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The map label for this gene is clpP [H]

Identifier: 119774361

GI number: 119774361

Start: 1506371

End: 1506979

Strand: Direct

Name: clpP [H]

Synonym: Sama_1224

Alternate gene names: 119774361

Gene position: 1506371-1506979 (Clockwise)

Preceding gene: 119774360

Following gene: 119774362

Centisome position: 34.98

GC content: 50.41

Gene sequence:

>609_bases
ATGCATAACGCACCGGAATCAGTATTCAATGCGCTCGTGCCCATGGTGGTGGAACAAACCGCAAAAGGTGAGCGTTCCTA
CGATATCTATTCACGTCTGCTGAAAGAGCGAGTCATCTTCCTGGTGGGGCAGGTTGAAGAGCACATGGCTAACCTGATTG
TTGCGCAGCTACTGTTTCTGGAATCCGAAAACCCAGATAAAGAGATTTATCTCTACATCAACTCACCGGGTGGCAGCGTG
ACTGCGGGTATGGCAATTTACGATACTATGCAGTTCATTAAGCCCAAGGTCAGCACCGTTTGTATCGGTCAGGCCTGCAG
TATGGGCGCTTTCCTGCTTGCCGGTGGTGAAAAAGGCATGCGCCATTGTTTGCCCAATTCCAGGGTAATGATCCACCAGC
CTTTAGGTGGTTTCCAGGGACAGGCATCGGATATCGCTATCCATGCGCAGGAAATTTTGGGTATCAAACACAAACTCAAC
CAGATGTTATCGCACCACACAGGGCAGCCAATGGAAGTGATTGAGCGTGACACTGACCGCGATAATTTCATGAGTGCAAC
CCAGGCCGTTGAGTACGGTCTGATCGATTCAGTGCTGACCAGTCGCTGA

Upstream 100 bases:

>100_bases
GCCGCGCTTAACCGCAGCTTGACTTGATTGGCGTTAAGCCATTTATAATGGCTCGTATGAGGCTCCTCATGCGGGCCATT
TTTATTTAGGGAAGGGATAA

Downstream 100 bases:

>100_bases
TTTTTGCATCGCTCTGGGCTAAGCTCAGATTGAAAGGTTGAGATAGAGAGACAAGCGACTGACAGGTCGCAAACGGGGTA
AACTAATGGGTGAGAACAAG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MHNAPESVFNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFLESENPDKEIYLYINSPGGSV
TAGMAIYDTMQFIKPKVSTVCIGQACSMGAFLLAGGEKGMRHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLN
QMLSHHTGQPMEVIERDTDRDNFMSATQAVEYGLIDSVLTSR

Sequences:

>Translated_202_residues
MHNAPESVFNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFLESENPDKEIYLYINSPGGSV
TAGMAIYDTMQFIKPKVSTVCIGQACSMGAFLLAGGEKGMRHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLN
QMLSHHTGQPMEVIERDTDRDNFMSATQAVEYGLIDSVLTSR
>Mature_202_residues
MHNAPESVFNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFLESENPDKEIYLYINSPGGSV
TAGMAIYDTMQFIKPKVSTVCIGQACSMGAFLLAGGEKGMRHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLN
QMLSHHTGQPMEVIERDTDRDNFMSATQAVEYGLIDSVLTSR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=57.4468085106383, Blast_Score=239, Evalue=1e-63,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=75.5208333333333, Blast_Score=319, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI17538017, Length=188, Percent_Identity=56.3829787234042, Blast_Score=230, Evalue=3e-61,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=58.5106382978723, Blast_Score=239, Evalue=8e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22336; Mature: 22336

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNAPESVFNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESENPDKEIYLYINSPGGSVTAGMAIYDTMQFIKPKVSTVCIGQACSMGAFLLAGGEKGM
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHEEHHHHHCCCEEEEECCCHHH
RHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLNQMLSHHTGQPMEVIERDTDR
HHCCCCCCEEEECCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCH
DNFMSATQAVEYGLIDSVLTSR
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHNAPESVFNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESENPDKEIYLYINSPGGSVTAGMAIYDTMQFIKPKVSTVCIGQACSMGAFLLAGGEKGM
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHEEHHHHHCCCEEEEECCCHHH
RHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKHKLNQMLSHHTGQPMEVIERDTDR
HHCCCCCCEEEECCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCH
DNFMSATQAVEYGLIDSVLTSR
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA