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The map label for this gene is mutL

Identifier: 119776159

GI number: 119776159

Start: 3600972

End: 3602924

Strand: Reverse

Name: mutL

Synonym: Sama_3027

Alternate gene names: 119776159

Gene position: 3602924-3600972 (Counterclockwise)

Preceding gene: 119776160

Following gene: 119776158

Centisome position: 83.67

GC content: 55.76

Gene sequence:

>1953_bases
ATGGCAATTCAGGTATTGCCACCTCAGTTGGCAAACCAGATTGCGGCTGGTGAGGTGGTAGAGCGCCCAGCCTCGGTGAT
AAAAGAGCTGGTGGAAAACAGTTTGGATGCGGGCGCTACCCGGGTCGATATTGATATCGATAAGGGCGGCAGCAAGCTTA
TCCGTATTCGCGACAATGGTGGCGGTATTCCGAAAGCGGAATTGGCGCTGGCACTGGCGCGCCATGCGACTTCCAAGGTG
CAAACCCTCGAAGATCTTGAAGCGATTCTGAGTTTTGGCTTTCGCGGGGAGGCATTGGCGAGTATCAGTTCTGTGTCACG
ACTGACACTGACGTCGCGCACCACAGAGCAAGCAGAAGCCTGGCAGGCCTATGCCGAGGGCTCGGAGGTGGCTATCCGGG
TGATGCCTGCGGCGCACCCTGTTGGTACCACCATTGAGGTGGCCGATCTCTTCTTTAATACCCCGGCACGGCGGCGATTT
CTCAAGAGTGACAAAACCGAGTTTACCCATATTGATGAATGGCTGAAGCGTATCGCTCTGATACGCTCTGACGTGCATTT
TTCCCTGAGCCACAATGGAAAGCCTGTGCGCCAGTATCGTTGCGCTGCGACTGATACTCAGTACTTGCAGAGGCTGGCTC
AGGTGGCAGGCAGGGCGTTTGCCGACAGCGCCATCAAGGTCGACTGTCAGCATGATGGCATGGGTTTGAGTGGCTATCTA
CAGTCACCAGCGCTCTCTGACATGGTGGATTGCCATTACTTTTATGTTAACGGCCGCCTGATCCGCGACCGATTGGTCAA
TCACGCGGTACGTCAGGCCTTCGGTGAGCTCGGGACCTTTGAACAGCCTGCCTTCGTGCTGAGTCTGACACTCGATCCCC
ATCAGGTGGATGTCAATGTGCATCCGGCCAAGCACGAGGTGCGTTTTCACCAAGCCCGATATGTGCATGACTTTATTTTG
CAGGTGTTGCAATCGGCATTAAGCCAGATGCAGGACTTGCCCTTGGCTGAGGAGCTGCCAAGGGCTCAAGAGTCCCCTGC
GTCGGTGAGAGAACATACGGCAGGATACGCGCCCTATACCTTTAACCGTGACGCTGCGACTGAAGCCGCCGGTGTTCTCA
GTAGTTTGCCGGACACTCAACGAAGTCAGCGCCAACCCGAGAAGGCTGCATCTGGGCAGCGCAGTAGCGTTGATGCTGGC
CTTTCTCAAGGTTCATCGGCCCATCGCGCGTCTCAAACCGGATTGGGGCAGTCGGGAAACGCTGCCACATTTGAAACATC
TGAACGCCATGGAAGTGGCTATTCGGGCGCAGGCCAGGGACAGCGTTATGTCCGGGACCAATTGTCCGGGCAACAGCGTC
AGGCGGCCCAGTATTATGCCGAGCTGTTGCACACTCCCGAGGTGGTAAGCACCAGCGGCAGTCTTCAGGCAGGTCTGCCC
ATGCCGCCCTTGCTGGCGGGCCGCTATTGGGTGTTGGCACAGGATGAGCATCTTCGCCTGTTGTCCATTAGCGATGCCGC
TAAAGCGCTTGTCGTACAGGAAATATTATCCAAGCTGCCAACGGGATTGGTGGGGCAGCCTCTGCTGATGCCGGTCGCGG
TTGCCGCCGATGCGGATTGGACGATGATATTGGCCGAACGGGAGTCGTTGCTCAGGCGTCTTGGTCTTGAACTGACAATT
CGGTATCAGCAGTTGATAATCAAAAAAGTGCCCCCATATCTGAGGGACAGTCAGCTGGCAAAGCTTATCCCTGAGTTTCT
GGAATGGATAAAGTTAGAGGTGCCAGCCGACGAAGCCCTGTGTCACTGGCTGGCTCAGTACGTGACAGGTTTTGATGCGG
CCCCCAAGGTGTGGCAGCGTATTCAGTCCCTTGAAGCGACTGAGCGGAATAAGATTTTAGAGAGTGCCAGAGATTTGCCC
TGGCAGACATGGCTAGATGAATACAAACACTGA

Upstream 100 bases:

