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The map label for this gene is msrAB [H]

Identifier: 119775126

GI number: 119775126

Start: 2421680

End: 2422609

Strand: Reverse

Name: msrAB [H]

Synonym: Sama_1991

Alternate gene names: 119775126

Gene position: 2422609-2421680 (Counterclockwise)

Preceding gene: 119775129

Following gene: 119775123

Centisome position: 56.26

GC content: 51.18

Gene sequence:

>930_bases
ATGAGAACGCTGAACGAATTTGAACGTTATGTAATCGAAGAGAAGGGGACAGAGCGCCCTTTCAGTGGTGAGTATTATCT
GCATAATGCCCAGGGCGTTTACTGTTGCAGGAAATGCGATGCGCCGCTGTATTTATCAGAGCACAAGTTCCACGCCCATT
GTGGCTGGCCTGCCTTTGATGATGAAATTCCTGGCGCTGTGGCAAGGCATACGGATGCAGACGGTCACAGGGTGGAAATC
GTCTGCGCATCCTGTGGCGGTCATTTGGGGCATGTATTTGAGGGTGAGTATCTTACTGAGAAAAACCTGAGGCACTGCGT
CAACTCGGTGTCCATGGTGTTTAAGAGCCATGAAGAGATGGAACAGGGACAGAAAACTATAAGCGAGGCCGGCCCAACTG
CCAATGCCTTTGCCACCTTTGGCGCCGGTTGTTTTTGGTGTGTTGAAGCGATTTTTTTAGCATTGAAAGGGGTGGTCAGC
GTCAAACCAGGCTACGCTGGTGGCCCTGCAGCCGATGCCAATTACAAAAGAGTGTGCGACGGTGATACAGGTCATGCGGA
AGTCGTTCATATCGAGTACAAGCCGGACGAGGTAAGCTTTGAGACTCTGATCGAGGTGTTCTTTCAAAGCCACGACCCCA
CCACCCTTAACCGCCAGGGTAACGATGTGGGAACCCAGTATCGTTCGGTGATATTTGCACATAATGAACCGCAGGCCGAG
GCCGCAGCAAAGGCGATAGAAGCCTTGACCAAGTCGGGCGCTTTCGATAACCCCATAGTGACCGAAGTGGTGGCTTTCGA
TGAGTTTTATCCCGCGGAAGACTATCACCATGACTATTTTGCCCGTAACGGCGAGCAGAGGTACTGTGCCCTGGTGGTAA
AACCCAAAGTCGACAAGTTTAAAAAGGCCTTTGCATCACTGCTGAAATAG

Upstream 100 bases:

>100_bases
GCTTTGGCGTAAATAAAGTATCGGTGGGCTTACCCGGTGCAATATAAGGCTCAAAACCCGGGTCAGCTCAGAATGAGTCT
CTTTAGCCGTTGGAGTAGCA

Downstream 100 bases:

>100_bases
CCTCATAGCTGAAATTGTCGGTATCAAAAAAAGCGGCCCGAGGGCCGCTTTCTTGATGGGTATGGATTCCCTTTAATCCA
ACTTGTCGTCGGCCACCCGA

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MRTLNEFERYVIEEKGTERPFSGEYYLHNAQGVYCCRKCDAPLYLSEHKFHAHCGWPAFDDEIPGAVARHTDADGHRVEI
VCASCGGHLGHVFEGEYLTEKNLRHCVNSVSMVFKSHEEMEQGQKTISEAGPTANAFATFGAGCFWCVEAIFLALKGVVS
VKPGYAGGPAADANYKRVCDGDTGHAEVVHIEYKPDEVSFETLIEVFFQSHDPTTLNRQGNDVGTQYRSVIFAHNEPQAE
AAAKAIEALTKSGAFDNPIVTEVVAFDEFYPAEDYHHDYFARNGEQRYCALVVKPKVDKFKKAFASLLK

Sequences:

>Translated_309_residues
MRTLNEFERYVIEEKGTERPFSGEYYLHNAQGVYCCRKCDAPLYLSEHKFHAHCGWPAFDDEIPGAVARHTDADGHRVEI
VCASCGGHLGHVFEGEYLTEKNLRHCVNSVSMVFKSHEEMEQGQKTISEAGPTANAFATFGAGCFWCVEAIFLALKGVVS
VKPGYAGGPAADANYKRVCDGDTGHAEVVHIEYKPDEVSFETLIEVFFQSHDPTTLNRQGNDVGTQYRSVIFAHNEPQAE
AAAKAIEALTKSGAFDNPIVTEVVAFDEFYPAEDYHHDYFARNGEQRYCALVVKPKVDKFKKAFASLLK
>Mature_309_residues
MRTLNEFERYVIEEKGTERPFSGEYYLHNAQGVYCCRKCDAPLYLSEHKFHAHCGWPAFDDEIPGAVARHTDADGHRVEI
VCASCGGHLGHVFEGEYLTEKNLRHCVNSVSMVFKSHEEMEQGQKTISEAGPTANAFATFGAGCFWCVEAIFLALKGVVS
VKPGYAGGPAADANYKRVCDGDTGHAEVVHIEYKPDEVSFETLIEVFFQSHDPTTLNRQGNDVGTQYRSVIFAHNEPQAE
AAAKAIEALTKSGAFDNPIVTEVVAFDEFYPAEDYHHDYFARNGEQRYCALVVKPKVDKFKKAFASLLK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=171, Percent_Identity=46.1988304093567, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI208609995, Length=171, Percent_Identity=46.1988304093567, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI208609993, Length=111, Percent_Identity=47.7477477477478, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI301336164, Length=117, Percent_Identity=42.7350427350427, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI301336162, Length=117, Percent_Identity=42.7350427350427, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI73089054, Length=117, Percent_Identity=42.7350427350427, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI37620216, Length=117, Percent_Identity=42.7350427350427, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI117606353, Length=125, Percent_Identity=39.2, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1790665, Length=156, Percent_Identity=44.8717948717949, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788077, Length=125, Percent_Identity=40, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=34.0136054421769, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17553450, Length=118, Percent_Identity=38.9830508474576, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115532676, Length=118, Percent_Identity=38.9830508474576, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319816, Length=120, Percent_Identity=51.6666666666667, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320881, Length=173, Percent_Identity=37.5722543352601, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24664627, Length=168, Percent_Identity=33.9285714285714, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24645799, Length=118, Percent_Identity=44.9152542372881, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45553335, Length=118, Percent_Identity=44.9152542372881, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356369, Length=118, Percent_Identity=44.9152542372881, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24664631, Length=169, Percent_Identity=34.3195266272189, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24645801, Length=129, Percent_Identity=41.0852713178295, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24645804, Length=129, Percent_Identity=41.0852713178295, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45553131, Length=159, Percent_Identity=32.7044025157233, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221378664, Length=117, Percent_Identity=41.8803418803419, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221378662, Length=124, Percent_Identity=39.5161290322581, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 34391; Mature: 34391

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLNEFERYVIEEKGTERPFSGEYYLHNAQGVYCCRKCDAPLYLSEHKFHAHCGWPAFD
CCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCCCEEECCCCEEEECCCCCCC
DEIPGAVARHTDADGHRVEIVCASCGGHLGHVFEGEYLTEKNLRHCVNSVSMVFKSHEEM
CCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EQGQKTISEAGPTANAFATFGAGCFWCVEAIFLALKGVVSVKPGYAGGPAADANYKRVCD
HHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCC
GDTGHAEVVHIEYKPDEVSFETLIEVFFQSHDPTTLNRQGNDVGTQYRSVIFAHNEPQAE
CCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHEEEEECCCCHHH
AAAKAIEALTKSGAFDNPIVTEVVAFDEFYPAEDYHHDYFARNGEQRYCALVVKPKVDKF
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEEECCCHHHH
KKAFASLLK
HHHHHHHCC
>Mature Secondary Structure
MRTLNEFERYVIEEKGTERPFSGEYYLHNAQGVYCCRKCDAPLYLSEHKFHAHCGWPAFD
CCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCCCEEECCCCEEEECCCCCCC
DEIPGAVARHTDADGHRVEIVCASCGGHLGHVFEGEYLTEKNLRHCVNSVSMVFKSHEEM
CCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EQGQKTISEAGPTANAFATFGAGCFWCVEAIFLALKGVVSVKPGYAGGPAADANYKRVCD
HHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCC
GDTGHAEVVHIEYKPDEVSFETLIEVFFQSHDPTTLNRQGNDVGTQYRSVIFAHNEPQAE
CCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHEEEEECCCCHHH
AAAKAIEALTKSGAFDNPIVTEVVAFDEFYPAEDYHHDYFARNGEQRYCALVVKPKVDKF
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEEECCCHHHH
KKAFASLLK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]