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The map label for this gene is serA [H]

Identifier: 119776081

GI number: 119776081

Start: 3505670

End: 3506899

Strand: Direct

Name: serA [H]

Synonym: Sama_2949

Alternate gene names: 119776081

Gene position: 3505670-3506899 (Clockwise)

Preceding gene: 119776079

Following gene: 119776082

Centisome position: 81.41

GC content: 55.45

Gene sequence:

>1230_bases
ATGGCGAAACATTCGCTGGACAAGGATAAGATCAAGTTCCTGCTGCTCGAAGGCGTCCACCAATCTGCGGTAGATGTACT
TGAGCGGGCGGGCTACACCAATATCGAATATCACAAGGCGTCCCTCGCCGATGAGGCGCTGGTCGCGTCCATCAAAGATG
CCCACTTCGTCGGCATTCGCTCCCGCACTCAACTGAGTGCCGAGGTGCTGAGCAAGGCCGAAAAACTGGTTGGAATTGGT
TGCTTCTGTATTGGTACCAACCAGGTTGACCTCAAGTCTGCCGAGCTGGCCGGTATCCCGGTATTTAACGCGCCCTTCTC
CAATACCCGCTCTGTGGCTGAGCTGGTATTGGGCGAAATCATCATGCTGATGCGCGGCATCCCCCAACGCAACGCCTTGT
GCCACCGTGGCGGCTGGCTCAAGAGTGCCAATGGCAGCGTGGAAGTGCGCGGCAAAACCCTGGGCGTGATTGGCTATGGC
CACATAGGTACCCAGCTTGGCATTCTGGCCGAAACCCTGGGTATGCGGGTGAAGTTTTTCGATATCGAAGACAAGCTGCC
ACTGGGCAACGCTCAGCAGGTGCATTCCTTTGAAGAATTGCTCGCCAACGCCGATGTGGTGAGCCTGCATGTGCCAGAAA
CCCCGCAGACCAAAAACATGATTGGCCATACTGAACTGGCCACCATGAAAAAGGGCAGTTTCCTGATTAACGCGTCCCGC
GGCACAGTGGTAGACATCGATGCTCTGTCAGCCGCGCTCAAAGAAGAGCACATTGCCGGCGCTGCCATCGACGTGTTCCC
GGTTGAGCCCAAGTCAAACGATGATGTGTTCCAAAGTCCTCTGCGTGGTCTGGACAATGTCATCCTGACCCCACATGTGG
GTGGTTCTACCGAAGAGGCCCAGGAAAACATTGGTATCGAAGTGGCTGGCAAGCTCGCCAAGTACTCAGACAACGGCTCC
ACCGTGTCTGCGGTGAACTTCCCCGAGGTATCCCTGCCGATGCACAAGGGCACCTCACGTTTGCTGCACATTCACAAAAA
CCGCCCCGGTATTCTTATCAAGATTAACCAGGCGTTTTCTGAAAAAGGTATCAACATTTCCGCCCAGTACCTGCAAACCA
CCGCAGATATAGGTTACGTGGTGATGGAAGTGGACACCCACCAGGCCGAGGAAGCACTCGAGCAGCTGCGTGGCATCGAA
GGCACCATCAGAACCCGTTTGCTGCACTGA

Upstream 100 bases:

>100_bases
CAGCCCTCCACACTGTGTAAAAAAAATGCTAATTTGGGCGGGCATTGACAGTCAGCAGACAAATAAAACCTATAGGCATT
AGAAAGAGGGTATCTACACC

Downstream 100 bases:

>100_bases
CAGTGACGCCAAAAAAGGCGCCCGGGGGGCGCCTTTTTATTTTTGCGTGTCAGGCCTGAATATGGTCATTCACCCGGCCA
TTGGGATCCGCTACAATCCC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAKHSLDKDKIKFLLLEGVHQSAVDVLERAGYTNIEYHKASLADEALVASIKDAHFVGIRSRTQLSAEVLSKAEKLVGIG
CFCIGTNQVDLKSAELAGIPVFNAPFSNTRSVAELVLGEIIMLMRGIPQRNALCHRGGWLKSANGSVEVRGKTLGVIGYG
HIGTQLGILAETLGMRVKFFDIEDKLPLGNAQQVHSFEELLANADVVSLHVPETPQTKNMIGHTELATMKKGSFLINASR
GTVVDIDALSAALKEEHIAGAAIDVFPVEPKSNDDVFQSPLRGLDNVILTPHVGGSTEEAQENIGIEVAGKLAKYSDNGS
TVSAVNFPEVSLPMHKGTSRLLHIHKNRPGILIKINQAFSEKGINISAQYLQTTADIGYVVMEVDTHQAEEALEQLRGIE
GTIRTRLLH

Sequences:

>Translated_409_residues
MAKHSLDKDKIKFLLLEGVHQSAVDVLERAGYTNIEYHKASLADEALVASIKDAHFVGIRSRTQLSAEVLSKAEKLVGIG
CFCIGTNQVDLKSAELAGIPVFNAPFSNTRSVAELVLGEIIMLMRGIPQRNALCHRGGWLKSANGSVEVRGKTLGVIGYG
HIGTQLGILAETLGMRVKFFDIEDKLPLGNAQQVHSFEELLANADVVSLHVPETPQTKNMIGHTELATMKKGSFLINASR
GTVVDIDALSAALKEEHIAGAAIDVFPVEPKSNDDVFQSPLRGLDNVILTPHVGGSTEEAQENIGIEVAGKLAKYSDNGS
TVSAVNFPEVSLPMHKGTSRLLHIHKNRPGILIKINQAFSEKGINISAQYLQTTADIGYVVMEVDTHQAEEALEQLRGIE
GTIRTRLLH
>Mature_408_residues
AKHSLDKDKIKFLLLEGVHQSAVDVLERAGYTNIEYHKASLADEALVASIKDAHFVGIRSRTQLSAEVLSKAEKLVGIGC
FCIGTNQVDLKSAELAGIPVFNAPFSNTRSVAELVLGEIIMLMRGIPQRNALCHRGGWLKSANGSVEVRGKTLGVIGYGH
IGTQLGILAETLGMRVKFFDIEDKLPLGNAQQVHSFEELLANADVVSLHVPETPQTKNMIGHTELATMKKGSFLINASRG
TVVDIDALSAALKEEHIAGAAIDVFPVEPKSNDDVFQSPLRGLDNVILTPHVGGSTEEAQENIGIEVAGKLAKYSDNGST
VSAVNFPEVSLPMHKGTSRLLHIHKNRPGILIKINQAFSEKGINISAQYLQTTADIGYVVMEVDTHQAEEALEQLRGIEG
TIRTRLLH

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=33.7539432176656, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI145580578, Length=253, Percent_Identity=34.7826086956522, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4557499, Length=253, Percent_Identity=34.7826086956522, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI61743967, Length=263, Percent_Identity=33.0798479087452, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4557497, Length=263, Percent_Identity=33.0798479087452, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI145580575, Length=253, Percent_Identity=34.7826086956522, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI6912396, Length=240, Percent_Identity=27.0833333333333, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=68.1265206812652, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1787645, Length=245, Percent_Identity=33.0612244897959, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=30.6201550387597, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788660, Length=311, Percent_Identity=28.2958199356913, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=327, Percent_Identity=33.9449541284404, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI25147481, Length=273, Percent_Identity=29.6703296703297, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=49.5169082125604, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=48.792270531401, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324964, Length=266, Percent_Identity=25.5639097744361, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=230, Percent_Identity=27.3913043478261, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=155, Percent_Identity=30.3225806451613, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=162, Percent_Identity=29.0123456790123, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=32.5581395348837, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=31.9230769230769, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=31.9230769230769, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=31.9230769230769, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=31.9230769230769, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=31.9230769230769, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574286, Length=270, Percent_Identity=31.1111111111111, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28571528, Length=302, Percent_Identity=27.8145695364238, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45552429, Length=257, Percent_Identity=29.5719844357977, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24585514, Length=257, Percent_Identity=29.5719844357977, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574282, Length=257, Percent_Identity=29.5719844357977, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45551003, Length=257, Percent_Identity=29.5719844357977, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574284, Length=257, Percent_Identity=29.5719844357977, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24585516, Length=278, Percent_Identity=25.5395683453237, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44212; Mature: 44081

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHSLDKDKIKFLLLEGVHQSAVDVLERAGYTNIEYHKASLADEALVASIKDAHFVGIR
CCCCCCCHHHHHHHEECCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEC
SRTQLSAEVLSKAEKLVGIGCFCIGTNQVDLKSAELAGIPVFNAPFSNTRSVAELVLGEI
CHHHHHHHHHHHHHHHHEEEEEEEECCCEECCCCCCCCCEEECCCCCCHHHHHHHHHHHH
IMLMRGIPQRNALCHRGGWLKSANGSVEVRGKTLGVIGYGHIGTQLGILAETLGMRVKFF
HHHHCCCCCCCCHHHCCCEEECCCCEEEECCEEEEEEEECCHHHHHHHHHHHHCCEEEEE
DIEDKLPLGNAQQVHSFEELLANADVVSLHVPETPQTKNMIGHTELATMKKGSFLINASR
ECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHEECCCCEEEECCC
GTVVDIDALSAALKEEHIAGAAIDVFPVEPKSNDDVFQSPLRGLDNVILTPHVGGSTEEA
CCEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCHHHH
QENIGIEVAGKLAKYSDNGSTVSAVNFPEVSLPMHKGTSRLLHIHKNRPGILIKINQAFS
HHCCCEEEECEEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEEHHHH
EKGINISAQYLQTTADIGYVVMEVDTHQAEEALEQLRGIEGTIRTRLLH
HCCCCEEHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCHHHHHCCCC
>Mature Secondary Structure 
AKHSLDKDKIKFLLLEGVHQSAVDVLERAGYTNIEYHKASLADEALVASIKDAHFVGIR
CCCCCCHHHHHHHEECCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEC
SRTQLSAEVLSKAEKLVGIGCFCIGTNQVDLKSAELAGIPVFNAPFSNTRSVAELVLGEI
CHHHHHHHHHHHHHHHHEEEEEEEECCCEECCCCCCCCCEEECCCCCCHHHHHHHHHHHH
IMLMRGIPQRNALCHRGGWLKSANGSVEVRGKTLGVIGYGHIGTQLGILAETLGMRVKFF
HHHHCCCCCCCCHHHCCCEEECCCCEEEECCEEEEEEEECCHHHHHHHHHHHHCCEEEEE
DIEDKLPLGNAQQVHSFEELLANADVVSLHVPETPQTKNMIGHTELATMKKGSFLINASR
ECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHEECCCCEEEECCC
GTVVDIDALSAALKEEHIAGAAIDVFPVEPKSNDDVFQSPLRGLDNVILTPHVGGSTEEA
CCEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCHHHH
QENIGIEVAGKLAKYSDNGSTVSAVNFPEVSLPMHKGTSRLLHIHKNRPGILIKINQAFS
HHCCCEEEECEEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEEHHHH
EKGINISAQYLQTTADIGYVVMEVDTHQAEEALEQLRGIEGTIRTRLLH
HCCCCEEHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]