Click here to switch to the map view.

The map label for this gene is msrA [H]

Identifier: 119774843

GI number: 119774843

Start: 2086791

End: 2087285

Strand: Reverse

Name: msrA [H]

Synonym: Sama_1707

Alternate gene names: 119774843

Gene position: 2087285-2086791 (Counterclockwise)

Preceding gene: 119774857

Following gene: 119774840

Centisome position: 48.47

GC content: 50.91

Gene sequence:

>495_bases
ATGTCACAATCCAATTCATCATTTGCCACTTTCGGCGCCGGCTGTTTTTGGGGTGTAGAGTATTTTTTCAGGCAGATCCC
CGGCGTTATCAACGCCACCTGCGGGTACATGGGCGGAAACGACAAGTACTCCCGCTATGAAGATGTCAAAAAAGGCATCA
CAGGCCATGCCGAAGTGGTGCAGGTGGAATTTGACCCAAGCCAGGTAAGCTTTGATGATTTGCTGCAGGTGTTTTGGAAA
AACCATAACCCTACCAGCCTCAACCAGCAGGGCGGCGATATAGGTACCCAGTATCGCAGCACCATCTTTTTCCACGACAA
GACACAAAAGGAACAGGCTGAAGCGTCGAAGCTCGCCCTTGCCCGCTCTGGCCGCTGGGGAACCCGTCATATAGTCACTG
AAATTGTACCGCTGCAGACCTTCCACGTTGCTGAGGAATATCACCAGAACTACATCGATAAAAACAACCTGCCCAGTTGC
CACATCGAGTATTGA

Upstream 100 bases:

>100_bases
CATGGATACACGGGAGCGGATAACAAACCGCTGTCACCCTCTTGCATTTCCACGTAAGTTTTATCACAATTTAGCCGTCC
AGACATCCATAGAGGTTTCC

Downstream 100 bases:

>100_bases
TACCGCAAGCCGATGAAACAAGTCGTTATCCAATAAAAAACGCGCCCAACGGCGCGTTTTTTATACCTTCATATCAAACT
GTGACAGCTTGATAGCCTTA

Product: protein-methionine-S-oxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MSQSNSSFATFGAGCFWGVEYFFRQIPGVINATCGYMGGNDKYSRYEDVKKGITGHAEVVQVEFDPSQVSFDDLLQVFWK
NHNPTSLNQQGGDIGTQYRSTIFFHDKTQKEQAEASKLALARSGRWGTRHIVTEIVPLQTFHVAEEYHQNYIDKNNLPSC
HIEY

Sequences:

>Translated_164_residues
MSQSNSSFATFGAGCFWGVEYFFRQIPGVINATCGYMGGNDKYSRYEDVKKGITGHAEVVQVEFDPSQVSFDDLLQVFWK
NHNPTSLNQQGGDIGTQYRSTIFFHDKTQKEQAEASKLALARSGRWGTRHIVTEIVPLQTFHVAEEYHQNYIDKNNLPSC
HIEY
>Mature_163_residues
SQSNSSFATFGAGCFWGVEYFFRQIPGVINATCGYMGGNDKYSRYEDVKKGITGHAEVVQVEFDPSQVSFDDLLQVFWKN
HNPTSLNQQGGDIGTQYRSTIFFHDKTQKEQAEASKLALARSGRWGTRHIVTEIVPLQTFHVAEEYHQNYIDKNNLPSCH
IEY

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=151, Percent_Identity=44.3708609271523, Blast_Score=123, Evalue=6e-29,
Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=43.0379746835443, Blast_Score=123, Evalue=8e-29,
Organism=Homo sapiens, GI208609993, Length=103, Percent_Identity=48.5436893203884, Blast_Score=93, Evalue=1e-19,
Organism=Escherichia coli, GI1790665, Length=150, Percent_Identity=46, Blast_Score=134, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17533973, Length=144, Percent_Identity=35.4166666666667, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=35.625, Blast_Score=106, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24664627, Length=143, Percent_Identity=39.8601398601399, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24664631, Length=143, Percent_Identity=40.5594405594406, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45553131, Length=138, Percent_Identity=38.4057971014493, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18653; Mature: 18522

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSNSSFATFGAGCFWGVEYFFRQIPGVINATCGYMGGNDKYSRYEDVKKGITGHAEVV
CCCCCCCCCHHCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEE
QVEFDPSQVSFDDLLQVFWKNHNPTSLNQQGGDIGTQYRSTIFFHDKTQKEQAEASKLAL
EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHEEEEECCCCHHHHHHHHHHHH
ARSGRWGTRHIVTEIVPLQTFHVAEEYHQNYIDKNNLPSCHIEY
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
>Mature Secondary Structure 
SQSNSSFATFGAGCFWGVEYFFRQIPGVINATCGYMGGNDKYSRYEDVKKGITGHAEVV
CCCCCCCCHHCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEE
QVEFDPSQVSFDDLLQVFWKNHNPTSLNQQGGDIGTQYRSTIFFHDKTQKEQAEASKLAL
EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHEEEEECCCCHHHHHHHHHHHH
ARSGRWGTRHIVTEIVPLQTFHVAEEYHQNYIDKNNLPSCHIEY
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]