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The map label for this gene is ada [H]

Identifier: 119775340

GI number: 119775340

Start: 2662444

End: 2663895

Strand: Reverse

Name: ada [H]

Synonym: Sama_2205

Alternate gene names: 119775340

Gene position: 2663895-2662444 (Counterclockwise)

Preceding gene: 119775342

Following gene: 119775339

Centisome position: 61.86

GC content: 57.71

Gene sequence:

>1452_bases
GTGTTCCAACAACTGCCCTCAGCGGAAATTTGCCAACGGGCGCGCATGAGCCGCGACGCCCGCTTCGACGGCCTGTTTTT
TACCGGCGTGTTTTCCACTGGCATCTATTGCCGGCCTATCTGTCCGGCCGCCGCTCCCAAGGAGGAGAATGTCCGCTATT
TCGCCTCTGCTCAGGCGGCTGCAGCAGCGGGTTTACGCCCTTGTCTGAGGTGTCGTCCCGAGTCGGCGCCCGGCTCATCG
CCCTGGCGTGGTACTGCGACGACTCTGTTCAGGGCCATGGCGCTCATAGATGCCGGGGCATTAAATGCAACTGACGATGA
AACGTACCAACCGGCTCAAACCCAGGCTCAGGCGATGGAAAGCCTCGCCGAGAGGGTAGGAGTTGGCAGCCGGTATCTTC
GCAAGCTATTTGGTGAGCAGTTGGGTATGTCGCCCAAAGCCTACGGTGACTATCGCCGCCTGCTGCTGGCCAAAGCGCTC
TTACATCAAACGTCACTGCCCATTACCGATGTGGCTTTTGCGGCTGGATTTGGATCGGTGCGGCGATTCAACGAAGTGTT
CCGTGAGCGACTCTCGTTAACGCCAAGCGCCATCCGTGCCGACAGCAAGGTGAAGGACAGTGGCATCTGTCTGCAGTTAA
GTTTCAGGCCCCCTTACGATTTTATGCGGCTCAGAGCCTTTTTTATGGCGCGGGCCATTCCCGGAGCCGAGTGGTTTTTT
AACGATGCAGGTGAGCCCTGTTACGGCCGTACCCTCATGGTTGCGGGCGATGCGGGCTGGTTTGAGGCTTGTTTGCTGGC
GGGTAAAAATGCCCTGGCGGTTAGTATCTTTCCGGGCGGGCGAGTCAGTGCGCTCAGCCAATGGCTTGCTGAAATCAAGC
GGGTACTGGATATCGACGCCAACCTTTCCCTCATTCATGAACATATCCAGGGCCACATGCCCGAGGGTGTGGTGCTCAAT
ACCATGACACTGCCGGGGGCAGGCAGTTTTTTTGAGGCCGCGTGCCGTGCGGTTTTGGGGCAACAGGTAAGCCTTGTGCA
GGCAACAAGGCTCTTGGGTCTGCTGACAGCAGAAACCACGCCTGAAGTCGAGCTGGGAGGCAGGCGTTGCCGGGTATTTC
CCACCGCTGAACAAGTAGCGTCGGCTACGCTCGAAAGCCTGAAAATGCCGGGAAGCCGGAAAAATGCACTGCGGGACATG
GCGGCGCTCTTTAGCCGTGATCCCGTGCCCGATGATGCCACTTTGCTCGCTGTAAAAGGAATAGGCCCCTGGACCGTGAG
TTATGCCCGCATGCGGGGATTGTCGGACCCGGATGTGTTGCTGGTCGGTGATTTGGTTGTAAAGCAAAAACTTACCGCCA
TGGGTTGGGCTAAGGTGCCTGATAGGCTAAAAAGTGACGTTTCTCCCTGGGGCAGTTATCTCACCCTGGCGCTGTGGCAC
ACAGAAATCTAA

Upstream 100 bases:

>100_bases
GAAGGGGGATACCGGATTTGGGTTGAGGGCCGATTTCCGCTGGTTGATACCCCTGGGCTCAGGTAAAGTGATTTTACATT
TACCCTATCCAGGTTTTGCC

Downstream 100 bases:

>100_bases
AAAATCGACCTGAGGCCGTAAGCGTTCATCTGACGATATATCAAGCCGATTTTACGCGAAGCAATAACCGGCCAAAGATA
ACCGTTTTGAGCGGCCCCCT

Product: Ada regulatory protein

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MFQQLPSAEICQRARMSRDARFDGLFFTGVFSTGIYCRPICPAAAPKEENVRYFASAQAAAAAGLRPCLRCRPESAPGSS
PWRGTATTLFRAMALIDAGALNATDDETYQPAQTQAQAMESLAERVGVGSRYLRKLFGEQLGMSPKAYGDYRRLLLAKAL
LHQTSLPITDVAFAAGFGSVRRFNEVFRERLSLTPSAIRADSKVKDSGICLQLSFRPPYDFMRLRAFFMARAIPGAEWFF
NDAGEPCYGRTLMVAGDAGWFEACLLAGKNALAVSIFPGGRVSALSQWLAEIKRVLDIDANLSLIHEHIQGHMPEGVVLN
TMTLPGAGSFFEAACRAVLGQQVSLVQATRLLGLLTAETTPEVELGGRRCRVFPTAEQVASATLESLKMPGSRKNALRDM
AALFSRDPVPDDATLLAVKGIGPWTVSYARMRGLSDPDVLLVGDLVVKQKLTAMGWAKVPDRLKSDVSPWGSYLTLALWH
TEI

Sequences:

>Translated_483_residues
MFQQLPSAEICQRARMSRDARFDGLFFTGVFSTGIYCRPICPAAAPKEENVRYFASAQAAAAAGLRPCLRCRPESAPGSS
PWRGTATTLFRAMALIDAGALNATDDETYQPAQTQAQAMESLAERVGVGSRYLRKLFGEQLGMSPKAYGDYRRLLLAKAL
LHQTSLPITDVAFAAGFGSVRRFNEVFRERLSLTPSAIRADSKVKDSGICLQLSFRPPYDFMRLRAFFMARAIPGAEWFF
NDAGEPCYGRTLMVAGDAGWFEACLLAGKNALAVSIFPGGRVSALSQWLAEIKRVLDIDANLSLIHEHIQGHMPEGVVLN
TMTLPGAGSFFEAACRAVLGQQVSLVQATRLLGLLTAETTPEVELGGRRCRVFPTAEQVASATLESLKMPGSRKNALRDM
AALFSRDPVPDDATLLAVKGIGPWTVSYARMRGLSDPDVLLVGDLVVKQKLTAMGWAKVPDRLKSDVSPWGSYLTLALWH
TEI
>Mature_483_residues
MFQQLPSAEICQRARMSRDARFDGLFFTGVFSTGIYCRPICPAAAPKEENVRYFASAQAAAAAGLRPCLRCRPESAPGSS
PWRGTATTLFRAMALIDAGALNATDDETYQPAQTQAQAMESLAERVGVGSRYLRKLFGEQLGMSPKAYGDYRRLLLAKAL
LHQTSLPITDVAFAAGFGSVRRFNEVFRERLSLTPSAIRADSKVKDSGICLQLSFRPPYDFMRLRAFFMARAIPGAEWFF
NDAGEPCYGRTLMVAGDAGWFEACLLAGKNALAVSIFPGGRVSALSQWLAEIKRVLDIDANLSLIHEHIQGHMPEGVVLN
TMTLPGAGSFFEAACRAVLGQQVSLVQATRLLGLLTAETTPEVELGGRRCRVFPTAEQVASATLESLKMPGSRKNALRDM
AALFSRDPVPDDATLLAVKGIGPWTVSYARMRGLSDPDVLLVGDLVVKQKLTAMGWAKVPDRLKSDVSPWGSYLTLALWH
TEI

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=288, Percent_Identity=30.9027777777778, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788542, Length=185, Percent_Identity=31.8918918918919, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 52622; Mature: 52622

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQQLPSAEICQRARMSRDARFDGLFFTGVFSTGIYCRPICPAAAPKEENVRYFASAQAA
CCCCCCCHHHHHHHHHCCCCCCCCEEEEHHHHCCEEEECCCCCCCCCCCCCEEHHHHHHH
AAAGLRPCLRCRPESAPGSSPWRGTATTLFRAMALIDAGALNATDDETYQPAQTQAQAME
HHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
SLAERVGVGSRYLRKLFGEQLGMSPKAYGDYRRLLLAKALLHQTSLPITDVAFAAGFGSV
HHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHH
RRFNEVFRERLSLTPSAIRADSKVKDSGICLQLSFRPPYDFMRLRAFFMARAIPGAEWFF
HHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHC
NDAGEPCYGRTLMVAGDAGWFEACLLAGKNALAVSIFPGGRVSALSQWLAEIKRVLDIDA
CCCCCCCCCCEEEEECCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCC
NLSLIHEHIQGHMPEGVVLNTMTLPGAGSFFEAACRAVLGQQVSLVQATRLLGLLTAETT
CHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
PEVELGGRRCRVFPTAEQVASATLESLKMPGSRKNALRDMAALFSRDPVPDDATLLAVKG
CCEEECCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEC
IGPWTVSYARMRGLSDPDVLLVGDLVVKQKLTAMGWAKVPDRLKSDVSPWGSYLTLALWH
CCCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCHHCCHHHHHCCCCCHHHHEEEEEE
TEI
CCC
>Mature Secondary Structure
MFQQLPSAEICQRARMSRDARFDGLFFTGVFSTGIYCRPICPAAAPKEENVRYFASAQAA
CCCCCCCHHHHHHHHHCCCCCCCCEEEEHHHHCCEEEECCCCCCCCCCCCCEEHHHHHHH
AAAGLRPCLRCRPESAPGSSPWRGTATTLFRAMALIDAGALNATDDETYQPAQTQAQAME
HHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
SLAERVGVGSRYLRKLFGEQLGMSPKAYGDYRRLLLAKALLHQTSLPITDVAFAAGFGSV
HHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHH
RRFNEVFRERLSLTPSAIRADSKVKDSGICLQLSFRPPYDFMRLRAFFMARAIPGAEWFF
HHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHC
NDAGEPCYGRTLMVAGDAGWFEACLLAGKNALAVSIFPGGRVSALSQWLAEIKRVLDIDA
CCCCCCCCCCEEEEECCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCC
NLSLIHEHIQGHMPEGVVLNTMTLPGAGSFFEAACRAVLGQQVSLVQATRLLGLLTAETT
CHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
PEVELGGRRCRVFPTAEQVASATLESLKMPGSRKNALRDMAALFSRDPVPDDATLLAVKG
CCEEECCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEC
IGPWTVSYARMRGLSDPDVLLVGDLVVKQKLTAMGWAKVPDRLKSDVSPWGSYLTLALWH
CCCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCHHCCHHHHHCCCCCHHHHEEEEEE
TEI
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]