Click here to switch to the map view.

The map label for this gene is lspA

Identifier: 119774062

GI number: 119774062

Start: 1119245

End: 1119751

Strand: Direct

Name: lspA

Synonym: Sama_0925

Alternate gene names: 119774062

Gene position: 1119245-1119751 (Clockwise)

Preceding gene: 119774061

Following gene: 119774063

Centisome position: 25.99

GC content: 52.86

Gene sequence:

>507_bases
ATGCAATTGAACTGGAAAGAAAGTGGCCTGCGCTGGTATTGGGTAGTAGTGGTGGTGTTTCTGGCCGACCAGCTGTCCAA
GCAGTGGGTACTGGCCAACTTTGACCTGTACGAGTCGGTCAAGCTGCTGCCGTTTTTTAACTTCACCTATGTGCGCAACT
ATGGCGCTGCCTTCAGCTTCCTGCATGATGCAGGGGGCTGGCAGCGCTGGCTGTTTACGGCGGTGGCTGTGGGCTTCAGC
GTGCTGTTAACCATTTGGCTGCGTAAGCAGCCAGCCAACATGGTGCGGCTGAATCTGGCCTACACCTTGGTGATTGGCGG
TGCGCTTGGTAATCTGATTGACCGTCTGCAACATGGCTTTGTGGTGGATTTCCTCGATTTTTATTGGAACACCGCCCATT
ACCCGGCGTTTAACATAGCAGATGCCGCCATCTTTATTGGTGCCGTGCTGATTATTATCGACAGCTTTAAAGCGTCCAGC
TCGGATGACAAGGCCATCAAGGAGTAA

Upstream 100 bases:

>100_bases
AGGATGTGGGTTCAGTTGAAGCGCACCCAAGCCTGTGTGGCCGCTGTGTGACCAACATTGAGGGTGAGGGCGAAGCCCGC
GCCTTCGCATAAGGATGGCC

Downstream 100 bases:

>100_bases
CACATGAGCCAAAAGTCGTTGCTGTGCCATATGAATATTCTCTTGTCTGACGGTTCTACCGCCGACAGCACCAAGGCGTC
GGGTAAGCCCGCTCGCCTCA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MQLNWKESGLRWYWVVVVVFLADQLSKQWVLANFDLYESVKLLPFFNFTYVRNYGAAFSFLHDAGGWQRWLFTAVAVGFS
VLLTIWLRKQPANMVRLNLAYTLVIGGALGNLIDRLQHGFVVDFLDFYWNTAHYPAFNIADAAIFIGAVLIIIDSFKASS
SDDKAIKE

Sequences:

>Translated_168_residues
MQLNWKESGLRWYWVVVVVFLADQLSKQWVLANFDLYESVKLLPFFNFTYVRNYGAAFSFLHDAGGWQRWLFTAVAVGFS
VLLTIWLRKQPANMVRLNLAYTLVIGGALGNLIDRLQHGFVVDFLDFYWNTAHYPAFNIADAAIFIGAVLIIIDSFKASS
SDDKAIKE
>Mature_168_residues
MQLNWKESGLRWYWVVVVVFLADQLSKQWVLANFDLYESVKLLPFFNFTYVRNYGAAFSFLHDAGGWQRWLFTAVAVGFS
VLLTIWLRKQPANMVRLNLAYTLVIGGALGNLIDRLQHGFVVDFLDFYWNTAHYPAFNIADAAIFIGAVLIIIDSFKASS
SDDKAIKE

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=164, Percent_Identity=50.609756097561, Blast_Score=168, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_SHEAM (A1S426)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926802.1
- STRING:   A1S426
- MEROPS:   A08.001
- GeneID:   4603177
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0925
- NMPDR:   fig|326297.7.peg.872
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   ADSSGWQ
- PhylomeDB:   A1S426
- ProtClustDB:   PRK00376
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 19224; Mature: 19224

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 114-114 ACT_SITE 141-141

Signals:

None

Transmembrane regions:

HASH(0x1237b270)-; HASH(0x127a57d0)-; HASH(0x125a4274)-; HASH(0x122c342c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNWKESGLRWYWVVVVVFLADQLSKQWVLANFDLYESVKLLPFFNFTYVRNYGAAFSF
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHEEECHHHHHHHHHHHHH
LHDAGGWQRWLFTAVAVGFSVLLTIWLRKQPANMVRLNLAYTLVIGGALGNLIDRLQHGF
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCH
VVDFLDFYWNTAHYPAFNIADAAIFIGAVLIIIDSFKASSSDDKAIKE
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
>Mature Secondary Structure
MQLNWKESGLRWYWVVVVVFLADQLSKQWVLANFDLYESVKLLPFFNFTYVRNYGAAFSF
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHEEECHHHHHHHHHHHHH
LHDAGGWQRWLFTAVAVGFSVLLTIWLRKQPANMVRLNLAYTLVIGGALGNLIDRLQHGF
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCH
VVDFLDFYWNTAHYPAFNIADAAIFIGAVLIIIDSFKASSSDDKAIKE
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA