Click here to switch to the map view.

The map label for this gene is yiaY [H]

Identifier: 119775589

GI number: 119775589

Start: 2962455

End: 2963603

Strand: Direct

Name: yiaY [H]

Synonym: Sama_2455

Alternate gene names: 119775589

Gene position: 2962455-2963603 (Clockwise)

Preceding gene: 119775577

Following gene: 119775590

Centisome position: 68.8

GC content: 56.74

Gene sequence:

>1149_bases
ATGGCTGCGAAATTTTTTATCCCTTCTGTTAACGTGCTCGGCCAGGGCGCCGTAGACGAGGCCATCGGTGACATAGTCAC
CCTGGGTTTTAAACAGGCCCTGATAGTCACAGATAAACCTTTGGTACAGATAGGTATTGCCGGTGAACTGGTGGAAAAAC
TCGGTGAGCGCGGTATTACCGCCGTCGTGTTCGATGGTGTACAACCCAACCCCACAACAGCCAACGTGGAGGCGGGCCTT
GCACTGCTCAACGCCCATGGCTGTGACTTTGTGATTTCCCTCGGCGGCGGCTCGCCCCACGACTGCGCCAAGGGCATCGC
CCTGGTCGCCACCAATGGCGGCAGCATCAAAGACTACGAAGGCGTCGATAAGTCCGCCAAGCCACAGTTGCCCCTGGTTG
CCATCAATACTACCGCCGGCACCGCCAGTGAAATGACCCGCTTTTGCATCATCACCGACGAGGCTCGCCATATTAAAATG
GCCATCGTCGACAAGCACACCACCCCCATTCTGTCGGTGAACGATCCTGAGTTGATGGTGAAAAAGCCAGCTGCCTTGAC
CGCGGCCACCGGGATGGATGCCCTGACCCACGCCGTTGAGGCTTATGTGTCTGTTGCCGCCAATCCCATCACAGATGCCT
GCGCCATCAAGGCCATCGAGCTTATTCAGCAATACCTTGAGCGGGCGGTGAAACAGGGGCAGGACCTACAGGCCCGCGAG
CAAATGGCCTATGCCCAGTTCCTCGCCGGTATGGCCTTTAACAACGCCAGCCTGGGTTATGTGCACGCTATGGCCCACCA
GCTCGGTGGCTTCTACGACCTGCCCCACGGTGTCTGTAACGCCCTGTTGCTGCCATACGTGCAGGAATACAACGCGGCGG
TGGCGGCGGCACGTTTGAAAGATGTCGCCAAAGCCATGGGTGTTGCCGTAGACGGGCTTGATGACCAAGAAGGTGCCAAG
GCCGCCATTAGTGCCATCAAGGCGCTGTCCAAGGCGGTAAACATCCCGGAGAATCTGACTGTGCTTGGCGTAAAAGAAGA
GGATATTCCGTTACTGGCCGACAACGCCCTCAAAGATGCCTGCGGATTTACCAACCCCAAACAGGCCACCCATGAGGAAA
TCTGTCAGATTTTCTGTAACGCACTTTAA

Upstream 100 bases:

>100_bases
TCGGGGCGTGAAGGTGGGCTGAAATCACACTTCGCCCCCATTCTGACTGATATCGTTAATAGAAGAAGAAATTCAATTTC
AGCTTAACGAGGTAGATATT

Downstream 100 bases:

>100_bases
TCTTCCCTGACGAGAGTCAACACCAGGCCCCCGAGTTCTTCACCGGGGGCCTTTTTGTTGGTATGGCAGTATTCGAGCCC
TGGAGGCGCTGTCTCGCATG

Product: alcohol dehydrogenase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAAKFFIPSVNVLGQGAVDEAIGDIVTLGFKQALIVTDKPLVQIGIAGELVEKLGERGITAVVFDGVQPNPTTANVEAGL
ALLNAHGCDFVISLGGGSPHDCAKGIALVATNGGSIKDYEGVDKSAKPQLPLVAINTTAGTASEMTRFCIITDEARHIKM
AIVDKHTTPILSVNDPELMVKKPAALTAATGMDALTHAVEAYVSVAANPITDACAIKAIELIQQYLERAVKQGQDLQARE
QMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNALLLPYVQEYNAAVAAARLKDVAKAMGVAVDGLDDQEGAK
AAISAIKALSKAVNIPENLTVLGVKEEDIPLLADNALKDACGFTNPKQATHEEICQIFCNAL

Sequences:

>Translated_382_residues
MAAKFFIPSVNVLGQGAVDEAIGDIVTLGFKQALIVTDKPLVQIGIAGELVEKLGERGITAVVFDGVQPNPTTANVEAGL
ALLNAHGCDFVISLGGGSPHDCAKGIALVATNGGSIKDYEGVDKSAKPQLPLVAINTTAGTASEMTRFCIITDEARHIKM
AIVDKHTTPILSVNDPELMVKKPAALTAATGMDALTHAVEAYVSVAANPITDACAIKAIELIQQYLERAVKQGQDLQARE
QMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNALLLPYVQEYNAAVAAARLKDVAKAMGVAVDGLDDQEGAK
AAISAIKALSKAVNIPENLTVLGVKEEDIPLLADNALKDACGFTNPKQATHEEICQIFCNAL
>Mature_381_residues
AAKFFIPSVNVLGQGAVDEAIGDIVTLGFKQALIVTDKPLVQIGIAGELVEKLGERGITAVVFDGVQPNPTTANVEAGLA
LLNAHGCDFVISLGGGSPHDCAKGIALVATNGGSIKDYEGVDKSAKPQLPLVAINTTAGTASEMTRFCIITDEARHIKMA
IVDKHTTPILSVNDPELMVKKPAALTAATGMDALTHAVEAYVSVAANPITDACAIKAIELIQQYLERAVKQGQDLQAREQ
MAYAQFLAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNALLLPYVQEYNAAVAAARLKDVAKAMGVAVDGLDDQEGAKA
AISAIKALSKAVNIPENLTVLGVKEEDIPLLADNALKDACGFTNPKQATHEEICQIFCNAL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=386, Percent_Identity=27.4611398963731, Blast_Score=128, Evalue=9e-30,
Organism=Escherichia coli, GI48994951, Length=381, Percent_Identity=69.0288713910761, Blast_Score=543, Evalue=1e-156,
Organism=Escherichia coli, GI1789163, Length=384, Percent_Identity=43.2291666666667, Blast_Score=323, Evalue=9e-90,
Organism=Escherichia coli, GI87082107, Length=377, Percent_Identity=37.6657824933687, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1787493, Length=411, Percent_Identity=32.6034063260341, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI1789386, Length=317, Percent_Identity=24.9211356466877, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=413, Percent_Identity=26.3922518159806, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6321181, Length=379, Percent_Identity=54.8812664907652, Blast_Score=413, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24657991, Length=406, Percent_Identity=26.8472906403941, Blast_Score=134, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39998; Mature: 39867

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKFFIPSVNVLGQGAVDEAIGDIVTLGFKQALIVTDKPLVQIGIAGELVEKLGERGIT
CCCEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHHCCCCE
AVVFDGVQPNPTTANVEAGLALLNAHGCDFVISLGGGSPHDCAKGIALVATNGGSIKDYE
EEEECCCCCCCCCCCHHHCEEEEECCCCEEEEECCCCCCCHHHCCEEEEEECCCCCCCCC
GVDKSAKPQLPLVAINTTAGTASEMTRFCIITDEARHIKMAIVDKHTTPILSVNDPELMV
CCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEECCCCCEEECCCCCEEE
KKPAALTAATGMDALTHAVEAYVSVAANPITDACAIKAIELIQQYLERAVKQGQDLQARE
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNALLLPYVQEYNAAVAAARLK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DVAKAMGVAVDGLDDQEGAKAAISAIKALSKAVNIPENLTVLGVKEEDIPLLADNALKDA
HHHHHHCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECHHHHHH
CGFTNPKQATHEEICQIFCNAL
CCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AAKFFIPSVNVLGQGAVDEAIGDIVTLGFKQALIVTDKPLVQIGIAGELVEKLGERGIT
CCEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHHCCCCE
AVVFDGVQPNPTTANVEAGLALLNAHGCDFVISLGGGSPHDCAKGIALVATNGGSIKDYE
EEEECCCCCCCCCCCHHHCEEEEECCCCEEEEECCCCCCCHHHCCEEEEEECCCCCCCCC
GVDKSAKPQLPLVAINTTAGTASEMTRFCIITDEARHIKMAIVDKHTTPILSVNDPELMV
CCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEECCCCCEEECCCCCEEE
KKPAALTAATGMDALTHAVEAYVSVAANPITDACAIKAIELIQQYLERAVKQGQDLQARE
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNALLLPYVQEYNAAVAAARLK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DVAKAMGVAVDGLDDQEGAKAAISAIKALSKAVNIPENLTVLGVKEEDIPLLADNALKDA
HHHHHHCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECHHHHHH
CGFTNPKQATHEEICQIFCNAL
CCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]