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The map label for this gene is hutH [H]

Identifier: 119774768

GI number: 119774768

Start: 1995924

End: 1997417

Strand: Direct

Name: hutH [H]

Synonym: Sama_1631

Alternate gene names: 119774768

Gene position: 1995924-1997417 (Clockwise)

Preceding gene: 119774766

Following gene: 119774769

Centisome position: 46.35

GC content: 55.76

Gene sequence:

>1494_bases
ATGCGTTTTAGATATGGTGTTGACCATCTCACTCTCGAAACCGTAAACGGCATTGCCAACGGCAGTATTCAGGCAGAGCT
GTGCCAGCAAGCCATCGACAAGATCAACGCCAGCCGCCATAACGTGGATGTGATGGCCGCATCCGACAAGGCCATTTACG
GCATTAACACCGGCTTTGGCCCCCTGTGCGATACCCAGATTTCCCCTGCCGAAACCCACCTGCTGCAAAAGAACCTGCTG
ATCACCCACGCCGTGGGCGTAGGTGAACCGATTGCCAAATCCATCTCCAAGCTGATGCTTATCACCAAGGTGCATGCACT
CAGTCAGGGCTTTTCGGGTATTCGTCTCGACGTGGTTGAGCGTATGTTGGCCTTTATCGCCCTTGACTTGATCCCTGTGG
TACCGGAGCAGGGCTCTGTGGGCGCATCCGGCGATTTGGCGCCGCTGTCGCATCTGTTTTTGCCGCTGCTCGGCGAAGGT
GAATTCTGGCAGGGCGATAAGATAGTGCCTGCCCGTGAGGCGCTTAAGGCCCATGGCCTTGAGCCGCTTGAACTGCACGC
CAAAGAAGGCCTGGCGCTGATTAACGGTACCCAGTTTATTTTGTCCCACGCCATCACAGCGCTGACCAAGATGGGCTATT
TGCTGGATTTGGCCGACCTGGCCGGAGCCATGAGCATTGAAGGCATGCAGGGTAGCCAGTCGCCGTTTCGCGCCGAGCTG
CACGAAATCCGCCCCTTCGCCGGTAACATCGAAGTGGCCGCCCGTATGCGCAGCTTCTTCAAAGACTCTGAGAACATGGC
TTCTCACGAAGATTGCGATCGGGTGCAGGACCCATACTCGTTGCGCTGTATCCCGCAGGTTCACGGCGCCTCGCGTAACG
CTTACAACCATTTGAAAGAGCTGGCCGAAATTGAAATGAACTCGGTCACCGACAACCCGATTGTCATCAGTGCAGAAGAG
GCCATTTCCGGCGGTGGTTTCCATGGTCAGCCACTGGCCATGGTACTGGATTACACCTCCATTGCTGCGGCTGAGCTGGG
TAACATTTCAGACCGCCGCTGCTATTTGCTGCTCGAAGGCCTGCATGGGTTGCCGCGTCTGCTCACCACCTCGGGTGGTC
TTAACTCTGGCATGATGATCCCTCAGTACGTGACCGCAGCGCTGGTTACCGAAAACAAGTCCCTGTGCTTCCCGCCGTCA
GCCGACAGCGTGCCCACCTCCATGGGGCAGGAAGACCATGTGTCCATGGGCAGTATCTCTGGCCGTAAACTCAACCAGAT
TTTGGGTAACCTGGAGAAAATCTTTGCCATTGAGCTGATGTATGCCGCCCAAGCCATTGATTTTCGCCGTCCCAACCGCT
GCTCGGATATTATTGAGCAAAACCATGCTCTTATCCGCGAAAAAGTGGCCAAGCTGGAAGAGGACCGCCTGCTCAAGCCC
GATATTGATGCCATTATTGCGCTGGTCAAGGCTCAGGCCTTTACCGTGAAGTAA

Upstream 100 bases:

>100_bases
TTATAAAACTTCAGCGACAAGCTAGCATGGGGGCAATAGGGGTAAACCTCCGGTTTTGCCCACAAATAAAAAAGATAAAA
CAAATTGTTAGGAGCCAAAG

Downstream 100 bases:

>100_bases
GGGGGAGGATGACAAGCATGGAAACCAATATGACTTTTGCTGAACAAATCAAACAAGGGATCCCAGCCGAGCTGCCTTCG
CCAAAGCCCTATCCGGCCGA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MRFRYGVDHLTLETVNGIANGSIQAELCQQAIDKINASRHNVDVMAASDKAIYGINTGFGPLCDTQISPAETHLLQKNLL
ITHAVGVGEPIAKSISKLMLITKVHALSQGFSGIRLDVVERMLAFIALDLIPVVPEQGSVGASGDLAPLSHLFLPLLGEG
EFWQGDKIVPAREALKAHGLEPLELHAKEGLALINGTQFILSHAITALTKMGYLLDLADLAGAMSIEGMQGSQSPFRAEL
HEIRPFAGNIEVAARMRSFFKDSENMASHEDCDRVQDPYSLRCIPQVHGASRNAYNHLKELAEIEMNSVTDNPIVISAEE
AISGGGFHGQPLAMVLDYTSIAAAELGNISDRRCYLLLEGLHGLPRLLTTSGGLNSGMMIPQYVTAALVTENKSLCFPPS
ADSVPTSMGQEDHVSMGSISGRKLNQILGNLEKIFAIELMYAAQAIDFRRPNRCSDIIEQNHALIREKVAKLEEDRLLKP
DIDAIIALVKAQAFTVK

Sequences:

>Translated_497_residues
MRFRYGVDHLTLETVNGIANGSIQAELCQQAIDKINASRHNVDVMAASDKAIYGINTGFGPLCDTQISPAETHLLQKNLL
ITHAVGVGEPIAKSISKLMLITKVHALSQGFSGIRLDVVERMLAFIALDLIPVVPEQGSVGASGDLAPLSHLFLPLLGEG
EFWQGDKIVPAREALKAHGLEPLELHAKEGLALINGTQFILSHAITALTKMGYLLDLADLAGAMSIEGMQGSQSPFRAEL
HEIRPFAGNIEVAARMRSFFKDSENMASHEDCDRVQDPYSLRCIPQVHGASRNAYNHLKELAEIEMNSVTDNPIVISAEE
AISGGGFHGQPLAMVLDYTSIAAAELGNISDRRCYLLLEGLHGLPRLLTTSGGLNSGMMIPQYVTAALVTENKSLCFPPS
ADSVPTSMGQEDHVSMGSISGRKLNQILGNLEKIFAIELMYAAQAIDFRRPNRCSDIIEQNHALIREKVAKLEEDRLLKP
DIDAIIALVKAQAFTVK
>Mature_497_residues
MRFRYGVDHLTLETVNGIANGSIQAELCQQAIDKINASRHNVDVMAASDKAIYGINTGFGPLCDTQISPAETHLLQKNLL
ITHAVGVGEPIAKSISKLMLITKVHALSQGFSGIRLDVVERMLAFIALDLIPVVPEQGSVGASGDLAPLSHLFLPLLGEG
EFWQGDKIVPAREALKAHGLEPLELHAKEGLALINGTQFILSHAITALTKMGYLLDLADLAGAMSIEGMQGSQSPFRAEL
HEIRPFAGNIEVAARMRSFFKDSENMASHEDCDRVQDPYSLRCIPQVHGASRNAYNHLKELAEIEMNSVTDNPIVISAEE
AISGGGFHGQPLAMVLDYTSIAAAELGNISDRRCYLLLEGLHGLPRLLTTSGGLNSGMMIPQYVTAALVTENKSLCFPPS
ADSVPTSMGQEDHVSMGSISGRKLNQILGNLEKIFAIELMYAAQAIDFRRPNRCSDIIEQNHALIREKVAKLEEDRLLKP
DIDAIIALVKAQAFTVK

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=484, Percent_Identity=41.7355371900826, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17567831, Length=478, Percent_Identity=40.7949790794979, Blast_Score=352, Evalue=2e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53869; Mature: 53869

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFRYGVDHLTLETVNGIANGSIQAELCQQAIDKINASRHNVDVMAASDKAIYGINTGFG
CCCCCCCCCEEHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCC
PLCDTQISPAETHLLQKNLLITHAVGVGEPIAKSISKLMLITKVHALSQGFSGIRLDVVE
CCCCCCCCHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
RMLAFIALDLIPVVPEQGSVGASGDLAPLSHLFLPLLGEGEFWQGDKIVPAREALKAHGL
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCC
EPLELHAKEGLALINGTQFILSHAITALTKMGYLLDLADLAGAMSIEGMQGSQSPFRAEL
CCHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHH
HEIRPFAGNIEVAARMRSFFKDSENMASHEDCDRVQDPYSLRCIPQVHGASRNAYNHLKE
HHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEHHHCCCCCHHHHHHHH
LAEIEMNSVTDNPIVISAEEAISGGGFHGQPLAMVLDYTSIAAAELGNISDRRCYLLLEG
HHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHEEHH
LHGLPRLLTTSGGLNSGMMIPQYVTAALVTENKSLCFPPSADSVPTSMGQEDHVSMGSIS
HCCHHHHHHCCCCCCCCCCHHHHHHHHHEECCCCEECCCCCCCCCCCCCCCCCCCCCCCC
GRKLNQILGNLEKIFAIELMYAAQAIDFRRPNRCSDIIEQNHALIREKVAKLEEDRLLKP
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DIDAIIALVKAQAFTVK
CHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRFRYGVDHLTLETVNGIANGSIQAELCQQAIDKINASRHNVDVMAASDKAIYGINTGFG
CCCCCCCCCEEHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCC
PLCDTQISPAETHLLQKNLLITHAVGVGEPIAKSISKLMLITKVHALSQGFSGIRLDVVE
CCCCCCCCHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
RMLAFIALDLIPVVPEQGSVGASGDLAPLSHLFLPLLGEGEFWQGDKIVPAREALKAHGL
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCC
EPLELHAKEGLALINGTQFILSHAITALTKMGYLLDLADLAGAMSIEGMQGSQSPFRAEL
CCHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHH
HEIRPFAGNIEVAARMRSFFKDSENMASHEDCDRVQDPYSLRCIPQVHGASRNAYNHLKE
HHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEHHHCCCCCHHHHHHHH
LAEIEMNSVTDNPIVISAEEAISGGGFHGQPLAMVLDYTSIAAAELGNISDRRCYLLLEG
HHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHEEHH
LHGLPRLLTTSGGLNSGMMIPQYVTAALVTENKSLCFPPSADSVPTSMGQEDHVSMGSIS
HCCHHHHHHCCCCCCCCCCHHHHHHHHHEECCCCEECCCCCCCCCCCCCCCCCCCCCCCC
GRKLNQILGNLEKIFAIELMYAAQAIDFRRPNRCSDIIEQNHALIREKVAKLEEDRLLKP
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DIDAIIALVKAQAFTVK
CHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA