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The map label for this gene is proC [H]

Identifier: 119775611

GI number: 119775611

Start: 2981064

End: 2981879

Strand: Direct

Name: proC [H]

Synonym: Sama_2478

Alternate gene names: 119775611

Gene position: 2981064-2981879 (Clockwise)

Preceding gene: 119775610

Following gene: 119775612

Centisome position: 69.23

GC content: 54.53

Gene sequence:

>816_bases
ATGCAAAATAAAAAAATCTGTTTCATCGGTGCCGGAAACATGAGCCGCGCCATCATTGGCGGCCTCATCAAGAGCGGCTA
CAGTGCCAGCCTCATCACGGCAACCAATCCAAGCTTGCCAAAACTCGACGCCCTGGCAGCCGACTATGGCATCAATACTT
CCCAGGACAATGTACCAAGCGCCTCGGCTGCCGATGTGATAGTGCTTTCAGTTAAGCCTCAGCTTATGCAGGCAGTATGT
GAGTCACTTGCCGGTGTCGTCGATGATAAATTGCTGATTACCATAGCCGCCGGTATCCCAGAAAACCGCTACCATGATTA
CTTCGGCAAACAGGTCAAGCTTATCCGCACTATGCCCAACACCCCCATGCAGTTGGGCCTTGGGATGACAGGTCTTTATG
CCCCTGCCGGCATGCCTGATGAAGACAAGGCCTTTGCTGAGTCGCTGATGCGCGCCTGTGGTGATATTGTCTGGGTGAAC
GAAGAGTCGGGTATAGATAAGGTTATTGCACTGGCAGGCAGTTCACCGGCCTACTTTTTCCTCTTTATCGAGGCCATGAT
TGAAGCAGGTGTCGAAATGGGGCTGCCAGAGGCCGACGCCCGTACCCTGGCGCAGCAAGCGGCCGTGGGTGCCGCTGCCA
TGGTAAAACAAAACCCGGGGCTGACCCCAGCCGAGCTCAGGGCCAATGTCACATCCAAAGGGGGCACCACGGCCGAAGCC
ATCGCCACTTTTGAAGCAGGCGGGCTGCGCACACTGGTAAAAGATGCCATGGGCAATTGTATTAAGCGGGCTGAAGAAAT
GGCCCGGAATTTTTAA

Upstream 100 bases:

>100_bases
AGCCGCTAAGGGCAATGCGCTGTGGCAATCATTGTATTTACGCGGCTTCGCCCCCATATTCTCGGTATCGCCAAGCCTTT
AAATTCAAACAGGAATAAAG

Downstream 100 bases:

>100_bases
GCCACAAAGTGGCAATACTTCGTTGATAATCTAAGGGCAAACCTCATGAATGCGATGGTTTTTTTAGTAAACACCCTGTT
TGATCTCTATCTGATGGTGG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MQNKKICFIGAGNMSRAIIGGLIKSGYSASLITATNPSLPKLDALAADYGINTSQDNVPSASAADVIVLSVKPQLMQAVC
ESLAGVVDDKLLITIAAGIPENRYHDYFGKQVKLIRTMPNTPMQLGLGMTGLYAPAGMPDEDKAFAESLMRACGDIVWVN
EESGIDKVIALAGSSPAYFFLFIEAMIEAGVEMGLPEADARTLAQQAAVGAAAMVKQNPGLTPAELRANVTSKGGTTAEA
IATFEAGGLRTLVKDAMGNCIKRAEEMARNF

Sequences:

>Translated_271_residues
MQNKKICFIGAGNMSRAIIGGLIKSGYSASLITATNPSLPKLDALAADYGINTSQDNVPSASAADVIVLSVKPQLMQAVC
ESLAGVVDDKLLITIAAGIPENRYHDYFGKQVKLIRTMPNTPMQLGLGMTGLYAPAGMPDEDKAFAESLMRACGDIVWVN
EESGIDKVIALAGSSPAYFFLFIEAMIEAGVEMGLPEADARTLAQQAAVGAAAMVKQNPGLTPAELRANVTSKGGTTAEA
IATFEAGGLRTLVKDAMGNCIKRAEEMARNF
>Mature_271_residues
MQNKKICFIGAGNMSRAIIGGLIKSGYSASLITATNPSLPKLDALAADYGINTSQDNVPSASAADVIVLSVKPQLMQAVC
ESLAGVVDDKLLITIAAGIPENRYHDYFGKQVKLIRTMPNTPMQLGLGMTGLYAPAGMPDEDKAFAESLMRACGDIVWVN
EESGIDKVIALAGSSPAYFFLFIEAMIEAGVEMGLPEADARTLAQQAAVGAAAMVKQNPGLTPAELRANVTSKGGTTAEA
IATFEAGGLRTLVKDAMGNCIKRAEEMARNF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=34.9624060150376, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI198041662, Length=269, Percent_Identity=30.1115241635688, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI24797095, Length=272, Percent_Identity=33.4558823529412, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI24797097, Length=272, Percent_Identity=33.4558823529412, Blast_Score=119, Evalue=2e-27,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=39.6296296296296, Blast_Score=169, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=35.0746268656716, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17540664, Length=285, Percent_Identity=29.4736842105263, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=284, Percent_Identity=27.112676056338, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21358587, Length=270, Percent_Identity=32.962962962963, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24648116, Length=279, Percent_Identity=32.6164874551971, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=33.9181286549708, Blast_Score=95, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28435; Mature: 28435

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKKICFIGAGNMSRAIIGGLIKSGYSASLITATNPSLPKLDALAADYGINTSQDNVPS
CCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCC
ASAADVIVLSVKPQLMQAVCESLAGVVDDKLLITIAAGIPENRYHDYFGKQVKLIRTMPN
CCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHEEEEECCCC
TPMQLGLGMTGLYAPAGMPDEDKAFAESLMRACGDIVWVNEESGIDKVIALAGSSPAYFF
CCHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCHHHH
LFIEAMIEAGVEMGLPEADARTLAQQAAVGAAAMVKQNPGLTPAELRANVTSKGGTTAEA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHH
IATFEAGGLRTLVKDAMGNCIKRAEEMARNF
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNKKICFIGAGNMSRAIIGGLIKSGYSASLITATNPSLPKLDALAADYGINTSQDNVPS
CCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCC
ASAADVIVLSVKPQLMQAVCESLAGVVDDKLLITIAAGIPENRYHDYFGKQVKLIRTMPN
CCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHEEEEECCCC
TPMQLGLGMTGLYAPAGMPDEDKAFAESLMRACGDIVWVNEESGIDKVIALAGSSPAYFF
CCHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCHHHH
LFIEAMIEAGVEMGLPEADARTLAQQAAVGAAAMVKQNPGLTPAELRANVTSKGGTTAEA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHH
IATFEAGGLRTLVKDAMGNCIKRAEEMARNF
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]