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The map label for this gene is truD [H]

Identifier: 119774177

GI number: 119774177

Start: 1258107

End: 1259189

Strand: Direct

Name: truD [H]

Synonym: Sama_1040

Alternate gene names: 119774177

Gene position: 1258107-1259189 (Clockwise)

Preceding gene: 119774176

Following gene: 119774178

Centisome position: 29.22

GC content: 57.16

Gene sequence:

>1083_bases
ATGACTGAGCTGACTTATCTTTACGGCAAGCCGGCTGTAAGCGCCGATATCCGCACCCACAACAGCGATTTTCAGGTAAA
GGAAATCCTGCCGTTCCTGCCCGATGGTGAGGGCGAGCACCACCTGCTGCATATCCGTAAAGATGGCCTGAACACGGCTC
AGGTGGCAGAGATGATTTCCAGATTTGCCAAGGTGCATCCCAAAGAAGTGACCTTTGCCGGTCAAAAAGACAAAAACGCC
ATTACAGAGCAGTGGTTTGGCGTGCGCATTCCCGGCAAGGAGACGCCAGACTGGGCTGCCATGAGCAATGAGCAGATGCA
GGTACTGTCGTTTGCCCGTCATGGTAAGAAGCTGCGCACCGGCGCGCTTTCAGGCAACCGCTTTACTTTGGTGCTGCGCA
ATGTTTCAGACCCAGAGGCGCTGGTTGCAAGGCTCGAGCTGGTGCGCGATGGCGGGGTGCCCAACTATTTTGGCGAGCAG
CGCTTTGGTCATGACGGTGGCAATCTTGTTAAAGCGCGGCAGATGTTCGAAGGCCGCAAAGTAAAAGACAGAAACAAACG
CAGTCTCTATCTCTCTGCGGTGCGCTCAGAGCTCTTTAATCAGGTGGCGAGTGCACGTCTGGCGCGTTTTGGCACAGCGC
CCATCGAGGGTGATTGTGTGATGCTGTCGGGCTCACGCAGCTTTTTTACGGCCGAAAGTTGGGATGACTCCCTGAATAAA
CGTCTTGCCGAGCAGGACATTCAGCTGTCGGCGCCACTTTGGGGCCGTGGTGAGCAGCTCGCCAAAGGCGACGCCGCAGC
ACTTGAATCTTCGGTGCTGGCAGCCTACGAGCTTGAGCGCAATGGTCTCGAAAAAGAAGGCCTTACCCAGGAGCGCCGAG
CACTGCTGCTGCGTCCTGAGCAGCTGAGCTTCAAGCTGGATGGCGATGCCCTGACCCTGGATTTCTGCCTGCCAGCGGGT
GCCTTTGCCACCAGTGTGCTCAGAGAGCTTTGCGAGTACACAGATATAAAAGAGCTGGAGTGGCGCCGGGCGGTGGCCGA
GCGTGATGCGCGGGAGGGCGACAATGCGCCTGCTGGTGAGTAA

Upstream 100 bases:

>100_bases
ATAATATCAACGTAAAAGCGACCACCACCGAGAAGCTTGGTTTCACCGGTCGCAAAGAAGGCATCGCCGTGGAAGCTGTG
GTGTTGATGGAGAATGTGAA

Downstream 100 bases:

>100_bases
CGATGATGGTGTGTATGCCCCGGGTATCAAGGCGCTGGCCGAGGCATTAAAGACCATTGCTCATGTGGATGTGGTGGCAC
CGGACAGAAACTGCTCCGCC

Product: pseudouridylate synthase

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D; tRNA-uridine isomerase D [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTELTYLYGKPAVSADIRTHNSDFQVKEILPFLPDGEGEHHLLHIRKDGLNTAQVAEMISRFAKVHPKEVTFAGQKDKNA
ITEQWFGVRIPGKETPDWAAMSNEQMQVLSFARHGKKLRTGALSGNRFTLVLRNVSDPEALVARLELVRDGGVPNYFGEQ
RFGHDGGNLVKARQMFEGRKVKDRNKRSLYLSAVRSELFNQVASARLARFGTAPIEGDCVMLSGSRSFFTAESWDDSLNK
RLAEQDIQLSAPLWGRGEQLAKGDAAALESSVLAAYELERNGLEKEGLTQERRALLLRPEQLSFKLDGDALTLDFCLPAG
AFATSVLRELCEYTDIKELEWRRAVAERDAREGDNAPAGE

Sequences:

>Translated_360_residues
MTELTYLYGKPAVSADIRTHNSDFQVKEILPFLPDGEGEHHLLHIRKDGLNTAQVAEMISRFAKVHPKEVTFAGQKDKNA
ITEQWFGVRIPGKETPDWAAMSNEQMQVLSFARHGKKLRTGALSGNRFTLVLRNVSDPEALVARLELVRDGGVPNYFGEQ
RFGHDGGNLVKARQMFEGRKVKDRNKRSLYLSAVRSELFNQVASARLARFGTAPIEGDCVMLSGSRSFFTAESWDDSLNK
RLAEQDIQLSAPLWGRGEQLAKGDAAALESSVLAAYELERNGLEKEGLTQERRALLLRPEQLSFKLDGDALTLDFCLPAG
AFATSVLRELCEYTDIKELEWRRAVAERDAREGDNAPAGE
>Mature_359_residues
TELTYLYGKPAVSADIRTHNSDFQVKEILPFLPDGEGEHHLLHIRKDGLNTAQVAEMISRFAKVHPKEVTFAGQKDKNAI
TEQWFGVRIPGKETPDWAAMSNEQMQVLSFARHGKKLRTGALSGNRFTLVLRNVSDPEALVARLELVRDGGVPNYFGEQR
FGHDGGNLVKARQMFEGRKVKDRNKRSLYLSAVRSELFNQVASARLARFGTAPIEGDCVMLSGSRSFFTAESWDDSLNKR
LAEQDIQLSAPLWGRGEQLAKGDAAALESSVLAAYELERNGLEKEGLTQERRALLLRPEQLSFKLDGDALTLDFCLPAGA
FATSVLRELCEYTDIKELEWRRAVAERDAREGDNAPAGE

Specific function: Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs [H]

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain [H]

Homologues:

Organism=Escherichia coli, GI1789102, Length=335, Percent_Identity=46.5671641791045, Blast_Score=275, Evalue=5e-75,
Organism=Drosophila melanogaster, GI21355799, Length=122, Percent_Identity=32.7868852459016, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR020119
- InterPro:   IPR011760 [H]

Pfam domain/function: PF01142 TruD [H]

EC number: NA

Molecular weight: Translated: 40151; Mature: 40020

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50984 TRUD ; PS01268 UPF0024

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELTYLYGKPAVSADIRTHNSDFQVKEILPFLPDGEGEHHLLHIRKDGLNTAQVAEMIS
CCCEEEEECCCCCCCEEEECCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHH
RFAKVHPKEVTFAGQKDKNAITEQWFGVRIPGKETPDWAAMSNEQMQVLSFARHGKKLRT
HHHHCCCCCEEECCCCCCHHHHHHHCEEECCCCCCCCHHHCCCCHHHHHHHHHCCCHHHH
GALSGNRFTLVLRNVSDPEALVARLELVRDGGVPNYFGEQRFGHDGGNLVKARQMFEGRK
CCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
VKDRNKRSLYLSAVRSELFNQVASARLARFGTAPIEGDCVMLSGSRSFFTAESWDDSLNK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEECCHHHHHHHH
RLAEQDIQLSAPLWGRGEQLAKGDAAALESSVLAAYELERNGLEKEGLTQERRALLLRPE
HHHHHCCEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEECCH
QLSFKLDGDALTLDFCLPAGAFATSVLRELCEYTDIKELEWRRAVAERDAREGDNAPAGE
HCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TELTYLYGKPAVSADIRTHNSDFQVKEILPFLPDGEGEHHLLHIRKDGLNTAQVAEMIS
CCEEEEECCCCCCCEEEECCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHH
RFAKVHPKEVTFAGQKDKNAITEQWFGVRIPGKETPDWAAMSNEQMQVLSFARHGKKLRT
HHHHCCCCCEEECCCCCCHHHHHHHCEEECCCCCCCCHHHCCCCHHHHHHHHHCCCHHHH
GALSGNRFTLVLRNVSDPEALVARLELVRDGGVPNYFGEQRFGHDGGNLVKARQMFEGRK
CCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
VKDRNKRSLYLSAVRSELFNQVASARLARFGTAPIEGDCVMLSGSRSFFTAESWDDSLNK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEECCHHHHHHHH
RLAEQDIQLSAPLWGRGEQLAKGDAAALESSVLAAYELERNGLEKEGLTQERRALLLRPE
HHHHHCCEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEECCH
QLSFKLDGDALTLDFCLPAGAFATSVLRELCEYTDIKELEWRRAVAERDAREGDNAPAGE
HCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]