>100_bases
TTTCTGTCATCAGTCTCAAACAGGCGAATAACCTTAAGTCCGACACCCTGCGTGTGGGCCAAAAGCTGGTGATCCCCAAA
GGATAAACAAGGAATACCCC

Downstream 100 bases:

>100_bases
CATGACTTCCCTGCCCAAGGTGCTGTTTCTAATGGGGCCAACGGCTTCAGGCAAGACGGCGCTGGCGCTGGACATGGCTG
AACATCACAACTGTGAGATT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MAIQVLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIDIDKGGSKLIRIRDNGGGIPKAELALALARHATSKV
QTLEDLEAILSFGFRGEALASISSVSRLTLTSRTTEQAEAWQAYAEGSEVAIRVMPAAHPVGTTIEVADLFFNTPARRRF
LKSDKTEFTHIDEWLKRIALIRSDVHFSLSHNGKPVRQYRCAATDTQYLQRLAQVAGRAFADSAIKVDCQHDGMGLSGYL
QSPALSDMVDCHYFYVNGRLIRDRLVNHAVRQAFGELGTFEQPAFVLSLTLDPHQVDVNVHPAKHEVRFHQARYVHDFIL
QVLQSALSQMQDLPLAEELPRAQESPASVREHTAGYAPYTFNRDAATEAAGVLSSLPDTQRSQRQPEKAASGQRSSVDAG
LSQGSSAHRASQTGLGQSGNAATFETSERHGSGYSGAGQGQRYVRDQLSGQQRQAAQYYAELLHTPEVVSTSGSLQAGLP
MPPLLAGRYWVLAQDEHLRLLSISDAAKALVVQEILSKLPTGLVGQPLLMPVAVAADADWTMILAERESLLRRLGLELTI
RYQQLIIKKVPPYLRDSQLAKLIPEFLEWIKLEVPADEALCHWLAQYVTGFDAAPKVWQRIQSLEATERNKILESARDLP
WQTWLDEYKH

Sequences:

>Translated_650_residues
MAIQVLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIDIDKGGSKLIRIRDNGGGIPKAELALALARHATSKV
QTLEDLEAILSFGFRGEALASISSVSRLTLTSRTTEQAEAWQAYAEGSEVAIRVMPAAHPVGTTIEVADLFFNTPARRRF
LKSDKTEFTHIDEWLKRIALIRSDVHFSLSHNGKPVRQYRCAATDTQYLQRLAQVAGRAFADSAIKVDCQHDGMGLSGYL
QSPALSDMVDCHYFYVNGRLIRDRLVNHAVRQAFGELGTFEQPAFVLSLTLDPHQVDVNVHPAKHEVRFHQARYVHDFIL
QVLQSALSQMQDLPLAEELPRAQESPASVREHTAGYAPYTFNRDAATEAAGVLSSLPDTQRSQRQPEKAASGQRSSVDAG
LSQGSSAHRASQTGLGQSGNAATFETSERHGSGYSGAGQGQRYVRDQLSGQQRQAAQYYAELLHTPEVVSTSGSLQAGLP
MPPLLAGRYWVLAQDEHLRLLSISDAAKALVVQEILSKLPTGLVGQPLLMPVAVAADADWTMILAERESLLRRLGLELTI
RYQQLIIKKVPPYLRDSQLAKLIPEFLEWIKLEVPADEALCHWLAQYVTGFDAAPKVWQRIQSLEATERNKILESARDLP
WQTWLDEYKH
>Mature_649_residues
AIQVLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIDIDKGGSKLIRIRDNGGGIPKAELALALARHATSKVQ
TLEDLEAILSFGFRGEALASISSVSRLTLTSRTTEQAEAWQAYAEGSEVAIRVMPAAHPVGTTIEVADLFFNTPARRRFL
KSDKTEFTHIDEWLKRIALIRSDVHFSLSHNGKPVRQYRCAATDTQYLQRLAQVAGRAFADSAIKVDCQHDGMGLSGYLQ
SPALSDMVDCHYFYVNGRLIRDRLVNHAVRQAFGELGTFEQPAFVLSLTLDPHQVDVNVHPAKHEVRFHQARYVHDFILQ
VLQSALSQMQDLPLAEELPRAQESPASVREHTAGYAPYTFNRDAATEAAGVLSSLPDTQRSQRQPEKAASGQRSSVDAGL
SQGSSAHRASQTGLGQSGNAATFETSERHGSGYSGAGQGQRYVRDQLSGQQRQAAQYYAELLHTPEVVSTSGSLQAGLPM
PPLLAGRYWVLAQDEHLRLLSISDAAKALVVQEILSKLPTGLVGQPLLMPVAVAADADWTMILAERESLLRRLGLELTIR
YQQLIIKKVPPYLRDSQLAKLIPEFLEWIKLEVPADEALCHWLAQYVTGFDAAPKVWQRIQSLEATERNKILESARDLPW
QTWLDEYKH

