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The map label for this gene is proA

Identifier: 119775647

GI number: 119775647

Start: 3020498

End: 3021760

Strand: Reverse

Name: proA

Synonym: Sama_2515

Alternate gene names: 119775647

Gene position: 3021760-3020498 (Counterclockwise)

Preceding gene: 119775648

Following gene: 119775645

Centisome position: 70.17

GC content: 55.34

Gene sequence:

>1263_bases
ATGGACGCTCAGGCTTATTTATTGCAGTTGGGTCAGGCCGCCAAGAGCTCAGGTTTTGCACTGGCAAACCTTGGCGTAAT
GGCCAAAAATCGCTTGCTGGGCCGGGTCGCCGCCGAACTTAAGTCGGCATTCGATGAGATTTTGGCTGCCAATGCCAAAG
ATGTGGCGGCTGCCCGAGCTTCGGGTTTGGGCGATGCCATGGTCGACCGGCTGCTGCTCAATGACGATAGGCTTAAGGGC
ATTATCGCCGATATCGATAATGTGATTTCCCTTGCCGACCCCATAGGTGAAGAGTTTGACAGTCGACTGTTGGATAACGG
TATGCGCCTGTGTCGTCGCCGTGTACCTCTGGGTGTGATTGGTGTTATTTACGAGGCCCGTCCCAACGTCACCGTGGAGA
TTGCGGTGCTGGCGCTGAAAACCGGTAACGCCGTCATTCTTCGTGGTGGTAAAGAAACCCTTGAGTCAAACCTGGCCCTT
GCCGCCGCCATTCGCCGTGCATTGGCCGGTGAAGGTTTGCCGGAAGATTGTGTGCAGCTGATAGATAATCCCGACCGCGC
CCTGGTCACTGGCCTGTTGAAGCTGGATAAATTCGTCGACATGATAGTGCCCAGAGGTGGTCAGGGGTTACAGCGGCTTT
GTGCTGAGCAGGCCACCATTCCAGTGATTTTGGGGGGCATTGGCATCTGCCATCTGTACCTGGATAGGGATGCCGATATC
AGTCGCGCTGCCAATGTGATTATCAATGCGAAGGTGCAGCGTCCTACAGTATGCAATGCGCTGGACACCTTACTTATTCA
CCGGGATAAACTCGACTGGTTGCCTACACTCGCCAGAGCGCTTCAGCAACAAGGCGTGAAGCTGGTGGCCTGCGAGCAAA
GCCTGGGTGCTCTCGCCGCTGCGGGTATCGAGGCAGAAGCAGCCAGCGATGAGAGTTTTGGCACCGAGTGGCTCTCACTC
ACTCTGGGGGTGAAGGTGGTTGCGGATATCGATGAGGCCATTGCCCATATTCGTCACTACTCCTCCGGGCATTCGGAGGC
GATTCTGACTGACAATCTCGCTGCAGCGACCCACTTTATGAATGAAGTTAACTCGGCCGCCGTGTACCTCAATGCATCCA
CCCGTTTTACCGATGGTGGTCAGTTTGGCTTTGGCGCAGAGGTGGCGGTCAGCACTCAAAAACTTCACGCAAGGGGGCCC
ATGGGACTTGAGGCTTTGACCACCTATAAGTGGCTGGGAGTTGGGGATTACAGCTGTCGATAA

Upstream 100 bases:

>100_bases
ACTCTGATGAGATTGAGCCACTGCTTGGTTATGACTATGGCGATGCCGTGGTGCATCGCAACGATATGGTGGTGTTGGAA
ATGATTGGGGAGGCCAAGTG

Downstream 100 bases:

>100_bases
ATTGTAAGTACTGAATATCAAGCATTAAAAAAGCCGCATTAAGCGGCTTTTTTAATAGCTAATCCCGGCTGCGCTTCATT
TGCAACTATGCTGCATCGCT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MDAQAYLLQLGQAAKSSGFALANLGVMAKNRLLGRVAAELKSAFDEILAANAKDVAAARASGLGDAMVDRLLLNDDRLKG
IIADIDNVISLADPIGEEFDSRLLDNGMRLCRRRVPLGVIGVIYEARPNVTVEIAVLALKTGNAVILRGGKETLESNLAL
AAAIRRALAGEGLPEDCVQLIDNPDRALVTGLLKLDKFVDMIVPRGGQGLQRLCAEQATIPVILGGIGICHLYLDRDADI
SRAANVIINAKVQRPTVCNALDTLLIHRDKLDWLPTLARALQQQGVKLVACEQSLGALAAAGIEAEAASDESFGTEWLSL
TLGVKVVADIDEAIAHIRHYSSGHSEAILTDNLAAATHFMNEVNSAAVYLNASTRFTDGGQFGFGAEVAVSTQKLHARGP
MGLEALTTYKWLGVGDYSCR

Sequences:

>Translated_420_residues
MDAQAYLLQLGQAAKSSGFALANLGVMAKNRLLGRVAAELKSAFDEILAANAKDVAAARASGLGDAMVDRLLLNDDRLKG
IIADIDNVISLADPIGEEFDSRLLDNGMRLCRRRVPLGVIGVIYEARPNVTVEIAVLALKTGNAVILRGGKETLESNLAL
AAAIRRALAGEGLPEDCVQLIDNPDRALVTGLLKLDKFVDMIVPRGGQGLQRLCAEQATIPVILGGIGICHLYLDRDADI
SRAANVIINAKVQRPTVCNALDTLLIHRDKLDWLPTLARALQQQGVKLVACEQSLGALAAAGIEAEAASDESFGTEWLSL
TLGVKVVADIDEAIAHIRHYSSGHSEAILTDNLAAATHFMNEVNSAAVYLNASTRFTDGGQFGFGAEVAVSTQKLHARGP
MGLEALTTYKWLGVGDYSCR
>Mature_420_residues
MDAQAYLLQLGQAAKSSGFALANLGVMAKNRLLGRVAAELKSAFDEILAANAKDVAAARASGLGDAMVDRLLLNDDRLKG
IIADIDNVISLADPIGEEFDSRLLDNGMRLCRRRVPLGVIGVIYEARPNVTVEIAVLALKTGNAVILRGGKETLESNLAL
AAAIRRALAGEGLPEDCVQLIDNPDRALVTGLLKLDKFVDMIVPRGGQGLQRLCAEQATIPVILGGIGICHLYLDRDADI
SRAANVIINAKVQRPTVCNALDTLLIHRDKLDWLPTLARALQQQGVKLVACEQSLGALAAAGIEAEAASDESFGTEWLSL
TLGVKVVADIDEAIAHIRHYSSGHSEAILTDNLAAATHFMNEVNSAAVYLNASTRFTDGGQFGFGAEVAVSTQKLHARGP
MGLEALTTYKWLGVGDYSCR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=409, Percent_Identity=37.1638141809291, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI21361368, Length=409, Percent_Identity=37.1638141809291, Blast_Score=249, Evalue=4e-66,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=58.5542168674699, Blast_Score=486, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17569967, Length=413, Percent_Identity=36.319612590799, Blast_Score=260, Evalue=9e-70,
Organism=Caenorhabditis elegans, GI17569969, Length=413, Percent_Identity=36.319612590799, Blast_Score=260, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6324899, Length=425, Percent_Identity=37.6470588235294, Blast_Score=278, Evalue=1e-75,
Organism=Drosophila melanogaster, GI21357643, Length=375, Percent_Identity=38.6666666666667, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_SHEAM (A1S8L1)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928387.1
- ProteinModelPortal:   A1S8L1
- SMR:   A1S8L1
- STRING:   A1S8L1
- GeneID:   4604762
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2515
- NMPDR:   fig|326297.7.peg.2355
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- PhylomeDB:   A1S8L1
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44639; Mature: 44639

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAQAYLLQLGQAAKSSGFALANLGVMAKNRLLGRVAAELKSAFDEILAANAKDVAAARA
CCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SGLGDAMVDRLLLNDDRLKGIIADIDNVISLADPIGEEFDSRLLDNGMRLCRRRVPLGVI
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GVIYEARPNVTVEIAVLALKTGNAVILRGGKETLESNLALAAAIRRALAGEGLPEDCVQL
EEEEECCCCCEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
IDNPDRALVTGLLKLDKFVDMIVPRGGQGLQRLCAEQATIPVILGGIGICHLYLDRDADI
HCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCH
SRAANVIINAKVQRPTVCNALDTLLIHRDKLDWLPTLARALQQQGVKLVACEQSLGALAA
HHHCCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHH
AGIEAEAASDESFGTEWLSLTLGVKVVADIDEAIAHIRHYSSGHSEAILTDNLAAATHFM
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHH
NEVNSAAVYLNASTRFTDGGQFGFGAEVAVSTQKLHARGPMGLEALTTYKWLGVGDYSCR
HHCCCEEEEEECCCEECCCCCCCCCCEEEEEHHHHHCCCCCCHHHHHHEEEEECCCCCCC
>Mature Secondary Structure
MDAQAYLLQLGQAAKSSGFALANLGVMAKNRLLGRVAAELKSAFDEILAANAKDVAAARA
CCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SGLGDAMVDRLLLNDDRLKGIIADIDNVISLADPIGEEFDSRLLDNGMRLCRRRVPLGVI
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GVIYEARPNVTVEIAVLALKTGNAVILRGGKETLESNLALAAAIRRALAGEGLPEDCVQL
EEEEECCCCCEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
IDNPDRALVTGLLKLDKFVDMIVPRGGQGLQRLCAEQATIPVILGGIGICHLYLDRDADI
HCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCH
SRAANVIINAKVQRPTVCNALDTLLIHRDKLDWLPTLARALQQQGVKLVACEQSLGALAA
HHHCCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHH
AGIEAEAASDESFGTEWLSLTLGVKVVADIDEAIAHIRHYSSGHSEAILTDNLAAATHFM
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHH
NEVNSAAVYLNASTRFTDGGQFGFGAEVAVSTQKLHARGPMGLEALTTYKWLGVGDYSCR
HHCCCEEEEEECCCEECCCCCCCCCCEEEEEHHHHHCCCCCCHHHHHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA