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The map label for this gene is f1pep1 [H]

Identifier: 119775226

GI number: 119775226

Start: 2533646

End: 2535802

Strand: Reverse

Name: f1pep1 [H]

Synonym: Sama_2091

Alternate gene names: 119775226

Gene position: 2535802-2533646 (Counterclockwise)

Preceding gene: 119775227

Following gene: 119775225

Centisome position: 58.89

GC content: 52.62

Gene sequence:

>2157_bases
ATGACAAGCAGAATCAGCACTCTAAGCCTGCTGACCCTGGGCTTTGCCCTGGGATTATCAGGCTGTCACACCAAAGACGC
GACCGTAGACGCCCCCGTGGCGGCTATCGCTTATCCTGCCAGCCAAACGGTTGCCATAAGCGAACAAATCCACGGCGTTG
AAGTGCAAGACCCTTATCGCTGGCTCGAAGAAAGCAGCCCTGAGACTGAGGATTGGGTCAAACGGCAACAGGCTTTTGGT
GAAGAATACCTTGCCGCCATCCCCAATAAACAAGTGGTGGTTGACCGCATTACCGAGCTGTGGAACTTTGAGAAAGTTGG
TGCACCTTTTGAGCACGGTGAAAATCGCTTTATATTCAGAAACAATGGCCTTCAATCACAAAACGTACTTTATGTGAGTG
AAAAGGGAGGTGATGAGCGGGTGTTGCTTGACCCCAATACGCTTTCAGCCGATGGCACTGTGGCCCTGTCCGGCGTCTCC
GTAAGCGGTGATGGCAAAACGCTGGCTTACGGCGTCTCCAAGTCAGGCTCCGACTGGCAGGAGTGGGCCTTTATCGATGT
GGCCACCGGTCGCAAGTTGGCCGACAGCCTGAACTGGATCAAATTTTCCCGTGCCGAATGGGCCCATGACAACAGTGGCG
TGTACTACTCTCGTTACGATGCGCCGGCTGGCGGCGATATCCTGGTCGATGTGAACTACAACCAGAAGGTGTATTTCCAT
CGTATTGGCGACGAGCAGGCCAAGGATACCCTGGTATACGAGCGCCCTGATCAACCAGAGTGGGGCTTTTCGTCCACGGT
GTCCGATGATGGTAACTTCTTGCTGATCAGCGTGTCAGTCGGTACAGACAGCCGCAATCGCTTTTTCTATAAACCACTGA
AAGATAAAAGTCTTAAAGTAGTTGAGTTGATGAGCGAACTGGAAGCTGAATACCAGTTCCTCGGCAATGAAGGTCCGGTG
TTCTACTTTAAGACCGATTTGGACGCACCAAGAGGTCGCATCATCGCCGTAGATACCCGCAATCCCGCCAAAGACAATTG
GCGTACCCTGGTACCAGAATCTCAGGACCCCATCGCTGAAGTCAGTATCATCAGCGAACACCTGGTGGTGAGTTACCTGC
ACGATGTGTTGGGTCAATTGTCCATTTACAACATGGATGGCGTAAAGCGTGAAGATGTGCCGCTGCCGGGTAAGGGCAAG
ATTGCCGGTCCCTACGGCAAGGCCAGCAAGCCTTACTTTTATTACATCTTCAACAGCTATGTACAGCCTCAGACCATCTA
CAAGTACGATCTGAATAAGGGCACCAATGAGGTGTTCAGTGCGCCCAAGGTATCCTTCAATCCGGATGACTATGTGTCTG
AGCAGGTGTTCTACACCAGCAAAGACGGTACCCGCATCCCCATGCTGGTCAGTTATAAGAAGGGCCTGAAGAAAGACGGT
AAAAATCCAACGCTGCTATATGCCTACGGCGGTTTCTCCATCTCCATGACCCCACGCTTCAGCCCGGCCACCATAGCCTG
GCTGGACATGGGCGGCATTTATGCGGTGCCGGCCCTGCGTGGTGGCAGCGAATACGGTGAAGAGTGGCACAAGGCCGGTA
TGTTCGGTAAAAAGCAAAACGTGTTTGACGACTATTTTGCTGCTGCCGAATATCTCATCAGCGAAAATTACACCAACAGC
AGCAAGCTTGGCGCCTATGGTCGCAGTAATGGTGGCCTCTTGATGGGCGCAGCCGTAACCCAGAGACCCGATTTGTTTGC
CGCCATCCTGCCTGCAGTGGGTGTACTGGATATGCTGCGCTTCCAAAAGTTCACCATAGGTTGGGCCTGGACGGCAGAAT
ATGGCAGTGCGGACAATGCCGAAGATTTTCCATACCTGCTGGCGTATTCGCCTTATCACAATGTGAAAGCGCAGACCTAT
CCTGCCACCATGGTGATGACAGCCGACCATGACGATCGCGTAGTACCGCTGCATAGCTTCAAGTTTGGTGCCATGCTGCA
GGCCAAACAGCAGGGACAAGCGCCTGTGATTATGCGAATTGAATCAAAGGCTGGCCATGGTGCCGGTAAACCCACGGCGA
TGCAGATTGCCGAGTTTGCCGACATCTATGCGTTTTTGTGGCAAAACTTCGGTTTAACCCTGCCAACTGAACTCTGA

Upstream 100 bases:

>100_bases
CGAAAGTTTCGCCACCATGTTTACCCGCCATTGCCACCTCCATTTTTGGGGGTATAGTGAGCAGCGGCAATGCACCTCTC
TACTGCAAAGGAAGACAACA

Downstream 100 bases:

>100_bases
ACGCAAAACGCACAAAAAATGCGTTGATACAAGGGGCTTTGGCCCCTTTTATCATTTATTTTTCTTTACAGTTGGCGGGG
GAGCGGCCATTCACAATCCC

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 718; Mature: 717

Protein sequence:

>718_residues
MTSRISTLSLLTLGFALGLSGCHTKDATVDAPVAAIAYPASQTVAISEQIHGVEVQDPYRWLEESSPETEDWVKRQQAFG
EEYLAAIPNKQVVVDRITELWNFEKVGAPFEHGENRFIFRNNGLQSQNVLYVSEKGGDERVLLDPNTLSADGTVALSGVS
VSGDGKTLAYGVSKSGSDWQEWAFIDVATGRKLADSLNWIKFSRAEWAHDNSGVYYSRYDAPAGGDILVDVNYNQKVYFH
RIGDEQAKDTLVYERPDQPEWGFSSTVSDDGNFLLISVSVGTDSRNRFFYKPLKDKSLKVVELMSELEAEYQFLGNEGPV
FYFKTDLDAPRGRIIAVDTRNPAKDNWRTLVPESQDPIAEVSIISEHLVVSYLHDVLGQLSIYNMDGVKREDVPLPGKGK
IAGPYGKASKPYFYYIFNSYVQPQTIYKYDLNKGTNEVFSAPKVSFNPDDYVSEQVFYTSKDGTRIPMLVSYKKGLKKDG
KNPTLLYAYGGFSISMTPRFSPATIAWLDMGGIYAVPALRGGSEYGEEWHKAGMFGKKQNVFDDYFAAAEYLISENYTNS
SKLGAYGRSNGGLLMGAAVTQRPDLFAAILPAVGVLDMLRFQKFTIGWAWTAEYGSADNAEDFPYLLAYSPYHNVKAQTY
PATMVMTADHDDRVVPLHSFKFGAMLQAKQQGQAPVIMRIESKAGHGAGKPTAMQIAEFADIYAFLWQNFGLTLPTEL

Sequences:

>Translated_718_residues
MTSRISTLSLLTLGFALGLSGCHTKDATVDAPVAAIAYPASQTVAISEQIHGVEVQDPYRWLEESSPETEDWVKRQQAFG
EEYLAAIPNKQVVVDRITELWNFEKVGAPFEHGENRFIFRNNGLQSQNVLYVSEKGGDERVLLDPNTLSADGTVALSGVS
VSGDGKTLAYGVSKSGSDWQEWAFIDVATGRKLADSLNWIKFSRAEWAHDNSGVYYSRYDAPAGGDILVDVNYNQKVYFH
RIGDEQAKDTLVYERPDQPEWGFSSTVSDDGNFLLISVSVGTDSRNRFFYKPLKDKSLKVVELMSELEAEYQFLGNEGPV
FYFKTDLDAPRGRIIAVDTRNPAKDNWRTLVPESQDPIAEVSIISEHLVVSYLHDVLGQLSIYNMDGVKREDVPLPGKGK
IAGPYGKASKPYFYYIFNSYVQPQTIYKYDLNKGTNEVFSAPKVSFNPDDYVSEQVFYTSKDGTRIPMLVSYKKGLKKDG
KNPTLLYAYGGFSISMTPRFSPATIAWLDMGGIYAVPALRGGSEYGEEWHKAGMFGKKQNVFDDYFAAAEYLISENYTNS
SKLGAYGRSNGGLLMGAAVTQRPDLFAAILPAVGVLDMLRFQKFTIGWAWTAEYGSADNAEDFPYLLAYSPYHNVKAQTY
PATMVMTADHDDRVVPLHSFKFGAMLQAKQQGQAPVIMRIESKAGHGAGKPTAMQIAEFADIYAFLWQNFGLTLPTEL
>Mature_717_residues
TSRISTLSLLTLGFALGLSGCHTKDATVDAPVAAIAYPASQTVAISEQIHGVEVQDPYRWLEESSPETEDWVKRQQAFGE
EYLAAIPNKQVVVDRITELWNFEKVGAPFEHGENRFIFRNNGLQSQNVLYVSEKGGDERVLLDPNTLSADGTVALSGVSV
SGDGKTLAYGVSKSGSDWQEWAFIDVATGRKLADSLNWIKFSRAEWAHDNSGVYYSRYDAPAGGDILVDVNYNQKVYFHR
IGDEQAKDTLVYERPDQPEWGFSSTVSDDGNFLLISVSVGTDSRNRFFYKPLKDKSLKVVELMSELEAEYQFLGNEGPVF
YFKTDLDAPRGRIIAVDTRNPAKDNWRTLVPESQDPIAEVSIISEHLVVSYLHDVLGQLSIYNMDGVKREDVPLPGKGKI
AGPYGKASKPYFYYIFNSYVQPQTIYKYDLNKGTNEVFSAPKVSFNPDDYVSEQVFYTSKDGTRIPMLVSYKKGLKKDGK
NPTLLYAYGGFSISMTPRFSPATIAWLDMGGIYAVPALRGGSEYGEEWHKAGMFGKKQNVFDDYFAAAEYLISENYTNSS
KLGAYGRSNGGLLMGAAVTQRPDLFAAILPAVGVLDMLRFQKFTIGWAWTAEYGSADNAEDFPYLLAYSPYHNVKAQTYP
ATMVMTADHDDRVVPLHSFKFGAMLQAKQQGQAPVIMRIESKAGHGAGKPTAMQIAEFADIYAFLWQNFGLTLPTEL

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=682, Percent_Identity=43.9882697947214, Blast_Score=567, Evalue=1e-161,
Organism=Homo sapiens, GI108860686, Length=271, Percent_Identity=29.1512915129151, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI284172438, Length=271, Percent_Identity=29.1512915129151, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI284172431, Length=271, Percent_Identity=29.1512915129151, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI284172420, Length=271, Percent_Identity=29.1512915129151, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI284172413, Length=271, Percent_Identity=29.1512915129151, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI70778815, Length=271, Percent_Identity=29.1512915129151, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI108860692, Length=270, Percent_Identity=28.8888888888889, Blast_Score=99, Evalue=2e-20,
Organism=Escherichia coli, GI1788150, Length=701, Percent_Identity=25.5349500713267, Blast_Score=201, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24583414, Length=712, Percent_Identity=42.2752808988764, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI221510989, Length=708, Percent_Identity=39.2655367231638, Blast_Score=505, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 79805; Mature: 79674

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRISTLSLLTLGFALGLSGCHTKDATVDAPVAAIAYPASQTVAISEQIHGVEVQDPYR
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCEECCHHH
WLEESSPETEDWVKRQQAFGEEYLAAIPNKQVVVDRITELWNFEKVGAPFEHGENRFIFR
HHHCCCCCHHHHHHHHHHHCHHHHHHCCCCEEHHHHHHHHHCHHHCCCCHHCCCCEEEEE
NNGLQSQNVLYVSEKGGDERVLLDPNTLSADGTVALSGVSVSGDGKTLAYGVSKSGSDWQ
CCCCCCCCEEEEECCCCCCEEEECCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCHH
EWAFIDVATGRKLADSLNWIKFSRAEWAHDNSGVYYSRYDAPAGGDILVDVNYNQKVYFH
HEEEEEECCCCHHHHCCCCEEECCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCEEEEE
RIGDEQAKDTLVYERPDQPEWGFSSTVSDDGNFLLISVSVGTDSRNRFFYKPLKDKSLKV
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCHHH
VELMSELEAEYQFLGNEGPVFYFKTDLDAPRGRIIAVDTRNPAKDNWRTLVPESQDPIAE
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCEECCCCCCCCHHH
VSIISEHLVVSYLHDVLGQLSIYNMDGVKREDVPLPGKGKIAGPYGKASKPYFYYIFNSY
HHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECC
VQPQTIYKYDLNKGTNEVFSAPKVSFNPDDYVSEQVFYTSKDGTRIPMLVSYKKGLKKDG
CCCCEEEEEECCCCCHHHHCCCCCCCCCCHHCCCEEEEECCCCCCCCEEEECHHHHHHCC
KNPTLLYAYGGFSISMTPRFSPATIAWLDMGGIYAVPALRGGSEYGEEWHKAGMFGKKQN
CCCEEEEEECCEEEEECCCCCCCEEEEEECCCEEEECEECCCHHHHHHHHHHCCCCCCCC
VFDDYFAAAEYLISENYTNSSKLGAYGRSNGGLLMGAAVTQRPDLFAAILPAVGVLDMLR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
FQKFTIGWAWTAEYGSADNAEDFPYLLAYSPYHNVKAQTYPATMVMTADHDDRVVPLHSF
HHHEEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCEECCEEEEEECCCCCCEEEEECC
KFGAMLQAKQQGQAPVIMRIESKAGHGAGKPTAMQIAEFADIYAFLWQNFGLTLPTEL
CCCHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TSRISTLSLLTLGFALGLSGCHTKDATVDAPVAAIAYPASQTVAISEQIHGVEVQDPYR
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCEECCHHH
WLEESSPETEDWVKRQQAFGEEYLAAIPNKQVVVDRITELWNFEKVGAPFEHGENRFIFR
HHHCCCCCHHHHHHHHHHHCHHHHHHCCCCEEHHHHHHHHHCHHHCCCCHHCCCCEEEEE
NNGLQSQNVLYVSEKGGDERVLLDPNTLSADGTVALSGVSVSGDGKTLAYGVSKSGSDWQ
CCCCCCCCEEEEECCCCCCEEEECCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCHH
EWAFIDVATGRKLADSLNWIKFSRAEWAHDNSGVYYSRYDAPAGGDILVDVNYNQKVYFH
HEEEEEECCCCHHHHCCCCEEECCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCEEEEE
RIGDEQAKDTLVYERPDQPEWGFSSTVSDDGNFLLISVSVGTDSRNRFFYKPLKDKSLKV
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCHHH
VELMSELEAEYQFLGNEGPVFYFKTDLDAPRGRIIAVDTRNPAKDNWRTLVPESQDPIAE
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCEECCCCCCCCHHH
VSIISEHLVVSYLHDVLGQLSIYNMDGVKREDVPLPGKGKIAGPYGKASKPYFYYIFNSY
HHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECC
VQPQTIYKYDLNKGTNEVFSAPKVSFNPDDYVSEQVFYTSKDGTRIPMLVSYKKGLKKDG
CCCCEEEEEECCCCCHHHHCCCCCCCCCCHHCCCEEEEECCCCCCCCEEEECHHHHHHCC
KNPTLLYAYGGFSISMTPRFSPATIAWLDMGGIYAVPALRGGSEYGEEWHKAGMFGKKQN
CCCEEEEEECCEEEEECCCCCCCEEEEEECCCEEEECEECCCHHHHHHHHHHCCCCCCCC
VFDDYFAAAEYLISENYTNSSKLGAYGRSNGGLLMGAAVTQRPDLFAAILPAVGVLDMLR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
FQKFTIGWAWTAEYGSADNAEDFPYLLAYSPYHNVKAQTYPATMVMTADHDDRVVPLHSF
HHHEEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCEECCEEEEEECCCCCCEEEEECC
KFGAMLQAKQQGQAPVIMRIESKAGHGAGKPTAMQIAEFADIYAFLWQNFGLTLPTEL
CCCHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]