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The map label for this gene is upp

Identifier: 119775231

GI number: 119775231

Start: 2540524

End: 2541150

Strand: Reverse

Name: upp

Synonym: Sama_2096

Alternate gene names: 119775231

Gene position: 2541150-2540524 (Counterclockwise)

Preceding gene: 119775237

Following gene: 119775229

Centisome position: 59.01

GC content: 53.59

Gene sequence:

>627_bases
ATGAAAGTCGTCGAAGTAAAACATCCCCTGGTTCGCCATAAAATTGGCCTGATGAGAGAAGCGGATATCAGCACCAAGCG
TTTCCGTGAACTGGCTGCCGAAGTGGGCAGTTTGCTCACCTACGAAGCCACTGCCGATTTAGAAACCGAAACCGTGACCA
TTGAAGGCTGGAATGGTCCGGTGCAGGTTGAGCAAATCAAGGGCAAAAAAGTGACAGTAGTGCCTATCCTTCGCGCCGGT
CTTGGCATGATGGACGGCGTCCTGGAGCATATCCCAAGCGCCCGTATTTCTGTGGTAGGTATCTACCGCGACGAAGAAAC
CCTTGAGCCAGTACCGTATTTCGAAAAGCTGTGCAGCCAGGTGGATGAGCGCATTGCGCTGGTGGTTGACCCCATGCTGG
CCACAGGCGGCTCCATGATTTCTACCATCGACCTGCTCAAGCAGCGCGGATGTAAGCAAATCAAGGCACTGGTACTGGTT
GCTGCCCCCGAAGGCTTGGCTGCACTGGAAAAAGCCCACCCGGATATCGAGCTCTACACCGCGTCTATCGACCGCTGCCT
GAATGAAAATGGCTACATTTTACCGGGCCTCGGTGATGCCGGTGACAAGATTTTTGGCACCAAATAA

Upstream 100 bases:

>100_bases
GATTCGGTGTTTGAACAAAACTTTATGTTTTATCGAGAGAACAAATCATCTAAAATTCCAGAAATTTGCCTGAAAAACGC
CAAAAGTCGCAGGAGTAGAC

Downstream 100 bases:

>100_bases
GCTGTTGTAAACAGCCGCCTTAAATGAAAAAGCGCCCTAGGGCGCTTTTTTTGTATCCAGCAGTACTTCTTTTAGGCTAT
CTGTCCGCTTATAGCACCAT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKVVEVKHPLVRHKIGLMREADISTKRFRELAAEVGSLLTYEATADLETETVTIEGWNGPVQVEQIKGKKVTVVPILRAG
LGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFEKLCSQVDERIALVVDPMLATGGSMISTIDLLKQRGCKQIKALVLV
AAPEGLAALEKAHPDIELYTASIDRCLNENGYILPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MKVVEVKHPLVRHKIGLMREADISTKRFRELAAEVGSLLTYEATADLETETVTIEGWNGPVQVEQIKGKKVTVVPILRAG
LGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFEKLCSQVDERIALVVDPMLATGGSMISTIDLLKQRGCKQIKALVLV
AAPEGLAALEKAHPDIELYTASIDRCLNENGYILPGLGDAGDKIFGTK
>Mature_208_residues
MKVVEVKHPLVRHKIGLMREADISTKRFRELAAEVGSLLTYEATADLETETVTIEGWNGPVQVEQIKGKKVTVVPILRAG
LGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFEKLCSQVDERIALVVDPMLATGGSMISTIDLLKQRGCKQIKALVLV
AAPEGLAALEKAHPDIELYTASIDRCLNENGYILPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=25.2475247524752, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=25.2475247524752, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=84.1346153846154, Blast_Score=370, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=24.3781094527363, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=24.3781094527363, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=158, Percent_Identity=40.5063291139241, Blast_Score=109, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45550449, Length=204, Percent_Identity=25.9803921568627, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573516, Length=204, Percent_Identity=25.9803921568627, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573514, Length=204, Percent_Identity=25.9803921568627, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573512, Length=204, Percent_Identity=25.9803921568627, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_SHEAM (A1S7E5)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927971.1
- ProteinModelPortal:   A1S7E5
- SMR:   A1S7E5
- STRING:   A1S7E5
- GeneID:   4604346
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2096
- NMPDR:   fig|326297.7.peg.1968
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- PhylomeDB:   A1S7E5
- ProtClustDB:   PRK00129
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22678; Mature: 22678

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVEVKHPLVRHKIGLMREADISTKRFRELAAEVGSLLTYEATADLETETVTIEGWNGP
CCEEECCCHHHHHHHHCHHCCCCCHHHHHHHHHHHHHHEEEECCCCCCEEEEEEECCCCC
VQVEQIKGKKVTVVPILRAGLGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFEKLCSQ
EEEEEECCCEEEEEHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
VDERIALVVDPMLATGGSMISTIDLLKQRGCKQIKALVLVAAPEGLAALEKAHPDIELYT
HHHHHHHEECHHHHCCCHHHHHHHHHHHCCHHHHHEEEEEECCCCHHHHHHCCCCEEEEH
ASIDRCLNENGYILPGLGDAGDKIFGTK
HHHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKVVEVKHPLVRHKIGLMREADISTKRFRELAAEVGSLLTYEATADLETETVTIEGWNGP
CCEEECCCHHHHHHHHCHHCCCCCHHHHHHHHHHHHHHEEEECCCCCCEEEEEEECCCCC
VQVEQIKGKKVTVVPILRAGLGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFEKLCSQ
EEEEEECCCEEEEEHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
VDERIALVVDPMLATGGSMISTIDLLKQRGCKQIKALVLVAAPEGLAALEKAHPDIELYT
HHHHHHHEECHHHHCCCHHHHHHHHHHHCCHHHHHEEEEEECCCCHHHHHHCCCCEEEEH
ASIDRCLNENGYILPGLGDAGDKIFGTK
HHHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA