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The map label for this gene is ppiA [H]

Identifier: 119775558

GI number: 119775558

Start: 2918971

End: 2919582

Strand: Direct

Name: ppiA [H]

Synonym: Sama_2424

Alternate gene names: 119775558

Gene position: 2918971-2919582 (Clockwise)

Preceding gene: 119775557

Following gene: 119775559

Centisome position: 67.79

GC content: 51.96

Gene sequence:

>612_bases
ATGAAAAAAATCATAGGATTGTTAATCGGCATAAACCTGGTCGCCTGTGGTGGTGGCAGTGACGACGCTGCGCCGGAAGT
ACCGGATAACCCAGTCACCTTCAAGGTCGATGCCTGTTACCTGATGAGCACCAATCTCGGGGACATAACACTTGCCATCG
ACACGACCAATACCCCCATCACCGGCAATAACTTCAAACAATATGTCGACAAAGGCTTTTACGATGGCACCCTGTTCCAC
CGCGCAGTAAACAACTTCGTTATTCAGGGCGGCGGGTATACCAGCGGCCTAGAGCCAAAAGATACGGATGCGGCGATTAA
AAACGAAGCCAGCGTGGGTTTCAGTAACGAGCGTGGCACCTTCGCCATGGCACGCACTGCAGCGCCGGATACAGCTACCT
CGCAGTTTTTTATCAACGTGCTGGACAACCCCCAGCTTGATTATTCTGCCAGCAGCTACGGCTATGCGGTATTTGGCAAG
GTACTTTCCGGAATGGAAGTCGTGGACCAAATCAGTATCGCCCCGGTACACAATGTAAACGGCTTCAGCGATGTGCCTGT
GGATGAAGTCGTGATTGAGTCGGTAACCGAAATGAATTGTCCCGCTGGCTGA

Upstream 100 bases:

>100_bases
AATTGCCCACCCATCAATTTCTGGTCACAATGCCTGCCTGCCAAGTGTCCGGCAGACAGTTAAAAGCAGTCGCACCCTGA
GGTGCTGTAAGGGATATAAG

Downstream 100 bases:

>100_bases
CAAAGTCAGTTTGCAGCCAATTCCAAGCCACCTCCAGGGTGGCTTTTTTTGTTCCGTCTTGAACACACTGAACCCGGATT
TAAACAGAGCATCTTGGGTA

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MKKIIGLLIGINLVACGGGSDDAAPEVPDNPVTFKVDACYLMSTNLGDITLAIDTTNTPITGNNFKQYVDKGFYDGTLFH
RAVNNFVIQGGGYTSGLEPKDTDAAIKNEASVGFSNERGTFAMARTAAPDTATSQFFINVLDNPQLDYSASSYGYAVFGK
VLSGMEVVDQISIAPVHNVNGFSDVPVDEVVIESVTEMNCPAG

Sequences:

>Translated_203_residues
MKKIIGLLIGINLVACGGGSDDAAPEVPDNPVTFKVDACYLMSTNLGDITLAIDTTNTPITGNNFKQYVDKGFYDGTLFH
RAVNNFVIQGGGYTSGLEPKDTDAAIKNEASVGFSNERGTFAMARTAAPDTATSQFFINVLDNPQLDYSASSYGYAVFGK
VLSGMEVVDQISIAPVHNVNGFSDVPVDEVVIESVTEMNCPAG
>Mature_203_residues
MKKIIGLLIGINLVACGGGSDDAAPEVPDNPVTFKVDACYLMSTNLGDITLAIDTTNTPITGNNFKQYVDKGFYDGTLFH
RAVNNFVIQGGGYTSGLEPKDTDAAIKNEASVGFSNERGTFAMARTAAPDTATSQFFINVLDNPQLDYSASSYGYAVFGK
VLSGMEVVDQISIAPVHNVNGFSDVPVDEVVIESVTEMNCPAG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=158, Percent_Identity=32.2784810126582, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI24308049, Length=165, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7706339, Length=171, Percent_Identity=30.4093567251462, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI22547215, Length=160, Percent_Identity=33.125, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI22547212, Length=160, Percent_Identity=33.125, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI7657473, Length=160, Percent_Identity=33.125, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1789763, Length=160, Percent_Identity=50.625, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1786736, Length=158, Percent_Identity=48.7341772151899, Blast_Score=148, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539496, Length=137, Percent_Identity=32.1167883211679, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=153, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532641, Length=161, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17506307, Length=160, Percent_Identity=32.5, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI19922376, Length=160, Percent_Identity=31.875, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19922912, Length=172, Percent_Identity=32.5581395348837, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17986117, Length=160, Percent_Identity=30.625, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21478; Mature: 21478

Theoretical pI: Translated: 4.06; Mature: 4.06

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIIGLLIGINLVACGGGSDDAAPEVPDNPVTFKVDACYLMSTNLGDITLAIDTTNTPI
CHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEECCCCEEEEEEECCCCCC
TGNNFKQYVDKGFYDGTLFHRAVNNFVIQGGGYTSGLEPKDTDAAIKNEASVGFSNERGT
CCCHHHHHHHCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
FAMARTAAPDTATSQFFINVLDNPQLDYSASSYGYAVFGKVLSGMEVVDQISIAPVHNVN
EEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCC
GFSDVPVDEVVIESVTEMNCPAG
CCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKIIGLLIGINLVACGGGSDDAAPEVPDNPVTFKVDACYLMSTNLGDITLAIDTTNTPI
CHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEECCCCEEEEEEECCCCCC
TGNNFKQYVDKGFYDGTLFHRAVNNFVIQGGGYTSGLEPKDTDAAIKNEASVGFSNERGT
CCCHHHHHHHCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
FAMARTAAPDTATSQFFINVLDNPQLDYSASSYGYAVFGKVLSGMEVVDQISIAPVHNVN
EEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCC
GFSDVPVDEVVIESVTEMNCPAG
CCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]