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The map label for this gene is pcm

Identifier: 119774179

GI number: 119774179

Start: 1259913

End: 1260548

Strand: Direct

Name: pcm

Synonym: Sama_1042

Alternate gene names: 119774179

Gene position: 1259913-1260548 (Clockwise)

Preceding gene: 119774178

Following gene: 119774180

Centisome position: 29.26

GC content: 54.25

Gene sequence:

>636_bases
ATGAACCAGACCGGCTCGACGGTGGCAATCAACCTTGCAAAGAAGTTGTATGACGCTGGGATCCGCGACAACCTCGTTTT
GCAGGCCATCGCCAACACGCCCCGGGAAATGTTTCTGGATGCAGCTCTGGCACACAAAGCCTATGAAAACACCGCGCTGC
CCATAGGTCAGGGGCAGACCATTTCCCAACCTTATATCGTGGCGCGCATGACAGAGCTGGTGATGCAAAACCGGCCTCAA
CGGGTGCTGGAAGTGGGTACGGGCTCTGGCTATCAGGCTGCTATCCTGGCGAAACTGGTACCAGAGCTTTGCACCATAGA
GCGGATTAAGGCACTGCAAATTCAGGCAAGGCAACGTCTTAAGCGTCTGGATTTGCACAATGTGTCTTTTAAGTATGGTG
ATGGCTGGCTGGGTTGGCCCAACCGTGGTCCCTTTGATGCCATCATGGTGACAGCCGCAGCCGCAAGCTTACCAACTGCT
TTACTTGAGCAATTGTCTGAAGGCGGGAGGCTCATTATTCCGGTGGGTGAGGATGCCCAGCAATTATTGGCCATTACCCG
CAAGGGGCAGGAGTATTCCTCCGAGGTCATTGAGTCGGTAAAGTTTGTGCCCTTGGTCAACGGAAACCTGGCGTAG

Upstream 100 bases:

>100_bases
TTGGTGCCGTGGCTGAAGGCTATGTGTCCATCACGCCGTTAACCGTCGACCTGACCGCACACAGTCAACTTAACGCACTG
GCAAACTGGATAGAAAAGAT

Downstream 100 bases:

>100_bases
GTCATTATGACTTCGGGAGCTGCTCATTCATGTTGAGATTGACAACTTGCTGCCTCTGTTTGCTCTTGTTGGCTGGTTGC
AGCATGCAGGCGCACTCACC

Product: protein-L-isoaspartate(D-aspartate) O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MNQTGSTVAINLAKKLYDAGIRDNLVLQAIANTPREMFLDAALAHKAYENTALPIGQGQTISQPYIVARMTELVMQNRPQ
RVLEVGTGSGYQAAILAKLVPELCTIERIKALQIQARQRLKRLDLHNVSFKYGDGWLGWPNRGPFDAIMVTAAAASLPTA
LLEQLSEGGRLIIPVGEDAQQLLAITRKGQEYSSEVIESVKFVPLVNGNLA

Sequences:

>Translated_211_residues
MNQTGSTVAINLAKKLYDAGIRDNLVLQAIANTPREMFLDAALAHKAYENTALPIGQGQTISQPYIVARMTELVMQNRPQ
RVLEVGTGSGYQAAILAKLVPELCTIERIKALQIQARQRLKRLDLHNVSFKYGDGWLGWPNRGPFDAIMVTAAAASLPTA
LLEQLSEGGRLIIPVGEDAQQLLAITRKGQEYSSEVIESVKFVPLVNGNLA
>Mature_211_residues
MNQTGSTVAINLAKKLYDAGIRDNLVLQAIANTPREMFLDAALAHKAYENTALPIGQGQTISQPYIVARMTELVMQNRPQ
RVLEVGTGSGYQAAILAKLVPELCTIERIKALQIQARQRLKRLDLHNVSFKYGDGWLGWPNRGPFDAIMVTAAAASLPTA
LLEQLSEGGRLIIPVGEDAQQLLAITRKGQEYSSEVIESVKFVPLVNGNLA

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=202, Percent_Identity=32.1782178217822, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1789100, Length=200, Percent_Identity=60.5, Blast_Score=248, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71983477, Length=173, Percent_Identity=32.3699421965318, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193207222, Length=137, Percent_Identity=33.5766423357664, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17981723, Length=216, Percent_Identity=31.9444444444444, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_SHEAM (A1S4E3)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926919.1
- ProteinModelPortal:   A1S4E3
- SMR:   A1S4E3
- STRING:   A1S4E3
- GeneID:   4603294
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1042
- NMPDR:   fig|326297.7.peg.982
- eggNOG:   COG2518
- HOGENOM:   HBG699907
- OMA:   YSVERIR
- PhylomeDB:   A1S4E3
- ProtClustDB:   CLSK907169
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 23022; Mature: 23022

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 62-62

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTGSTVAINLAKKLYDAGIRDNLVLQAIANTPREMFLDAALAHKAYENTALPIGQGQT
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
ISQPYIVARMTELVMQNRPQRVLEVGTGSGYQAAILAKLVPELCTIERIKALQIQARQRL
CCCCHHHHHHHHHHHCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRLDLHNVSFKYGDGWLGWPNRGPFDAIMVTAAAASLPTALLEQLSEGGRLIIPVGEDAQ
HHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHH
QLLAITRKGQEYSSEVIESVKFVPLVNGNLA
HHHHHHHCCHHHHHHHHHHHHHEEECCCCCC
>Mature Secondary Structure
MNQTGSTVAINLAKKLYDAGIRDNLVLQAIANTPREMFLDAALAHKAYENTALPIGQGQT
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
ISQPYIVARMTELVMQNRPQRVLEVGTGSGYQAAILAKLVPELCTIERIKALQIQARQRL
CCCCHHHHHHHHHHHCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRLDLHNVSFKYGDGWLGWPNRGPFDAIMVTAAAASLPTALLEQLSEGGRLIIPVGEDAQ
HHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHH
QLLAITRKGQEYSSEVIESVKFVPLVNGNLA
HHHHHHHCCHHHHHHHHHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA