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The map label for this gene is gap [H]

Identifier: 119774941

GI number: 119774941

Start: 2198300

End: 2199739

Strand: Reverse

Name: gap [H]

Synonym: Sama_1806

Alternate gene names: 119774941

Gene position: 2199739-2198300 (Counterclockwise)

Preceding gene: 119774944

Following gene: 119774940

Centisome position: 51.08

GC content: 51.39

Gene sequence:

>1440_bases
ATGAGTGCTGATAAACACCTGCAAAGCTGGCAAGAAAGATTTGAACTGGCCGAGGCCATGCAACCTCTGCTGGGTAAACT
GTATCGCAACCAAGGTGTAGAAGTTGTTGTCTATGGCAAGCCTCTGCTGAACGCCTCTACCATTGATATTATCAAGGCTC
ACCGTCTGGTGCGTCGCCACGTGGGTGACAAACTGCGTTTGCGCGAAAGCTTCCCCTTTATTGAGGTGCTGAGCAAGCTG
GCAGTGAAGCAGTGTAAAGTTGATATCGGCAAACTCGCCGTTAACTACTGGCGTAACCACAGCGACGCCAGCGAAATAGA
AGCCTATATGGCCTCAGAACTTGCCAGCGCCATTGATCACGCTGATGAAGTAGAACCAAGAGACGTGGTTCTTTACGGTT
TCGGTCGTATTGGCCGTCTGTTGGCGCGTCTGCTGATTGAACGTACTGGCCGCAGCAACAAACTGCGTCTGCGTGCCATC
GTTATCCGTGGCGGCCGTGCTGGCGATCTGGAGAAGCGTGCAAGCCTGTTGCGCCGTGATTCAGTTCATGGTCCTTTCAA
CGGTTCTGTTGAAATCGATGAAGAAAACAATGCCTTGATTGCCAACGGTACCTACATCCAAATCATCTATGCCAACGGCC
CGGAAGAAGTGGATTACACCAAGTATGGTATTAAAGATGCGTTGGTTGTAGACAACACTGGTGTGTGGAAAGACGAAGCA
GGTCTTGGACTGCACCTGAAGAGCCCAGGAGCTGCCAAGGTACTGCTCACTGCGCCTGCCAAAGGTAACATCAAGAACAT
CGTATTCGGTGTGAATGATAACGATATTCTCGATGAAGACACTATCGTCTCTGCCGCATCTTGCACCACCAACGCCATCA
CCCCGGTGCTTAAGGCCATCAACGATAAGTACGGTATCGAAAACGGTCATGTGGAAACCATCCACTCATATACCAACGAC
CAGAACCTGATTGATAACTACCATAAGGCCGATCGCCGTGGTCGCAGCGCCCCGCTGAACATGGTTATCACTGAAACCGG
TGCTGCCAAGGCCGTTGCCAAGGCGCTGCCTGTGCTGGCTGGTCGTTTGACCGGTAACGCTATTCGTGTTCCGACGCCAA
ACGTGTCAATGGCCATTCTGAGCCTGAACCTGAACAGCGAAACCAGCAAAGATGATATCAACGACTATCTGCTGGACGTC
GCGTTGCATTCACCACTGCAAAACCAGATTGATTTCACCAACTCCACTGAAATCGTGTCCAGCGACCTGGTTGGCTCTCG
TTACGCCGGTGTAGTGGACTCACAGGCCACCATCGCTGACGGTAAGCGTGCCATTCTGTATGTTTGGTATGACAACGAGT
TTGGTTACAGCTGCCAGGTAGTAGGCGTGATGCAGAAAATGCTGGGTCTGAATCACCAGTCTCTGCCTCTGTCTGAATAA

Upstream 100 bases:

>100_bases
TGGGACCTGGGTCCCGGATAAAACTGATTATGGTCGTTTCTGTTTGTTACTCAAACCTTTCTGTAAATAAATATAGAAAA
GTGAGATAAAGGACCTGTAC

Downstream 100 bases:

>100_bases
CGAAAAAGCGCAGTAAAAGCCCGGCTATGCCGGGCTTTTTTATGGGTAGCACAATAATGCAGCATACGGACTGACAATAG
TAAAAAAGCCATTGACTGAG

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MSADKHLQSWQERFELAEAMQPLLGKLYRNQGVEVVVYGKPLLNASTIDIIKAHRLVRRHVGDKLRLRESFPFIEVLSKL
AVKQCKVDIGKLAVNYWRNHSDASEIEAYMASELASAIDHADEVEPRDVVLYGFGRIGRLLARLLIERTGRSNKLRLRAI
VIRGGRAGDLEKRASLLRRDSVHGPFNGSVEIDEENNALIANGTYIQIIYANGPEEVDYTKYGIKDALVVDNTGVWKDEA
GLGLHLKSPGAAKVLLTAPAKGNIKNIVFGVNDNDILDEDTIVSAASCTTNAITPVLKAINDKYGIENGHVETIHSYTND
QNLIDNYHKADRRGRSAPLNMVITETGAAKAVAKALPVLAGRLTGNAIRVPTPNVSMAILSLNLNSETSKDDINDYLLDV
ALHSPLQNQIDFTNSTEIVSSDLVGSRYAGVVDSQATIADGKRAILYVWYDNEFGYSCQVVGVMQKMLGLNHQSLPLSE

Sequences:

>Translated_479_residues
MSADKHLQSWQERFELAEAMQPLLGKLYRNQGVEVVVYGKPLLNASTIDIIKAHRLVRRHVGDKLRLRESFPFIEVLSKL
AVKQCKVDIGKLAVNYWRNHSDASEIEAYMASELASAIDHADEVEPRDVVLYGFGRIGRLLARLLIERTGRSNKLRLRAI
VIRGGRAGDLEKRASLLRRDSVHGPFNGSVEIDEENNALIANGTYIQIIYANGPEEVDYTKYGIKDALVVDNTGVWKDEA
GLGLHLKSPGAAKVLLTAPAKGNIKNIVFGVNDNDILDEDTIVSAASCTTNAITPVLKAINDKYGIENGHVETIHSYTND
QNLIDNYHKADRRGRSAPLNMVITETGAAKAVAKALPVLAGRLTGNAIRVPTPNVSMAILSLNLNSETSKDDINDYLLDV
ALHSPLQNQIDFTNSTEIVSSDLVGSRYAGVVDSQATIADGKRAILYVWYDNEFGYSCQVVGVMQKMLGLNHQSLPLSE
>Mature_478_residues
SADKHLQSWQERFELAEAMQPLLGKLYRNQGVEVVVYGKPLLNASTIDIIKAHRLVRRHVGDKLRLRESFPFIEVLSKLA
VKQCKVDIGKLAVNYWRNHSDASEIEAYMASELASAIDHADEVEPRDVVLYGFGRIGRLLARLLIERTGRSNKLRLRAIV
IRGGRAGDLEKRASLLRRDSVHGPFNGSVEIDEENNALIANGTYIQIIYANGPEEVDYTKYGIKDALVVDNTGVWKDEAG
LGLHLKSPGAAKVLLTAPAKGNIKNIVFGVNDNDILDEDTIVSAASCTTNAITPVLKAINDKYGIENGHVETIHSYTNDQ
NLIDNYHKADRRGRSAPLNMVITETGAAKAVAKALPVLAGRLTGNAIRVPTPNVSMAILSLNLNSETSKDDINDYLLDVA
LHSPLQNQIDFTNSTEIVSSDLVGSRYAGVVDSQATIADGKRAILYVWYDNEFGYSCQVVGVMQKMLGLNHQSLPLSE

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7657116, Length=339, Percent_Identity=35.9882005899705, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI7669492, Length=337, Percent_Identity=37.0919881305638, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI1788079, Length=335, Percent_Identity=36.7164179104478, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789295, Length=341, Percent_Identity=33.1378299120235, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17534677, Length=340, Percent_Identity=35, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17534679, Length=340, Percent_Identity=34.7058823529412, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17568413, Length=341, Percent_Identity=36.3636363636364, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI32566163, Length=341, Percent_Identity=36.3636363636364, Blast_Score=169, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322468, Length=339, Percent_Identity=36.283185840708, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6322409, Length=339, Percent_Identity=36.283185840708, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6321631, Length=339, Percent_Identity=36.8731563421829, Blast_Score=189, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17933600, Length=337, Percent_Identity=36.7952522255193, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI18110149, Length=337, Percent_Identity=36.7952522255193, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI19922412, Length=331, Percent_Identity=36.8580060422961, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI85725000, Length=337, Percent_Identity=36.4985163204748, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI22023983, Length=337, Percent_Identity=36.4985163204748, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 52624; Mature: 52492

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADKHLQSWQERFELAEAMQPLLGKLYRNQGVEVVVYGKPLLNASTIDIIKAHRLVRRH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
VGDKLRLRESFPFIEVLSKLAVKQCKVDIGKLAVNYWRNHSDASEIEAYMASELASAIDH
CCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ADEVEPRDVVLYGFGRIGRLLARLLIERTGRSNKLRLRAIVIRGGRAGDLEKRASLLRRD
HCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHC
SVHGPFNGSVEIDEENNALIANGTYIQIIYANGPEEVDYTKYGIKDALVVDNTGVWKDEA
CCCCCCCCCEEEECCCCEEEECCCEEEEEECCCCCCCCHHHCCCCCEEEECCCCCCCCCC
GLGLHLKSPGAAKVLLTAPAKGNIKNIVFGVNDNDILDEDTIVSAASCTTNAITPVLKAI
CCEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCHHEEHHCCCHHHHHHHHHHH
NDKYGIENGHVETIHSYTNDQNLIDNYHKADRRGRSAPLNMVITETGAAKAVAKALPVLA
HHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHH
GRLTGNAIRVPTPNVSMAILSLNLNSETSKDDINDYLLDVALHSPLQNQIDFTNSTEIVS
HHCCCCEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCHHHHH
SDLVGSRYAGVVDSQATIADGKRAILYVWYDNEFGYSCQVVGVMQKMLGLNHQSLPLSE
HHCCCCHHCCCCCCCCEECCCCEEEEEEEECCCCCCEEEHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SADKHLQSWQERFELAEAMQPLLGKLYRNQGVEVVVYGKPLLNASTIDIIKAHRLVRRH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
VGDKLRLRESFPFIEVLSKLAVKQCKVDIGKLAVNYWRNHSDASEIEAYMASELASAIDH
CCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ADEVEPRDVVLYGFGRIGRLLARLLIERTGRSNKLRLRAIVIRGGRAGDLEKRASLLRRD
HCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHC
SVHGPFNGSVEIDEENNALIANGTYIQIIYANGPEEVDYTKYGIKDALVVDNTGVWKDEA
CCCCCCCCCEEEECCCCEEEECCCEEEEEECCCCCCCCHHHCCCCCEEEECCCCCCCCCC
GLGLHLKSPGAAKVLLTAPAKGNIKNIVFGVNDNDILDEDTIVSAASCTTNAITPVLKAI
CCEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCHHEEHHCCCHHHHHHHHHHH
NDKYGIENGHVETIHSYTNDQNLIDNYHKADRRGRSAPLNMVITETGAAKAVAKALPVLA
HHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHH
GRLTGNAIRVPTPNVSMAILSLNLNSETSKDDINDYLLDVALHSPLQNQIDFTNSTEIVS
HHCCCCEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCHHHHH
SDLVGSRYAGVVDSQATIADGKRAILYVWYDNEFGYSCQVVGVMQKMLGLNHQSLPLSE
HHCCCCHHCCCCCCCCEECCCCEEEEEEEECCCCCCEEEHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8508805; 10360571; 2401296; 7877172 [H]