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The map label for this gene is 119774315

Identifier: 119774315

GI number: 119774315

Start: 1439543

End: 1440259

Strand: Direct

Name: 119774315

Synonym: Sama_1178

Alternate gene names: NA

Gene position: 1439543-1440259 (Clockwise)

Preceding gene: 119774314

Following gene: 119774317

Centisome position: 33.43

GC content: 55.23

Gene sequence:

>717_bases
ATGAGGATTGCAATAAGCTGGTGTACTGCGTTGATGATAGGGACTATTGCCAATACGCAGGCACTGGAAATCACGCCCTT
GTCTGATGGGCTTTTCCTGCACCAGAGCGAGAAAGAAGTCGAAGGCTTTGGCAAAGTCTCCGCCAATGGTCTGATAATCG
TGGATGGCAAAGAGGCGTTTGTGGTGGATACGCCCTGGACGGATGCCGATGCAGAGGCCTTGCTCGAATGGACAAAGGCT
AAAGACTTAACCGTAAAAGCCGTGCTCGCCACCCATTGGCATGAAGACAGGGCCGGCAGCTTTGGGGTATTTGAGAGAGC
CGGTATCGCCACCCTAAGCTCTGAGGCGACCCAGGCCCTTTTGAGGCAACATCAAAAGACGCTGGCGACCCACACCTTCA
GTGGCGACGAAATACAGTATTTTGGCAACAAGGTAGAGGTGTTTTATCCCGGTGCTGGCCATGCGATGGATAATCTGGTG
GTGTACCTGCCTCACGAAAAGCTGCTCTTTGGCGGCTGCCTGGTGCGGGAGGCGTCAACCCGGTTTATGGGGTTTTATGG
CGATGGCTCATTGCCTGACTGGCCTGAGTCCATGTCGCGGCTGATAGCGAAATTCCCTGAAGTCATCACAGTGGTGCCGG
GCCATGGCGCGCTGGGGGATAAGCGCCTGCTTGAACACACAAGGGGGCTGGCAGAGGCCGCGCTCAAGGCACAATAA

Upstream 100 bases:

>100_bases
GTGCCTGATAAGGCGTTTTGAGGGGATACGGCTTGTTGACCCAGAGATGTATGAATAGCGCCGCCTCGTGCGGCGCTTTT
GTTCTGATAAAGGAGTGTCC

Downstream 100 bases:

>100_bases
AGCGGGTTAGCCGGATTAATCGAGCCCCAAGCGGGCTTCTGATTCCAGCCACTTGGCCCTGCTCAGTGGCTGATTATTTT
CACCTTCGAGGGCTTTTCTG

Product: Beta-lactamase

Products: NA

Alternate protein names: BLAIMP; Beta-lactamase type II; Penicillinase [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MRIAISWCTALMIGTIANTQALEITPLSDGLFLHQSEKEVEGFGKVSANGLIIVDGKEAFVVDTPWTDADAEALLEWTKA
KDLTVKAVLATHWHEDRAGSFGVFERAGIATLSSEATQALLRQHQKTLATHTFSGDEIQYFGNKVEVFYPGAGHAMDNLV
VYLPHEKLLFGGCLVREASTRFMGFYGDGSLPDWPESMSRLIAKFPEVITVVPGHGALGDKRLLEHTRGLAEAALKAQ

Sequences:

>Translated_238_residues
MRIAISWCTALMIGTIANTQALEITPLSDGLFLHQSEKEVEGFGKVSANGLIIVDGKEAFVVDTPWTDADAEALLEWTKA
KDLTVKAVLATHWHEDRAGSFGVFERAGIATLSSEATQALLRQHQKTLATHTFSGDEIQYFGNKVEVFYPGAGHAMDNLV
VYLPHEKLLFGGCLVREASTRFMGFYGDGSLPDWPESMSRLIAKFPEVITVVPGHGALGDKRLLEHTRGLAEAALKAQ
>Mature_238_residues
MRIAISWCTALMIGTIANTQALEITPLSDGLFLHQSEKEVEGFGKVSANGLIIVDGKEAFVVDTPWTDADAEALLEWTKA
KDLTVKAVLATHWHEDRAGSFGVFERAGIATLSSEATQALLRQHQKTLATHTFSGDEIQYFGNKVEVFYPGAGHAMDNLV
VYLPHEKLLFGGCLVREASTRFMGFYGDGSLPDWPESMSRLIAKFPEVITVVPGHGALGDKRLLEHTRGLAEAALKAQ

Specific function: Confers resistance to imipenem and broad-spectrum beta- lactams. Also hydrolyzes carbapenems [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 25955; Mature: 25955

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAISWCTALMIGTIANTQALEITPLSDGLFLHQSEKEVEGFGKVSANGLIIVDGKEAF
CEEEHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCHHHHCCCCCCCCCEEEECCCCEE
VVDTPWTDADAEALLEWTKAKDLTVKAVLATHWHEDRAGSFGVFERAGIATLSSEATQAL
EEECCCCCCCHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHH
LRQHQKTLATHTFSGDEIQYFGNKVEVFYPGAGHAMDNLVVYLPHEKLLFGGCLVREAST
HHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCCCCCCEEEEECCCCEEHHHHHEECCCC
RFMGFYGDGSLPDWPESMSRLIAKFPEVITVVPGHGALGDKRLLEHTRGLAEAALKAQ
EEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIAISWCTALMIGTIANTQALEITPLSDGLFLHQSEKEVEGFGKVSANGLIIVDGKEAF
CEEEHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCHHHHCCCCCCCCCEEEECCCCEE
VVDTPWTDADAEALLEWTKAKDLTVKAVLATHWHEDRAGSFGVFERAGIATLSSEATQAL
EEECCCCCCCHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHH
LRQHQKTLATHTFSGDEIQYFGNKVEVFYPGAGHAMDNLVVYLPHEKLLFGGCLVREAST
HHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCCCCCCEEEEECCCCEEHHHHHEECCCC
RFMGFYGDGSLPDWPESMSRLIAKFPEVITVVPGHGALGDKRLLEHTRGLAEAALKAQ
EEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8141584 [H]