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The map label for this gene is phhA [H]

Identifier: 119775357

GI number: 119775357

Start: 2685807

End: 2686598

Strand: Reverse

Name: phhA [H]

Synonym: Sama_2222

Alternate gene names: 119775357

Gene position: 2686598-2685807 (Counterclockwise)

Preceding gene: 119775364

Following gene: 119775356

Centisome position: 62.39

GC content: 52.53

Gene sequence:

>792_bases
ATGAGTACACAGTATGTTGCCCGCAAACCTGATGCGCACGGCGTAATTGCCTATCCGGATCAGGAAAACGAAATTTGGGC
AGAGCTTTATGCACGTCAGGCAGTGAATCTGCCCGGACGTGCCTGTCAGGAATATCTGGATGGCCTGGAGCGTCTGGCGC
TGCCCAAGGATCGTGTGCCACAACTGGCTGAAGTTGATGAGGTGCTGCTGGATACCACTGGCTGGAAAACGGCGGCGGTG
CCGGCGCTGATTTCTTTTGAGCGCTTTTTCGAACTGCTGGCGAGCCGTCAGTTTCCCGTGGCCACCTTTATCCGCAGCCG
GGAAGAGTTTGATTATCTGCAAGAGCCGGATATTTTTCATGAAATCTTTGGTCATTGCCCACTGCTGACCAATCCCGCCT
TTGCCAATTTTTCCCACATCTATGGCAAGCTGGGCCTGGCGGCCACCAAAGAGGAACGGGTGTATTTGGCCAGACTCTAT
TGGTTTACCGTGGAATTTGGCCTCCTGAAGCCAAGGGATGGTGAGCTGCGTATCTACGGTGGCGGCATCCTGAGTTCACC
CGGCGAAACGCTGTATGCCATGGGTGATAAACCCTTGAGAAAACCGTTTGATTTGCTGGATGTGCTGCGGACACCCTATC
GTATTGATATTATGCAGCCCGTCTATTTTGAAATTGAACATATTGATTTCCTTGATGAGATTGCCCGTATGGACATCATG
CAATCCGTCACCCGAGCCAGACAACTAGGGCTGCATGCCCCCTTGTTTGAGCCCAAGGCCAAGGCCGTTTAA

Upstream 100 bases:

>100_bases
TTGCTAGCAGAGGACGCAGGAATAAAACGTGAGGCAGTTAACAAAAATCCGCCCTTGGAACACTATTGGGGGGTTGAAGT
TAACCTGAAGTGAACCCGAG

Downstream 100 bases:

>100_bases
ATAAATAGAAGAATTACAGGAGCAGTAATGAGCGAATTAGCATCCATGAAGTGCGAAGCCTGCCAGGCTGATGCCCCCAA
GGTCACTGACGCCGAACTGG

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSTQYVARKPDAHGVIAYPDQENEIWAELYARQAVNLPGRACQEYLDGLERLALPKDRVPQLAEVDEVLLDTTGWKTAAV
PALISFERFFELLASRQFPVATFIRSREEFDYLQEPDIFHEIFGHCPLLTNPAFANFSHIYGKLGLAATKEERVYLARLY
WFTVEFGLLKPRDGELRIYGGGILSSPGETLYAMGDKPLRKPFDLLDVLRTPYRIDIMQPVYFEIEHIDFLDEIARMDIM
QSVTRARQLGLHAPLFEPKAKAV

Sequences:

>Translated_263_residues
MSTQYVARKPDAHGVIAYPDQENEIWAELYARQAVNLPGRACQEYLDGLERLALPKDRVPQLAEVDEVLLDTTGWKTAAV
PALISFERFFELLASRQFPVATFIRSREEFDYLQEPDIFHEIFGHCPLLTNPAFANFSHIYGKLGLAATKEERVYLARLY
WFTVEFGLLKPRDGELRIYGGGILSSPGETLYAMGDKPLRKPFDLLDVLRTPYRIDIMQPVYFEIEHIDFLDEIARMDIM
QSVTRARQLGLHAPLFEPKAKAV
>Mature_262_residues
STQYVARKPDAHGVIAYPDQENEIWAELYARQAVNLPGRACQEYLDGLERLALPKDRVPQLAEVDEVLLDTTGWKTAAVP
ALISFERFFELLASRQFPVATFIRSREEFDYLQEPDIFHEIFGHCPLLTNPAFANFSHIYGKLGLAATKEERVYLARLYW
FTVEFGLLKPRDGELRIYGGGILSSPGETLYAMGDKPLRKPFDLLDVLRTPYRIDIMQPVYFEIEHIDFLDEIARMDIMQ
SVTRARQLGLHAPLFEPKAKAV

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI31795563, Length=234, Percent_Identity=36.3247863247863, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI88900503, Length=215, Percent_Identity=37.6744186046512, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI88900505, Length=215, Percent_Identity=37.6744186046512, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI88900501, Length=215, Percent_Identity=37.6744186046512, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4759248, Length=225, Percent_Identity=35.5555555555556, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI4557819, Length=225, Percent_Identity=35.1111111111111, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17531391, Length=213, Percent_Identity=40.8450704225352, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71980736, Length=231, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI115532103, Length=236, Percent_Identity=29.2372881355932, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI115533973, Length=236, Percent_Identity=29.2372881355932, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71980731, Length=155, Percent_Identity=29.6774193548387, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17136774, Length=215, Percent_Identity=35.8139534883721, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI17136776, Length=215, Percent_Identity=35.8139534883721, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24660393, Length=212, Percent_Identity=35.8490566037736, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI62472054, Length=212, Percent_Identity=35.8490566037736, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24654994, Length=193, Percent_Identity=36.2694300518135, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 30140; Mature: 30009

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQYVARKPDAHGVIAYPDQENEIWAELYARQAVNLPGRACQEYLDGLERLALPKDRVP
CCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHCCC
QLAEVDEVLLDTTGWKTAAVPALISFERFFELLASRQFPVATFIRSREEFDYLQEPDIFH
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHH
EIFGHCPLLTNPAFANFSHIYGKLGLAATKEERVYLARLYWFTVEFGLLKPRDGELRIYG
HHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
GGILSSPGETLYAMGDKPLRKPFDLLDVLRTPYRIDIMQPVYFEIEHIDFLDEIARMDIM
CCEECCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
QSVTRARQLGLHAPLFEPKAKAV
HHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
STQYVARKPDAHGVIAYPDQENEIWAELYARQAVNLPGRACQEYLDGLERLALPKDRVP
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHCCC
QLAEVDEVLLDTTGWKTAAVPALISFERFFELLASRQFPVATFIRSREEFDYLQEPDIFH
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHH
EIFGHCPLLTNPAFANFSHIYGKLGLAATKEERVYLARLYWFTVEFGLLKPRDGELRIYG
HHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
GGILSSPGETLYAMGDKPLRKPFDLLDVLRTPYRIDIMQPVYFEIEHIDFLDEIARMDIM
CCEECCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
QSVTRARQLGLHAPLFEPKAKAV
HHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]