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The map label for this gene is uvrY [H]

Identifier: 119774744

GI number: 119774744

Start: 1964790

End: 1965434

Strand: Direct

Name: uvrY [H]

Synonym: Sama_1607

Alternate gene names: 119774744

Gene position: 1964790-1965434 (Clockwise)

Preceding gene: 119774741

Following gene: 119774745

Centisome position: 45.63

GC content: 50.39

Gene sequence:

>645_bases
TTGATTTCTGTATATTTGGTCGACGATCACGAGTTGGTTCGTACCGGGATCCGCAGGATCCTGGAAGATGAGCGGGGTAT
CAAGGTTGTGGGTGAGGCGCCTGATGGTGAAACCGCTGTCAGCTGGTCCAAACAGAATGAAGCTGACGTCGTACTGATGG
ACATGAATATGCCCGGTATCGGCGGTATCGAAGCAACCCGTAAAATTCTGCGTTATCAGCCTCACGCACGCATTATTGTG
TTATCCATGCACACTGAAGATCCTTTCCCGACCAAGGTCATGCAGGCAGGGGCGTTTGGTTATCTCACCAAGGGAGCCAA
GCCACCGGAAGTGCTGCAAGCTATCCGTCAGGTTGCCTGTGGGCAGCGTTATCTCTCGCCTGAAATTGCCCAGCAGATGG
CCTTGAGCCAACTGACTCAGACAGACGAAAATCCATTCAAGCAGGTATCAGAGCGCGAACTGCAAATCGCGATGATGATT
ATCAACAGCATGAAGGTGAACGATATTGCCGAGCAGTTGAATTTGAGCCCCAAGACGGTGAACAGCTACCGCTATCGCCT
ATTTGCCAAATTAGGCATCAGCAGTGACGTTGAACTGACCCGTTTGGCTATTCGACATAAGATTATTGATCCCGGCAAGT
TTTAA

Upstream 100 bases:

>100_bases
ATGCTTTGCCAGTCACCTATAATTTGGGATAAATTAACGCTGCTGGGCGCAAGGAGCGTGGCCAGCTACGTAAAAACAAA
AATAAACAGGGTGGTGCAAC

Downstream 100 bases:

>100_bases
GCGTGTTTGACCATAAAGCCTTTTTAAAAACGGTTTCCAGTGCCAGTGGCGTCTACCGCATGTATGACGCTGCGGCTGAG
GTTATCTATGTAGGAAAGGC

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MISVYLVDDHELVRTGIRRILEDERGIKVVGEAPDGETAVSWSKQNEADVVLMDMNMPGIGGIEATRKILRYQPHARIIV
LSMHTEDPFPTKVMQAGAFGYLTKGAKPPEVLQAIRQVACGQRYLSPEIAQQMALSQLTQTDENPFKQVSERELQIAMMI
INSMKVNDIAEQLNLSPKTVNSYRYRLFAKLGISSDVELTRLAIRHKIIDPGKF

Sequences:

>Translated_214_residues
MISVYLVDDHELVRTGIRRILEDERGIKVVGEAPDGETAVSWSKQNEADVVLMDMNMPGIGGIEATRKILRYQPHARIIV
LSMHTEDPFPTKVMQAGAFGYLTKGAKPPEVLQAIRQVACGQRYLSPEIAQQMALSQLTQTDENPFKQVSERELQIAMMI
INSMKVNDIAEQLNLSPKTVNSYRYRLFAKLGISSDVELTRLAIRHKIIDPGKF
>Mature_214_residues
MISVYLVDDHELVRTGIRRILEDERGIKVVGEAPDGETAVSWSKQNEADVVLMDMNMPGIGGIEATRKILRYQPHARIIV
LSMHTEDPFPTKVMQAGAFGYLTKGAKPPEVLQAIRQVACGQRYLSPEIAQQMALSQLTQTDENPFKQVSERELQIAMMI
INSMKVNDIAEQLNLSPKTVNSYRYRLFAKLGISSDVELTRLAIRHKIIDPGKF

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=66.824644549763, Blast_Score=290, Evalue=7e-80,
Organism=Escherichia coli, GI1790102, Length=202, Percent_Identity=37.1287128712871, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1788521, Length=204, Percent_Identity=33.8235294117647, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786747, Length=207, Percent_Identity=25.1207729468599, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=31.1475409836066, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788546, Length=201, Percent_Identity=28.3582089552239, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24051; Mature: 24051

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVYLVDDHELVRTGIRRILEDERGIKVVGEAPDGETAVSWSKQNEADVVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEECCCCCCCEEEEECCCCCC
GGIEATRKILRYQPHARIIVLSMHTEDPFPTKVMQAGAFGYLTKGAKPPEVLQAIRQVAC
CCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHCCCCHHHCCCCCCHHHHHHHHHHHH
GQRYLSPEIAQQMALSQLTQTDENPFKQVSERELQIAMMIINSMKVNDIAEQLNLSPKTV
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHH
NSYRYRLFAKLGISSDVELTRLAIRHKIIDPGKF
HHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MISVYLVDDHELVRTGIRRILEDERGIKVVGEAPDGETAVSWSKQNEADVVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEECCCCCCCEEEEECCCCCC
GGIEATRKILRYQPHARIIVLSMHTEDPFPTKVMQAGAFGYLTKGAKPPEVLQAIRQVAC
CCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHCCCCHHHCCCCCCHHHHHHHHHHHH
GQRYLSPEIAQQMALSQLTQTDENPFKQVSERELQIAMMIINSMKVNDIAEQLNLSPKTV
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHH
NSYRYRLFAKLGISSDVELTRLAIRHKIIDPGKF
HHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]