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The map label for this gene is pgcA [H]

Identifier: 119774326

GI number: 119774326

Start: 1456456

End: 1458213

Strand: Direct

Name: pgcA [H]

Synonym: Sama_1189

Alternate gene names: 119774326

Gene position: 1456456-1458213 (Clockwise)

Preceding gene: 119774325

Following gene: 119774327

Centisome position: 33.82

GC content: 59.67

Gene sequence:

>1758_bases
ATGGATACCCAGCTCGCATTCAAGGTAAAACACTGGTTGGCAAGGGATCCCGACGCCAAGAGTCGCGCCGCACTGGAGGC
TTTGGTGGCGGCAGGGGATGACAGAGCGCTTGAGGCCGCCTTCGATGGCAGACTGGCCTTTGGCACCGCTGGTATCCGCG
GTATTGTCGGCCCGGGCCCCATGGGCATGAATCGCCTGCTGGTGCGTGAAACCAGTGCAGGTCTGGGCGCATATCTGGAG
GCACAAATTAAGGATGCCAAGCGTCGGGGGCTGGTCATTGGTTTTGATGGCCGCCATGACTCACGGGTATTCGCCCACGA
TGCGGCCTGTGTGCTCAGCGCCATGGGCTTTAAAGTGCGCCTGACCAGCCATGTAGCCCCCACGCCGCTGGTGGCCTTCG
GGGTAAAACATTTTGAAGCGGCCGCCGGTATCGTTGTCACCGCCAGCCATAACCCGCCCAAATACAATGGCTACAAGGTG
TATTGGGAAAATGGCGCGCAGATTATTCCGCCCCACGATGCAGGCATTGCGGCCTGTATTGACCGCGCGGCCAATCTTGA
ATTGCCCTGGATGCCAGAGCCCGAAGCGGTAAAACAGGGGCGACTTTCCTTTTTGCAGGATGATTTTTTCGAGCGCTATC
GCCGCGCCATTTTACATTCGCCATTGCTGCATCCCGCCGGTGAGAGTCAGGCGGGCCGAGCCAGTCTGGGGATTGCCTAT
ACTGCGATGCACGGCGTCGGCGCCCCCATGGCTGAGCGGGTGCTCAGGGACGCAGGTTTCAGCCAGGTATACAGCGTGGC
TGCCCAGCGCGAGCCCGATGGTAATTTCCCCACGGTGAATTTCCCCAATCCCGAGGAACCCGGTGCCATGGACATGGTTA
TCGCCGAGGCCGGTGACAAAGGTGCCTTGTTGGCCTGTGCCAACGATCCGGACGCCGACCGGTTCGCGCTGGCTGCCCGC
CAGAGCGATGGCGGGTATCGGATGTTGTCGGGGGATCAGACCGGCGCTTTATTGTGTGACTATCTGCTGTCCCATTGGCA
GGGGGCGGGTGTGCCGCTGGTGGGCAACACTATAGTGTCCTCTGCCCTCCTGCACGCCATTGCCGCCCATTATGGTGCCC
ACAGCTATACCACGCTTACCGGCTTTAAGTGGCTGATGAATACAGCACAGCAGCTGGAAACGCCGCAGCAGCCGTTTCTC
TTTGCCTATGAAGAAGCCCTGGGGTACACGGTGGGCAATCTGGTGTGGGATAAAGATGGCATCAGCGCCCAACTGTGTTT
TGCCAATCTGGCCGCCGAACTTCTGGCAGAAGGAAAAGATGTGTGGGCGGCGCTGGAGCGACTCTATCGCCGCCATGGGC
TCTATGTTAACCGGCAGGTGAGCATTGCCCTTGGGGAAGGGACGCCGGATATAGGTGCCTGGCTCAGGGACAATCCTCCA
ACCGAGATAGATAAGCGGCCTGTGGTTGCCCGGGAAGACTTAAAGCGGCTGCGTAAAGTCTATGCCGATGGCCGGGAAGA
GGAGATTGCTCTGCCTGCCAGCGATGTACTCATTTACCATTTGGGCGCCTCGGACGCCACGCCTGGCTCCACCGCCCGGG
TTATAGTGAGGCCATCGGGTACTGAGCCCAAGATAAAATGCTACTACGAGCTGGTATTACCCATGGCAGACGATATTGCT
ATGGCCGACGCCCAGCTCCAGGGGGATGCCTTGATGACGGCACTGGTGGATGGTCATCAGGCGGGCCTGCCCCGCTGA

Upstream 100 bases:

>100_bases
CAGCCAGATTGCAGTTTTCAACCCATCATAGGTGCTGTATTTGGACGTTTGGAATAGATGAAGGTCACTGCAGGGTTACG
AGGTGGCACAAGGAGAGGTT

Downstream 100 bases:

>100_bases
AACCGAAAAAATCCGACTTCTGACAAACCCTGCTGACACCATGTTGTCAGCAGGGGGGGATTAAGCTGACTCTATCGATG
AAGCGCGAAGTAATACCTAC

Product: phosphoglucomutase/phosphomannomutase family protein

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MDTQLAFKVKHWLARDPDAKSRAALEALVAAGDDRALEAAFDGRLAFGTAGIRGIVGPGPMGMNRLLVRETSAGLGAYLE
AQIKDAKRRGLVIGFDGRHDSRVFAHDAACVLSAMGFKVRLTSHVAPTPLVAFGVKHFEAAAGIVVTASHNPPKYNGYKV
YWENGAQIIPPHDAGIAACIDRAANLELPWMPEPEAVKQGRLSFLQDDFFERYRRAILHSPLLHPAGESQAGRASLGIAY
TAMHGVGAPMAERVLRDAGFSQVYSVAAQREPDGNFPTVNFPNPEEPGAMDMVIAEAGDKGALLACANDPDADRFALAAR
QSDGGYRMLSGDQTGALLCDYLLSHWQGAGVPLVGNTIVSSALLHAIAAHYGAHSYTTLTGFKWLMNTAQQLETPQQPFL
FAYEEALGYTVGNLVWDKDGISAQLCFANLAAELLAEGKDVWAALERLYRRHGLYVNRQVSIALGEGTPDIGAWLRDNPP
TEIDKRPVVAREDLKRLRKVYADGREEEIALPASDVLIYHLGASDATPGSTARVIVRPSGTEPKIKCYYELVLPMADDIA
MADAQLQGDALMTALVDGHQAGLPR

Sequences:

>Translated_585_residues
MDTQLAFKVKHWLARDPDAKSRAALEALVAAGDDRALEAAFDGRLAFGTAGIRGIVGPGPMGMNRLLVRETSAGLGAYLE
AQIKDAKRRGLVIGFDGRHDSRVFAHDAACVLSAMGFKVRLTSHVAPTPLVAFGVKHFEAAAGIVVTASHNPPKYNGYKV
YWENGAQIIPPHDAGIAACIDRAANLELPWMPEPEAVKQGRLSFLQDDFFERYRRAILHSPLLHPAGESQAGRASLGIAY
TAMHGVGAPMAERVLRDAGFSQVYSVAAQREPDGNFPTVNFPNPEEPGAMDMVIAEAGDKGALLACANDPDADRFALAAR
QSDGGYRMLSGDQTGALLCDYLLSHWQGAGVPLVGNTIVSSALLHAIAAHYGAHSYTTLTGFKWLMNTAQQLETPQQPFL
FAYEEALGYTVGNLVWDKDGISAQLCFANLAAELLAEGKDVWAALERLYRRHGLYVNRQVSIALGEGTPDIGAWLRDNPP
TEIDKRPVVAREDLKRLRKVYADGREEEIALPASDVLIYHLGASDATPGSTARVIVRPSGTEPKIKCYYELVLPMADDIA
MADAQLQGDALMTALVDGHQAGLPR
>Mature_585_residues
MDTQLAFKVKHWLARDPDAKSRAALEALVAAGDDRALEAAFDGRLAFGTAGIRGIVGPGPMGMNRLLVRETSAGLGAYLE
AQIKDAKRRGLVIGFDGRHDSRVFAHDAACVLSAMGFKVRLTSHVAPTPLVAFGVKHFEAAAGIVVTASHNPPKYNGYKV
YWENGAQIIPPHDAGIAACIDRAANLELPWMPEPEAVKQGRLSFLQDDFFERYRRAILHSPLLHPAGESQAGRASLGIAY
TAMHGVGAPMAERVLRDAGFSQVYSVAAQREPDGNFPTVNFPNPEEPGAMDMVIAEAGDKGALLACANDPDADRFALAAR
QSDGGYRMLSGDQTGALLCDYLLSHWQGAGVPLVGNTIVSSALLHAIAAHYGAHSYTTLTGFKWLMNTAQQLETPQQPFL
FAYEEALGYTVGNLVWDKDGISAQLCFANLAAELLAEGKDVWAALERLYRRHGLYVNRQVSIALGEGTPDIGAWLRDNPP
TEIDKRPVVAREDLKRLRKVYADGREEEIALPASDVLIYHLGASDATPGSTARVIVRPSGTEPKIKCYYELVLPMADDIA
MADAQLQGDALMTALVDGHQAGLPR

