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The map label for this gene is glcA [C]

Identifier: 119775573

GI number: 119775573

Start: 2933648

End: 2935291

Strand: Direct

Name: glcA [C]

Synonym: Sama_2439

Alternate gene names: 119775573

Gene position: 2933648-2935291 (Clockwise)

Preceding gene: 119775572

Following gene: 119775574

Centisome position: 68.13

GC content: 57.91

Gene sequence:

>1644_bases
ATGACATTCGTTCAACTTCTCGCCAGCTTGTCGCCTGTGATCAGCGTTATGCTGTTCCTGGTGCTGCTCAGGCTCCCTGC
ATCCAAGGCCATGCCCATTTCGGCGGTGGTCACGGCGCTCGCCGCCATTCTGGTCTGGCAAATGGATACCCAAATGCTGG
CCGCTTCCGTGGTGGAGGGCCTGCTGTCTGCCCTGACGCCACTGTCCATCATCTTCGGGGCAGTGTTCCTGCTGAACACC
CTCAAGTATTCCGGTGCCATGGATACCATCCGCGCCGGTTTTACCAATATCAGTGCTGATGCACGGGTGCAGGTCATCAT
CATCTGCTGGCTGTTCGGCGCCTTTATTGAAGGTTCGGCTGGCTTTGGTACGCCGGCCGCCATTGGCGCGCCCTTGTTGG
TACTGCTGGGCATTCCACCTGTGGCCGCAGCGGTGGTGGCACTCATTGCCGACTCCGCCAGTGTGTCTTTCGGTGCCATC
GGCTTGCCAGTGCTCTTTGGTATGGAGCAAGGCCTGATTGAAGGCGGTACCAGCATGGCGGCAGCTCAGATAGCCGAACA
TGGTGGCCATTTCAGCGACTATGCCCGCTATATCGCCATGCACATGATTAGCATCGACCTTATTACAGGAACCCTGATCC
CACTGGTCATGGTCACTGTCCTGACCGGTTTCTTCGGCCGTAAGAAGTCCTTTGCCGAAGGCCTCGCCATCTGGAAATTT
GCCATCTTTGCCGGCCTTGCCTTTACTGTGCCTGCGTGGATCATCAACTTTATCGCCGGTCCCGAGTTTCCTTCGGTAAT
CGGTGCCCTGCTTGGTATGGCGATGGTCATCCCGGTTGCCCGCAAAGGCTGGCTGCTGCCCAAAACCTCCTGGCACGATT
TCGAAGAATCCACCGAGAACGGTAACGATGTACCCCATACCGAGGTACGTTTCAGCCAGCTGGCTGCCTGGACACCTTAC
CTGGTGATGGCCGCTCTGCTGGTTGCCAGCCGCACCATAGCGCCCCTCAAAGCCTGGCTTGGCGGCTTTAACATCAGCTG
GACTCACTTGTTGGGCACAGATCTGAAGGCCAGCTTTGCTACCCTTTATGCACCGGGCGCCTTCTTTGTGCTGGTGTGTC
TGCTGGGTTTTGTGCTGTTCAAAATGCGCTCTGATGCCATGCGCAACTCCGTGACTGTGTCACTCAAGTCCATGATCCCA
ACAGTGATTTCTCTTGGTGCCTCTGTGCCCATGGTGAAAATCTTCCTGAACTCAGGCGCCAATGAGGCGGGACTCGCCTC
CATGCCTGTAGCGCTGGCCGATATGCTCGCGGGCTCCATGGGCGCCGTATGGAACTGGATGGCGCCAGTGGTCGGTATCT
TCGGAGCCTTCCTGTCCGGCAGCGCCACCTTCTCCAACATGATGTTCTCTGGCCTGCAGTACAGCGTGGCCGACAACATT
GGCGCCAACCATGCGTTGACCCTGGCGCTGCAAGGCATAGGCGCCAACGCCGGTAACATGATGTGCGTCATGAACGTGGT
CGCCGCCGCGACCGTGGTGGGCATGGCTGGACGTGAGTCAGAAATTATCCGCAAGACCATGCCGGTTGCGCTGGGGTATG
CCCTACTTGCCGGAACCATAGCAACCCTTTGGGGCGGATTCTAA

Upstream 100 bases:

>100_bases
AACGTTTATTTAGCCATGCAAATCGCCGCGCAAAACAATAATCAGGGCGATGGGTCGACAGCGATGTCGGCAAAAACACG
CAACCAAAGAAGAGGCAATC

Downstream 100 bases:

>100_bases
TCCCGCCGAAGCCATAAAGGGCCAGCCTGGTTTGGCTGGCCCAAAGGATTGACGACTCCAACTTGAGTCACCTGTGTAGA
GAGCAAACTATGTCTGTCGA

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MTFVQLLASLSPVISVMLFLVLLRLPASKAMPISAVVTALAAILVWQMDTQMLAASVVEGLLSALTPLSIIFGAVFLLNT
LKYSGAMDTIRAGFTNISADARVQVIIICWLFGAFIEGSAGFGTPAAIGAPLLVLLGIPPVAAAVVALIADSASVSFGAI
GLPVLFGMEQGLIEGGTSMAAAQIAEHGGHFSDYARYIAMHMISIDLITGTLIPLVMVTVLTGFFGRKKSFAEGLAIWKF
AIFAGLAFTVPAWIINFIAGPEFPSVIGALLGMAMVIPVARKGWLLPKTSWHDFEESTENGNDVPHTEVRFSQLAAWTPY
LVMAALLVASRTIAPLKAWLGGFNISWTHLLGTDLKASFATLYAPGAFFVLVCLLGFVLFKMRSDAMRNSVTVSLKSMIP
TVISLGASVPMVKIFLNSGANEAGLASMPVALADMLAGSMGAVWNWMAPVVGIFGAFLSGSATFSNMMFSGLQYSVADNI
GANHALTLALQGIGANAGNMMCVMNVVAAATVVGMAGRESEIIRKTMPVALGYALLAGTIATLWGGF

Sequences:

>Translated_547_residues
MTFVQLLASLSPVISVMLFLVLLRLPASKAMPISAVVTALAAILVWQMDTQMLAASVVEGLLSALTPLSIIFGAVFLLNT
LKYSGAMDTIRAGFTNISADARVQVIIICWLFGAFIEGSAGFGTPAAIGAPLLVLLGIPPVAAAVVALIADSASVSFGAI
GLPVLFGMEQGLIEGGTSMAAAQIAEHGGHFSDYARYIAMHMISIDLITGTLIPLVMVTVLTGFFGRKKSFAEGLAIWKF
AIFAGLAFTVPAWIINFIAGPEFPSVIGALLGMAMVIPVARKGWLLPKTSWHDFEESTENGNDVPHTEVRFSQLAAWTPY
LVMAALLVASRTIAPLKAWLGGFNISWTHLLGTDLKASFATLYAPGAFFVLVCLLGFVLFKMRSDAMRNSVTVSLKSMIP
TVISLGASVPMVKIFLNSGANEAGLASMPVALADMLAGSMGAVWNWMAPVVGIFGAFLSGSATFSNMMFSGLQYSVADNI
GANHALTLALQGIGANAGNMMCVMNVVAAATVVGMAGRESEIIRKTMPVALGYALLAGTIATLWGGF
>Mature_546_residues
TFVQLLASLSPVISVMLFLVLLRLPASKAMPISAVVTALAAILVWQMDTQMLAASVVEGLLSALTPLSIIFGAVFLLNTL
KYSGAMDTIRAGFTNISADARVQVIIICWLFGAFIEGSAGFGTPAAIGAPLLVLLGIPPVAAAVVALIADSASVSFGAIG
LPVLFGMEQGLIEGGTSMAAAQIAEHGGHFSDYARYIAMHMISIDLITGTLIPLVMVTVLTGFFGRKKSFAEGLAIWKFA
IFAGLAFTVPAWIINFIAGPEFPSVIGALLGMAMVIPVARKGWLLPKTSWHDFEESTENGNDVPHTEVRFSQLAAWTPYL
VMAALLVASRTIAPLKAWLGGFNISWTHLLGTDLKASFATLYAPGAFFVLVCLLGFVLFKMRSDAMRNSVTVSLKSMIPT
VISLGASVPMVKIFLNSGANEAGLASMPVALADMLAGSMGAVWNWMAPVVGIFGAFLSGSATFSNMMFSGLQYSVADNIG
ANHALTLALQGIGANAGNMMCVMNVVAAATVVGMAGRESEIIRKTMPVALGYALLAGTIATLWGGF

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=570, Percent_Identity=30.8771929824561, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1790031, Length=564, Percent_Identity=29.2553191489362, Blast_Score=156, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 57288; Mature: 57157

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCC
>Mature Secondary Structure 
TFVQLLASLSPVISVMLFLVLLRLPASKAMPISAVVTALAAILVWQMDTQMLAASVVEG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]