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=329, Percent_Identity=34.9544072948328, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI4505913, Length=355, Percent_Identity=27.3239436619718, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI310128478, Length=355, Percent_Identity=27.3239436619718, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4505911, Length=331, Percent_Identity=28.0966767371601, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI189458898, Length=331, Percent_Identity=28.0966767371601, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=28.0757097791798, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=29.0598290598291, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI310128480, Length=307, Percent_Identity=24.7557003257329, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI91992162, Length=264, Percent_Identity=25, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI91992160, Length=264, Percent_Identity=25, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1790612, Length=649, Percent_Identity=46.9953775038521, Blast_Score=489, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71991825, Length=319, Percent_Identity=35.423197492163, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=350, Percent_Identity=26.2857142857143, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=347, Percent_Identity=36.3112391930836, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324247, Length=373, Percent_Identity=24.6648793565684, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325093, Length=350, Percent_Identity=25.4285714285714, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=360, Percent_Identity=23.0555555555556, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136968, Length=332, Percent_Identity=34.9397590361446, Blast_Score=183, Evalue=4e-46,
Organism=Drosophila melanogaster, GI17136970, Length=194, Percent_Identity=34.5360824742268, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_SHEAM (A1SA23)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928899.1
- ProteinModelPortal:   A1SA23
- STRING:   A1SA23
- GeneID:   4605274
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_3027
- NMPDR:   fig|326297.7.peg.2844
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FTHIDEW
- PhylomeDB:   A1SA23
- ProtClustDB:   PRK00095
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 71718; Mature: 71587

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQVLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIDIDKGGSKLIRIRDNG
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCC
GGIPKAELALALARHATSKVQTLEDLEAILSFGFRGEALASISSVSRLTLTSRTTEQAEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCHHHHHH
WQAYAEGSEVAIRVMPAAHPVGTTIEVADLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
HHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
IRSDVHFSLSHNGKPVRQYRCAATDTQYLQRLAQVAGRAFADSAIKVDCQHDGMGLSGYL
HHHCCEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
QSPALSDMVDCHYFYVNGRLIRDRLVNHAVRQAFGELGTFEQPAFVLSLTLDPHQVDVNV
CCCCHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEE
HPAKHEVRFHQARYVHDFILQVLQSALSQMQDLPLAEELPRAQESPASVREHTAGYAPYT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHCCCCCCCC
FNRDAATEAAGVLSSLPDTQRSQRQPEKAASGQRSSVDAGLSQGSSAHRASQTGLGQSGN
CCCCHHHHHHHHHHHCCCCHHHHCCCHHHHCCCCHHHHHHHHCCCCHHHHHHCCCCCCCC
AATFETSERHGSGYSGAGQGQRYVRDQLSGQQRQAAQYYAELLHTPEVVSTSGSLQAGLP
CCEEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCC
MPPLLAGRYWVLAQDEHLRLLSISDAAKALVVQEILSKLPTGLVGQPLLMPVAVAADADW
CCCHHCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCC
TMILAERESLLRRLGLELTIRYQQLIIKKVPPYLRDSQLAKLIPEFLEWIKLEVPADEAL
EEHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEECCCCHHHH
CHWLAQYVTGFDAAPKVWQRIQSLEATERNKILESARDLPWQTWLDEYKH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
>Mature Secondary Structure 
AIQVLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIDIDKGGSKLIRIRDNG
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCC
GGIPKAELALALARHATSKVQTLEDLEAILSFGFRGEALASISSVSRLTLTSRTTEQAEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCHHHHHH
WQAYAEGSEVAIRVMPAAHPVGTTIEVADLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
HHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
IRSDVHFSLSHNGKPVRQYRCAATDTQYLQRLAQVAGRAFADSAIKVDCQHDGMGLSGYL
HHHCCEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
QSPALSDMVDCHYFYVNGRLIRDRLVNHAVRQAFGELGTFEQPAFVLSLTLDPHQVDVNV
CCCCHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEE
HPAKHEVRFHQARYVHDFILQVLQSALSQMQDLPLAEELPRAQESPASVREHTAGYAPYT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHCCCCCCCC
FNRDAATEAAGVLSSLPDTQRSQRQPEKAASGQRSSVDAGLSQGSSAHRASQTGLGQSGN
CCCCHHHHHHHHHHHCCCCHHHHCCCHHHHCCCCHHHHHHHHCCCCHHHHHHCCCCCCCC
AATFETSERHGSGYSGAGQGQRYVRDQLSGQQRQAAQYYAELLHTPEVVSTSGSLQAGLP
CCEEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCC
MPPLLAGRYWVLAQDEHLRLLSISDAAKALVVQEILSKLPTGLVGQPLLMPVAVAADADW
CCCHHCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCC
TMILAERESLLRRLGLELTIRYQQLIIKKVPPYLRDSQLAKLIPEFLEWIKLEVPADEAL
EEHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEECCCCHHHH
CHWLAQYVTGFDAAPKVWQRIQSLEATERNKILESARDLPWQTWLDEYKH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA