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The map label for this gene is grxD [H]

Identifier: 119775054

GI number: 119775054

Start: 2346156

End: 2346488

Strand: Reverse

Name: grxD [H]

Synonym: Sama_1919

Alternate gene names: 119775054

Gene position: 2346488-2346156 (Counterclockwise)

Preceding gene: 119775059

Following gene: 119775052

Centisome position: 54.49

GC content: 49.25

Gene sequence:

>333_bases
ATGGAAACAGTAGAAAGAATCAAGCAGCAAATTGCTGAAAACCCAATCATTGTCTACATGAAGGGTTCTCCAAAGCTGCC
AAGCTGTGGTTTCTCTGCCCGCGTTGCCGAGATGATGATTAACATTGGTGAGCAGTTTGCCTATGTGGATATCCTGCAAC
ATCCGGATATCCGTGCTGAGCTGCCGAAGTATGCCAACTGGCCAACCTTCCCACAGCTGTGGGTCGAAGGTGAACTGATC
GGCGGTTGCGACATCCTGACCGAGATGTTCCAAAAAGGCGAACTGCAGCCGCTTATCAAAGAAGTGGCCGCCAAGTACAA
AACGGAAGAATAA

Upstream 100 bases:

>100_bases
TTACAAACTGTGGGATTTTGTTCCGCCGCCCGCTGGCGTACAATATAGGCCACGTGTAAGACATCAAAGCCCCTATGGGG
ATGCCAAGTCAGGAATCAAA

Downstream 100 bases:

>100_bases
GCTTCAGGTTTTGCCTTGTAAGAAAAGCCCCGCCAAGCGGGGCTTTTTTGTGGCTGTAATTCAGTGTAGTAATCTTTGGC
ACTGAGTGACATCGCGCATC

Product: glutaredoxin-like protein

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin [H]

Number of amino acids: Translated: 110; Mature: 110

Protein sequence:

>110_residues
METVERIKQQIAENPIIVYMKGSPKLPSCGFSARVAEMMINIGEQFAYVDILQHPDIRAELPKYANWPTFPQLWVEGELI
GGCDILTEMFQKGELQPLIKEVAAKYKTEE

Sequences:

>Translated_110_residues
METVERIKQQIAENPIIVYMKGSPKLPSCGFSARVAEMMINIGEQFAYVDILQHPDIRAELPKYANWPTFPQLWVEGELI
GGCDILTEMFQKGELQPLIKEVAAKYKTEE
>Mature_110_residues
METVERIKQQIAENPIIVYMKGSPKLPSCGFSARVAEMMINIGEQFAYVDILQHPDIRAELPKYANWPTFPQLWVEGELI
GGCDILTEMFQKGELQPLIKEVAAKYKTEE

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters [H]

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI95113651, Length=96, Percent_Identity=39.5833333333333, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI42516576, Length=100, Percent_Identity=36, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1787943, Length=108, Percent_Identity=75.9259259259259, Blast_Score=184, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71988159, Length=86, Percent_Identity=39.5348837209302, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71988153, Length=85, Percent_Identity=40, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17556042, Length=107, Percent_Identity=33.6448598130841, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6325198, Length=107, Percent_Identity=39.2523364485981, Blast_Score=93, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6321022, Length=83, Percent_Identity=39.7590361445783, Blast_Score=83, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320303, Length=87, Percent_Identity=37.9310344827586, Blast_Score=82, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24642023, Length=85, Percent_Identity=43.5294117647059, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19921242, Length=96, Percent_Identity=38.5416666666667, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 12544; Mature: 12544

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METVERIKQQIAENPIIVYMKGSPKLPSCGFSARVAEMMINIGEQFAYVDILQHPDIRAE
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCCC
LPKYANWPTFPQLWVEGELIGGCDILTEMFQKGELQPLIKEVAAKYKTEE
CCCCCCCCCCCHHEECCCEECCHHHHHHHHHCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
METVERIKQQIAENPIIVYMKGSPKLPSCGFSARVAEMMINIGEQFAYVDILQHPDIRAE
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCCC
LPKYANWPTFPQLWVEGELIGGCDILTEMFQKGELQPLIKEVAAKYKTEE
CCCCCCCCCCCHHEECCCEECCHHHHHHHHHCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]