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=582, Percent_Identity=35.0515463917526, Blast_Score=321, Evalue=2e-87,
Organism=Homo sapiens, GI31377548, Length=612, Percent_Identity=31.5359477124183, Blast_Score=268, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI71993870, Length=616, Percent_Identity=34.0909090909091, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71993878, Length=334, Percent_Identity=35.9281437125749, Blast_Score=189, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6323934, Length=573, Percent_Identity=33.6823734729494, Blast_Score=269, Evalue=1e-72,
Organism=Drosophila melanogaster, GI20129809, Length=575, Percent_Identity=35.304347826087, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24651977, Length=469, Percent_Identity=37.953091684435, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24653722, Length=447, Percent_Identity=33.7807606263982, Blast_Score=227, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 63054; Mature: 63054

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTQLAFKVKHWLARDPDAKSRAALEALVAAGDDRALEAAFDGRLAFGTAGIRGIVGPGP
CCCCEEHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCEEEEECCCCCCCCCCCC
MGMNRLLVRETSAGLGAYLEAQIKDAKRRGLVIGFDGRHDSRVFAHDAACVLSAMGFKVR
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEHHHHHHHHHHCCCEEE
LTSHVAPTPLVAFGVKHFEAAAGIVVTASHNPPKYNGYKVYWENGAQIIPPHDAGIAACI
EECCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCEEECCCCCHHHHHH
DRAANLELPWMPEPEAVKQGRLSFLQDDFFERYRRAILHSPLLHPAGESQAGRASLGIAY
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCEEE
TAMHGVGAPMAERVLRDAGFSQVYSVAAQREPDGNFPTVNFPNPEEPGAMDMVIAEAGDK
EHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCC
GALLACANDPDADRFALAARQSDGGYRMLSGDQTGALLCDYLLSHWQGAGVPLVGNTIVS
CEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCEECHHHHH
SALLHAIAAHYGAHSYTTLTGFKWLMNTAQQLETPQQPFLFAYEEALGYTVGNLVWDKDG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCCHHCEEECCCC
ISAQLCFANLAAELLAEGKDVWAALERLYRRHGLYVNRQVSIALGEGTPDIGAWLRDNPP
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCCC
TEIDKRPVVAREDLKRLRKVYADGREEEIALPASDVLIYHLGASDATPGSTARVIVRPSG
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEECCCCCCCCCCEEEEEECCC
TEPKIKCYYELVLPMADDIAMADAQLQGDALMTALVDGHQAGLPR
CCCCEEEEEEEECCCCCCHHHHCCHHCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDTQLAFKVKHWLARDPDAKSRAALEALVAAGDDRALEAAFDGRLAFGTAGIRGIVGPGP
CCCCEEHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCEEEEECCCCCCCCCCCC
MGMNRLLVRETSAGLGAYLEAQIKDAKRRGLVIGFDGRHDSRVFAHDAACVLSAMGFKVR
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEHHHHHHHHHHCCCEEE
LTSHVAPTPLVAFGVKHFEAAAGIVVTASHNPPKYNGYKVYWENGAQIIPPHDAGIAACI
EECCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCEEECCCCCHHHHHH
DRAANLELPWMPEPEAVKQGRLSFLQDDFFERYRRAILHSPLLHPAGESQAGRASLGIAY
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCEEE
TAMHGVGAPMAERVLRDAGFSQVYSVAAQREPDGNFPTVNFPNPEEPGAMDMVIAEAGDK
EHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCC
GALLACANDPDADRFALAARQSDGGYRMLSGDQTGALLCDYLLSHWQGAGVPLVGNTIVS
CEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCEECHHHHH
SALLHAIAAHYGAHSYTTLTGFKWLMNTAQQLETPQQPFLFAYEEALGYTVGNLVWDKDG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCCHHCEEECCCC
ISAQLCFANLAAELLAEGKDVWAALERLYRRHGLYVNRQVSIALGEGTPDIGAWLRDNPP
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCCC
TEIDKRPVVAREDLKRLRKVYADGREEEIALPASDVLIYHLGASDATPGSTARVIVRPSG
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEECCCCCCCCCCEEEEEECCC
TEPKIKCYYELVLPMADDIAMADAQLQGDALMTALVDGHQAGLPR
CCCCEEEEEEEECCCCCCHHHHCCHHCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]