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The map label for this gene is grxA [H]

Identifier: 119775216

GI number: 119775216

Start: 2524255

End: 2524515

Strand: Direct

Name: grxA [H]

Synonym: Sama_2081

Alternate gene names: 119775216

Gene position: 2524255-2524515 (Clockwise)

Preceding gene: 119775215

Following gene: 119775217

Centisome position: 58.62

GC content: 53.26

Gene sequence:

>261_bases
ATGTACGTTGTAATTTTTGGCCGTCCCGGCTGCCCCTATTGCGTTCGCGCCGAGCAACTTTGTGAGCAGCTTGCCGAAAA
ACGTGAAGACTTCCGCTTCCGCTATGTGGATATCCATGCCGAAGGGATCAGTAAAGAAGACCTGTCCAAGACGGTTGGCA
AGCCAGTGGAAACCGTGCCGCAGATTTTTGTGGACAAGACCCATGTAGGTGGCTGCACCGATTTTGAGGCCTATGTTCGC
GAGCACAATCTGCTGGCCTGA

Upstream 100 bases:

>100_bases
CAAACCCGCGCTCGTTTTGAAGACTAAAGACAGCCACGGATTATCAAAACCACCCTGGCTGTGATATAACAGCCACACAG
TATCGTTCTGAGGAGACTAC

Downstream 100 bases:

>100_bases
GCCCGATACAAAAAGCCTGCTTAATGCAGGCTTTTTGTTGGCTGTTCAGTCTCTTGCTGGTATGCAAATGGATTCATGGC
TATGCTGAATTAATGTCGGC

Product: glutaredoxin 1

Products: deoxyribonucleotides [C]

Alternate protein names: Grx1 [H]

Number of amino acids: Translated: 86; Mature: 86

Protein sequence:

>86_residues
MYVVIFGRPGCPYCVRAEQLCEQLAEKREDFRFRYVDIHAEGISKEDLSKTVGKPVETVPQIFVDKTHVGGCTDFEAYVR
EHNLLA

Sequences:

>Translated_86_residues
MYVVIFGRPGCPYCVRAEQLCEQLAEKREDFRFRYVDIHAEGISKEDLSKTVGKPVETVPQIFVDKTHVGGCTDFEAYVR
EHNLLA
>Mature_86_residues
MYVVIFGRPGCPYCVRAEQLCEQLAEKREDFRFRYVDIHAEGISKEDLSKTVGKPVETVPQIFVDKTHVGGCTDFEAYVR
EHNLLA

Specific function: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione re

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787073, Length=82, Percent_Identity=65.8536585365854, Blast_Score=124, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011902
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 9850; Mature: 9850

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVVIFGRPGCPYCVRAEQLCEQLAEKREDFRFRYVDIHAEGISKEDLSKTVGKPVETVP
CEEEEECCCCCCHHHCHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHCCCHHHHH
QIFVDKTHVGGCTDFEAYVREHNLLA
HHHHCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MYVVIFGRPGCPYCVRAEQLCEQLAEKREDFRFRYVDIHAEGISKEDLSKTVGKPVETVP
CEEEEECCCCCCHHHCHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHCCCHHHHH
QIFVDKTHVGGCTDFEAYVREHNLLA
HHHHCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribonucleotides [C]

Specific reaction: ribonucleotides = deoxyribonucleotides [C]

General reaction: deoxyribonucleotide biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]