Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 119775699

GI number: 119775699

Start: 3073056

End: 3074306

Strand: Reverse

Name: hemA

Synonym: Sama_2567

Alternate gene names: 119775699

Gene position: 3074306-3073056 (Counterclockwise)

Preceding gene: 119775703

Following gene: 119775698

Centisome position: 71.39

GC content: 54.76

Gene sequence:

>1251_bases
ATGAGCCTTGTAGCAATCGGGATAAACCATAAAACGGCCACCGTCGATCTTCGCGAAAAGGTCGCCTTCTCCCCGGACAA
AATCCATGATGCGATGCGAAGCCTCGCCTGTACCACCTCATCCAATGAGGCGGTGATTGTCTCTACCTGTAACCGTACCG
AACTATACTGTAACAACGCCCGTGCTGAGGAAGTGATCCACTGGCTGGAGAGTTACCACAACCTGAGCCACGATGAGCTT
ATGCCCTGTGTCTATCACCATGAGGGGCAGGAAGCGGTGCGGCATCTGATGCGGGTAGCCTCGGGGCTGGATTCGCTGGT
ACTGGGCGAGCCGCAAATTCTTGGTCAGGTGAAACAGTCATTTGCCAAGGCCAAAGAGGCCGGCACAGTGGCTGTAACGC
TGGACCGCCTTTTCCAGAGCACCTTCTCGGTTGCCAAAAAGGTCCGGACCGAAACTGAAATCGGGACCGCGGCCGTGTCT
GTGGCCTTTGCCGCCGTCAGCATGGCCAAACATATCTTCTCTTCACTGGCATCTACCAAGGTATTGCTGATTGGTGCCGG
TGAAACCATAGAGCTGGTAGCCAGACACCTGAAAGAAAACGGGGTGTCATCCATGGTCGTGGCCAACCGTACCGTGGAGC
GCGCCCAAGCCATGTGCGAAGAGTTTGGCGCTACCGCTATTACGCTCTCGCAAATTCCGGATTTTCTCCCAAAGGCCGAT
ATCGTGATATCCTCTACCGCCAGTCCGCTGCCTATTCTTGGCAAAGGCATGGTAGAAAAGGCACTCAAGCAGCGTCGACA
TCAACCTATGTTATTGGTTGATATAGCAGTTCCTCGTGATATTGAGGCGGAAGTCGGAGAACTCGACGACGCCTTCCTGT
ACACGGTCGACGATCTGCAGAGCATCATCGAACAGAATATGGCCTCCCGAAAGGAGGCGGCCGAGCAAGCCGAAGTGATA
GCCCAGGAGCAATCTTTCCTGTTTATGGATTGGATCCGCTCGCTGGAGTCGGTAGACAGTATTCGCGAATATCGCACTGC
CAGTATGGCAATCAAAGATGAATTGGTAGAACGGGCCCTCAATAAGCTGGCGCAGGGGGCCGATGGCGAGCAAGTTATTC
TGGAGCTTGCCAACAAACTGACCAATCGCTTGATCCATGCACCGACTCAGGCCCTGACGACCGCCAGTCGTCAGGGGGAC
CTCAATACTCTGGGGCAACTTCGGACCGCGCTCGGCCTGGATAAACACTGA

Upstream 100 bases:

>100_bases
CTTTATTCGGTTTTGTTAAGCCTATTCTGTTTTTAATGGCCCCAATTCAGTAGAATGGCGTAATTCACACAAGCGCCGCA
CAGGATCCAGAAAGAGTCAG

Downstream 100 bases:

>100_bases
GACTTTTGAGAGTTAAATGAAGGAATCCGTCATCCGCAAGCTGGAAGGCTTGCTCGAGCGCAACGAAGAAGTATTGGCGC
TGCTCAGCGACGCCAGCATC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSLVAIGINHKTATVDLREKVAFSPDKIHDAMRSLACTTSSNEAVIVSTCNRTELYCNNARAEEVIHWLESYHNLSHDEL
MPCVYHHEGQEAVRHLMRVASGLDSLVLGEPQILGQVKQSFAKAKEAGTVAVTLDRLFQSTFSVAKKVRTETEIGTAAVS
VAFAAVSMAKHIFSSLASTKVLLIGAGETIELVARHLKENGVSSMVVANRTVERAQAMCEEFGATAITLSQIPDFLPKAD
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVGELDDAFLYTVDDLQSIIEQNMASRKEAAEQAEVI
AQEQSFLFMDWIRSLESVDSIREYRTASMAIKDELVERALNKLAQGADGEQVILELANKLTNRLIHAPTQALTTASRQGD
LNTLGQLRTALGLDKH

Sequences:

>Translated_416_residues
MSLVAIGINHKTATVDLREKVAFSPDKIHDAMRSLACTTSSNEAVIVSTCNRTELYCNNARAEEVIHWLESYHNLSHDEL
MPCVYHHEGQEAVRHLMRVASGLDSLVLGEPQILGQVKQSFAKAKEAGTVAVTLDRLFQSTFSVAKKVRTETEIGTAAVS
VAFAAVSMAKHIFSSLASTKVLLIGAGETIELVARHLKENGVSSMVVANRTVERAQAMCEEFGATAITLSQIPDFLPKAD
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVGELDDAFLYTVDDLQSIIEQNMASRKEAAEQAEVI
AQEQSFLFMDWIRSLESVDSIREYRTASMAIKDELVERALNKLAQGADGEQVILELANKLTNRLIHAPTQALTTASRQGD
LNTLGQLRTALGLDKH
>Mature_415_residues
SLVAIGINHKTATVDLREKVAFSPDKIHDAMRSLACTTSSNEAVIVSTCNRTELYCNNARAEEVIHWLESYHNLSHDELM
PCVYHHEGQEAVRHLMRVASGLDSLVLGEPQILGQVKQSFAKAKEAGTVAVTLDRLFQSTFSVAKKVRTETEIGTAAVSV
AFAAVSMAKHIFSSLASTKVLLIGAGETIELVARHLKENGVSSMVVANRTVERAQAMCEEFGATAITLSQIPDFLPKADI
VISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVGELDDAFLYTVDDLQSIIEQNMASRKEAAEQAEVIA
QEQSFLFMDWIRSLESVDSIREYRTASMAIKDELVERALNKLAQGADGEQVILELANKLTNRLIHAPTQALTTASRQGDL
NTLGQLRTALGLDKH

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=57.6555023923445, Blast_Score=471, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_SHEAM (A1S8R3)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928439.1
- ProteinModelPortal:   A1S8R3
- SMR:   A1S8R3
- STRING:   A1S8R3
- GeneID:   4604814
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2567
- NMPDR:   fig|326297.7.peg.2407
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   A1S8R3
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 45511; Mature: 45379

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 105-105 BINDING 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVAIGINHKTATVDLREKVAFSPDKIHDAMRSLACTTSSNEAVIVSTCNRTELYCNNA
CCEEEEECCCCEEEEEHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCC
RAEEVIHWLESYHNLSHDELMPCVYHHEGQEAVRHLMRVASGLDSLVLGEPQILGQVKQS
CHHHHHHHHHHHHCCCHHHHCHHHHHCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
FAKAKEAGTVAVTLDRLFQSTFSVAKKVRTETEIGTAAVSVAFAAVSMAKHIFSSLASTK
HHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VLLIGAGETIELVARHLKENGVSSMVVANRTVERAQAMCEEFGATAITLSQIPDFLPKAD
EEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCC
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVGELDDAFLYTVDDLQ
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHCCCCCHHEEEHHHHH
SIIEQNMASRKEAAEQAEVIAQEQSFLFMDWIRSLESVDSIREYRTASMAIKDELVERAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKLAQGADGEQVILELANKLTNRLIHAPTQALTTASRQGDLNTLGQLRTALGLDKH
HHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLVAIGINHKTATVDLREKVAFSPDKIHDAMRSLACTTSSNEAVIVSTCNRTELYCNNA
CEEEEECCCCEEEEEHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCC
RAEEVIHWLESYHNLSHDELMPCVYHHEGQEAVRHLMRVASGLDSLVLGEPQILGQVKQS
CHHHHHHHHHHHHCCCHHHHCHHHHHCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
FAKAKEAGTVAVTLDRLFQSTFSVAKKVRTETEIGTAAVSVAFAAVSMAKHIFSSLASTK
HHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VLLIGAGETIELVARHLKENGVSSMVVANRTVERAQAMCEEFGATAITLSQIPDFLPKAD
EEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCC
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEAEVGELDDAFLYTVDDLQ
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHCCCCCHHEEEHHHHH
SIIEQNMASRKEAAEQAEVIAQEQSFLFMDWIRSLESVDSIREYRTASMAIKDELVERAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKLAQGADGEQVILELANKLTNRLIHAPTQALTTASRQGDLNTLGQLRTALGLDKH
HHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA