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The map label for this gene is mdtA [H]

Identifier: 119775477

GI number: 119775477

Start: 2808408

End: 2809520

Strand: Direct

Name: mdtA [H]

Synonym: Sama_2342

Alternate gene names: 119775477

Gene position: 2808408-2809520 (Clockwise)

Preceding gene: 119775474

Following gene: 119775478

Centisome position: 65.22

GC content: 56.6

Gene sequence:

>1113_bases
ATGAACGCGATGAATTGCCACAGGTGGATAAAACACCTGCCCCTGCTTCTGGGGCTGGGTGTATTGTCTGCCTGTCAGGA
AAAGGATGCCGGGCCATTCAATGACAGCACTCCGCCCACCGTAATCACCCAGAGCCTGAGTCTGAGTGACGGCTATCAAA
GGCCGCTGGAATTCAGTGGCACCATCCGCGCTGCCAACACCACTGGTGTGGGCTTTGAATTGGCAGGCAAGCTCAGTGGC
CTCTATGCCGACAGTGGTGACAGGGTACGAAAAGGCCAGCAGCTTGCGGCACTTGATACCAGTTTACTTAAAGCCGAGCA
GCAGGAGCTTCAGGCTGCATTGAGCCAAAACAGCGCCGATCTCAGTCTGGCCCAATCTACGCTGAAGCGAAGCCTGGAAC
TCAAAAAACAAGGATATGTGTCCAGCCAACAACTGGATGAACTCGAAGGGCGACTGGGTAGCCTAGAAGGAGCCCGGGAG
CGCCTTAAAGCCAGTCTGTATGCCAATACCCTCAAACTGGAAAAATCCCGGCTATTGGCCCCGTTCGATGGCAGTATCGG
TAGCCGCAGTTTCAACCTGGGCGAAGTCGTTCCCCTGGGGCAACCGGTGTTCGTATTGGTTGAAGACAAAGCCGCTCAGG
CCCACGTCGGGGTACCGGCGGACATCGCCAAAAGCCTCACCCAGGGGCAACTGATGGACTTACGTGTTGGCCGTGAGCAC
TACCGCGCCGTGCTTGCGGGGATCAACCCCTCCATCGACCCTGTTACACGCACCGTTGGGCTAAGACTGTCACTCCCCTC
CGATGCCGGCGTCCTTAACGGTGAGATTGCCTACCTTCATTATCAGCAGCAGGTAAATACGCCCGGCTACTGGGTGCCAG
TCTCGGCACTCACCGATGGCCTTCGGGGCCTTTGGAACCTTTATGTGGTTGAACCCCGTGGAGAAAACGAATTTGTGGTC
GAGCGCCGGGACGTGGAAATCCTCTTTACCGATAGAGACAGGGCCTACCTCATTGGCGCCCTGAATGCGGGGGATCAAAT
CGTCACTCAGGGATTGCATAAATTGGTGGTGGGCGAGCATGTCCAGCCCATGACAGCCCTTGCCACGAGGTAA

Upstream 100 bases:

>100_bases
ATAGACTAGACAGTCCAGTTTTACCAAAATAGACTAGACAGTCCAGTTTAACCATTTTTTAACCGGCACCCTACCGGAGC
GATACCAACAGGAAACACAC

Downstream 100 bases:

>100_bases
ACCATGATTAAAGCCTTTGTGGAAAACGGCCGGCTGGCGGCACTTTTTATTGCGCTCTTGCTGGTCGCCGGGCTTGGCGC
CATGAGTGCCCTGCCCCGGC

Product: secretion protein HlyD

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MNAMNCHRWIKHLPLLLGLGVLSACQEKDAGPFNDSTPPTVITQSLSLSDGYQRPLEFSGTIRAANTTGVGFELAGKLSG
LYADSGDRVRKGQQLAALDTSLLKAEQQELQAALSQNSADLSLAQSTLKRSLELKKQGYVSSQQLDELEGRLGSLEGARE
RLKASLYANTLKLEKSRLLAPFDGSIGSRSFNLGEVVPLGQPVFVLVEDKAAQAHVGVPADIAKSLTQGQLMDLRVGREH
YRAVLAGINPSIDPVTRTVGLRLSLPSDAGVLNGEIAYLHYQQQVNTPGYWVPVSALTDGLRGLWNLYVVEPRGENEFVV
ERRDVEILFTDRDRAYLIGALNAGDQIVTQGLHKLVVGEHVQPMTALATR

Sequences:

>Translated_370_residues
MNAMNCHRWIKHLPLLLGLGVLSACQEKDAGPFNDSTPPTVITQSLSLSDGYQRPLEFSGTIRAANTTGVGFELAGKLSG
LYADSGDRVRKGQQLAALDTSLLKAEQQELQAALSQNSADLSLAQSTLKRSLELKKQGYVSSQQLDELEGRLGSLEGARE
RLKASLYANTLKLEKSRLLAPFDGSIGSRSFNLGEVVPLGQPVFVLVEDKAAQAHVGVPADIAKSLTQGQLMDLRVGREH
YRAVLAGINPSIDPVTRTVGLRLSLPSDAGVLNGEIAYLHYQQQVNTPGYWVPVSALTDGLRGLWNLYVVEPRGENEFVV
ERRDVEILFTDRDRAYLIGALNAGDQIVTQGLHKLVVGEHVQPMTALATR
>Mature_370_residues
MNAMNCHRWIKHLPLLLGLGVLSACQEKDAGPFNDSTPPTVITQSLSLSDGYQRPLEFSGTIRAANTTGVGFELAGKLSG
LYADSGDRVRKGQQLAALDTSLLKAEQQELQAALSQNSADLSLAQSTLKRSLELKKQGYVSSQQLDELEGRLGSLEGARE
RLKASLYANTLKLEKSRLLAPFDGSIGSRSFNLGEVVPLGQPVFVLVEDKAAQAHVGVPADIAKSLTQGQLMDLRVGREH
YRAVLAGINPSIDPVTRTVGLRLSLPSDAGVLNGEIAYLHYQQQVNTPGYWVPVSALTDGLRGLWNLYVVEPRGENEFVV
ERRDVEILFTDRDRAYLIGALNAGDQIVTQGLHKLVVGEHVQPMTALATR

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=360, Percent_Identity=25.8333333333333, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081796, Length=364, Percent_Identity=25.5494505494505, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789929, Length=372, Percent_Identity=23.6559139784946, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40146; Mature: 40146

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAMNCHRWIKHLPLLLGLGVLSACQEKDAGPFNDSTPPTVITQSLSLSDGYQRPLEFSG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCC
TIRAANTTGVGFELAGKLSGLYADSGDRVRKGQQLAALDTSLLKAEQQELQAALSQNSAD
EEEECCCCCCCEEECCCCCCEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
LSLAQSTLKRSLELKKQGYVSSQQLDELEGRLGSLEGARERLKASLYANTLKLEKSRLLA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEHHHHCCC
PFDGSIGSRSFNLGEVVPLGQPVFVLVEDKAAQAHVGVPADIAKSLTQGQLMDLRVGREH
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCEEHHHHCHHH
YRAVLAGINPSIDPVTRTVGLRLSLPSDAGVLNGEIAYLHYQQQVNTPGYWVPVSALTDG
HHHHHHCCCCCCCCHHHEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCEEEEHHHHHHH
LRGLWNLYVVEPRGENEFVVERRDVEILFTDRDRAYLIGALNAGDQIVTQGLHKLVVGEH
HHHHEEEEEECCCCCCCEEEEECCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCC
VQPMTALATR
CCCHHHHCCC
>Mature Secondary Structure
MNAMNCHRWIKHLPLLLGLGVLSACQEKDAGPFNDSTPPTVITQSLSLSDGYQRPLEFSG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCC
TIRAANTTGVGFELAGKLSGLYADSGDRVRKGQQLAALDTSLLKAEQQELQAALSQNSAD
EEEECCCCCCCEEECCCCCCEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
LSLAQSTLKRSLELKKQGYVSSQQLDELEGRLGSLEGARERLKASLYANTLKLEKSRLLA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEHHHHCCC
PFDGSIGSRSFNLGEVVPLGQPVFVLVEDKAAQAHVGVPADIAKSLTQGQLMDLRVGREH
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCEEHHHHCHHH
YRAVLAGINPSIDPVTRTVGLRLSLPSDAGVLNGEIAYLHYQQQVNTPGYWVPVSALTDG
HHHHHHCCCCCCCCHHHEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCEEEEHHHHHHH
LRGLWNLYVVEPRGENEFVVERRDVEILFTDRDRAYLIGALNAGDQIVTQGLHKLVVGEH
HHHHEEEEEECCCCCCCEEEEECCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCC
VQPMTALATR
CCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA