Click here to switch to the map view.

The map label for this gene is deoA

Identifier: 119774111

GI number: 119774111

Start: 1177666

End: 1178997

Strand: Direct

Name: deoA

Synonym: Sama_0974

Alternate gene names: 119774111

Gene position: 1177666-1178997 (Clockwise)

Preceding gene: 119774110

Following gene: 119774112

Centisome position: 27.35

GC content: 56.01

Gene sequence:

>1332_bases
ATGTTTCTGGCACAAGAGATTATTCGCAAAAAACGCAACGCAGAGGCCCTCAGCAAAGAAGAAATTCAATTCTTTGTGAA
GGGGATTACCGACAACAGCGTATCCGAAGGACAGATTGCCGCGCTGGGTATGGCGGTATATTTCAATGACATGACCATGG
ACGAGCGTATTGCGCTGACCACGGCCATGCGCGATTCAGGTACCGTGCTCAACTGGGATAGCCTGGGGTTGAACGGCCCT
GTTATTGATAAGCACAGCACAGGCGGTGTGGGCGATGTGATTTCGCTGATGCTCGGCCCCATGGCCGCAGCCTGTGGTGG
TTATGTGCCCATGATTTCGGGCCGGGGGCTGGGTCATACCGGTGGCACACTGGATAAGTTTGACGCCATTCCCGGTTACC
AAACCGAGCCCTCCAGCGAGCTGTTCCGCAAAGTGGTAAAAGAAGCCGGTGTTGCCATTATTGGCCAAACCGGGGATCTG
GTGCCCGCCGACAAGCGTTTCTATTCCATTCGAGACAACACCGCCACAGTTGAGTCCATTTCACTTATCACCGCATCGAT
TCTGTCCAAGAAGCTGGCCGCAGGCCTGGATGCGCTGGCAATGGACGTCAAGGTAGGCAGCGGCGCCTTTATGCCGACCT
ACGAAGCCTCGTTGGAACTCGCGCGCTCCATTACCGCCGTGGCTAACGGCGCCGGCACCAAAACCACAGCGCTGCTCACC
GACATGAATCAGGTGTTGGCTTCCTGCGCCGGTAACGCGCTGGAAGTGAAAGAAGCCGTGGATTTCCTGACCGGAAAATA
CCGTAATCCTCGCCTTTACGAAGTCACCATGGGCCTGTGCGCCGAGATGCTGGTGCTGGGTGGTCTGGCCGCCAATGACG
CCGATGCCCGTACCAAGCTCAACACAGTGCTGGATAACGGCCGTGCTGCCGAGATTTTTGGCAAGATGGTGTCCGGCCTG
GGCGGCCCTGCTGATTTCGTTGAAAGTTACGATAAGTATCTGCCCAAGGCATCCATAATACGCCCCGTGTACGCAGAACG
TGACGGCTTTGCCTATAGTATGGTGACCCGTGAGCTGGGTCTTGCCGTGGTCACTCTGGGTGGTGGCCGTCGCAAGCCCG
GTGATGCACTGGATTACAGTGTAGGCTTGTCCAACGTGTGTGCCCTTGGTCAGCCAATAAACAAAGACACGCCGCTTGCC
GTAATCCATGCCCAGTCTGAGGCCGCTTTTGAAGAAGCCGCCAGGGCCGTTCGTGGGGCTATCACTGTCAGCGACAAGCA
ACCCGAAAAAACACCTGAGATCTATCAGTACGTACGTGCTGAAGATCTGTAA

Upstream 100 bases:

>100_bases
TTGGCTAATATGAGTCTGTAATATTTTTACAGTTTCGACGTTCCAGAGGACGAATTGTCGGTAGAAACTGAAAGCTACCG
ACATTCTTGGAGACAGCAGT

Downstream 100 bases:

>100_bases
GGGGAAGAGTTATGAAACGTACCATTATTTTGATGCTGGACTCCTTCGGCATCGGTGCTGCCGATGATGCAGACAAGTTC
GGCGACGTGGGGTCAGACAC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MFLAQEIIRKKRNAEALSKEEIQFFVKGITDNSVSEGQIAALGMAVYFNDMTMDERIALTTAMRDSGTVLNWDSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKEAGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLAAGLDALAMDVKVGSGAFMPTYEASLELARSITAVANGAGTKTTALLT
DMNQVLASCAGNALEVKEAVDFLTGKYRNPRLYEVTMGLCAEMLVLGGLAANDADARTKLNTVLDNGRAAEIFGKMVSGL
GGPADFVESYDKYLPKASIIRPVYAERDGFAYSMVTRELGLAVVTLGGGRRKPGDALDYSVGLSNVCALGQPINKDTPLA
VIHAQSEAAFEEAARAVRGAITVSDKQPEKTPEIYQYVRAEDL

Sequences:

>Translated_443_residues
MFLAQEIIRKKRNAEALSKEEIQFFVKGITDNSVSEGQIAALGMAVYFNDMTMDERIALTTAMRDSGTVLNWDSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKEAGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLAAGLDALAMDVKVGSGAFMPTYEASLELARSITAVANGAGTKTTALLT
DMNQVLASCAGNALEVKEAVDFLTGKYRNPRLYEVTMGLCAEMLVLGGLAANDADARTKLNTVLDNGRAAEIFGKMVSGL
GGPADFVESYDKYLPKASIIRPVYAERDGFAYSMVTRELGLAVVTLGGGRRKPGDALDYSVGLSNVCALGQPINKDTPLA
VIHAQSEAAFEEAARAVRGAITVSDKQPEKTPEIYQYVRAEDL
>Mature_443_residues
MFLAQEIIRKKRNAEALSKEEIQFFVKGITDNSVSEGQIAALGMAVYFNDMTMDERIALTTAMRDSGTVLNWDSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKEAGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLAAGLDALAMDVKVGSGAFMPTYEASLELARSITAVANGAGTKTTALLT
DMNQVLASCAGNALEVKEAVDFLTGKYRNPRLYEVTMGLCAEMLVLGGLAANDADARTKLNTVLDNGRAAEIFGKMVSGL
GGPADFVESYDKYLPKASIIRPVYAERDGFAYSMVTRELGLAVVTLGGGRRKPGDALDYSVGLSNVCALGQPINKDTPLA
VIHAQSEAAFEEAARAVRGAITVSDKQPEKTPEIYQYVRAEDL

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=442, Percent_Identity=39.1402714932127, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI4503445, Length=442, Percent_Identity=39.1402714932127, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI166158922, Length=442, Percent_Identity=39.1402714932127, Blast_Score=277, Evalue=1e-74,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=66.8949771689498, Blast_Score=606, Evalue=1e-174,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_SHEAM (A1S475)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926851.1
- ProteinModelPortal:   A1S475
- SMR:   A1S475
- STRING:   A1S475
- GeneID:   4603226
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0974
- NMPDR:   fig|326297.7.peg.914
- eggNOG:   COG0213
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- PhylomeDB:   A1S475
- ProtClustDB:   PRK05820
- HAMAP:   MF_01628
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02643
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 46931; Mature: 46931

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLAQEIIRKKRNAEALSKEEIQFFVKGITDNSVSEGQIAALGMAVYFNDMTMDERIALT
CCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEE
TAMRDSGTVLNWDSLGLNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEECCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYQTEPSSELFRKVVKEAGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLAAGLDALAMDVKVGSGAFMPTYEASLELARSITAVANGAGTKTTALLT
HHHHHHHHHHHHHHCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNALEVKEAVDFLTGKYRNPRLYEVTMGLCAEMLVLGGLAANDADARTKL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHHHH
NTVLDNGRAAEIFGKMVSGLGGPADFVESYDKYLPKASIIRPVYAERDGFAYSMVTRELG
HHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCHHHHCCCCCCHHHHHHHHC
LAVVTLGGGRRKPGDALDYSVGLSNVCALGQPINKDTPLAVIHAQSEAAFEEAARAVRGA
EEEEEECCCCCCCCCCCCHHHCHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCC
ITVSDKQPEKTPEIYQYVRAEDL
EEECCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MFLAQEIIRKKRNAEALSKEEIQFFVKGITDNSVSEGQIAALGMAVYFNDMTMDERIALT
CCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEE
TAMRDSGTVLNWDSLGLNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEECCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYQTEPSSELFRKVVKEAGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLAAGLDALAMDVKVGSGAFMPTYEASLELARSITAVANGAGTKTTALLT
HHHHHHHHHHHHHHCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNALEVKEAVDFLTGKYRNPRLYEVTMGLCAEMLVLGGLAANDADARTKL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHHHH
NTVLDNGRAAEIFGKMVSGLGGPADFVESYDKYLPKASIIRPVYAERDGFAYSMVTRELG
HHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCHHHHCCCCCCHHHHHHHHC
LAVVTLGGGRRKPGDALDYSVGLSNVCALGQPINKDTPLAVIHAQSEAAFEEAARAVRGA
EEEEEECCCCCCCCCCCCHHHCHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCC
ITVSDKQPEKTPEIYQYVRAEDL
EEECCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA