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The map label for this gene is neuC [H]

Identifier: 119775467

GI number: 119775467

Start: 2798035

End: 2799201

Strand: Direct

Name: neuC [H]

Synonym: Sama_2332

Alternate gene names: 119775467

Gene position: 2798035-2799201 (Clockwise)

Preceding gene: 119775466

Following gene: 119775468

Centisome position: 64.98

GC content: 43.53

Gene sequence:

>1167_bases
ATGCGGAAGATTTCCGTTGTGACAGCAACCCGAGCAGAATATGGATTGTTGAGAGGATTACTCGAGGACATCAATGCAGC
ATCGGAGCTGGAATTACAGCTGATCGTTACCGGCACTCACCTTTCTCCGGAATTTGGACTCACGCTTCGACAAATCGAAG
AGGATGGCTTTTGCATCAACAAAAAGGTGGAAATACTCTTGTCATCCGATACAGCTGTTGGCGTCAGCAAGAGTATGGGA
CTGGCATTGATAAGTTTTGCCGAAGTGTTTGATGAGCTGAAACCCGACATACTCGTGGTATTGGGCGATAGATATGAACT
CATTCCGATTGTTTCTGCTGCCAATATCGCCAGGATACCAGTGGCACATCTGAGTGGTGGAGAGCTTACTGAAGGGGCAA
TTGATGAACTGATTCGCCATTCAGTAACAAAGATGTCTCAACTGCATTTTACCGCGATGGAGGAGTATTCAAGACGAGTC
GTTCAGATGGGTGAACTCCCTTCGAGAGTGTTTACCGTGGGCGAGATAGGCCTGGATAATCTCAAACGTATTCAACTGAG
TTCTAAAGTTGAATTTGAAAACAGCATACACCGTAAATTGATGCCTAAAAACTTGCTGATTACTTATCATCCGGAAACTA
CCCAAGAGGTTGAGAAAGTTCGTAATGATTTTGAGCTTATCCTAAAGGCCCTTGACCAATTAGATAACACGCTGCTCATT
TTTACGAATGCAAATTCCGACGTAGGCGGCCGCTCTGTCAATATGATGATCGACGAATATGTCGATAGCCACCCAGAAAA
ATCTATCGCATTTACTTCTTTGGGAGTAAAAAGGTATTTATCCGCATTACAGTATGTTGATGCGGTTGTAGGTAACTCAT
CCAGTGGAATCGTTGAAGCCCCTTCATTCAGGATAGCTACCATCAATATTGGTGAAAGACAAAAGGGAAGAGTGCGTGCA
TCAAGCGTTGTAGATGTCGACGTGGATAGTGAGCAAATCCTCAAGGCCTTAGAAGCCATTTATTCTGACGACTTTAAAGC
ACACTTGAAAGAAACTGTAAACCCATATGGAAAGGGTGATAGCGTCCAAAAAGTGATTGCTGTGTTGAAATCTGTTGACT
TAGATAGCTTAAAGAGAAAGCCATTTTATGACCTCACTATTGGCTGA

Upstream 100 bases:

>100_bases
TGGATGTCAGACGTCCGGGAGATGGAATTTCCCCTTCTCGCTGGGATGAGGTAATCGGCAGTATCGCCAAAAAGGACTAT
CAATCAGGAGACCTCATTTA

Downstream 100 bases:

>100_bases
TAAACTCCCGATTGGTGGTGAGCAAGAAATAGCTTTTGATGGCCTATATTATGGGACTACAAACAGTGGACGCTCGTCGC
TTCGTTGGGCATTGCACTCT

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MRKISVVTATRAEYGLLRGLLEDINAASELELQLIVTGTHLSPEFGLTLRQIEEDGFCINKKVEILLSSDTAVGVSKSMG
LALISFAEVFDELKPDILVVLGDRYELIPIVSAANIARIPVAHLSGGELTEGAIDELIRHSVTKMSQLHFTAMEEYSRRV
VQMGELPSRVFTVGEIGLDNLKRIQLSSKVEFENSIHRKLMPKNLLITYHPETTQEVEKVRNDFELILKALDQLDNTLLI
FTNANSDVGGRSVNMMIDEYVDSHPEKSIAFTSLGVKRYLSALQYVDAVVGNSSSGIVEAPSFRIATINIGERQKGRVRA
SSVVDVDVDSEQILKALEAIYSDDFKAHLKETVNPYGKGDSVQKVIAVLKSVDLDSLKRKPFYDLTIG

Sequences:

>Translated_388_residues
MRKISVVTATRAEYGLLRGLLEDINAASELELQLIVTGTHLSPEFGLTLRQIEEDGFCINKKVEILLSSDTAVGVSKSMG
LALISFAEVFDELKPDILVVLGDRYELIPIVSAANIARIPVAHLSGGELTEGAIDELIRHSVTKMSQLHFTAMEEYSRRV
VQMGELPSRVFTVGEIGLDNLKRIQLSSKVEFENSIHRKLMPKNLLITYHPETTQEVEKVRNDFELILKALDQLDNTLLI
FTNANSDVGGRSVNMMIDEYVDSHPEKSIAFTSLGVKRYLSALQYVDAVVGNSSSGIVEAPSFRIATINIGERQKGRVRA
SSVVDVDVDSEQILKALEAIYSDDFKAHLKETVNPYGKGDSVQKVIAVLKSVDLDSLKRKPFYDLTIG
>Mature_388_residues
MRKISVVTATRAEYGLLRGLLEDINAASELELQLIVTGTHLSPEFGLTLRQIEEDGFCINKKVEILLSSDTAVGVSKSMG
LALISFAEVFDELKPDILVVLGDRYELIPIVSAANIARIPVAHLSGGELTEGAIDELIRHSVTKMSQLHFTAMEEYSRRV
VQMGELPSRVFTVGEIGLDNLKRIQLSSKVEFENSIHRKLMPKNLLITYHPETTQEVEKVRNDFELILKALDQLDNTLLI
FTNANSDVGGRSVNMMIDEYVDSHPEKSIAFTSLGVKRYLSALQYVDAVVGNSSSGIVEAPSFRIATINIGERQKGRVRA
SSVVDVDVDSEQILKALEAIYSDDFKAHLKETVNPYGKGDSVQKVIAVLKSVDLDSLKRKPFYDLTIG

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI190014632, Length=390, Percent_Identity=30, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI298566312, Length=390, Percent_Identity=30, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI4885285, Length=390, Percent_Identity=30, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI298566325, Length=365, Percent_Identity=29.3150684931507, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI298566315, Length=333, Percent_Identity=26.4264264264264, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 42908; Mature: 42908

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKISVVTATRAEYGLLRGLLEDINAASELELQLIVTGTHLSPEFGLTLRQIEEDGFCIN
CCEEEEEEECHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCEEECCCCCEEC
KKVEILLSSDTAVGVSKSMGLALISFAEVFDELKPDILVVLGDRYELIPIVSAANIARIP
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEECCCCCCCE
VAHLSGGELTEGAIDELIRHSVTKMSQLHFTAMEEYSRRVVQMGELPSRVFTVGEIGLDN
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHCCCCH
LKRIQLSSKVEFENSIHRKLMPKNLLITYHPETTQEVEKVRNDFELILKALDQLDNTLLI
HHEEHHCCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEE
FTNANSDVGGRSVNMMIDEYVDSHPEKSIAFTSLGVKRYLSALQYVDAVVGNSSSGIVEA
EECCCCCCCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
PSFRIATINIGERQKGRVRASSVVDVDVDSEQILKALEAIYSDDFKAHLKETVNPYGKGD
CCEEEEEEECCCCCCCCEEECEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCH
SVQKVIAVLKSVDLDSLKRKPFYDLTIG
HHHHHHHHHHHCCHHHHCCCCCEEECCC
>Mature Secondary Structure
MRKISVVTATRAEYGLLRGLLEDINAASELELQLIVTGTHLSPEFGLTLRQIEEDGFCIN
CCEEEEEEECHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCEEECCCCCEEC
KKVEILLSSDTAVGVSKSMGLALISFAEVFDELKPDILVVLGDRYELIPIVSAANIARIP
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEECCCCCCCE
VAHLSGGELTEGAIDELIRHSVTKMSQLHFTAMEEYSRRVVQMGELPSRVFTVGEIGLDN
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHCCCCH
LKRIQLSSKVEFENSIHRKLMPKNLLITYHPETTQEVEKVRNDFELILKALDQLDNTLLI
HHEEHHCCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEE
FTNANSDVGGRSVNMMIDEYVDSHPEKSIAFTSLGVKRYLSALQYVDAVVGNSSSGIVEA
EECCCCCCCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
PSFRIATINIGERQKGRVRASSVVDVDVDSEQILKALEAIYSDDFKAHLKETVNPYGKGD
CCEEEEEEECCCCCCCCEEECEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCH
SVQKVIAVLKSVDLDSLKRKPFYDLTIG
HHHHHHHHHHHCCHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]