Click here to switch to the map view.

The map label for this gene is norM [H]

Identifier: 119774896

GI number: 119774896

Start: 2156410

End: 2157771

Strand: Reverse

Name: norM [H]

Synonym: Sama_1761

Alternate gene names: 119774896

Gene position: 2157771-2156410 (Counterclockwise)

Preceding gene: 119774898

Following gene: 119774895

Centisome position: 50.11

GC content: 53.01

Gene sequence:

>1362_bases
ATGCTCAACGTGGGCTTTCAAGCCAAAAAACTCATTCAATTGGCCTTGCCGGTGCTGATAGCACAGGTTACCCAAACCAT
GATGGGATTTATTGACACCCTGATGGCCGGTCGTGTCAGCGCCGTTGATATGGCCGCTGTGGCTGTGGGCACCAGTCTAT
GGTTGCCTGCCCTGCTGTTTGTGCAGGGGCTGTTGATGGCGTTTACTCCGGTGTTTTCCCAGCTTCATGGCGCTGATGAC
GAAGCCTCTATACGACCACTGGCATACCAGGCCGCTTATATTGCCATAATTGGCGCTTTCGCTGTGATGCTGTTTCTCGG
ACTTTCGTCAGAAATTCTGACCCGGATGGATCTTGAAACCGACCTTCGCCAGCTGTCGGAGGGATATCTTTTTGGGTTTC
TCTGGGGTGTTCCCGCCTTTGTGATGTATCAGGTGCTAAGGGGTATGAGCGAAGGGATTTCCTATACCTTGCCCACCATG
GTCATTGGATTTGTGGGACTGGCGGTCAATATTCCGGCCAACTACATCTTCATCTACGGCCACTTCGGCATGCCAGCCAT
GGGCGGCGCGGGCTGCGGTGTTGCCACGGCGCTGGTATTTTGGGCCATGTTAATAGCCATGTTGATTTATATGGCATTTC
ACAAAAAGTTTGCCCTCGTTTCCCCCTTTAAGGCATTTGAGCAGCCCAAGATATCCACCATGTGGCGCATGACCAAGCTG
GGGTTTCCAATCGCCATGGCGCTGTTTTTTGAAGTCAGCCTGTTTGCCATCATCGCCCTGCTACTGGCGCCATTAGGGGC
GAATGTGGTGGCCGGTCATCAAATAGCGCTCAATTTTTCATCCATTGTGTTTATGCTGCCGCTTTCTATTGGATTGGCTG
TGTCAATTCGCATCGGTTATTATCTCGGCCGTGAGAAAGCTGACGTGGCTGCACTGGTAGCAAAGGTCGGCCTGGGCCTG
GCCCTGTTTTTAGCCTCCATTACTGCAGTTATTACCGTGGTATTCAGGGTTGAAATTGCCAGACTCTACAACACCGACCC
CAACGTGGTCGCACTGGCCTCCAGTCTGATGCTGATGGCGGCGCTCTATCAACTGTCTGATTCAGTACAGGTCGTGGCCG
CTGGTGCCCTGCGTGGTTATAAAGATACCCGCAGCGCGTTTTACATTACCCTGATCTCCTACTGGGCCATTGGTATGACG
CTGGGCTATACCCTCGCCTACACCGATTGGCTGGTACCGGCCATGGGGGCACACGGGTTCTGGACCGGACTCATTGCTGG
GCTCACCACGGCCGCAGCTCTCTTTGCGATCCGTTTGAGATACATTCAAAAAACAGCGCCGAGCTTTCACTTTGTCCAAT
AA

Upstream 100 bases:

>100_bases
CGCCAGGGTGTGCATTCCCCGGCGCTTTTCCAGTGCCACCAACTCGCAGGTGGCTTGCACGATACCAGTAAACATTCATT
TTTCCTTTAAGGCGTTTTTT

Downstream 100 bases:

>100_bases
GCTTCTCATCAAGCCAACTCCTCACTGAGTTTTTCGGGAGGAGTTGCGCAGCAAATCACCATTTGAGGTGGACAGCAGAT
ATTTTTACTTGCATGTCAGC

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MLNVGFQAKKLIQLALPVLIAQVTQTMMGFIDTLMAGRVSAVDMAAVAVGTSLWLPALLFVQGLLMAFTPVFSQLHGADD
EASIRPLAYQAAYIAIIGAFAVMLFLGLSSEILTRMDLETDLRQLSEGYLFGFLWGVPAFVMYQVLRGMSEGISYTLPTM
VIGFVGLAVNIPANYIFIYGHFGMPAMGGAGCGVATALVFWAMLIAMLIYMAFHKKFALVSPFKAFEQPKISTMWRMTKL
GFPIAMALFFEVSLFAIIALLLAPLGANVVAGHQIALNFSSIVFMLPLSIGLAVSIRIGYYLGREKADVAALVAKVGLGL
ALFLASITAVITVVFRVEIARLYNTDPNVVALASSLMLMAALYQLSDSVQVVAAGALRGYKDTRSAFYITLISYWAIGMT
LGYTLAYTDWLVPAMGAHGFWTGLIAGLTTAAALFAIRLRYIQKTAPSFHFVQ

Sequences:

>Translated_453_residues
MLNVGFQAKKLIQLALPVLIAQVTQTMMGFIDTLMAGRVSAVDMAAVAVGTSLWLPALLFVQGLLMAFTPVFSQLHGADD
EASIRPLAYQAAYIAIIGAFAVMLFLGLSSEILTRMDLETDLRQLSEGYLFGFLWGVPAFVMYQVLRGMSEGISYTLPTM
VIGFVGLAVNIPANYIFIYGHFGMPAMGGAGCGVATALVFWAMLIAMLIYMAFHKKFALVSPFKAFEQPKISTMWRMTKL
GFPIAMALFFEVSLFAIIALLLAPLGANVVAGHQIALNFSSIVFMLPLSIGLAVSIRIGYYLGREKADVAALVAKVGLGL
ALFLASITAVITVVFRVEIARLYNTDPNVVALASSLMLMAALYQLSDSVQVVAAGALRGYKDTRSAFYITLISYWAIGMT
LGYTLAYTDWLVPAMGAHGFWTGLIAGLTTAAALFAIRLRYIQKTAPSFHFVQ
>Mature_453_residues
MLNVGFQAKKLIQLALPVLIAQVTQTMMGFIDTLMAGRVSAVDMAAVAVGTSLWLPALLFVQGLLMAFTPVFSQLHGADD
EASIRPLAYQAAYIAIIGAFAVMLFLGLSSEILTRMDLETDLRQLSEGYLFGFLWGVPAFVMYQVLRGMSEGISYTLPTM
VIGFVGLAVNIPANYIFIYGHFGMPAMGGAGCGVATALVFWAMLIAMLIYMAFHKKFALVSPFKAFEQPKISTMWRMTKL
GFPIAMALFFEVSLFAIIALLLAPLGANVVAGHQIALNFSSIVFMLPLSIGLAVSIRIGYYLGREKADVAALVAKVGLGL
ALFLASITAVITVVFRVEIARLYNTDPNVVALASSLMLMAALYQLSDSVQVVAAGALRGYKDTRSAFYITLISYWAIGMT
LGYTLAYTDWLVPAMGAHGFWTGLIAGLTTAAALFAIRLRYIQKTAPSFHFVQ

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=445, Percent_Identity=21.5730337078652, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI22907060, Length=429, Percent_Identity=21.6783216783217, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI38261960, Length=481, Percent_Identity=20.7900207900208, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI48994890, Length=439, Percent_Identity=51.0250569476082, Blast_Score=430, Evalue=1e-121,
Organism=Escherichia coli, GI226510954, Length=446, Percent_Identity=23.7668161434978, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321821, Length=373, Percent_Identity=23.3243967828418, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320545, Length=425, Percent_Identity=22.3529411764706, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48960; Mature: 48960

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]