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The map label for this gene is pth

Identifier: 119775704

GI number: 119775704

Start: 3079326

End: 3079913

Strand: Reverse

Name: pth

Synonym: Sama_2572

Alternate gene names: 119775704

Gene position: 3079913-3079326 (Counterclockwise)

Preceding gene: 119775705

Following gene: 119775703

Centisome position: 71.52

GC content: 52.55

Gene sequence:

>588_bases
ATGTGCGATATTAAACTGATTGTGGGTCTGGCCAACCCTGGGGCGGAATACGCTCAAACCCGCCATAATGCGGGTGCCTG
GTATGTCGAAGAGCTGGCCCGCATTGCCAATGTGAGTCTGGCGCCTGACCCCAAGTATTTCGGTTTAACGGCAAGGGCAA
TTCTGTGTGGTAAGGATGTGCGTTTGCTTATCCCCTCAACCTTTATGAACTTAAGTGGCAAGTCGGTGGCGGCGTTGGCG
AATTTTTTCCGCATTGAACCGGAACAGATTCTGGTGGCCCATGACGAGCTGGATATGGAGCCCGGTGTGGCCAGGTTCAA
GTTGGGTGGTGGGCACGGCGGCCACAATGGTCTTAAAGACATCATTGCCAAAATGGGCAACAACAAAAATTTCTATCGTT
TGCGGATAGGCATTGGTCATCCGGGCGACAAAAACAAGGTCAGCGGGTATGTGCTGGGTAAGGCGCCCGCGACCGAGCAG
GAAAAGATGAATGCGGCGATAGATGAAGCCGTGCGCAGCACCGAAATCCTGTTCAAGCAAGACATGACCAAGGCAATGCA
CAGATTGCATTCCTTCAAGGCCGAATAA

Upstream 100 bases:

>100_bases
TTGGGACGTGCAATTGGGTGCTAAAATGCGCCGTTTTCAACACCTGTGCCCGGGTTTTGGCCTAGCCTGAAACGGGTCCG
GGACAAGAGTTCTGTTTTCC

Downstream 100 bases:

>100_bases
TCAGTTAAGCAAGTAAGTCAAATAAAGGGTTATAGCTATGGGTTTTAAATGTGGCATCGTTGGTCTGCCCAACGTTGGTA
AATCAACGCTCTTCAACGCG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MCDIKLIVGLANPGAEYAQTRHNAGAWYVEELARIANVSLAPDPKYFGLTARAILCGKDVRLLIPSTFMNLSGKSVAALA
NFFRIEPEQILVAHDELDMEPGVARFKLGGGHGGHNGLKDIIAKMGNNKNFYRLRIGIGHPGDKNKVSGYVLGKAPATEQ
EKMNAAIDEAVRSTEILFKQDMTKAMHRLHSFKAE

Sequences:

>Translated_195_residues
MCDIKLIVGLANPGAEYAQTRHNAGAWYVEELARIANVSLAPDPKYFGLTARAILCGKDVRLLIPSTFMNLSGKSVAALA
NFFRIEPEQILVAHDELDMEPGVARFKLGGGHGGHNGLKDIIAKMGNNKNFYRLRIGIGHPGDKNKVSGYVLGKAPATEQ
EKMNAAIDEAVRSTEILFKQDMTKAMHRLHSFKAE
>Mature_195_residues
MCDIKLIVGLANPGAEYAQTRHNAGAWYVEELARIANVSLAPDPKYFGLTARAILCGKDVRLLIPSTFMNLSGKSVAALA
NFFRIEPEQILVAHDELDMEPGVARFKLGGGHGGHNGLKDIIAKMGNNKNFYRLRIGIGHPGDKNKVSGYVLGKAPATEQ
EKMNAAIDEAVRSTEILFKQDMTKAMHRLHSFKAE

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=175, Percent_Identity=36, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1787455, Length=192, Percent_Identity=69.7916666666667, Blast_Score=259, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_SHEAM (A1S8R8)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928444.1
- ProteinModelPortal:   A1S8R8
- SMR:   A1S8R8
- STRING:   A1S8R8
- GeneID:   4604819
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2572
- NMPDR:   fig|326297.7.peg.2412
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- PhylomeDB:   A1S8R8
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21331; Mature: 21331

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCDIKLIVGLANPGAEYAQTRHNAGAWYVEELARIANVSLAPDPKYFGLTARAILCGKDV
CCCEEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEECCEEEEEEECCCC
RLLIPSTFMNLSGKSVAALANFFRIEPEQILVAHDELDMEPGVARFKLGGGHGGHNGLKD
EEEECHHHHCCCCCHHHHHHHHHHCCHHHEEEECCCCCCCCCCEEEEECCCCCCCHHHHH
IIAKMGNNKNFYRLRIGIGHPGDKNKVSGYVLGKAPATEQEKMNAAIDEAVRSTEILFKQ
HHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
DMTKAMHRLHSFKAE
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MCDIKLIVGLANPGAEYAQTRHNAGAWYVEELARIANVSLAPDPKYFGLTARAILCGKDV
CCCEEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEECCEEEEEEECCCC
RLLIPSTFMNLSGKSVAALANFFRIEPEQILVAHDELDMEPGVARFKLGGGHGGHNGLKD
EEEECHHHHCCCCCHHHHHHHHHHCCHHHEEEECCCCCCCCCCEEEEECCCCCCCHHHHH
IIAKMGNNKNFYRLRIGIGHPGDKNKVSGYVLGKAPATEQEKMNAAIDEAVRSTEILFKQ
HHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
DMTKAMHRLHSFKAE
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA