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The map label for this gene is tmk

Identifier: 119775178

GI number: 119775178

Start: 2479863

End: 2480489

Strand: Reverse

Name: tmk

Synonym: Sama_2043

Alternate gene names: 119775178

Gene position: 2480489-2479863 (Counterclockwise)

Preceding gene: 119775179

Following gene: 119775177

Centisome position: 57.6

GC content: 55.5

Gene sequence:

>627_bases
ATGACGCAGAATCCCGGTAAATTCATTGTGATTGAGGGGCTTGAAGGCGCAGGTAAGTCCAGTGCCATCACACTGGTACA
TGACTTTATCGAGAAGCACACCGGCATGGCACCAGTGTGCACACGGGAGCCCGGTGGCACGCCGCTGGCGGAAAAAATCC
GCGACCTTGTGAAAAATGCCGAGCCTGGCGATCCTCTCTGTGATGAGGCCGAATGTTTGCTGTTTTACGCGGCCCGTGCT
CAGTTGGTGGCAAACGTCATCAAGCCCTCGCTGGCATCGGGTCGTTGGGTACTGGGAGACAGACACAATCTATCGTCCAT
CGCTTATCAGGGCGGTGGCCGCGGGTTGATGTCTTTGGTCAAAACCATCAGTGACGCCACCCTGGGCGGATTTAAGCCGG
ATCTGACGCTTTATCTCGATATAGATCCCTTGCTGGGACTGGAGCGCGCTGCCCGTCGCGGCGCTCTGGACAGGATAGAG
CAACAGGAAATTGACTTTTTTCACCGCGCACGAGCGACCTTTCTTGCTCAGGCGAGGGATGACAGCTCCATAGTGGTAAT
TGACGCTTCCAAGCCGCTTAACGAGGTACACAAGGACATTCTTGCCTGCTTAAGCACAGCCCTGTAG

Upstream 100 bases:

>100_bases
ATTATCTTTACTTTGTGTCCAGAAACGATGGCAGCCACGTATTTTCCCGCACACTCGCTGAACACAATCGCGCAGTAAAC
CAATTTCAGAGAAAACAAAA

Downstream 100 bases:

>100_bases
AGGGCAAGGAGACCTATGACTGCCATTCCCTGGCTTTCCCAGCCTTTGGCCGATTTTACGGCGCTGCTAACCGCCGGGCG
CATGCCCCATGCGGTGTTGG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTQNPGKFIVIEGLEGAGKSSAITLVHDFIEKHTGMAPVCTREPGGTPLAEKIRDLVKNAEPGDPLCDEAECLLFYAARA
QLVANVIKPSLASGRWVLGDRHNLSSIAYQGGGRGLMSLVKTISDATLGGFKPDLTLYLDIDPLLGLERAARRGALDRIE
QQEIDFFHRARATFLAQARDDSSIVVIDASKPLNEVHKDILACLSTAL

Sequences:

>Translated_208_residues
MTQNPGKFIVIEGLEGAGKSSAITLVHDFIEKHTGMAPVCTREPGGTPLAEKIRDLVKNAEPGDPLCDEAECLLFYAARA
QLVANVIKPSLASGRWVLGDRHNLSSIAYQGGGRGLMSLVKTISDATLGGFKPDLTLYLDIDPLLGLERAARRGALDRIE
QQEIDFFHRARATFLAQARDDSSIVVIDASKPLNEVHKDILACLSTAL
>Mature_207_residues
TQNPGKFIVIEGLEGAGKSSAITLVHDFIEKHTGMAPVCTREPGGTPLAEKIRDLVKNAEPGDPLCDEAECLLFYAARAQ
LVANVIKPSLASGRWVLGDRHNLSSIAYQGGGRGLMSLVKTISDATLGGFKPDLTLYLDIDPLLGLERAARRGALDRIEQ
QEIDFFHRARATFLAQARDDSSIVVIDASKPLNEVHKDILACLSTAL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=202, Percent_Identity=55.4455445544555, Blast_Score=213, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_SHEAM (A1S792)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927918.1
- ProteinModelPortal:   A1S792
- STRING:   A1S792
- GeneID:   4604293
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2043
- NMPDR:   fig|326297.7.peg.1918
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   A1S792
- ProtClustDB:   PRK00698
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22449; Mature: 22318

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNPGKFIVIEGLEGAGKSSAITLVHDFIEKHTGMAPVCTREPGGTPLAEKIRDLVKNA
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHCC
EPGDPLCDEAECLLFYAARAQLVANVIKPSLASGRWVLGDRHNLSSIAYQGGGRGLMSLV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCEEECCCCCHHHHEECCCCHHHHHHH
KTISDATLGGFKPDLTLYLDIDPLLGLERAARRGALDRIEQQEIDFFHRARATFLAQARD
HHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DSSIVVIDASKPLNEVHKDILACLSTAL
CCCEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQNPGKFIVIEGLEGAGKSSAITLVHDFIEKHTGMAPVCTREPGGTPLAEKIRDLVKNA
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHCC
EPGDPLCDEAECLLFYAARAQLVANVIKPSLASGRWVLGDRHNLSSIAYQGGGRGLMSLV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCEEECCCCCHHHHEECCCCHHHHHHH
KTISDATLGGFKPDLTLYLDIDPLLGLERAARRGALDRIEQQEIDFFHRARATFLAQARD
HHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DSSIVVIDASKPLNEVHKDILACLSTAL
CCCEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA