAGKRKLTLKSS
EEEECHHHHHHHCCCCCEEEECCCHHHCCCEEEEEEEEEECCCCEEEEEECCEEEEEECC
DLEHYRGERGRRGAKLPRGLQRVDSVELGEGDTPAL
CHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]